The role of sterols in morphogenetic processes and dimorphism in fungi

Microbiology

Volumn 76, Issue 1, 2007, Pages 1-13

  Mysyakina, I S ^a   Funtikova, N S ^a  

^a WINOGRADSKY INSTITUTE OF MICROBIOLOGY   (Russian Federation)

Author keywords

Dimorphic fungi; Dimorphism; Ergosterol; Morphogenesis; Phospholipids

Indexed keywords

FUNGI;

EID: 33847648012     PISSN: 00262617     EISSN: None     Source Type: Journal    
DOI: 10.1134/S0026261707010018     Document Type: Review

References (165)

1. Martinez-Espinosa, A.D., Ruiz-Herrera, J., Leon- Ramirez, C.G., and Gold, S.E., MAP Kinase and cAMP Signaling Pathways Modulate the pH-Induced Yeast-to- Mycelium Dimorphic Transition in the Corn Smut Fungus Ustilago maydis, Curr. Microbiol., 2004, vol. 49, pp. 274-281.
2. Marques, E.R., Ferreira, M.E.S., Drummond, R.D., Felix, J.M., Menossi, M., Savlidi, M., Travassos, L.R., Puccia, R., Batista, W.L., Carvalho, K.C., Goldman, M.H.S., and Goldman, G.H., Identification of Genes Preferentially Expressed in the Pathogenic Yeast Phase of Paracoccidioides brasiliensis, Using Suppression Subtraction Hybridization and Differential Macroarray Analysis, Mol. Gen. Genom., 2004, vol. 271, pp. 667-677.
3. Ghormade, V. and Deshpande, M.V., Fungal Spore Germination into Yeast or Mycelium: Possible Implications of Dimorphism in Evolution and Human Pathogenesis, Naturwissenschaften, 2000, vol. 87, pp. 236-240.
4. Reyna-Lopez, G.E. and Ruiz-Herrera, J., Specificity of DNA Methylation Changes during Fungal Dimorphism and Its Relationship to Polyamines, Curr. Microbiol., 2004, vol. 48, pp. 118-123.
5. Niimi, M., Shepherd, M.G., and Monk, B.C., Differential Profiles of Soluble Proteins during the Initiation of Morphogenesis in Candida albicans, Arch. Microbiol., 1996, vol. 166, pp. 260-268.
6. Aquino-Pinero, E.E. and Rodriques-del Valle, N., Different Protein Kinase C Isoforms Are Present in the Yeast and Mycelium Forms of Sporothrix schenckii, Mycopathology, 1997, vol. 138, pp. 109-115.
7. Amin, A., Joshi, M., and Deshpande, M.V., Morphology- Associated Expression of NADP-Dependent Glutamate Dehydrogenases during Yeast-Mycelium Transition of a Dimorphic Fungus Benjaminiella poitrasii, Antonie van Leeuwenhoek, 2004, vol. 85, pp. 327-334.
8. Ruiz-Herrera, J. and Sentandreu, R., Different Effectors of Dimorphism in Yarrowia lipolytica, Arch. Microbiol., 2002, vol. 178, pp. 477-483.
9. McIntyre, M., Breum, J., Arnau, J., and Nielsen, J., Growth Physiology and Dimorphism of Mucor circinelloides (syn. racemosus) during Submerged Batch Cultivation, Appl. Microbiol. Biotechnol., 2002, vol. 58, pp. 495-502.
10. Orlowski, M., Mucor Dimorphism, Microbiol. Rev., 1991, vol. 55, pp. 234-258.
11. Friedenthal, M., Epstein, A., and Passeron, S., Effect of Potassium Cyanide, Glucose and Anaerobiosis on Morphogenesis of Mucor rouxii, J. Gen. Microbiol., 1974, vol. 82, pp. 15-24.
12. Funtikova, N.S., Mysyakina, I.S., and Poglazova, M.N., Morphogenesis and Lipid Composition of Mucor Fungi Grown in the Presence of Chloroanilines in Submerged Culture, Mikrobiologiya, 1999, vol. 68, no. 4, pp. 467- 472
13. [Mikrobiology (Engl. Transl.), vol. 68, no. 4, pp. 406-411].
14. Ito, E., Cihlar, R.L., and Inderlied, C.B., Lipid Synthesis during Morphogenesis in Mucor racemosus, J. Bacteriol., 1982, vol. 153, pp. 880-887.
15. Lubbehusen, T.L., Nielsen, J., and McIntyre, M., Morphology and Physiology of the Dimorphic Fungus Mucor circinelloides (syn. M. racemosus) during Anaerobic Growth, Mycol. Res., 2003, vol. 107, pp. 223-230.
16. Gordon, P.A., Stewart, P.R., and Clark-Walker, G.D., Fatty Acid and Sterol Composition of Mucor genevensis in Relation to Dimorphism and Anaerobic Growth, J. Bacteriol., 1971, vol. 107, pp. 114-120.
17. Illingworth, R.F., Rose, A.H., and Beckett, A., Changes in the Lipid Composition and Fine Structure of Saccharomyces cerevisiae during Ascus Formation, J. Bacteriol., 1973, vol. 113, pp. 373-386.
18. Calvo, A.M., Gardner, H.W., and Keller, N.P., Genetic Connection between Fatty Acid Metabolism and Sporulation in Aspergillus nidulans, J. Biol. Chem., 2001, vol. 276, pp. 25766-25774.
19. Safe, S. and Caldwell, J., The Effect of Growth Environment on the Chloroform-Methanol and Alcali-Extractable Cell Wall and Cytoplasmic Lipid Levels of Mucor rouxii, Can. J. Microbiol., 1975, vol. 21, pp. 79-84.
20. Ghannoum, M.A., Janini, G., Khamis, L., and Radwan, S.S., Dimorphism-Associated Variations in the Lipid Composition of Candida albicans, J. Gen. Microbiol., 1986, vol. 132, pp. 2367-2375.
21. Toledo, M.S., Levery, S.B., Straus, A.H., and Takahashi, H.K., Dimorphic Expression of Cerebrosides in the Mycopathogen Sporothrix schenckii, J. Lipid Res., 2000, vol. 41, pp. 797-806.
22. Kobayashi, S.D. and Cutler, J.E., Candida albicans Hyphal Formation and Virulence: Is There a Clearly Defined Role?, Trends Microbiol., 1998, vol. 6, pp. 92-94.
23. Andrews, D.L., Garcia-Pedrajas, M.D., and Gold, S.E., Fungal Dimorphism Regulated Gene Expression in Ustilago maydis: I. Filament Up-Regulated Genes, Mol. Plant Pathol., 2004, vol. 5, pp. 281-293.
24. Ruiz-Herrera, J., Elorza, M.V., Valentin, E., and Sentandreu, R., Molecular Organization of the Cell Wall of Candida albicans and Its Relation to Pathogenicity, FEMS Yeast Res., 2006, vol. 6, pp. 14.29.
25. Smith, S.J. and Parks, L.W., Requirement of Heme To Replace the Sparking Sterol Function in the Yeast Saccharomyces cerevisiae, Biochim. Biophys. Acta, 1997, vol. 1345, pp. 71-76.
26. Weete, J.D., Structure and Function of Sterols in Fungi, Adv. Lipid Res., 1989, vol. 23, pp. 115-167.
27. Jee, H. and Ko, W., Stimulation of Sexual Reproduction in Phytophthora castorum and P. parasitica by Fatty Acids and Related Compounds, Mycol. Res., 1997, vol. 101, pp. 1140-1144.
28. Parks, L.W., Metabolism of Sterols in Yeast, CRC Crit. Rev. Microbiol., 1978, vol. 6, pp. 300-341.
29. Andreasen, A.A. and Stier, T.J.B., Anaerobic Nutrition of Saccharomyces cerevisiae, J. Cell Comp. Physiol., 1953, vol. 41, pp. 23-26.
30. Lorenz, R.T. and Parks, L.W., Involvement of Heme Components in Sterol Metabolism of Saccharomyces cerevisiae, Lipids, 1991, vol. 26, pp. 598-603.
31. Loubbardi, A., Marcireau, C., Rarst, F., and Guilloton, M., Sterol Uptake Induced by an Impairment of Pyridoxal Phosphate Synthesis in Saccharomyces cerevisiae: Cloning and Sequencing of the PDX3 Gene Encoding Pyridoxine (Pyridoxamine) Phosphate Oxidase, J. Bacteriol., 1995, vol. 177, pp. 1817-1823.
32. Davies, B.S.J., Wang, H.S., and Rine, J., Dual Activators of the Sterol Biosynthetic Pathway of Saccharomyces cerevisiae: Similar Activation/Regulatory Domains but Different Response Mechanisms, Mol. Cell. Biol., 2005, vol. 25, pp. 7375-7385.
33. Casey, W.M., Keesler, G.A., and Parks, L.W., Regulation of Partitioned Sterol Biosynthesis in Saccharomyces cerevisiae, J. Bacteriol., 1992, vol. 174, pp. 7283- 7288.
34. Kato, T., Sterol Biosynthesis in Fungi. A Target for Broad Spectrum Fungicides, Chemistry of Plant Protection, Haug, G. et al., Eds., Berlin: Springer, 1986, vol. 1, pp. 1-24.
35. Fryberg, M., Avruch, L., Oehlschlager, A.C., and Unrau, A.M., Nuclear Demethylation and C-24 Alkylation during Ergosterol Biosynthesis in Saccharomyces cerevisiae, Can. J. Biochem., 1975, vol. 53, pp. 881- 889.
36. Mysyakina, I.S., Funtikova, N.S., and Medvedev, F.A., Sterol Composition of the Arthrospores and Mycelium of the Fungus Mucor hiemalis, Mikrobiologiya, 2002, vol. 71, no. 4, pp. 475-481
37. [Microbiology (Engl. Transl.), vol. 71, no. 4, pp. 404-409].
38. Vanden Bossche, H., Marichal, P., le Jeune, L., Coene, M.-C., Gorrens, J., and Cools, W., Effects of Itraconazole on Cytochrome P-450-Dependent Sterol 14α-Demethylation and Reduction of 3-Ketosteroids in Cryptococcus neoformans, Antimicrob. Agents Chemother., 1993, vol. 37, pp. 2101-2105.
39. Joseph-Horn, T. and Hollomon, D.W., Molecular Mechanisms of Azole Resistance in Fungi, FEMS Microbiol. Lett., 1997, vol. 149, pp. 141-149.
40. Mejanelle, L., Lopez, J.F., Gunde-Cimerman, N., and Grimalt, J.O., Ergosterol Biosynthesis in Novel Melanized Fungi from Hypersaline Environments, J. Lipid Res., 2001, vol. 42, pp. 352-358.
41. Petrovic, U., Gunde-Cimerman, N., and Plemenitas, A., Salt Stress Affects Sterol Biosynthesis in the Halophilic Black Yeast Hortaea werneckii, FEMS Microbiol. Lett., 1999, vol. 180, pp. 325-330.
42. Balish, E., Methionine Biosynthesis and S-Adenosylmethionine Degradation during an Induced Morphogenesis of Candida albicans, Can. J. Microbiol., 1973, vol. 19, p. 847.
43. Garcia, J.R. and Sypherd, S., S-Adenosylmethionine and Morphogenesis in Mucor racemosus, Curr. Microbiol., 1984, vol. 10, pp. 111-116.
44. Lambert, R.H. and Garcia, J.R., Evidence of Morphology- Specific Isozymes in Candida albicans, Curr. Microbiol., 1990, vol. 20, pp. 215-221.
45. Parker, S.R. and Nes, W.D., Regulation of Sterol Biosynthesis and Its Phylogenetic Implications, ACS Symp., 1994. Ser. 497, pp. 110.145.
46. Nes, W.D., Hanners, P.K., and Parish, E.J., Control of Fungal Sterol C-24 Alkylation. Importance to Developmental Regulation, Biochem. Biophys. Res. Commun., 1986, vol. 139, pp. 410-415.
47. Nes, W.D., Enzyme Mechanisms for Sterol C-Methylation, Phytochemistry, 2003, vol. 64, pp. 75-95.
48. Nes, W.R., Sekula, B.C., Nes, W.D., and Adler, J.H., The Functional Importance of Structural Features of Ergosterol in Yeast, J. Biol. Chem., 1978, vol. 253, pp. 6218-6225.
49. Nes, W.D., Biosynthesis and Requirements for Sterols in Growth and Reproduction of Oomycetes, ACS Symp., 1987. Ser. 325, pp. 303.328.
50. Mysyakina, I.S. and Funtikova, N.S., Changes in the Lipid Composition of Mucor hiemalis Sporangiospores Related to the Age of the Spore-Forming Culture, Mikrobiologiya, 2003, vol. 72, no. 4, pp. 516-520
51. [Microbiology (Engl. Transl.), vol. 72, no. 4, pp. 461-465].
52. Baumann, N.A., Sullivan, D.P., Ohvo-Rekila, H., Simonot, C., Pottekat, A., Klaassen, Z., Beh, C.T., and Menon, A.K., Transport of Newly Synthesized Sterol to the Sterol-Enriched Plasma Membrane Occurs via Nonvesicular Equilibration, Biochemistry, 2005, vol. 44, pp. 5816-5826.
53. Ravchaudhuri, S., Im, Y.J., Hurley, J.H., and Prinz, W.A., Nonvesicular Sterol Movement from Plasma Membrane to ER Requires Oxysterol-Binding Protein-Related Proteins and Phosphoinositides, J. Cell Biol., 2006, vol. 173, pp. 107-119.
54. Billheimer, J.T and Reinhart, M.P., Intracellular Trafficking of Sterols, Subcellular Biochemistry: Intracellular Transfer of Lipid Molecules, Hilderson, H.G., Ed., New York: Plenum, 1990, vol. 16, pp. 301-331.
55. Soustre, I., Dupuy, P.-H., Silve, S., and Loison, G., Sterol Metabolism and ERG2 Gene Regulation in the Yeast Saccharomyces cerevisiae, FEBS Lett., 2000, vol. 470, pp. 102-106.
56. Beh, C.T., Cool, L., Phillips, J., and Rine, J., Overlapping Function of the Yeast Oxysterol-Binding Protein Homologues, Genetics, 2001, vol. 157, pp. 1117-1140.
57. Beh, C.T. and Rine, J., A Role for Yeast Oxysterol- Binding Protein Homologs in Endocytosis and in the Maintenance of Intracellular Sterol-Lipid Distribution, J. Cell Sci., 2004, vol. 117, pp. 2983-2996.
58. Weete, J.D and Ghandi, S.R., Biochemistry and Molecular Biology of Fungal Sterols, The Mycota. V. III. Biochemistry and molecular biology, Brambl, R. and Marzluf, G.A., Eds., Berlin: Springer, 1996, pp. 421-438.
59. Vanden Bossche, H., Engelen, M., and Rochette, F., Antifungal Agents of Use in Animal Health-Chemical, Biochemical and Pharmacological Aspects, J. Vet. Pharmacol. Ther., 2003, vol. 26, pp. 5-29.
60. Ryder, N.S. and Meth, H., Allylamine Antifungal Drags, Curr. Topics Med. Mycol., 1992, vol. 4, pp. 158- 188.
61. Debieu, D., Bach., Lasseron, A., Malosse, C., and Leroux, P., Effects of Sterol Biosynthesis Inhibitor Fungicides in the Phytopathogenic Fungus, Nectria haematococca- Ergosterol Depletion versus Precursor or Abnormal Sterol Accumulation as the Mechanism of Fungitoxicity, Pestic. Sci., 1998, vol. 54, pp. 157-167.
62. Ryder, N.S., Frank, I., and Dupont, M.C., Ergosterol Biosynthesis Inhibition by the Thiocarbamate Antifungal Agents, Tolnaftate and Tolciclate, Antimicrob. Agents Chemother., 1986, vol. 29, pp. 858-860.
63. Polak, A., Mode of Action Studies, Chemotherapy of Fungal Diseases, Ryley, J.F., Ed., Berlin: Springer, 1990, pp. 153-182.
64. Vanden Bossche, H., Willemsens, G., and Marishal, P., Anti-Candida Drugs-the Biochemical Basis for Their Activity, CRC Crit. Rev. Microbiol., 1987, vol. 15, pp. 57-72.
65. Bolard, J., How Do the Polyene Macrolide Antibiotics Affect the Cellular Membrane Properties, Biochim. Biophys. Acta, 1986, vol. 864, pp. 257-304.
66. Geraghty, P. and Kavanagh, K., Disruption of Mitochondrial Function in Candida albicans Leads to Reduced Cellular Ergosterol Levels and Elevated Growth in the Presence of Amphotericine B, Arch. Microbiol., 2003, vol. 179, pp. 295-300.
67. Hamdan, J.S. and Casali, A.K., Effect of Amphotericin B on the Lipids of Yeast Cells of Sporothrix schenckii, Mycopathologia, 1996, vol. 136, pp. 125-131.
68. Mysyakina, I.S., The Effect of Nystatin on Lipogenesis in Fusarium solani, Mikrobiologiya, 1989, vol. 58, no. 2, pp. 346-347.
69. Mysyakina, I.S. and Funtikova, N.S., Lipid Composition of the Mucor INMI Fungus in Nystatin-Decreased Growth Conditions, Mikrobiologiya, 1991, vol. 60, no. 4, pp. 645-651
70. [Microbiology (Engl. Transl.), vol. 60, no. 4, pp. 443-448].
71. Vanden Bossche, H., Biochemical Targets for Antifungal Azole Derivatives: Hypothesis on the Mode of Action, Curr. Topics Med. Mycol., 1985, vol. 1, pp. 313-351.
72. Vanden Bossche, H., Importance and Role of Sterols in Fungal Membranes, Biochemistry of Cell Walls and Membranes in Fungi, Kuhn, P.J. et al., Eds., Berlin, 1990, pp. 135-157.
73. Georgopapadakou, N.H., Dix, B.A., Smith, S.A., Freudenberger, J., and Funke, P.T., Effect of Antifungal Agents on Lipid Biosynthesis and Membrane Integrity in Candida albicans, Antimicrob. Agents Chemother., 1987, vol. 31, pp. 46-51.
74. Kelly, S.I., Keena, S., Bligh, H.F.J., Watson, P.F., Stansfield, I., Ellis, S.W., and Kelly, D.E., Lanosterol to Ergosterol Enzymology, Inhibition, and Genetics, Biochemistry of Cell Walls and Membranes in Fungi, Kuhn, P.J. et al., Eds., Berlin, 1990, pp. 223-243.
75. Brasseur, R., Vandenbosch, C., Vanden Bossche, H., and Ruysschaert, J.M., Mode of Insertion of Miconazole, Ketokonazole and Deacylated Ketokonazole in Lipid Layers, Biochem. Pharmacol., 1983, vol. 32, pp. 2175-2180.
76. Cooke, D.T. and Burden, R.S., Lipid Modulation of Plasma Membrane-Bound ATPases, Physiologia Plantarum, 1990, vol. 78, pp. 153-159.
77. Borgers, M., Mechanism of Action of Antifungal Drugs, with Special Reference to the Imidazole Derivatives, Rev. Infect. Dis., 1980, vol. 2, pp. 520-534.
78. Kelly, S.I., Lamb, D.C., Baldwin, B.C., Corran, A.J., and Kelly, D.E., Characterization of Saccharomyces cerevisiae CYP61, Sterol Δ22-Desaturase, and Inhibition by Azole Antifungal Agents, J. Biol. Chem., 1997, vol. 272, pp. 9986-9988.
79. 5 Reductase Complex Efficiently Drives the Entire Sterol 14-Demethylation (Cyp51) Reaction, FEBS Lett., 1999, vol. 462, pp. 283-288.
80. Lamb, D.C., Maspahy, S., Kelly, D.E., Manning, N.J., Geber, A., Bennett, J.E., and Kelly, S.L., Purification, Reconstitution, and Inhibition of Cytochrome P450 Sterol Δ22 Desaturase from the Pathogenic Fungus Candida glabrata, Antimicrob. Agents Chemother., 1999, vol. 43, pp. 1725-1728.
81. Marishal, P., Gorrens, J., Laurijssens, L., Vermuyten, K., Van Hove, C., Le Jeune, L., Verhausselt, P., Sanglard, D., Borgers, M., Ramaekers, F.C., Odds, F., and Vanden Bossche, H., Accumulation of 3-Ketosteroids Induced by Itraconazole and Ketokonazole in Azole Resistant Clinical Candida albicans Isolates, Antimicrob. Agents Chemother., 1999, vol. 43, pp. 2663-2670.
82. Vanden Bossche, H., Engelen, M., and Rochette, F., Antifungal Agents of Use in Animal Health-Chemical, Biochemical and Pharmacological Aspects, J. Vet. Pharmacol. Ther., 2003, vol. 26, pp. 5-29.
83. Watson, P.F., Rose, M.E., Ellis, S.W., England, H., and Kelly, S.L., Defective Sterol C5-6 Desaturation and Azole Resistance: A New Hypothesis for the Mode of Action of Azole Antifungals, Biochem. Biophys. Res. Commun., 1989, vol. 164, pp. 1170-1175.
84. Diaz-Guerra, T.M., Mellado, E., Cuenca-Estrella, M., and Rodriguez-Tudela, J.L., A Point Mutation in the 14α-Sterol Demethylase Gene cyp51A Contributes to Itraconazole Resistance in Aspergillus fumigatus, Antimicrob. Agents Chemother., 2003, vol. 47, pp. 1120- 1124.
85. Geber, A., Hitchcock, C.A., Swartz, J.E., Pullen, F.S., Marsden, K.E., Kwon-Chung, K.J., and Bennett, J.E., Deletion of the Candida glabrata ERG3 and ERG11 Genes: Effect on Cell Viability, Cell Growth, Sterol Composition, and Antifungal Susceptibility, Antimicrob. Agents Chemother., 1995, vol. 39, pp. 2708-2717.
86. Henry, K.W., Nickels, J.T., and Edlind, T.D., ROX1 and ERG Regulation in Saccharomyces cerevisiae: Implications for Antifungal Susceptibility, Eukaryot. Cell, 2002, vol. 1, pp. 1041-1044.
87. Henry, K.W., Nickels, J.T., and Edlind, T.D., Upregulation of ERG Genes in Candida Species by Azoles and Other Sterol Biosynthesis Inhibitors, Antimicrob. Agents Chemother., 2000, vol. 44, pp. 2693-2700.
88. Silver, P.M., Oliver, B.G., and White, T.C., Role of Candida albicans Transcription Factor Ups2p in Drug Resistance and Sterol Metabolism, Eukaryot. Cell, 2004, vol. 3, pp. 1391-1397.
89. MacPherson, S., Akashe, B., Weber, S., De Deken, X., Raymond, M., and Turcotte, B., Candida albicans Zinc Cluster Protein Ups2p Confers Resistance to Antifungal Drugs and Is an Activator of Ergosterol Biosynthesis Genes, Antimicrob. Agents Chemother., 2005, vol. 49, pp. 1745-1752.
90. Del Sorbo, G., Schoonbeek, H., and De Waard, M.A., Fungal Transporters Involved in Efflux of Natural Toxic Compounds and Fungicides, Fungal Genet. Biol., 2000, vol. 30, pp. 1-15.
91. Xiong, Q., Hassan, S.A., Wilson, W.K., Han, X.Y., May, G.S., Tarrand, J.J., and Matsuda, S.P.T., Cholesterol Import by Aspergillus fumigatus and Its Influence on Antifungal Potency of Sterol Biosynthesis Inhibitors, Antimicrob. Agents Chemother., 2005, vol. 49, pp. 518-524.
92. Pier, A.C., Cabanes, F.J., Chermette, R., Ferreiros, I., Guillot, J., Jensens, H.E., and Santurio, J.M., Prominent Animal Mycoses from Various Regions of the World, Med. Mycol., 2000, vol. 38, no. Suppl. 1, pp. 47-58.
93. Dahl, J. and Dahl, C., Stimulation of Cell Proliferation and Polyphosphoinositol Metabolism in Saccharomyces cerevisiae by Ergosterol, Biochem. Biophys. Res. Commun., 1985, vol. 113, pp. 844-850.
94. Dahl, C. and Dahl, J., Cholesterol and Cell Function, Biology of cholesterol, Yeagle, P.L., Ed., Boca Raton: CRC, 1988, pp. 147-170.
95. v-src Involved in Yeast Cell Cycle Control: Positive In Vivo Regulation by Sterol, Proc. Natl. Acad. Sci. USA, 1987, vol. 84, pp. 4012- 4016.
96. Rodriguez, R.J. and Parks, L.W., Structural and Physiological Features of Sterols Necessary To Satisfy the Bulk Membrane and Sparking Sterol Requirements in Yeast Auxotrophs, Arch. Biochem. Biophys., 1983, vol. 225, pp. 861-871.
97. Ramgopal, M., Zundel, M., and Bloch, K., Sterol Effect on Phospholipid Biosynthesis in the Yeast Strain GL7, J. Lipid Res., 1990, vol. 31, pp. 653-658.
98. Lorenz, R.T., Casey, W.M., and Parks, L.W., Structural Discrimination in the Sparking Function of Sterols in the Yeast Saccharomyces cerevisiae, J. Bacteriol., 1989, vol. 171, pp. 6169-6173.
99. Hippe, S., Influence of Fungicides on Fungal Fine Structure, Electron Microscopy of Plant Pathogens, Mendgen, K. and Lesemann, D.E., Eds., Berlin: Springer, 1991, pp. 317-331.
100. Kollar, R., Petrakova, E., Ashwell, G., Robbins, P.W., and Cabib, E., Architecture of Yeast Cell Wall. The Linkage between Chitin and β(1-3)-Glucan, J. Biol. Chem., 1995, vol. 270, pp. 1170-1178.
101. Feofilova, E.P., Kletochnaya stenka gribov (The Fungal Cell Wall), Moscow: Nauka, 1983.
102. Bartnicki-Garcia, S., Ruiz-Herrera, J., and Bracker, C.E., Chitosomes and Chitin Synthesis, Fungal Walls and Hyphal Growth, Burnett, J.H. and Trinci, A.P.J., Eds., Cambridge: Cambridge Univ. Press, 1979, pp. 1-25.
103. Yarden, O. and Yanofski, C., Chitin Synthase I Plays a Major Role in Cell Wall Biogenesis in Neurospora crassa, Genes Dev., 1991, vol. 5, pp. 2420-2430.
104. Duran, A. and Cabib, E., Solubilization and Partial Purification of Yeast Chitin Synthetase, J. Biol. Chem., 1978, vol. 253, pp. 4419-4425.
105. Vermeulen, C.A. and Wessels, J.G.H., Evidence for a Phospholipid Requirement of Chitin Synthase in Schizophyllum commune, Curr. Microbiol., 1983, vol. 8, pp. 67-71.
106. Montgomery, G.W.G. and Gooday, G.W., Phospholipid- Enzyme Interaction of Chitin Synthase of Coprinus cinereus, FEMS Microbiol. Lett., 1985, vol. 27, pp. 29-33.
107. Binks, P.R., Robson, G.D., Goosey, M.W., Humfreys, A.M., and Trinci, A.P.J., Chitin Synthesis in Fusarium graminearum and Its Inhibition by Edifenphos (Hinosan), J. Gen. Microbiol., 1990, vol. 137, pp. 615-620.
108. Mashida, S., Todoriki, S., Hamamatsu, S., and Saito, M., Phospholipid Requirements of Membrane-Bound Chitin Synthase from Absidia glauca, FEMS Microbiol. Lett., 1994, vol. 115, pp. 235-240.
109. Gooday, G.W. and Schofield, D.A., Regulation of Chitin Synthesis during Growth of Fungal Hyphae: the Possible Participation of Membrane Stress, Can. J. Bot., 1995, vol. 73, no. Suppl. 1, pp. S114-S121.
110. Despande, M., O'Donnel, R., and Gooday, G.W., Regulation of Chitin Synthase Activity in the Dimorphic Fungus Benjaminiella poitrasii by External Osmotic Pressure, FEMS Microbiol. Lett., 1997, vol. 152, pp. 327-332.
111. Vanden Bossche, H., Marishal, P., Gorrens, J., Geerts, H., and Janssen, P.A.J., Mode of Action Studies. Basis for the Search of New Antifungal Drugs, Ann. N.Y. Acad. Sci., 1988, vol. 544, pp. 191-207.
112. Pesti, M., Campbell, J.M., and Peberdy, J.F., Alteration of Ergosterol Content and Chitin Synthase Activity in Candida albicans, Curr. Microbiol., 1981, vol. 5, pp. 187-190.
113. Chiew, Y.Y., Sullivan, P.A., and Shepherd, M.G., The Effect of Ergosterol and Alcohols on Germ-Tube For mation and Chitin Synthase in Candida albicans, Can. J. Biochem., 1982, vol. 60, pp. 15-20.
114. Davies, M. and Mariott, M.S., Inhibitory Effect of Imidazole Antifungals on the Yeast.Mycelial Transformation in Candida albicans, Mycosen, 1981, vol. 25, pp. 481-486.
115. Borgers, M., Vanden Bossche, H., and de Brabander, M., The Mechanism of Action of the New Antimycotic Ketokonazole, Am. J. Med., 1983, vol. 72, pp. 2-8.
116. Chattaway, F.W., Holmes, M.R., and Barlow, A.J.F., Cell Wall Composition of the Mycelial and Blastospore Forms of Candida albicans, J. Gen. Microbiol., 1978, vol. 51, pp. 367-376.
117. Vanden Bossche, H., Ruyssehaert, J.M., Defrise-Quertain, F., Willemsens, G., Cornelissen, F., Marishal, P., Cools, W., and Cutsern, J., Biochemical Differences between Yeast and Mycelia. Do They Determine the Antimycotic Activity of Ketokonazole?, Proc. 13th Int. Congr. Chemother., Spitzy, H. and Karrer, K., Eds.,Vienna, 1983, pp. 3-9.
118. Kerkenaar, A. and Barug, D., Fluorescence Microscope Studies of Ustilago maydis and Penicillium italicum after Treatment with Imazalil or Fenpropimorph, Pestic. Sci., 1984, vol. 15, pp. 199.205.
119. Marishal, P., Gorrens, J., and Vanden Bossche, H., The Action of Itraconazole and Ketokonazole on Growth and Sterol Synthesis in Aspergillus fumigatus and Aspergillus niger, Sabouraudia: J. Med. Vet. Mycol., 1985, vol. 23, pp. 13-21.
120. Barug, D., Samson, R.A., and Kerkenaar, A., Microscopic Studies of Candida albicans and Torulopsis glabrata after In Vitro Treatment with Bifonazole, Arzneimittel- Forschung, 1983, vol. 33, pp. 779-782.
121. Hector, R.F and Braun, P.C., The Effect of Bifonazole on Chitin Synthesis in Candida albicans, Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents, Fromtling, R.A. et al., Eds., Barcelona: Science Publishers, 1987, pp. 369-382.
122. Odds, F.K., Morphogenesis in Candida albicans, CRC Crit. Rev. Microbiol., 1985, vol. 12, pp. 45-93.
123. Odds, F.C., Cockayne, A., Hayward, J., and Abbott, A.B., Effects of Imidazole and Triazole-Derivative Antifungal Compounds on the Growth and Morphological Development of Candida albicans Hyphae, J. Gen. Microbiol., 1985, vol. 131, pp. 2581-2589.
124. Leinhos, G.M.E., Gold, R.E., Duggelin, M., and Duggenheim, R., Development and Morphology of Uncinula necator Following Treatment with the Fungicides Kresoxim-Methyl and Penconazole, Mycol. Res., 1997, vol. 101, pp. 1033-1046.
125. Kang, Z.S., Huang, L.L., Krieg, U., Maulermachnik, A., and Buchenauer, H., Effects of Tebuconazole on Morphology, Structure, Cell Wall Components and Trichothecene Production of Fusarium culmorum In Vitro, Pest Management Sci., 2001, vol. 57, pp. 491-500.
126. Heath, I.B., Bridging the Divide: Cytoskeleton.Plasma Membrane.Cell Wall Interactions in Growth and Development, Biology of the Fungal Cell, Howard, R.C. and Gow, N.A.R., Eds., Berlin: Springer, 2001, pp. 201-223.
127. Pereyra, E., Argimon, S., Jackson, S.L., and Moreno, S., RGD-Containing Peptides and Cyclic AMP Have Antagonistic Roles in the Morphology of Mucor rouxii, Protoplasma, 2003, vol. 222, pp. 23-30.
128. McDaniel, D.P. and Robertson, R.W., γ-Tubulin Is a Component of the Spitzenkörper and Centrosomes in Hyphal-Tip Cells of Allomyces macrogynus, Protoplasma, 1998, vol. 203, pp. 118-123.
129. Torralba, S., Raudaskoski, M., Pedregosa, A.M., and Laborda, F., Effect Cytochalasin A on Apical Growth, Actin Cytoskeleton Organization and Enzyme Secretion in Aspergillus nidulans, Microbiology (UK), 1998, vol. 144, pp. 45-53.
130. Heath, J.B., Preservation of Labile Cortical Array of Actin Filaments in Growing Hyphal Tips of the Fungus Saprolegnia ferax, Eur. J. Cell Biol., 1987, vol. 44, pp. 10-16.
131. Adams, A.E.M. and Pringle, J.R., Relationship of Actin and Tubulin Distribution to Bud Growth in Wild Type and Morphogenetic Mutant Saccharomyces cerevisiae, J. Cell Biol., 1984, vol. 98, pp. 934-945.
132. Ishijima, S.A., Konomi, M., Takagi, T., Sato, M., Ishiguro, J., and Osumi, M., Ultrastructure of Cell Wall of the cps8 Actin Mutant Cell in Schizosaccharomyces pombe, FEMS Microbiol. Lett., 1999, vol. 180, pp. 31-37.
133. Schmidt, M., Bowers, B., Varma, A., Dong-Hyun, Roh., and Cabib, E., In Budding Yeast, Contraction of the Actomyosin Ring and Formation of the Primary Septum at Cytokinesis Depend on Each Other, J. Cell Sci., 2002, vol. 115, pp. 293-302.
134. Swan, T.M. and Watson, K., Stress Tolerance in a Yeast Sterol Auxotroph: Role of Ergosterol, Heat Shock Proteins and Trehalose, FEMS Microbiol. Lett., 1998, vol. 169, pp. 191-187.
135. Ladbooke, B.O., Williams, R.M., and Chapman, D., Studies on Lecithin.Cholesterol.Water Interaction by Differential Scanning Calorymetry and X-Ray Diffraction, Biochim. Biophys. Acta, 1969, vol. 150, pp. 333-340.
136. Mangla, A.T. and Nes, W.D., Sterol C-Methyl Transferase from Prototheca wickerhamii - .Mechanism, Sterol Specificity and Inhibition, Bioorg. Med. Chem., 2000, vol. 8, pp. 925-936.
137. Nes, W.D., Parker, S.R., Crumley, P.G., and Ross, S.A., Regulation of Phytosterol Biosynthesis, Lipid Metabolism in Plants, Moore, T.S., Ed., Boca Raton, FL: CRC, 1993, pp. 389-426.
138. Venkatramesh, M., De-an, Guo., Jia, Z., and Nes, W.D., Mechanism and Structural Requirements for the Transformation of Substrates by the (S)-Adenosyl.LMethionine: Δ24(25)-Sterol Methyl Transferase from Saccharomyces cerevisiae, Biochim. Biophys. Acta, 1996, vol. 1299, pp. 313-324.
139. Crowley, J.H., Tove, S., and Parks, L.W., A Calcium- Dependent Ergosterol Mutant of Saccharomyces cerevisiae, Curr. Genet., 1998, vol. 34, pp. 93-99.
140. Inoue, I., Seishima, M., and Kitajima, Y., Effects of Azole Antifungal Agents on Ionomycin-Induced Changes in Intracellular Calcium Concentration in Trichophyton rubrum, Mycol. Res., 1998, vol. 102, pp. 193-198.
141. Reissig, J.L. and Linney, S.G., Calcium as a Branching Signal in Neurospora crassa, J. Bacteriol., 1983, vol. 154, pp. 1397-1402.
142. 2+-ATPase Homologue, PMR1, Is Required for Normal Golgi Function and Localized in a Novel Golgi-Like Distribution, Mol. Biol. Cell, 1992, vol. 3, pp. 633-654.
143. Swaint, E., Baudryt, K., Stukeyi, J., McDonought, V., Germann, M., and Nickels, J.T., Sterol-Dependent Regulation of Sphingolipid Metabolism in Saccharomyces cerevisiae, J. Biol. Chem., 2002, vol. 277, pp. 26177- 26184.
144. Patton, J.L., Srinivasan, B., Dickson, R.C., and Lester, R.L., Phenotypes of Sphingolipid-Dependent Strains of Saccharomyces cerevisiae, J. Bacteriol., 1992, vol. 174, pp. 7180-7184.
145. Krishnamurthy, S.S. and Prasad, R., Membrane Fluidity Affects Functions of Cdr1p, a Multidrug ABC Transporter of Candida albicans, FEMS Microbiol. Lett., 1999, vol. 173, pp. 475-481.
146. Daum, G., Lees, N.D., Bard, M., and Dickson, R., Biochemistry, Cell Biology and Molecular Biology of Lipids of Saccharomyces cerevisiae, Yeast, 1998, vol. 14, pp. 1471-1510.
147. Umebayashi, K. and Nakano, A., Ergosterol Is Required for Targeting of Tryptophan Permease to the Yeast Plasma Membrane, J. Cell Biol., 2003, vol. 161, pp. 1117-1133.
148. De Nollin, S., Van Belle, H., Goosens, F., Thone, F., and Borgers, M., Cytochemical and Biochemical Studies of Yeasts after In Vivo Exposure to Miconazole, Antimicrob. Agents Chemother., 1977, vol. 11, pp. 500-513.
149. Wilm, K. and Stahl, A.J.C., Effects of Econazole Nitrate on Yeast Cells and Mitochondria, Biochem. Pharmacol., 1983, vol. 32, pp. 1825-1830.
150. Mysyakina, I.S. and Funtikova, N.S., Lipid Composition of the Yeastlike and Mycelial Mucor hiemalis Cells Grown in the Presence of 4-Chloroaniline, Mikrobiologiya, 2000, vol. 69, no. 6, pp. 790-795
151. [Microbiology (Engl. Transl.), vol. 69, no. 6, pp. 670-675].
152. Mysyakina, I.S. and Funtikova, N.S., Lipid Composition of the Arthrospores, Yeastlike Cells, and Mycelium of the Fungus Mucor hiemalis, Mikrobiologiya, 2001, vol. 70, no. 4, pp. 465-470
153. [Microbiology (Engl. Transl.), vol. 70, no. 4, pp. 403-407].
154. Mysyakina, I.S. and Funtikova, N.S., Sterols of the Fungus Mucor hiemalis Sporangiospores, Mikrobiologiya, 2003, vol. 72, no. 6, pp. 862-863
155. [Microbiology (Engl. Transl.), vol. 72, no. 6, pp. 762-763].
156. Funtikova, N.S. and Mysyakina, I.S., Sporangiospores of the Fungus Mucor lusitanicus 12M: Correlation between Lipid Composition, Viability, and Morphology of Growth upon Germination, Mikrobiologiya, 2003, vol. 72, no. 6, pp. 775-779
157. [Microbiology (Engl. Transl.), vol. 72, no. 6, pp. 686-689].
158. Weete, J.D., Sancholle, M.S., and Montant, C., Effects of Triazoles on Fungi: Lipid Composition of Taphrina deformans, Biochim. Biophys. Acta, 1983, vol. 752, pp. 19-29.
159. Taylor, F.R. and Parks, L.W., Metabolic Interconversion of Free Sterols and Steryl Esters in Saccharomyces cerevisiae, J. Bacteriol., 1978, vol. 136, pp. 531-537.
160. Leber, R., Zinser, E., Hrastnik, C., Paltauf, F., and Daum, G., Export of Steryl Esters from Lipid Particles and Release of Free Sterols in the Yeast Saccharomyces cerevisiae, Biochim. Biophys. Acta, 1995, vol. 1234, pp. 119-126.
161. Bayley, R.B. and Parks, L.W., Yeast Sterol Esters and Their Relationship to the Growth of Yeast, J. Bacteriol., 1975, vol. 124, pp. 606-612.
162. Shapiro, B.E. and Gealt, M.A., Ergosterol and Lanosterol from Aspergillus nidulans, J. Gen. Microbiol., 1982, vol. 128, pp. 1053-1056.
163. Akhrem, A.A. and Titov, Yu.Ya., Steroidy i mikroorganizmy (Steroids and Microorganisms), Moscow: Nauka, 1970.
164. Funtikova, N.S. and Mysyakina, I.S., The Dependence of Dimorphism in the Fungus Mucor lusitanicus 12M on the Preparation Conditions of Sporangiospores, Mikrobiologiya, 2004, vol. 73, no. 6, pp. 851-853
165. [Microbiology (Engl. Transl.), vol. 73, no. 6, pp. 734-736].