First-generation antihistamines diphenhydramine and chlorpheniramine reverse cytokine-afforded eosinophil survival by enhancing apoptosis

Allergy and Asthma Proceedings

Volumn 28, Issue 1, 2007, Pages 79-86

  Hasala, Hannele ^a,b,c   Moilanen, Eeva ^a,b,c   Janka Junttila, Mirkka ^a,b,c   Giembycz, Mark A ^a,d   Kankaanranta, Hannu ^a,b,c,e  

^a Tampere University Hospital ^*

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c Tampere University Hospital   (Canada)

^d UNIVERSITY OF CALGARY   (Canada)

^e TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

Antihistamines; Apoptosis; Eosinophils; IL 5; JNK

Indexed keywords

EID: 33847647655     PISSN: 10885412     EISSN: None     Source Type: Journal    
DOI: 10.2500/aap.2007.28.2961     Document Type: Review

References (34)

1. Giembycz MA, and Lindsay MA. Pharmacology of the eosinophil. Pharmacol Rev 51:213-340, 1999.
2. Kankaanranta H, Moilanen E, and Zhang X. Pharmacological regulation of human eosinophil apoptosis. Curr Drug Targets Inflamm Allergy 4:433-445, 2005.
3. Howarth PH. Eosinophils and rhinitis. Clin Exp Allergy Rev 5:55-63, 2005.
4. Kankaanranta H, Lindsay MA, Giembycz MA, et al. Delayed eosinophil apoptosis in asthma. J Allergy Clin Immunol 106:77-83, 2000.
5. Wedi B, Raap U, Lewrick H, et al. Delayed eosinophil programmed cell death in vitro: A common feature of inhalant allergy and extrinsic and intrinsic atopic dermatitis. J Allergy Clin Immunol 100:536-543, 1997.
6. Simon HU, Yousefi S, Schranz C, et al. Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia. J Immunol 158:3902-3908, 1997.
7. Haslett C. Granulocyte apoptosis and its role in the resolution and control of lung inflammation. Am J Respir Crit Care Med 160:S5-S11, 1999.
8. Simon HU. Eosinophil apoptosis in allergic diseases - An emerging new issue. Clin Exp Allergy 28:1321-1324, 1998.
9. Ohta K, and Yamashita N. Apoptosis of eosinophils and lymphocytes in allergic inflammation. J Allergy Clin Immunol 104: 14-21, 1999.
10. Walsh GM. Human eosinophils: Their accumulation, activation, and fate. Br J Haematol 97:701-709, 1997.
11. MacGlashan D Jr. Histamine: A mediator of inflammation. J Allergy Clin Immunol 112:553-559, 2003.
12. Church MK. Non-H1-receptor effects of antihistamines. Clin Exp Allergy 29:39-48, 1999.
13. Walsh GM. Anti-inflammatory properties of antihistamines: An update. Clin Exp Allergy Rev 5:21-25, 2005.
14. Domae M, Sagara H, Sakaue M, et al. The antiallergic drug oxatomide promotes human eosinophil apoptosis and suppresses IL-5-induced eosinophil survival. J Allergy Clin Immunol 111:567-572, 2003.
15. Vancheri C, Mastruzzo C, Tomaselli V, et al. The effect of fexofenadine on expression of intercellular adhesion molecule 1 and induction of apoptosis on peripheral eosinophils. Allergy Asthma Proc 26:292-298, 2005.
16. Hasala H, Malm-Erjefalt M, Erjefalt J, et al. Ketotifen induces primary necrosis of human eosinophils. J Ocul Pharmacol Ther 21:318-327, 2005.
17. Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 103:239-252, 2000.
18. Kankaanranta H, De Souza PM, Barnes PJ, et al. SB 203580, an inhibitor of p38 mitogen-activated protein kinase, enhances constitutive apoptosis of cytokine-deprived human eosinophils. J Pharmacol Exp Ther 290:621-628, 1999.
19. Zhang X, Moilanen E, Lahti A, et al. Regulation of eosinophil apoptosis by nitric oxide: Role of c-Jun-N-terminal kinase and signal transducer and activator of transcription 5. J Allergy Clin Immunol 112:93-101, 2003.
20. Gardai SJ, Hoontrakoon R, Goddard CD, et al. Oxidant-mediated mitochondrial injury in eosinophil apoptosis: Enhancement by glucocorticoids and inhibition by granulocyte-macrophage colony-stimulating factor. J Immunol 170:556-566, 2003.
21. Kankaanranta H, De Souza PM, Giembycz MA, et al. Human eosinophil isolation and the measurement of apoptosis. In Methods in Molecular Medicine: Asthma, Vol. 44. Chung KF, and Adcock IM (Eds). London: Humana Press, 99-110, 2000.
22. Nicoletti I, Migliorati G, Pagliacci MC, et al. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139:271-279, 1991.
23. Ciprandi G, Cirillo I, Vizzaccaro A, et al. Airway function and nasal inflammation in seasonal allergic rhinitis and asthma. Clin Exp Allergy 34:891-896, 2004.
24. Passalacqua G, Ciprandi G, and Canonica GW. The nose-lung interaction in allergic rhinitis and asthma: United airways disease. Curr Opin Allergy Clin Immunol 1:7-13, 2001.
25. Passalacqua G, Ciprandi G, Pasquali M, et al. An update on the asthma-rhinitis link. Curr Opin Allergy Clin Immunol 4:177-183, 2004.
26. Togias A. Rhinitis and asthma: Evidence for respiratory system integration. J Allergy Clin Immunol 111:1171-1183, 2003.
27. Agrawal DK. Anti-inflammatory properties of desloratadine. Clin Exp Allergy 34:1342-1348, 2004.
28. Kowalski ML, Lewandowska A, Wozniak J, et al. Inhibition of nasal polyp mast cell and eosinophil activation by desloratadine. Allergy 60:80-85, 2005.
29. Ciprandi G, Cirillo I, Vizzaccaro A, et al. Levocetirizine improves nasal obstruction and modulates cytokine pattern in patients with seasonal allergic rhinitis: A pilot study. Clin Exp Allergy 34:958-964, 2004.
30. Reinartz SM, Overbeek SE, Kleinjan A, et al. Desloratadine reduces systemic allergic inflammation following nasal provocation in allergic rhinitis and asthma patients. Allergy 60:1301-1307, 2005.
31. Sedgwick JB, and Busse WW. Inhibitory effect of cetirizine on cytokine-enhanced in vitro eosinophil survival. Ann Allergy Asthma Immunol 78:581-585, 1997.
32. Mullol J, Roca-Ferrer J, Alobid I, et al. Effect of desloratadine on epithelial cell granulocyte-macrophage colony-stimulating factor secretion and eosinophil survival. Clin Exp Allergy 36: 52-58, 2006.
33. Tsuiki H, Tnani M, Okamoto I, et al. Constitutively active forms of c-Jun NH2-terminal kinase are expressed in primary glial tumors. Cancer Res 63:250-255, 2003.
34. Cui J, Holgado-Madruga M, Su W, et al. Identification of a specific domain responsible for JNK2alpha2 autophosphorylation. J Biol Chem 280:9913-9920, 2005.