Investigation of association of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population

International Journal of Colorectal Disease

Volumn 22, Issue 4, 2007, Pages 419-424

  Pearce, Alexandra B ^a   Fisher, Sheila A ^a   Prescott, Natalie J ^a   Onnie, Clive M ^a   Pattni, Reenal ^a   Green, Peter ^a   Forbes, Alastair ^b   Mansfield, John ^c   Sanderson, Jeremy ^d   Schreiber, Stefan ^e   Lewis, Cathryn M ^a   Mathew, Christopher G ^a  

^a GUY S HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^e UNIVERSITY OF KIEL   (Germany)

Author keywords

Association; DLG5; Inflammatory bowel disease

Indexed keywords

ARGININE; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CELL PROTEIN; GLYCINE; LEUCINE; TRYPTOPHAN;

ARTICLE; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; CROHN DISEASE; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; ENTERITIS; GENE FREQUENCY; GENE INTERACTION; GENE MUTATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PHENOTYPE; PRIORITY JOURNAL; SMOKING; ULCERATIVE COLITIS; UNITED KINGDOM;

CASE-CONTROL STUDIES; COHORT STUDIES; COLITIS, ULCERATIVE; CROHN DISEASE; ENGLAND; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INFLAMMATORY BOWEL DISEASES; MEMBRANE PROTEINS; PHENOTYPE; POLYMORPHISM, GENETIC; SMOKING; TUMOR SUPPRESSOR PROTEINS;

EID: 33847366601     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-006-0151-4     Document Type: Article

References (20)

1. Mathew CG, Lewis CM (2004) Genetics of inflammatory bowel disease: progress and prospects. Hum Mol Genet 13:R161-R168
2. Schreiber S, Rosensteil P, Albrecht M, Hampe J, Krawczak M (2005) Genetics of Crohn disease, an archetypal inflammatory barrier disease. Nat Rev Genet 6:376-388
3. Hampe JA, Cuthbert A, Croucher PJ, Mirza MM, Mascheretti S, Fisher S, Frenzel H, King K, Hasselmeyer A, MacPherson AJS, Bridger S, van Deventer S, Forbes A, Nikolaus S, Lennard-Jones JE, Foelsch UR, Krawczak M, Lewis C, Schreiber S, Mathew CG (2001) Association between insertion mutation in NOD2 gene and Crohn's Disease in German and British populations. Lancet 357:1925-1928
4. Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Almer S, Tysk C, O'Morain CA, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J, Colombel JF, Sahbatou M, Thomas G (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411:599-603
5. Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Nunez G, Cho JH (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411:603-606
6. Bonen, DK, Cho JH (2003) The genetics of inflammatory bowel disease. Gastroenterol 124:521-536
7. Van Heel DA, Fisher SA, Kirby A, Daly MJ, Rioux JD, Lewis CM (2004) Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs. Hum Mol Genet 13:763-770
8. Hampe J, Schreiber S, Shaw SH, Lau KF, Bridger S, Macpherson AJS, Cardon LR, Sakul H, Harris TJR, Buckler A, Hall J, Stokkers P, van Deventer SJH, Nurnberg P, Mirza MM, Lee JCW, Lennard-Jones JE, Mathew CG, Curran ME (1999) A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort. Am J Hum Genet 64:808-816
9. Stoll M, Corneliussen B, Costello CM, Waetzig GH, Mellgard B, Kock WA, Rosenstiel P, Albrecht M, Croucher PJP, Seegert D, Nikolaus S, Hampe J, Lengauer T, Pierrou S, Foelsch IR, Mathew CG, Lagerstrom-Fermer M, Schreiber S (2004) Genetic variation in DLG5 is associated with inflammatory bowel disease. Nat Genet 36:476-480
10. Daly MJ, Pearce AV, Farwell L, Fisher SA, Latiano A, Prescott NJ, Forbes A, Mansfield J, Sanderson J, Langelier D, Cohen A, Bitton A, Wild G, Lewis CM, Annese V, Mathew CG, Rioux JD (2005) Association of DLG5 R30Q variant with inflammatory bowel disease. Eur J Hum Genet 13:835-839
11. Lennard-Jones JE (1989) Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl 170:2-6, discussion 16-19
12. Ronaghi M, Uhlen M, Nyren P (1998) A sequencing method based on real-time pyrophosphate. Science 281:363-365
13. Cuthbert AP, Fisher SA, Mirza MM, King K, Hampe J, Croucher PJP, Mascheretti S, Sanderson J, Forbes A, Mansfield J, Schreiber S, Lewis CM, Mathew CG (2002) The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Gastroenterol 122:867-874
14. Ahmad T, Armuzzi A, Bunce M, Mulcahy-Hawes K, Marshall SE, Orchard TR, Crawshaw J, Large O, de Silva A, Cook JT, Barnardo M, Cullen S, Welsh KI, Jewell DP (2002) The molecular classification of the clinical manifestations of Crohn's disease. Gastroenterol 122:854-866
15. Mirza MM, Fisher SA, King K, Cuthbert AP, Hampe J, Sanderson J, Mansfield J, Donaldson P, Macpherson A, Forbes A, Schreiber S, Lewis CM, Mathew CG (2003) Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease. Am J Hum Genet 72:1018-1022
16. Birrenbach T, Bocker U (2004) Inflammatory bowel disease and smoking: A review of epidemiology, pathophysiology, and therapeutic implications. Inflamm Bowel Dis 10:848-859
17. Hampe J, Grebe J, Nikolaus S, Solberg C, Croucher PJ, Mascheretti S, Jahnsen J, Moum B, Klump B, Krawczak M, Mirza MM, Foelsch UR, Vatn M, Schreiber S (2002) Association of NOD2 (CARD15) genotype with clinical course of Crohn's disease: A cohort study. Lancet 359:1661-1665
18. Yamazaki K, Takazoe M, Tanaka T, Ichimori T, Saito S, Iida A, Onouchi Y, Hata A, Nakamura Y (2004) Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with Crohn disease. J Hum Genet 49:664-668
19. Noble CL, Nimmo ER, Smith L, Arnott ID, Satsangi J (2005) DLG5 variants do not influence susceptibility to inflammatory bowel disease in the Scottish population. Gut 54:1416-1420
20. Török HP, Glas J, Tonenchi L, Lohse P, Muller-Myhsok B, Limbersky O, Neugebauer C, Schnitzler F, Seiderer J, Tillack C, Brand S, Brunnler G, Jagiello P, Epplen JT, Griga T, Klein W, Schiemann U, Folwaczny M, Pochsenkuhn T, Folwaczny C (2005) Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease. Gut 54:1354-1357