Acute Sirolimus Pulmonary Toxicity in an Infant Heart Transplant Recipient: Case Report and Literature Review

Journal of Heart and Lung Transplantation

Volumn 26, Issue 3, 2007, Pages 296-298

  Das, Bibhuti B ^a   Shoemaker, Lawrence ^a   Subramanian, Sujata ^b   Johnsrude, Christopher ^a   Recto, Michael ^a   Austin, Erle H ^a  

^a University of Louisville School of Medicine   (United States)

^b KOSAIR CHILDREN'S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; COTRIMOXAZOLE; HYDROCORTISONE; IMMUNOGLOBULIN; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; RAPAMYCIN; TACROLIMUS; THYMOCYTE ANTIBODY;

ACUTE RESPIRATORY FAILURE; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; CASE REPORT; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; HEART LEFT VENTRICLE FAILURE; HEART TRANSPLANTATION; HEART VENTRICLE TACHYCARDIA; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFANT; LOADING DRUG DOSE; ORTHOTOPIC TRANSPLANTATION; PRIORITY JOURNAL; THORAX RADIOGRAPHY;

ACUTE DISEASE; CHYLOTHORAX; FEMALE; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFANT; LUNG DISEASES, INTERSTITIAL; RADIOGRAPHY, THORACIC; RESPIRATORY INSUFFICIENCY; SIROLIMUS;

EID: 33847391264     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.healun.2006.12.004     Document Type: Article

References (12)

1. Gupta P., Kaufman S., and Fishbein T.M. Sirolimus for solid organ transplantation in children. Pediatr Transplant 9 (2005) 269-276
2. Hamour I.M., Mittal T.K., Bell A.D., and Banner N. Reversible sirolimus-associated pneumonitis after heart transplantation. J Heart Lung Transplant 25 (2006) 241-244
3. Lee V.W.S., and Chapman J.R. Sirolimus: its role in nephrology. Nephrology 10 (2005) 606-614
4. Champion L., Stern M., Israel-Biet D., et al. Sirolimus-associated pneumonitis: 24 cases in renal transplant recipients. Ann Intern Med 144 (2006) 505-509
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6. Mingos M.A., and Kane G.C. Sirolimus-induced interstitial pneumonitis in a renal transplant patient. Respir Care 50 (2005) 1659-1661
7. Rehm B., Keller F., Mayer J., and Stracke S. Resolution of sirolimus-induced pneumonitis after conversion to everolimus. Transplant Proc 38 (2006) 711-713
8. Chau E.M.C., and Chow W.H. Sirolimus-induced pneumonitis presenting as acute respiratory distress syndrome. J Heart Lung Transplant 24 (2006) 867-868
9. Amigues L., Klouche K., Massanet P., et al. Sirolimus-associated acute respiratory distress syndrome in a renal transplant recipient. Transplant Proc 37 (2005) 2830-2831
10. Howard L., Gopalan D., Griffiths M., and Mahadeva R. Sirolimus-induced pulmonary hypersensitivity associated with a CD4 T-cell infiltrate. Chest 129 (2006) 1718-1721
11. Pham P.T.T., Pham P.C.T., Danovitch G.M., et al. Sirolimus-associated pulmonary toxicity. Transplantation 77 (2004) 1215-1220
12. Morelon E., Stern M., Israel-Biet D., et al. Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients. Transplantation 72 (2001) 787-790