메뉴 건너뛰기




Volumn 33, Issue 3, 2007, Pages 292-301

An in vitro/in vivo screening assay as a sensitive tool to assess endocrine disruptive activity in surface water

Author keywords

Drinking water; Estrogenic activity; Fathead minnow; Non spawning male fish assay; River waters; Vitellogenin

Indexed keywords

BIODIVERSITY; FISHING VESSELS; HISTOLOGY; HORMONES; POTABLE WATER; RIVERS; RNA; STATISTICAL TESTS; SURFACE WATERS;

EID: 33847363719     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/j.envint.2006.10.002     Document Type: Article
Times cited : (16)

References (44)
  • 1
    • 0034819875 scopus 로고    scopus 로고
    • Description and evaluation of a short-term reproduction test with the fathead minnow (Pimephales promelas)
    • Ankley G.T., Jensen K.M., Kahl M.D., Korte J.J., and Makynen E.A. Description and evaluation of a short-term reproduction test with the fathead minnow (Pimephales promelas). Environ Toxicol Chem 20 6 (2001) 1276-1290
    • (2001) Environ Toxicol Chem , vol.20 , Issue.6 , pp. 1276-1290
    • Ankley, G.T.1    Jensen, K.M.2    Kahl, M.D.3    Korte, J.J.4    Makynen, E.A.5
  • 2
    • 1542581468 scopus 로고    scopus 로고
    • Consequences of xenoestrogen exposure on male reproductive function in spottail shiners (Notropis hudsonius)
    • Aravindakshan J., Paquet V., Gregory M., Dufresne J., Fournier M., Marcogliese D.J., et al. Consequences of xenoestrogen exposure on male reproductive function in spottail shiners (Notropis hudsonius). Toxicol Sci 78 (2004) 156-165
    • (2004) Toxicol Sci , vol.78 , pp. 156-165
    • Aravindakshan, J.1    Paquet, V.2    Gregory, M.3    Dufresne, J.4    Fournier, M.5    Marcogliese, D.J.6
  • 3
    • 0033015289 scopus 로고    scopus 로고
    • Analysis and occurrence of estrogenic hormones and their glucuronides in surface water and waste water in The Netherlands
    • Belfroid A.C., Van der Horst A., Vethaak A.D., Schäfer A.J., Rijs G.B.J., Wegener J., et al. Analysis and occurrence of estrogenic hormones and their glucuronides in surface water and waste water in The Netherlands. Sci Total Environ 225 (1999) 101-108
    • (1999) Sci Total Environ , vol.225 , pp. 101-108
    • Belfroid, A.C.1    Van der Horst, A.2    Vethaak, A.D.3    Schäfer, A.J.4    Rijs, G.B.J.5    Wegener, J.6
  • 4
    • 33750975075 scopus 로고    scopus 로고
    • Development of chronic tests for endocrine active chemicals Part 2. An extended fish early-life stage test with an androgenic chemical in the fathead minnow (Pimephales promelas)
    • Bogers R., De Vries-Buitenweg S., Van Gils M., Baltussen E., Hargreaves A., Van De Waart B., De Roode D., Legler J., and Murk A. Development of chronic tests for endocrine active chemicals Part 2. An extended fish early-life stage test with an androgenic chemical in the fathead minnow (Pimephales promelas). Aquat Toxicol 80 (2006) 119-130
    • (2006) Aquat Toxicol , vol.80 , pp. 119-130
    • Bogers, R.1    De Vries-Buitenweg, S.2    Van Gils, M.3    Baltussen, E.4    Hargreaves, A.5    Van De Waart, B.6    De Roode, D.7    Legler, J.8    Murk, A.9
  • 5
    • 0034525388 scopus 로고    scopus 로고
    • Estrogen-induced vitellogenin-mRNA and protein in sheepshead minnow (Cyprinodon variegatus)
    • Bowman C.J., Kroll K.J., Hemmer M.J., Folmar L.C., and Denslow N.D. Estrogen-induced vitellogenin-mRNA and protein in sheepshead minnow (Cyprinodon variegatus). Gen Comp Endocrinol 120 (2000) 300-313
    • (2000) Gen Comp Endocrinol , vol.120 , pp. 300-313
    • Bowman, C.J.1    Kroll, K.J.2    Hemmer, M.J.3    Folmar, L.C.4    Denslow, N.D.5
  • 6
    • 0020804585 scopus 로고
    • Estrogen stabilizes vitellogenin-mRNA against cytoplasmic degradation
    • Brock M.L., and Shapiro D.J. Estrogen stabilizes vitellogenin-mRNA against cytoplasmic degradation. Cell 34 1 (1983) 207-214
    • (1983) Cell , vol.34 , Issue.1 , pp. 207-214
    • Brock, M.L.1    Shapiro, D.J.2
  • 7
    • 0001606106 scopus 로고    scopus 로고
    • Histological fixation of the testes: use of Davidson's fluid as an alternative to Bouin's fluid
    • Creasy D.M., and Jonassen H. Histological fixation of the testes: use of Davidson's fluid as an alternative to Bouin's fluid. Vet Pathol 36 (1999) 518
    • (1999) Vet Pathol , vol.36 , pp. 518
    • Creasy, D.M.1    Jonassen, H.2
  • 9
    • 0034020362 scopus 로고    scopus 로고
    • Comparative estrogenicity of estradiol, ethynyl estradiol and diethylstilbestrol in an in vivo, male sheepshead minnow (Cyprinodon variegatus), vitellogenin bioassay
    • Folmar L.C., Hemmer M., Hemmer R., Bowman C., Kroll K., and Denslow N.D. Comparative estrogenicity of estradiol, ethynyl estradiol and diethylstilbestrol in an in vivo, male sheepshead minnow (Cyprinodon variegatus), vitellogenin bioassay. Aquat Toxicol 49 (2000) 77-88
    • (2000) Aquat Toxicol , vol.49 , pp. 77-88
    • Folmar, L.C.1    Hemmer, M.2    Hemmer, R.3    Bowman, C.4    Kroll, K.5    Denslow, N.D.6
  • 11
    • 0037010208 scopus 로고    scopus 로고
    • A comparison of the estrogenic potencies of estradiol, ethinylestradiol, diethylstilbestrol, nonylphenol and methoxychlor in vivo and in vitro
    • Folmar L.C., Hemmer M.J., Denslow N.D., Kroll K., Chen J., Cheek A., et al. A comparison of the estrogenic potencies of estradiol, ethinylestradiol, diethylstilbestrol, nonylphenol and methoxychlor in vivo and in vitro. Aquat Toxicol 60 (2002) 101-110
    • (2002) Aquat Toxicol , vol.60 , pp. 101-110
    • Folmar, L.C.1    Hemmer, M.J.2    Denslow, N.D.3    Kroll, K.4    Chen, J.5    Cheek, A.6
  • 12
    • 0031259841 scopus 로고    scopus 로고
    • Disruption of sexual differentiation in genetic male common carp (Cyprinus carpio) exposed to an alkylphenol during different life stages
    • Gimeno S., Komen H., Venderbrosch P.W.M., and Bowmer T. Disruption of sexual differentiation in genetic male common carp (Cyprinus carpio) exposed to an alkylphenol during different life stages. Environ Sci Toxicol 31 (1997) 2884-2890
    • (1997) Environ Sci Toxicol , vol.31 , pp. 2884-2890
    • Gimeno, S.1    Komen, H.2    Venderbrosch, P.W.M.3    Bowmer, T.4
  • 14
    • 0036229743 scopus 로고    scopus 로고
    • Vitellogenin-mRNA regulation and plasma clearance in male sheepshead minnows, (Cyprinodon variegatus) after cessation of exposure to 17 beta-estradiol and p-nonylphenol
    • Hemmer M.J., Bowman C.J., Hemmer B.L., Friedman S.D., Marcovich D., Kroll K.J., et al. Vitellogenin-mRNA regulation and plasma clearance in male sheepshead minnows, (Cyprinodon variegatus) after cessation of exposure to 17 beta-estradiol and p-nonylphenol. Aquat Toxicol 58 1-2 (2002) 99-112
    • (2002) Aquat Toxicol , vol.58 , Issue.1-2 , pp. 99-112
    • Hemmer, M.J.1    Bowman, C.J.2    Hemmer, B.L.3    Friedman, S.D.4    Marcovich, D.5    Kroll, K.J.6
  • 15
    • 0001214463 scopus 로고
    • Pathological effects of orally administered estradiol to rainbow trout
    • Hermann R.L., and Kincaid H.L. Pathological effects of orally administered estradiol to rainbow trout. Aquaculture 72 (1988) 165-172
    • (1988) Aquaculture , vol.72 , pp. 165-172
    • Hermann, R.L.1    Kincaid, H.L.2
  • 17
    • 2442477284 scopus 로고    scopus 로고
    • Comparative responses of molluscs and fish to environmental estrogens and an estrogenic effluent
    • Jobling S., Casey D., Rogers-Gray T., Oehlmann J., Schulte-Oehlmann U., Pawlowski S., et al. Comparative responses of molluscs and fish to environmental estrogens and an estrogenic effluent. Aquat Toxicol 66 2 (2004) 207-222
    • (2004) Aquat Toxicol , vol.66 , Issue.2 , pp. 207-222
    • Jobling, S.1    Casey, D.2    Rogers-Gray, T.3    Oehlmann, J.4    Schulte-Oehlmann, U.5    Pawlowski, S.6
  • 18
    • 12244252783 scopus 로고    scopus 로고
    • The presence of morphologically intermediate papilla syndrome in United Kingdom populations of sand goby (Pomatoschistus spp.): endocrine disruption?
    • Kirby M.F., Bignell J., Brown E., Craft J.A., Davies I., Dyer R.A., et al. The presence of morphologically intermediate papilla syndrome in United Kingdom populations of sand goby (Pomatoschistus spp.): endocrine disruption?. Environ Toxicol Chem 22 (2003) 239-251
    • (2003) Environ Toxicol Chem , vol.22 , pp. 239-251
    • Kirby, M.F.1    Bignell, J.2    Brown, E.3    Craft, J.A.4    Davies, I.5    Dyer, R.A.6
  • 19
    • 31244432624 scopus 로고    scopus 로고
    • Surveys of plasma vitellogenin and intersex in male flounder (Platichthys flesus) as measures of endocrine disruption by estrogenic contamination in United Kingdom estuaries: temporal trends, 1996 to 2001
    • Kirby M.F., Allen Y.T., Dyer R.A., Feist S.W., Katsiadaki I., Matthiessen P., et al. Surveys of plasma vitellogenin and intersex in male flounder (Platichthys flesus) as measures of endocrine disruption by estrogenic contamination in United Kingdom estuaries: temporal trends, 1996 to 2001. Environ Toxicol Chem 23 (2004) 748-758
    • (2004) Environ Toxicol Chem , vol.23 , pp. 748-758
    • Kirby, M.F.1    Allen, Y.T.2    Dyer, R.A.3    Feist, S.W.4    Katsiadaki, I.5    Matthiessen, P.6
  • 20
    • 0031952864 scopus 로고    scopus 로고
    • Reproductive impairment and induction of alkaline-labile phosphate, a biomarker of estrogen exposure, in fathead Minnows (Pimephales promelas) exposed to waterborne 17b-estradiol
    • Kramer V.J., Miles-Richardson S., Pierens S.L., and Giesy J. Reproductive impairment and induction of alkaline-labile phosphate, a biomarker of estrogen exposure, in fathead Minnows (Pimephales promelas) exposed to waterborne 17b-estradiol. Aquat Toxicol 50 (1998) 335-360
    • (1998) Aquat Toxicol , vol.50 , pp. 335-360
    • Kramer, V.J.1    Miles-Richardson, S.2    Pierens, S.L.3    Giesy, J.4
  • 21
    • 0034830871 scopus 로고    scopus 로고
    • Effects of the synthetic estrogen 17α-ethinylestradiol on the life-cycle of the fathead minnow (Pimephales promelas)
    • Länge R., Hutchinson T.H., Croudance C.P., Siegmund S., Schweinfurth H., Hampe P., et al. Effects of the synthetic estrogen 17α-ethinylestradiol on the life-cycle of the fathead minnow (Pimephales promelas). Environ Toxicol Chem 20 (2001) 1216-1227
    • (2001) Environ Toxicol Chem , vol.20 , pp. 1216-1227
    • Länge, R.1    Hutchinson, T.H.2    Croudance, C.P.3    Siegmund, S.4    Schweinfurth, H.5    Hampe, P.6
  • 22
    • 0033054361 scopus 로고    scopus 로고
    • Development of a stably transfected estrogen receptor-mediated luciferase reporter gene assay in the human T47D breast cancer cell line
    • Legler J., van den Brink CE., Brouwer A., Murk AJ., van der Saag PT., Vethaak P.T., et al. Development of a stably transfected estrogen receptor-mediated luciferase reporter gene assay in the human T47D breast cancer cell line. Toxicol Sci 48 (1999) 55-66
    • (1999) Toxicol Sci , vol.48 , pp. 55-66
    • Legler, J.1    van den Brink, CE.2    Brouwer, A.3    Murk, AJ.4    van der Saag, PT.5    Vethaak, P.T.6
  • 23
    • 0037107507 scopus 로고    scopus 로고
    • Comparison of in vivo and in vitro reporter gene assays for short-term screening of estrogenic activity
    • Legler J., Zeinstra L., Schuitemaker F., Lanser P., Bogerd J., Brouwer A., et al. Comparison of in vivo and in vitro reporter gene assays for short-term screening of estrogenic activity. Environ Sci Technol 36 (2002) 4410-4415
    • (2002) Environ Sci Technol , vol.36 , pp. 4410-4415
    • Legler, J.1    Zeinstra, L.2    Schuitemaker, F.3    Lanser, P.4    Bogerd, J.5    Brouwer, A.6
  • 24
    • 0242500453 scopus 로고    scopus 로고
    • In vitro biomonitoring in solid phase matrices reveals the presence of unknown compounds with estrogenic activity
    • Legler J., Leonards P., Spenkelink A., and Murk A.J. In vitro biomonitoring in solid phase matrices reveals the presence of unknown compounds with estrogenic activity. Ecotoxicology 12 (2003) 239-249
    • (2003) Ecotoxicology , vol.12 , pp. 239-249
    • Legler, J.1    Leonards, P.2    Spenkelink, A.3    Murk, A.J.4
  • 25
    • 0026340620 scopus 로고
    • Changes in hepatic mixed function oxygenase (MFO) activity, plasma steroid levels and age at maturity of a white sicker (Catastomus commersoni) population exposed to bleached kraft pulp mill effluent
    • McMaster M.E., Van Der Kraak G.J., Portt C.B., Munkittrick K.R., Sibley P.K., Smith I.R., et al. Changes in hepatic mixed function oxygenase (MFO) activity, plasma steroid levels and age at maturity of a white sicker (Catastomus commersoni) population exposed to bleached kraft pulp mill effluent. Aquat Toxicol 21 (1991) 199-218
    • (1991) Aquat Toxicol , vol.21 , pp. 199-218
    • McMaster, M.E.1    Van Der Kraak, G.J.2    Portt, C.B.3    Munkittrick, K.R.4    Sibley, P.K.5    Smith, I.R.6
  • 26
    • 0035025255 scopus 로고    scopus 로고
    • In vitro estrogenicity of brominated diphenyl ethers (PBDEs), hydroxylated PBDEs and polybrominated bisphenol A compounds
    • Meerts I., Letcher R.J., Hoving S., Marsh G., Bergman A., Lemmen J.G., et al. In vitro estrogenicity of brominated diphenyl ethers (PBDEs), hydroxylated PBDEs and polybrominated bisphenol A compounds. Environ Health Perspect 109 (2001) 399-407
    • (2001) Environ Health Perspect , vol.109 , pp. 399-407
    • Meerts, I.1    Letcher, R.J.2    Hoving, S.3    Marsh, G.4    Bergman, A.5    Lemmen, J.G.6
  • 27
    • 0033065406 scopus 로고    scopus 로고
    • Expression of the vitellogenin gene in the liver of juvenile whitefish (Coregonus lavaretus L. s.l.) exposed to effluents from pulp and paper mills
    • Mellanen P., Soimasuo M., Holmbom B., Oikari A., and Santti R. Expression of the vitellogenin gene in the liver of juvenile whitefish (Coregonus lavaretus L. s.l.) exposed to effluents from pulp and paper mills. Ecotoxicol Environ Saf 43 2 (1999) 133-137
    • (1999) Ecotoxicol Environ Saf , vol.43 , Issue.2 , pp. 133-137
    • Mellanen, P.1    Soimasuo, M.2    Holmbom, B.3    Oikari, A.4    Santti, R.5
  • 28
    • 0035142487 scopus 로고    scopus 로고
    • Estrogenic potency of chemicals detected in sewage treatment plant effluents as determined by in vivo assays with japanese medaka (Orizias latipes)
    • Metcalfe C.D., Metcalfe T.L., Kiparissis Y., Koenig B.G., Khan C., Hughes R.J., et al. Estrogenic potency of chemicals detected in sewage treatment plant effluents as determined by in vivo assays with japanese medaka (Orizias latipes). Environ Toxicol Chem 20 2 (2001) 297-308
    • (2001) Environ Toxicol Chem , vol.20 , Issue.2 , pp. 297-308
    • Metcalfe, C.D.1    Metcalfe, T.L.2    Kiparissis, Y.3    Koenig, B.G.4    Khan, C.5    Hughes, R.J.6
  • 29
    • 0032694716 scopus 로고    scopus 로고
    • Effects if waterborne exposure to 4-nonylphenol and nonylphenol exthoxylate on secundary sex characteristics and gonads of fathead minnows (Pimephales promelas)
    • Miles-Richardson S.R., Kramer V.J., Fitzgerald S.D., Render J.A., Yamini B., Barbee S.J., et al. Effects if waterborne exposure to 4-nonylphenol and nonylphenol exthoxylate on secundary sex characteristics and gonads of fathead minnows (Pimephales promelas). Aquat Toxicol 47 (1999) 129-145
    • (1999) Aquat Toxicol , vol.47 , pp. 129-145
    • Miles-Richardson, S.R.1    Kramer, V.J.2    Fitzgerald, S.D.3    Render, J.A.4    Yamini, B.5    Barbee, S.J.6
  • 31
    • 33847383049 scopus 로고    scopus 로고
    • Chemical study on estrogens
    • National Institute for Coastal and Marine Management (RIKZ), The Hague, the Netherlands
    • Okkerman P.C., Groshart C.P., and Pijnenburg A.M.C.M. Chemical study on estrogens. Report no. 2001.028 (2001), National Institute for Coastal and Marine Management (RIKZ), The Hague, the Netherlands
    • (2001) Report no. 2001.028
    • Okkerman, P.C.1    Groshart, C.P.2    Pijnenburg, A.M.C.M.3
  • 32
    • 0036379726 scopus 로고    scopus 로고
    • Induction of vitellogenin and histological effects in wild fathead minnows from a lake experimentally treated with the synthetic estrogen, ethynylestradiol
    • Palace V.P., Evans R.E., Wautier K., Baron C., Vandenbyllardt L., Vandersteen W., et al. Induction of vitellogenin and histological effects in wild fathead minnows from a lake experimentally treated with the synthetic estrogen, ethynylestradiol. Water Qual Res J Can 37 3 (2002) 637-650
    • (2002) Water Qual Res J Can , vol.37 , Issue.3 , pp. 637-650
    • Palace, V.P.1    Evans, R.E.2    Wautier, K.3    Baron, C.4    Vandenbyllardt, L.5    Vandersteen, W.6
  • 33
    • 0036143069 scopus 로고    scopus 로고
    • Utility of a juvenile fathead minnow screening assay for detecting (anti- -) estrogenic substances
    • Panter G.H., Hutchinson T.H., Länge R., Lye C.M., Sumpter J.P., Zerulla M., et al. Utility of a juvenile fathead minnow screening assay for detecting (anti- -) estrogenic substances. Environ Toxicol Chem 21 (2002) 319-326
    • (2002) Environ Toxicol Chem , vol.21 , pp. 319-326
    • Panter, G.H.1    Hutchinson, T.H.2    Länge, R.3    Lye, C.M.4    Sumpter, J.P.5    Zerulla, M.6
  • 34
    • 0345659225 scopus 로고    scopus 로고
    • Changes in growth and secondary sex characteristics of fathead minnows exposed to bleached sulfite mill effluent
    • Parrott J.L., Wood C.S., Boutot P., and Dunn S. Changes in growth and secondary sex characteristics of fathead minnows exposed to bleached sulfite mill effluent. Environ Toxicol Chem 22-12 (2003) 2908-2915
    • (2003) Environ Toxicol Chem , vol.22-12 , pp. 2908-2915
    • Parrott, J.L.1    Wood, C.S.2    Boutot, P.3    Dunn, S.4
  • 35
    • 1642375438 scopus 로고    scopus 로고
    • Effects of 17α-ethinylestradiol in a fathead minnow (Pimephales promelas) gonadal recrudescence assay
    • Pawlowski S., van Aerle R., Tyler C.R., and Braunbeck T. Effects of 17α-ethinylestradiol in a fathead minnow (Pimephales promelas) gonadal recrudescence assay. Ecotoxicol Environ Saf 57 (2004) 330-435
    • (2004) Ecotoxicol Environ Saf , vol.57 , pp. 330-435
    • Pawlowski, S.1    van Aerle, R.2    Tyler, C.R.3    Braunbeck, T.4
  • 37
    • 0000621408 scopus 로고    scopus 로고
    • Long-term temporal changes in the estrogenic composition of treated sewage effluent and its biological effects on fish
    • Rodgers-Gray T.P., Jobling S., Morris S., Kelly C., Kirby S., and Janbakhsh A. Long-term temporal changes in the estrogenic composition of treated sewage effluent and its biological effects on fish. Environ Sci Technol 34 (2000) 1521-1528
    • (2000) Environ Sci Technol , vol.34 , pp. 1521-1528
    • Rodgers-Gray, T.P.1    Jobling, S.2    Morris, S.3    Kelly, C.4    Kirby, S.5    Janbakhsh, A.6
  • 38
    • 0035992450 scopus 로고    scopus 로고
    • Effect of ethinylestradiol on the reproduction and induction of vitellogenin and testis-ova in medaka (Orizias latipes)
    • Seki M., Yokota H., Matsubara H., Tsuruda Y., Maeda M., Tadokoro H., et al. Effect of ethinylestradiol on the reproduction and induction of vitellogenin and testis-ova in medaka (Orizias latipes). Environ Toxicol Chem 21 8 (2002) 1692-1698
    • (2002) Environ Toxicol Chem , vol.21 , Issue.8 , pp. 1692-1698
    • Seki, M.1    Yokota, H.2    Matsubara, H.3    Tsuruda, Y.4    Maeda, M.5    Tadokoro, H.6
  • 39
    • 0036188884 scopus 로고    scopus 로고
    • Reduction in the estrogenic activity of a treated sewage effluent discharge to an English river as a result of a decrease in the concentration of industrially derived surfactants
    • Sheahan D.A., Brighty G.C., Daniel M., Jobling S., Harries J.E., Hurst M.R., et al. Reduction in the estrogenic activity of a treated sewage effluent discharge to an English river as a result of a decrease in the concentration of industrially derived surfactants. Environ Toxicol Chem 21 3 (2002) 515-519
    • (2002) Environ Toxicol Chem , vol.21 , Issue.3 , pp. 515-519
    • Sheahan, D.A.1    Brighty, G.C.2    Daniel, M.3    Jobling, S.4    Harries, J.E.5    Hurst, M.R.6
  • 40
    • 0001594949 scopus 로고
    • Seasonal changes in the histology of the gonads and dorsal skin of the fathead minnow, Pimephales promelas
    • Smith R.J.F. Seasonal changes in the histology of the gonads and dorsal skin of the fathead minnow, Pimephales promelas. Can J Zool 56 (1978) 2103-2109
    • (1978) Can J Zool , vol.56 , pp. 2103-2109
    • Smith, R.J.F.1
  • 41
    • 0036837675 scopus 로고    scopus 로고
    • Timing of exposure to a pulp and paper effluent influences the manifestation of reproductive effects in rainbow trout
    • Van den Heuvel M.R., and Ellis R.J. Timing of exposure to a pulp and paper effluent influences the manifestation of reproductive effects in rainbow trout. Environ Toxicol Chem 21 11 (2002) 2338-2347
    • (2002) Environ Toxicol Chem , vol.21 , Issue.11 , pp. 2338-2347
    • Van den Heuvel, M.R.1    Ellis, R.J.2
  • 43
    • 20144363944 scopus 로고    scopus 로고
    • An integrated assessment of estrogenic contamination and biological effects in the aquatic environment of The Netherlands
    • Vethaak A.D., Lahr J., Schrap S.M., Belfroid A.C., Rijs G.B.J., Gerritsen A., et al. An integrated assessment of estrogenic contamination and biological effects in the aquatic environment of The Netherlands. Chemosphere 59 (2005) 511-524
    • (2005) Chemosphere , vol.59 , pp. 511-524
    • Vethaak, A.D.1    Lahr, J.2    Schrap, S.M.3    Belfroid, A.C.4    Rijs, G.B.J.5    Gerritsen, A.6
  • 44
    • 0037598881 scopus 로고    scopus 로고
    • Developmental estrogenic exposure in zebrafish (Danio rerio): II. Histological evaluation of gametogenesis and organ toxicity
    • Weber L.P., Hill R.L., and Janz D.M. Developmental estrogenic exposure in zebrafish (Danio rerio): II. Histological evaluation of gametogenesis and organ toxicity. Aquat Toxicol 63 (2003) 431-446
    • (2003) Aquat Toxicol , vol.63 , pp. 431-446
    • Weber, L.P.1    Hill, R.L.2    Janz, D.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.