Mono- or diphenylpyridazines connected to N-(2,4-difluorophenyl)-N′- heptylurea as Acyl-CoA:cholesterol acyltransferase inhibitors

Journal of Medicinal Chemistry

Volumn 48, Issue 24, 2005, Pages 7708-7713

  Gelain, Arianna ^a   Bettinelli, Ilaria ^a   Barlocco, Daniela ^a   Kwon, Byoung Mog ^b   Jeong, Tae Sook ^b   Cho, Kyung Hyun ^b   Toma, Lucio ^c  

^a UNIVERSITY OF MILAN   (Italy)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; LECIMIBIDE; N (2,4 DIFLUOROPHENYL) N' HEPTYL N' [5 [(5,6 DIPHENYLPYRIDAZIN 3 YL)AMINO]PENTYL]UREA; N (2,4 DIFLUOROPHENYL) N' HEPTYL N' [5 [(5,6 DIPHENYLPYRIDAZIN 3 YL)THIO]PENTYL]UREA; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GEOMETRY; LIVER MICROSOME; NONHUMAN; RAT;

ACETYL-COA C-ACETYLTRANSFERASE; ANIMALS; CELL LINE; HUMANS; MICROSOMES, LIVER; MODELS, MOLECULAR; PHENYLUREA COMPOUNDS; PROTEIN ISOFORMS; PYRIDAZINES; RATS; STEROL O-ACYLTRANSFERASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 28144457982     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050703x     Document Type: Article

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