Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks

Journal of Psychiatric Research

Volumn 41, Issue 7, 2007, Pages 579-584

  Thoeringer, Christoph K ^a   Binder, Elisabeth B ^a,b   Salyakina, Daria ^a   Erhardt, Angelika ^a   Ising, Marcus ^a   Unschuld, Paul G ^a   Kern, Nikola ^a   Lucae, Susanne ^a   Brueckl, Tanja M ^a   Mueller, Marianne B ^a   Fuchs, Brigitte ^a   Puetz, Benno ^a   Lieb, Roselind ^a   Uhr, Manfred ^a   Holsboer, Florian ^a   Mueller Myhsok, Bertram ^a   Keck, Martin E ^a,c  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Case control genetic association study; Diazepam binding inhibitor (DBI); Panic disorder; Single nucleotide polymorphisms

Indexed keywords

DIAZEPAM BINDING INHIBITOR; METHIONINE; VALINE;

ADULT; ALLELE; ANXIETY DISORDER; ARTICLE; BRAIN DYSFUNCTION; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE STRUCTURE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GERMANY; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROMODULATION; NUCLEOTIDE SEQUENCE; PANIC; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGORAPHOBIA; ALLELES; ANXIETY DISORDERS; CASE-CONTROL STUDIES; COMORBIDITY; DIAZEPAM BINDING INHIBITOR; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GERMANY; HUMANS; MALE; PANIC DISORDER; POLYMORPHISM, SINGLE NUCLEOTIDE; VARIATION (GENETICS);

EID: 33847328285     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2006.06.001     Document Type: Article

References (34)

1. Bandelow B. Assessing the efficacy of treatments for panic disorder and agoraphobia, II: the panic and Agoraphobia Scale. International Clinical Psychopharmacology 10 (1995) 73-81
2. Binder E.B., Salyakina D., Lichtner P., Wochnik G.M., Ising M., Pütz B., et al. Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nature Genetics 36 (2004) 1319-1325
3. Brambilla P., Perez J., Barale F., Schettini G., and Soares J.C. GABAergic dysfunction in mood disorders. Molecular Psychiatry 8 (2003) 721-737
4. Costa E., and Guidotti A. Diazepam binding inhibitor (DBI): A peptide with multiple biological actions. Life Science 49 (1991) 325-344
5. Ferrarese C., Appollonio I., Bianchi G., Frigo M., Marzorati C., Pecora N., et al. Benzodiazepine receptors and diazepam binding inhibitor: A possible link between stress, anxiety and the immune system. Psychoneuroendocrinology 18 (1993) 3-22
6. Finn D.A., Rutledge-Gorman M.T., and Crabbe J.C. Genetic animals of anxiety. Neurogenetics 4 (2003) 109-135
7. Flint J., Corley R., Defries J.C., Fulker D.W., Gray J.A., Miller S., et al. A simple genetic-basis for a complex psychological trait in laboratory mice. Science 269 (1995) 1432-1435
8. Flint J., Valdar W., Shifman S., and Mott R. Strategies for mapping and cloning quantitative trait genes in rodents. Nature Reviews Genetics 6 (2005) 271-286
9. Gabriel S.B., Schaffner S.F., Nguyen H., Moore J.M., Roy J., Blumenstiel B., et al. The structure of haplotype blocks in the human genome. Science 296 (2002) 2225-2229
10. Guidotti A. Role of DBI in brain and its posttranslational processing products in normal and abnormal behavior. Neuropharmacology 12 (1991) 1425-1433
11. Hamilton S.P., Fyer A.J., Durner M., Heiman G.A., de Leon A.B., Hodge S.E., et al. Further genetic evidence for a panic disorder syndrome mapping to chromosome 13q. Proceedings of the National Academy of Science 100 (2003) 2550-2555
12. Hattori E., Ebihara M., Yamada K., Ohba H., Shibuya H., and Yoshikawa T. Identification of a compound short tandem repeat stretch in the 5′-upstream region of the cholecystokinin gene, and its association with panic disorder but not with schizophrenia. Molecular Psychiatry 6 (2001) 465-470
13. Henderson N.D., Turri M.G., DeFries J., and Flint J. QTL analysis of multiple behavioral measures of anxiety in mice. Behavior Genetics 34 (2004) 267-293
14. Herzog C.D., Stackman R.W., and Walsh T.J. Intraseptal Flumazenil enhances, while diazepam binding inhibitor impairs, performance in a working memory task. Neurobiology of Learning and Memory 66 (1996) 341-352
15. Hettema J.M., Prescott C.A., and Kendler K.S. A population-based twin study of generalized anxiety disorder in men and women. Journal of Nervous and Mental Disease 189 (2001) 413-420
16. Niu N., Rice S.R., Heston L.L., and Sobell J.L. Multiple missense mutations in the diazepam binding inhibitor (DBI) gene identified in schizophrenia but lack of disease association. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 125 (2004) 10-19
17. Nutt D.J., Glue P., Lawson C., and Wilson S.G. Flumazenil provocation of panic attacks. Evidence for altered benzodiazepine receptor sensitivity in panic disorder. Archives of the General Psychiatry 47 (1990) 917-925
18. Payeur R., Lydiard R.B., Ballenger J.C., Laraia M.T., Fossey M.D., and Zealberg J. CSF diazepam-binding inhibitor concentrations in panic disorder. Biological Psychiatry 32 (1992) 712-716
19. Rothe C, Koszycki D, Bradwejn J, King N, Deluca V, Tharmalingam S, et al. Association of the Val158Met catechol-o-methyltransferase genetic polymorphism with Panic Disorder. Neuropsychopharmacology, 2006 [Epub ahead of print].
20. Roy A. Cerebrospinal fluid diazepam binding inhibitor in depressed patients and normal controls. Neuropharmacology 30 (1991) 1441-1444
21. Rupprecht R., and Holsboer F. Neuropsychopharmacological properties of neuroactive steroids. Steroids 64 (1999) 83-91
22. Singer J.B., Hill A.E., Nadeau J.H., and Lander E.S. Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice. Genetics 169 (2005) 855-862
23. Smoller J.W., Acierno J.S., Rosenbaum J.F., Biederman J., Pollack M.H., Meminger S., et al. Targeted genome screen of panic disorder and anxiety disorder proneness using homology to murine QTL regions. American Journal of Medical Genetics 105 (2001) 195-206
24. Stroehle A., Romeo E., di Michele F., Pasini A., Hermann B., Gajewsky G., et al. Induced panic attacks shift gamma-aminobutyric acid type A receptor modulatory neuroactive steroid composition in patients with panic disorder. Preliminary results. Archives of the General Psychiatry 60 (2003) 161-168
25. Sudakov S.K., Medvedeva O.F., Rusakova I.V., Terebilina N.N., and Goldberg S.R. Differences in genetic predisposition to high anxiety in two inbred rat strains: Role of substance P, diazepam binding inhibitor fragment and neuropeptide Y. Psychopharmacology 154 (2001) 327-335
26. Talbot C.J., Nicod A., Cherny S.S., Fulker D.W., Collins A.C., and Flint J. High-resolution mapping of quantitative trait loci in outbred mice. Nature Genetics 21 (1999) 305-308
27. Thorgeirsson T.E., Oskarsson H., Desnica N., Kostic J.P., Stefansson J.G., Kolbeinsson H., et al. Anxiety with panic disorder linked to chromosome9q in Island. American Journal of Human Genetics 72 (2003) 1221-1230
28. Turri M.G., Datta S.R., DeFries J., Henderson N.D., and Flint J. QTL analysis identifies multiple behavioral dimensions in ethological tests of anxiety in laboratory mice. Current Biology 11 (2001) 725-734
29. Turri M.G., Henderson N.D., DeFries J., and Flint J. Quantitative trait locus mapping in laboratory mice derived from a replicated selection experiment for open-field activity. Genetics 158 (2001) 1217-1226
30. Villafuerte S., and Burmeister M. Untangling genetic networks of panic, phobia, fear and anxiety. Genome Biology 4 (2003) 224
31. Wittchen H.U., Zaudig M., and Fydrich T. Strukturiertes klinisches Interview für DSM-IV. Achse I und II (1997), Hogrefe, Göttingen, Germany
32. Wittchen H.U., Hoefler M., and Gander F. Screening for mental disorders: performance of the Composite International Diagnostic - Screener (CID-S). International Journal of Methods in Psychiatric Research 8 (1999) 59-70
33. Woo J.M., Yoon K.S., and Yu B.H. Catechol-O-methyltransferase genetic polymorphism in panic disorder. American Journal of Psychiatry 159 (2002) 1785-1787
34. Zisterer D.M., and Williams D.C. Peripheral-type benzodiazepine receptors. General Pharmacology 29 (1997) 305-314