Microwave assisted, palladium catalyzed aminocarbonylations of heteroaromatic bromides using solid Mo(CO)6 as the carbon monoxide source

Tetrahedron Letters

Volumn 48, Issue 13, 2007, Pages 2339-2343

  Letavic, Michael A ^a   Ly, Kiev S ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUND; BROMIDE; CARBON MONOXIDE; MOLYBDENUM; PALLADIUM;

AMINOCARBONYLATION; ARTICLE; CARBONYLATION; CATALYSIS; CHEMICAL REACTION; MICROWAVE RADIATION; REACTION ANALYSIS; REACTION TIME;

EID: 33847287705     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.01.133     Document Type: Article

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16. See Ref. 7. For the reaction of bromobenzene with piperidine the authors report 87% yield of phenyl-piperidin-1-yl-methanone under similar conditions upon heating in the microwave at 170 °C for 10 min. We obtained a 63% yield of phenyl-piperidin-1-yl-methanone using the conditions described in Scheme 2.