Local immunotherapy

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 53, Issue 10, 1998, Pages 933-943

  Malling, H J ^a,b   Abreu Nogueira, J ^a   Alvarez Cuesta, E ^a   Bjorksten B ^a   Bousquet, J ^a   Caillot, D ^a   Canonica, G W ^a   Passalacqua, G ^a   Saxonis Papageorgiou, P ^a   Valovirta, E ^a  

^a 1 EAACI Immunotherapy Subcommittee ^*

^b University of Copenhagen   (Denmark)

Author keywords

Bronchial immunotherapy; Clinical efficacy; Nasal immunotherapy; Oral immunotherapy; Sublingual immunotherapy

Indexed keywords

HOUSE DUST ALLERGEN; POLLEN EXTRACT;

ALLERGIC RHINITIS; ASTHMA; BRONCHOSPASM; DESENSITIZATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERANCE; HUMAN; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; IMMUNOTHERAPY; PRIORITY JOURNAL; REVIEW; URTICARIA;

EID: 0242653739     PISSN: 01054538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1398-9995.1998.tb03793.x     Document Type: Review

References (89)

1. Watkins AD. The role of alternative therapies in the treatment of allergic diseases. Clin Exp Allergy 1994;24:813-25.
2. Holt PG, Batty JE, Turner KJ. Inhibition of specific IgE responses in mice by pre-exposure to inhaled antigen. Immunology 1981;42:409-17.
3. Holt PG, Sedgewick JD. Suppression of IgE responses following inhalation of antigen. A natural homeostatic mechanism which limits sensitization to aeroallergens. Immunol Today 1987;8:14-26.
4. Holt PG, Britten D, Scdgewick JD. Suppression of IgE responses by antigen inhalation: studies on the role of genetic and environmental factors. Immunology 1987;60:97-102.
5. Holt PG, McMenamin C. Defence against allergic sensitization in healthy lung: the role of inhalation tolerance. Clin Exp Allergy 1989;19:55-62.
6. Mowart AM. The regulation of immune response to dietary proteins. Immunol Today 1987;8:93-6.
7. Holt PG, Vines J, Britten D. Sublingual allergen administration. I. Selective suppression of IgE production in rats by high allergen doses. Clin Allergy 1988;18:229-34.
8. Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994; 265: 1237-40.
9. Eriksson K, Ahlfors E, George-Chandy A, Kaiserlian D, Czerkinsky C. Antigen presentation in the murine oral epithelium. Immunology 1996;88:147-52.
10. van-Wilsem EJ, van-Hoogstraten IM, Breve J, Scheper RJ, Kraal G. Dendritic cells of the oral mucosa and the induction of oral tolerance. A local affair. Immunology 1994;83:128-32.
11. Hasseus B, Dahlgren U, Bergenholtz G, Jontell M. Antigen presenting capacity of Langerhans cells from rat oral epithelium. J Oral Pathol Med 1995;24:56-60.
12. Manetti R, Parronchi P, Giudizi MG, et al. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J Exp Med 1993;177:1199-1204.
13. Macatinia SE, Hosken NA, Litton M, et al. Dendritic cells produce IL-12 and direct the development of ThI cells from naive CD4+ T cells. J Immunol 1995;154:5071-9.
14. Bagnasco M, Mariani G, Passalacqua G, et al. Absorption and distribution kinetics of the major Parietaria judaica (Par j 1) allergen administered by noninjectable routes to healthy human beings. J Allergy Clin Immunol 1997;100: 122-9.
15. Cohn JR, Pizzi A. Determinants of patient compliance with allergen immunotherapy. J Allergy Clin Immunol 1993;91: 734-7.
16. Malling H-J, Wecke B. Immunotherapy. EAACI Position paper. Allergy 1993;38 Suppl 14:9-45.
17. Hejjaoui J, Ferrando R, Dhivert H, Michel FB, Bousquet J. Systemic reactions occurring during immunotherapy with standardized pollen extracts. J Allergy Clin Immunol 1992;89:925-33.
18. Tabar AI, Garcia BE, Rodriguez A, Olaguibel JM, Muro MD, Quirce S. A prospective safely-monitoring study of immunotherapy with biologically standardized extracts. Allergy 1993;48:450-3.
19. Curtis HH. The immunizing cure of hay fever. Med News (NY) 1900;77:16-18.
20. Black JH. The oral administration of pollen. J Lab Clin Med 1927;12:1156-9.
21. Feinberg SM, Foran FL, Lichtenstein MR. Oral pollen therapy in ragweed pollinosis. J Am Med Assoc 1940;115: 23-9.
22. Committee on the Safety of Medicine. CSM update, Desensitizing vaccines. BMJ 1986;293:948.
23. Greenberg MA, Kaufman CR, Gonzales GE. Late and immediate systemic allergic reactions to inhalant allergen immunotherapy. J Allergy Clion Immunol 1986; 77:865-70.
24. Lockey RF, Benedict LM, Turkeltaub PC, Bukantz SC. Fatalities from immunotherapy and skin testing. J Allergy Clin Immunol 1987;79:660-77.
25. Dreborg S, Frew A, editors. Allergen standardization and skin tests. Allergy 1993;48 Suppl 14:49-82.
26. Giovane AL, Bardare M, Passalacqua G, et al. A three-year double-blind placebo-controlled study with specific oral immunotherapy to Dermatophagoides: evidence of safely and efficacy in paediatric patients. Clin Exp Allergy 1994;24:53-9.
27. Malling H-J. New ideas in allergen-specific immunotherapy. Am J Rhinol 1990;4:155-8.
28. Johansson SGO, Deuschl H, Zellerström O. Use of glutaraldehyde-modified timothy grass pollen extract in nasal hyposensitisation treatment of hay fever. Int Arch Allergy Appl Immunol 1979;60:447-60.
29. Nickelsen JA, Goldstein S, Mueller U, Wypych J, Reisman RE, Arhesman CE. Local intranasal immunotherapy for ragweed allergic rhinitis. I. Clinical response. J Allergy Clin Immunol 1981;68:33-40.
30. Welsh PW, Zimmermann EM, Yunginger JW, Kern EB, Gleich GJ. Preseasonal intranasal immunotherapy with nebulized short ragweed extract. J Allergy Clin Immunol 1981;67:237-42.
31. Schumacher MJ, Pain MC. Intranasal immunotherapy and polymerized grass pollen allergens. Allergy 1982;37:241-8.
32. Georgitis JW, Reisman RE, Clayton WF, Mueller UR, Wypych JI, Arhesman CE. Local intranasal immunotherapy for grass-allergic rhinitis. J Allergy Clin Immunol 1983;71:71-6.
33. Georgitis JW, Clayton WF, Wypych JI, Barde SH, Reisman RE. Further evaluation of local intranasal immunotherapy with aqueous and allergoid grass extracts. J Allergy Clin Immunol 1984;74:694-700.
34. Andri L, Senna GE, Betteli C, et al. Local nasal immunotherapy in allergic rhinitis to Parietaria. A double-blind controlled study. Allergy 1992;47:318-23.
35. Andri L, Senna G, Betteli C, Givanni S, Andri G, Falagiani P. Local nasal immunolherapy for Dermatophagoides-induced rhinitis: efficacy of a powder extract. J Allergy Clin Immunol 1993;91:987-96.
36. Passalacqua G, Albano M, Ruffoni S, et al. Nasal immunotherapy to Parietaria: evidence of reduction of local inflammation. Am J Respir Crit Care Med 1995;152:461-6.
37. D'Amato G, Lobefalo G, Liccardi G, Cazzola M. A double-blind, placebo-controlled trial of local nasal immunolherapy in allergic rhinitis to Parietaria pollen. Clin Exp Allergy 1995;25:141-8.
38. Andri L, Senna G, Andri G, et al. Local nasal immunotherapy for birch allergic rhinitis with extract in powder form. Clin Exp Allergy 1995;25:1092-9.
39. Andri L, Senna G, Betteli C, et al. Local nasal immunotherapy wilh extract in powder form is effective and safe in grass-pollen rhinitis. A double blind study. J Allergy Clin Immunol 1996;97:34-41.
40. Cirla AM, Sforza N, Roffi,GP, et al. Preseasonal intranasal immunotherapy in birch-alder allergic rhinitis. A double-blind study. Allergy 1996;51:299-305.
41. Bardare M, Zani G, Novembre E, Vierucci A. Local nasal immunotherapy with a powder extract for grass pollen induced rhinitis in pediatric ages: a controlled study. J Investig Allergol Immunol 1996;6:359-63.
42. Metha SB, Morrison Smith J. Nasal hyposensitization and hay fever. Clin Allergy 1975;5:279-84.
43. Georgitis JW, Nickelsen JA, Wypych JI, Kane JH, Reisman RE. Local nasal immunotherapy. Efficacy of low-dose aqueous ragweed extract. J Allergy Clin Immunol 1985;75: 496-500.
44. Georgitis JW, Nickelsen JA, Wypych JI, Barde SH, Clayton WF, Reisman RE. Local intranasal immunotherapy with high-dose polymerized ragweed extract. Int Arch Allergy Appl Immunol 1986;81:170-3.
45. Ariano R, Panzani RC, Chiapella M, Augeri G, Falagiani P. Local immunotherapy of seasonal allergic rhinitis in children due to Parietaria pollen. A preliminary report. Pediatr Asthma Allergy Immunol 1993;7:227-37.
46. Welsh PW, Butterfield JH, Yungingcr W, Agarwal MK, Gjeich GJ. Allergen controlled study of intranasal immunotherapy for ragweed hay fever. J Allergy Clin Immunol 1983;71:454-60.
47. Gasparini A, Di Franco G, Malavenda A. Preliminary evaluation of the nasal local specific immunotherapy in mite-sensitive respiratory patients. Perspect ENT Immunol 1991;5:29-33.
48. Filiaci F, Zambetti G, Lo Vecchio A. Specific local immunotherapy with macronized dust in the treatment of seasonal allergic rhinopathy caused by Gramincae. Perspect ENT Immunol 1989;3:170-6.
49. Gaglani B, Borish L, Bartelson BL, Buchmeier A, Keller L, Nelson HS. Nasal immunotherapy in weed-induced rhinitis. Ann Allergy Asthma Immunol 1997;79:259-65.
50. Passalacqua G, Alhano M, Pronzato C, et al. Long-term follow-up of nasal immunotherapy to Parietaria: clinical and local immunological effects. Clin Exp Allergy 1997;27:904-8.
51. Crimi E, Voltolini S, Troisc C, et al. Local immunotherapy with Dermatophagoides extract in asthma. J Allergy Clin Immunol 1991;87:721-8.
52. Tari MG, Mancino M, Monti G. Immunotherapy by inhalation of allergen in powder in house dust allergic asthma: a double-blind study. J Investig Allergol Clin Immunol 1992;2:59-67.
53. Taudorf E, Wecke B. Orally administered grass pollen. Allergy 1983;38:561-4.
54. Björkstén B, Möller C, Broberger U, et al. Clinical and immunological effects of oral immunotherapy with a standardized birch pollen extract. Allergy 1986;41:290-5.
55. Creticos PS, Naclerio RM, Adkinson F, Norman PS. Efficacy, safety and kinetics of oral ragweed immunotherapy in the treatment of seasonal allergic rhinitis. J Allergy Clin Immunol 1990;85:165.
56. Leng X, Fu YX, Ye ST, Duan SQ. A double-blind trial of oral immunotherapy for Artemisia pollen asthma with evaluation of bronchial response to pollen allergen and serum-specific IgE antibody. Ann Allergy 1990;64: 27-31.
57. Cooper PJ, Darbyshire J, Nunn AJ, Warner JO. A controlled trial of oral hyposensitization in pollen asthma and rhinitis in children. Clin Allergy 1984;14:541-50.
58. Taudorf E, Laursen LC, Djurup R, et al. Oral administration of grass pollen to hay fever patients. An efficacy study in oral hyposensitization. Allergy 1985;40:321-35.
59. Möller C, Dreborg S, Lanner Å, Björkstén B. Oral immunotherapy of children with rhinoconjunctivitis due to birch pollen allergy. A double blind study. Allergy 1986;41:271-9.
60. Mosbech H, Dreborg S, Madsen F, et al. High dose grass pollen tablets used for hyposensitization in hay fever patients. A one-year double blind placebo controlled study. Allergy 1987;42:451-5.
61. Taudorf E, Laursen LC, Lanner Å, et al. Oral immunotherapy in birch pollen hay fever. J Allergy Clin Immunol 1987;80:153-61.
62. Oppenheimer J, Areson JG, Nelson HS. Safety and efficacy of oral immunotherapy with standardized cat extract. J Allergy Clin Immunol 1994;93:61-7.
63. Einarsson R, Renck B. Taudorf E. In vitro studies of degradation of birch and timothy pollen allergen preparations by human duodenal juice. Allergy 1988;43:469-72.
64. van Deusen MA, Angelini BL, Cordoro KM, Seiler BA, Wood L, Skoner DP. Efficacy and safety of oral immunotherapy with short ragweed extract. Ann Allergy Asthma Immunol 1997;78:573-80.
65. Litwin A, Flanagan M, Entis G, et al. Oral immunotherapy with short ragweed extract in a novel encapsulated preparation: a double-blind study. J Allergy Clin Immunol 1997;100:30-8.
66. Taudorf E, Laursen L, Lanner A, Björkstén B, Dreborg S, Wecke B. Specific IgE, IgG, and IgA antibody response to oral immunotherapy in birch pollinosis. J Allergy Clin Immunol 1989;83:589-94.
67. Scadding K, Brostoff J. Low dose sublingual therapy in patients with allergic rhinitis due to dust mite. Clin Allergy 1986;16:483-91.
68. Reilly D, Taylor MA, Beattie NGM, et al. Is evidence for homeopathy reproducible? Lancet 1994;344:1601-6.
69. van Niekerk CH, De Wet JI. Efficacy of grass-maize pollen oral immunotherapy in patients with seasonal hay fever: a double blind study. Clin Allergy 1987;17:507-13.
70. Feliziani V, Marfisi RM, Parmiani S. Rush immunotherapy with sublingual administration of grass allergen extract. Allergol Immunopathol (Madr) 1993;21:173-8.
71. Nelson HS, Oppenheimer J, Vatsia GA, Bucheimer A. A double blind placebo controlled evaluation of sublingual immunotherapy with standardized cat extract. J Allergy Clin Immunol 1993;92:229-36.
72. Casanovas M, Guerra F, Moreno C, Miguel R, Maranon F, Daza JC. Double blind placebo controlled clinical trial of prescasonal treatment with allergenic extracts of Olea europaea pollen administered sublingually. J Investig Allergol Clin Immunol 1994;4:305-14.
73. D'Ambrosio FP. Ricciardi L, Isola S, Puccinelli P, Musarra A. Rush sublingual immunotherapy in Parietaria allergic patients. Allergol Immunopathol (Madr) 1996;24: 146-51.
74. Tari MG, Mancino M, Monti G. Efficacy of sublingual immunotherapy in patients with rhinitis and asthma due to house dust mite. A double blind study. Allergol Immunopathol (Madr) 1990;18:277-84.
75. Sabbah A, Hassoun S, Le Sellin J, André C, Sicard H. A double blind placebo controlled trial by the sublingual route of immunotherapy with a standardized grass pollen extract. Allergy 1994;49:309-13.
76. Feliziani V, Lattuada G, Parmiani S, Dall'Aglio PP. Safety and efficacy of sublingual rush immunotherapy with grass allergen extracts. A double blind study. Allergol Immunopathol (Madr) 1995;23:224-30.
77. Troise C, Voltolini S, Canessa A, Pecora S, Negrini AC. Sublingual immunotherapy in Parietaria pollen induced rhinitis: a double blind study. J Investig Allergol Clin Immunol 1995;5:25-30.
78. Hirsch T, Sahn M, Leupold W. Double-blind placebo-controlled study of sublingual immunotherapy with house dust mite extract (D.pt.) in children. Pediatr Allergy Immunol 1997;8:21-7.
79. Passalacqua G, Albano M, Fregonese L, et al. Randomised controlled trial of local allergoid immunotherapy on allergic inflammation in mite-induced rhinoconjunctivitis. Lancet 1998;351:629-32.
80. Rebien W, Puttonen E, Maasch HJ, Stix E, Wahn U. Clinical and immunological response to oral and subcutaneous immunotherapy with grass pollen extracts. A prospective study. Eur J Pediatr 1982;138:341-4.
81. Palacios AS, Medina FS, Rua-Figueroa AL, Millares CB, Santos SR, Marrero JAG. Comparative clinical-immunological study of oral and subcutaneous immunotherapy in children with extrinsic bronchial asthma. Allergol Immunopathol (Madr) 1989;17:323-9.
82. Urbanek R, Bürgelin KH, Kahle W, Wahn U. Oral immunotherapy with grass pollen in enterosoluble capsules. Eur J Pediatr 1990;149:545-50.
83. Moscato G, Rossi G, Dellabianca A, Pisati A, Vinci G, Biale C. Local immunotherapy by inhalation of a powder extract in asthma due to house dust mite Dermatophagoides pteronyssinus: a double-blind comparison with parenteral immunotherapy. J Investig Allergol Clin Immunol 1991; 1:383-94.
84. Corbetta L, Pesiri P, Ferro G, Mander A. Improvement of fog and exercise induced asthma after local and subcutaneous immunotherapy in mile asthma. Allergol Immunopathol (Madr) 1992;20:60-6.
85. Piazza I, Bizzaro N. Humoral response to subcutaneous, oral, and nasal immunotherapy for allergie rhinitis due to Dermatophagoides pteromyssinus. Ann Allergy 1993;71:461-9.
86. Bernadis P, Agnoletto M, Puccinelli P, Parmiani S, Pozzan M. Injective versus sublingual immunotherapy in Alternaria tennis allergic patients. J Investig Allergol Clin Immunol 1996;6:55-62.
87. Quirino T, Iemoli E, Siciliani E, Parmiani S, Milazzo F. Sublingual versus injective immunotherapy in grass pollen allergic patients: a double blind (double dummy) study. Clin Exp Allergy 1996;26:1253-61.
88. Horak F, Wheeler AW. Oral hyposensitisation with entericcoated allergens as extension therapy following a basic subcutaneous course of injections. Int Arch Appl Immunol 1987;84:74-8.
89. Trede NS, Urbanek R. Combination of parenteral and oral immunotherapy in grass pollen-allergic children. A double-blind controlled study of clinical and immunological efficacy. Allergy 1989;44:272-80.