Synthesis and biological evaluation of unprecedented classes of spiro-β-lactams and azido-β-lactams as acyl-CoA:cholesterol acyltransferase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 7, 2007, Pages 1946-1950

  Benfatti, Fides ^a   Cardillo, Giuliana ^a   Gentilucci, Luca ^a   Tolomelli, Alessandra ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Lactams; Acyl CoA cholesterol O acyltransferase; Azides; Cholesterol absorption inhibition; Spiro derivatives

Indexed keywords

AZIDE; BETA LACTAM DERIVATIVE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; EPOXIDE; HYDROXYL GROUP; SPIRO COMPOUND;

ARTICLE; BIOLOGICAL ACTIVITY; COMPARATIVE STUDY; DIASTEREOISOMER; DRUG DETERMINATION; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; RING OPENING; STEREOCHEMISTRY;

ABSORPTION; ACYL COENZYME A; BETA-LACTAMS; CATALYSIS; CHEMISTRY, PHARMACEUTICAL; CHOLESTEROL; DRUG DESIGN; ENZYME INHIBITORS; EPOXY COMPOUNDS; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; STEROL O-ACYLTRANSFERASE;

EID: 33847607994     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.01.027     Document Type: Article

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