Benzo[a]pyrene up-regulates the expression of the proliferating cell nuclear antigen (PCNA) and multixenobiotic resistance polyglycoprotein (P-gp) in Baltic Sea blue mussels (Mytilus edulis L.)

Comparative Biochemistry and Physiology - C Toxicology and Pharmacology

Volumn 145, Issue 2, 2007, Pages 265-274

  Prevodnik, Andreas ^a,b   Lilja, Karl ^a,b   Bollner, Tomas ^a  

^a School of Life Sciences Södertörn University   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Benzo a pyrene; Biomarker; Ecotoxicology; Genotoxicity; Heat shock proteins; Multixenobiotic resistance protein; Proliferating cell nuclear antigen; Retinoblastoma 110 protein

Indexed keywords

BENZO[A]PYRENE; BIOCHEMICAL MARKER; CYCLINE; GLYCOPROTEIN P; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 70; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; RETINOBLASTOMA PROTEIN;

ARTICLE; BALTIC SEA; CELL PROLIFERATION; DNA ADDUCT; DNA DAMAGE; DNA REPAIR; ECOTOXICOLOGY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL STRESS; GENOTOXICITY; IMMUNOCYTOCHEMISTRY; MUSSEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; UPREGULATION; WATER POLLUTANT; WATER POLLUTION; WESTERN BLOTTING;

ANIMALIA; MYTILUS EDULIS;

EID: 33847409768     PISSN: 15320456     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpc.2006.12.014     Document Type: Article

References (51)

1. Accomando R., Viarengo A., Moore M.N., and Marchi B. Effects of ageing on nuclear DNA integrity and metabolism in mussel cells (Mytilus edulis L). Int. J. Biochem. Cell Biol. 31 (1999) 443-450
2. Adriana M.D., Holmes E., and Kleinow K.M. P-glycoprotein in the catfish intestine: inducibility by xenobiotics and functional properties. Aquat. Toxicol. 55 (2001) 157-170
3. Aït-Aïssa S., Porcher J.M., Arrigo A.P., and Lambre C. Activation of the hsp70 promoter by environmental inorganic and organic chemicals: relationships with cytotoxicity and lipophilicity. Toxicology 145 (2000) 147-157
4. Akcha F., Izuel C., Venier P., Budzinski H., Burgeot T., and Narbonne J.F. Enzymatic biomarker measurement and study of DNA adduct formation in benzo[a]pyrene-contaminated mussels, Mytilus galloprovincialis. Aquat. Toxicol. 49 (2000) 269-287
5. Bard S.M. Multixenobiotic resistance as a cellular defense mechanism in aquatic organisms. Aquat. Toxicol. 48 (2000) 357-389
6. Blas-Machado U., Taylor H.W., and Means J.C. Apoptosis, PCNA, and p53 in Fundulus grandis fish liver after in vivo exposure to N-methyl-N′-nitro-N-nitrcssoguanidine and 2-aminofluorene. Toxicol. Pathol. 28 (2000) 601-609
7. Brown D.C., Bradley B.P., and Tedengren M. Genetic and environmental-regulation of hsp70 expression. Mar. Environ. Res. 39 (1995) 181-184
8. Brown M., Davies I.M., Moffat C.F., and Craft J.A. Application of SSH and a macroarray to investigate altered gene expression in Mytilus edulis in response to exposure to benzo[a]pyrene. Mar. Environ. Res. 62 (2006) S128
9. Callaghan A., Parker J.A.N.P., and Holloway G.J. The use of variance in enzyme activity as an indicator of long-term exposure to toxicant-stressed environments in Culex pipens mosquitoes. Funct. Ecol. 12 (1998) 436-441
10. Canova S., Degan P., Peters L.D., Livingstone D.R., Voltan R., and Venier P. Tissue dose, DNA adducts, oxidative DNA damage and CYP1A-immunopositive proteins in mussels exposed to waterborne benzo[a]pyrene. Mutat. Res., Fundam. Mol. Mech. Mutagen. 399 (1998) 17-30
11. Chen J.H., Stoeber K., Kingsbury S., Ozanne S.E., Williams G.H., and Hales C.N. Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts. J. Biol. Chem. 279 (2004) 49439-49446
12. Ciocan C., and Sunila I. Disseminated neoplasia in blue mussels, Mytilus galloprovincialis, from the Black Sea, Romania. Mar. Pollut. Bull. 50 (2005) 1335-1339
13. Cox L.S. Who binds wins: competition for PCNA rings out cell-cycle changes. Trends Cell Biol. 7 (1997) 493-498
14. Dolcetti L., Dalla Zuanna L., and Venier P. DNA adducts in mussels and fish exposed to bulky genotoxic compounds. Mar. Environ. Res. 54 (2002) 481-486
15. Donkin P., Widdows J., Evans S.V., Worrall C.M., and Carr M. Quantitative structure activity relationships for the effect of hydrophobic organic-chemicals on rate of feeding by mussels (Mytilus edulis). Aquat. Toxicol. 14 (1989) 277-294
16. Epel D. Use of multidrug transporters as first lines of defense against toxins in aquatic organisms. Comp. Biochem. Physiol. A 120 (1998) 23-28
17. Ericson G., Skarphé{eth}insdóttir H., Dalla Zuanna L., and Svavarsson J. DNA adducts as indicators of genotoxic exposure in indigenous and transplanted mussels, Mytilus edulis L. from Icelandic coastal sites. Mutat. Res., Genet. Toxicol. Environ. Mutagen. 516 (2002) 91-99
18. Eufemia N.A., and Epel D. Induction of the multixenobiotic defense mechanism (MXR), P-glycoprotein, in the mussel Mytilus californianus as a general cellular response to environmental stresses. Aquat. Toxicol. 49 (2000) 89-100
19. Forbes V.E., and Depledge M.H. Environmental stress and the distribution of traits within populations. In: Baird D.J., Maltby L., Greig-Smith P.W., and Douben P.E.T. (Eds). Ecotoxicology: Ecological Dimensions (1996), Chapman and Hall, London 71-76
20. Gomez-Mendikute A., Elizondo M., Venier P., and Cajaraville M. Characterization of mussel gill cells in vivo and in vitro. Cell Tissue Res. 321 (2005) 131-140
21. Halldórsson H.P., Svavarsson J., and Granmo Å. The effect of pollution on scope for growth of the mussel (Mytilus edulis L.) in Iceland. Mar. Environ. Res. 59 (2005) 47-64
22. Harvey J.S., and Parry J.M. The detection of genotoxin-induced DNA adducts in the common mussel Mytilus edulis. Mutagenesis 12 (1997) 153-158
23. Higgins C. P-glycoprotein and cell-volume activated chloride channels. J. Bioenerg. Biomembranes 127 (1992) 63-70
24. Holloway G.J., Crocker H.J., and Callaghan A. The effects of novel and stressful environments on trait distribution. Funct. Ecol. 11 (1997) 579-584
25. Kautsky N., Johannesson K., and Tedengren M. Genotypic and phenotypic differences between Baltic and North Sea populations of Mytilus edulis evaluated through reciprocal transplantations: growth and morphology. Mar. Ecol., Prog. Ser. 59 (1990) 203-210
26. Kurelec B. The multixenobiotic resistance mechanism in aquatic organisms. Crit. Rev. Toxicol. 22 (1992) 23-43
27. Kurelec B. The genotoxic disease syndrome. Mar. Environ. Res. 35 (1993) 341-348
28. Kurelec B., Lucić D., Pivčević B., and Krča S. Induction and reversion of multixenobiotic resistance in the marine snail Monodonta turbinata. Mar. Biol. 123 (1995) 305-312
29. Luedeking A., and Koehler A. Identification of six mRNA sequences of genes related to multixenobiotic resistance (MXR) and biotransformation in Mytilus edulis. Mar. Ecol., Prog. Ser. 238 (2002) 115-124
30. Luedeking A., and Koehler A. Regulation of expression of multixenobiotic resistance (MXR) genes by environmental factors in the blue mussel Mytilus edulis. Aquat. Toxicol. 69 (2005) 1-10
31. Lyons C., Dowling V., Tedengren M., Gardeström J., Hartl M.G.J., O'Brien N., van Pelt F., O'Halloran J., and Sheehan D. Variability of heat shock proteins and glutathione S-transferase in gill and digestive gland of blue mussel, Mytilus edulis. Mar. Environ. Res. 56 (2003) 585-597
32. Maga G., and Hübscher U. Proliferating cell nuclear antigen (PCNA): a dancer with many partners. J. Cell Sci. 116 (2003) 3051-3060
33. Marigomez I., Lekube X., and Cancio I. Immunochemical localisation of proliferating cells in mussel digestive gland tissue. Histochem. J. 31 (1999) 781-788
34. Martinez P.G., and Livingstone D.R. Benzo a Pyrene-Dione-stimulated oxyradical production by microsomes of digestive gland of the common mussel, Mytilus edulis L. Mar. Environ. Res. 39 (1995) 185-189
35. Mitchelmore C.L., Birmelin C., Chipman J.K., and Livingstone D.R. Evidence for cytochrome P-450 catalysis and free radical involvement in the production of DNA strand breaks by benzo a pyrene and nitroaromatics in mussel (Mytilus edulis L.) digestive gland cells. Aquat. Toxicol. 41 (1998) 193-212
36. Ohlson L.C.E., Koroxenidou L., and Porsch-Hällström I. Mitoinhibitory effects of the tumor promoter 2-acetylaminofluorene in rat liver: loss of E2F-1 and E2F-3 expression and cdk 2 kinase activity in late G1. J. Hepatol. 40 (2004) 957-962
37. Orlando E.F., and Guilette L.J.J. A re-examination of variation associated with environmentally stressed organisms. Hum. Reprod. Updat. 7 (2001) 265-272
38. Ostroumov S.A., and Widdows J. Inhibition of mussel suspension feeding by surfactants of three classes. Hydrobiologia 556 (2006) 381-386
39. Pisoni M., Cogotzi L., Frigeri A., Corsi I., Bonacci S., Iacocca A., Lancini L., Mastrototaro F., Focardi S., and Svelto M. DNA adducts, benzo[a]pyrene monooxygenase activity, and lysosomal membrane stability in Mytilus galloprovincialis from different areas in Taranto coastal waters (Italy). Environ. Res. 96 (2004) 163-175
40. Porte C., Biosca X., Sole M., and Albaiges J. The integrated use of chemical analysis, cytochrome P450 and stress proteins in mussels to assess pollution along the Galician coast (NW Spain). Environ. Pollut. 112 (2001) 261-268
41. Rössner P., Binková B., and Šram R.J. Heat shock proteins hsp32 and hsp70 as biomarkers of an early response? In vitro induction of heat shock proteins after exposure of cell culture to carcinogenic compounds and their real mixtures. Mutat. Res., Genet. Toxicol. Environ. Mutagen. 542 (2003) 105-116
42. Shan B., Xu J., Zhuo Y., Morris C.A., and Morris G.F. Induction of p53-dependent activation of the human proliferating cell nuclear antigen gene in chromatin by ionizing radiation. J. Biol. Chem. 278 (2003) 44009-44017
43. Skarphé{eth}insdóttir H., Ericson G., Dalla Zuanna L., and Gilek M. Tissue differences, dose-response relationship and persistence of DNA adducts in blue mussels (Mytilus edulis L.) exposed to benzo[a]pyrene. Aquat. Toxicol. 62 (2003) 165-177
44. Snyder M.J., Girvetz E., and Mulder E.P. Induction of marine mollusc stress proteins by chemical or physical stress. Arch. Environ. Contam. Toxicol. 41 (2001) 22-29
45. Sokołowski A., Wołowicz M., Hummel H., Smolarz-Górska K., Fichet D., Radenac G., Thiriot-Quievreux C., and Namiesnik J. Abnormal features of Macoma balthica (Bivalvia) in the Baltic Sea: alerting symptoms of environmental adversity?. Mar. Pollut. Bull. 49 (2004) 17-22
46. Stegeman J.J. Benzo[a]pyrene oxidation and microsomal-enzyme activity in the mussel (Mytilus edulis) and other bivalve mollusk species from the Western North Atlantic. Mar. Biol. 89 (1985) 21-30
47. Tedengren M., and Kautsky N. Comparative study of the physiology and its probable effect on size in blue mussels (Mytilus edulis L.) from the North Sea and the northern Baltic. Ophelia 25 (1986) 147-155
48. Tedengren M., and Kautsky N. Comparative stress response to diesel oil and salinity changes of the blue mussel, Mytilus edulis, from the Baltic and North Seas. Ophelia 28 (1987) 1-9
49. Tedengren M., Olsson B., Bradley B.P., and Zhou L. Heavy metal uptake, physiological response and survival of the blue mussel (Mytilus edulis) from marine and brackish waters in relation to the induction of heat-shock protein 70. Hydrobiologia 393 (1999) 261-269
50. Weinberg R.A. The retinoblastoma protein and cell cycle control. Cell 81 (1995) 323-330
51. Werner I., Kline K.F., and Hollibaugh J.T. Stress protein expression in Ampelisca abdita (Amphipoda) exposed to sediments from San Francisco Bay. Mar. Environ. Res. 45 (1998) 417-430