New agents in the treatment of premature ejaculation

Neuropsychiatric Disease and Treatment

Volumn 2, Issue 4, 2006, Pages 489-503

  McMahon, Chris G ^a   McMahon, Chelsea N ^b   Leow, Liang Joo ^c  

^a Australian Centre for Sexual Health   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

^c Austin Health   (United States)

Author keywords

Dapoxetine; Ejaculo selective serotonin transport inhibitors (ESSTIs); Intravaginal ejaculatory latency time (IELT); Premature ejaculation; Selective serotonin re uptake inhibitors (SSRIs); UK 390,957

Indexed keywords

ALCOHOL; CITALOPRAM; CLOMIPRAMINE; DAPOXETINE; DAPOXETINE N OXIDE; DINORDAPOXETINE; DRUG METABOLITE; FLUOXETINE; FLUVOXAMINE; NORDAPOXETINE; PAROXETINE; PLACEBO; SEROTONIN RECEPTOR; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; SILDENAFIL; TADALAFIL; UK 390957; UNCLASSIFIED DRUG;

ANXIETY; AREA UNDER THE CURVE; ARTICLE; CARDIOVASCULAR DISEASE; CHEMOSENSITIVITY; CLINICAL TRIAL; DIARRHEA; DISTRESS SYNDROME; DIZZINESS; DOSAGE SCHEDULE COMPARISON; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG ALCOHOL INTERACTION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG DOSE COMPARISON; DRUG ELIMINATION; DRUG EXPOSURE; DRUG HALF LIFE; DRUG INDUCED HEADACHE; DRUG MECHANISM; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG WITHDRAWAL; ERECTILE DYSFUNCTION; EVIDENCE BASED MEDICINE; FATIGUE; FOOD DRUG INTERACTION; HEMATOLOGIC DISEASE; HUMAN; KIDNEY DISEASE; LATENT PERIOD; LIBIDO; LIPID DIET; LIVER DISEASE; LOW DRUG DOSE; NAUSEA; PATHOGENESIS; PREMATURE EJACULATION; REPEATED DRUG DOSE; SEXUAL BEHAVIOR; SEXUAL SATISFACTION; SIDE EFFECT; SINGLE DRUG DOSE; SWEATING; VOMITING; YAWNING;

EID: 33847285988     PISSN: 11766328     EISSN: None     Source Type: Journal    
DOI: 10.2147/nedt.2006.2.4.489     Document Type: Article

References (84)

1. Ahlenius S, Larsson K, Svensson L, et al. 1981. Effects of a new type of 5-HT receptor agonist on male rat sexual behavior. Pharmacol Biochem Behav, 15:785-92.
2. [APA] American Psychiatric Association. 1994. Diagnostic and Statistical Manual of Mental Disorders, DSM-IV, 4th ed. Washington D.C.:APA.
3. Bhatia MS, Malik SC. 1991. Dhat syndrome-a useful diagnostic entity in Indian culture. Br J Psychiatry, 159:691-5.
4. Byers ES, Grenier G. 2003. Premature or rapid ejaculation: heterosexual couples' perceptions of men's ejaculatory behavior. Arch Sex Behav, 32(3):261-70.
5. Clement P, Bernabe P, Gengo P, et al 2006. Dapoxetine inhibits p-Chloroamphetamine-induced ejaculation in Anesthetized Rats., Book of Abstracts - 8th Congress of the European Society for Sexual Medicine. J Sex Med p. 55: abstract P-02-159.
6. Cremers TI, De Boer P, Liao Y, et al. 2000. Augmentation with a 5-HT1A, but not a 5-HT1B receptor antagonist critically depends on the dose of citalopram. Eur J Pharmacol, 397:63-74.
7. de Jong TR, Pattij T, Veening JG, et al. 2005. Citalopram combined with WAY 100635 inhibits ejaculation and ejaculation-related Fos immunoreactivity. Eur J Pharmacol, 509:49-59. Epub 2005 Jan 21.
8. Deveaugh-Geiss J, Landau P, Katz R. 1989. Preliminary results from a multicentre trial of clomipramine in obsessive compulsive disorder. Psychopharmacol Bull, 25:36-40.
9. Devenaugh-Geiss J, Landau P, Katz R. 1989. Premilinary compulsive disorder. Psychopharmacol Bull, 25:36-40.
10. Dresser MJ, Jazrawi RP, Desai D, et al. 2005. Dapoxetine for the treatment of premature ejaculation: Lack of interaction with PDE5 inhibitors. J Urol, 174:201-abstract 739.
11. Dresser MJ, Lindert K, Lin D. 2004. Pharmacokinetics of single and multiple escalating doses of dapoxetine in healthy volunteers. Clin Pharmacol Ther, 75:113 (abstract p1).
12. Dresser M, Modi NB, Staehr P, et al. 2005 The effect of food on the pharmacokinetics of dapoxetine, a new on-demand treatment for premature ejaculation. J Sex Med, 2005. 3(Suppl 1): p. 25: abstract 37.
13. Fasolo CB, Mirone V, Gentile V, et al. 2005. Premature ejaculation: prevalence and associated conditions in a sample of 12,558 men attending the Andrology Prevention Week 2001-A study of the Italian Society of Andrology (SIA). J Sex Med, 2(3):376-82.
14. Gengo RJ, Giuliano F, McKenna KE, et al. 2005. Monoaminergic transporter binding and inhibition profile of dapoxetine, a medication for the treatment of premature ejaculation. J Urol, 173(4):230 -abstract 878.
15. Gengo PJ, Marson L, Gravitt A. 2006. Actions of dapoxetine in ejaculation and sexual behaviour in rats. Book of Abstracts - 8th Congress of the European Society for Sexual Medicine. J Sex Med. p. 28: abstract MP-01-074.
16. Giuliano F, Bernabe J, Gengo P, et al. 2006. pudendal motoneuron relex discharges in anesthetized rats are dealayed by dapoxetine. Book of Abstracts - 8th Congress of the European Society for Sexual Medicine. J Sex Med. p. 12: abstract PS-03-027.
17. Grenier G, Byers S. 1992. Evaluating models of premature ejaculation: a review. Can J Hum Sex, 3:115-22.
18. Grenier G, Byers ES. 1997. The relationships among ejaculatory control, ejaculatory latency, and attempts to prolong heterosexual intercourse. Arch Sex Behav, 26:27-47.
19. Hellstrom WJ, Althof S, Gittelman M, et al. 2005. Dapoxetine for the treatment of men with premature ejaculation (PE): dose-finding analysis. J Urol, 173:238-abstract 877.
20. Hellstrom WJ, Gittelman M, Althof S. 2004. Dapoxetine HCl for the treatment of premature ejaculation: A Phase II, randomised, double-blind, placebo controlled study. J Sex Med, 1(Suppl 1): 59, 097.:
21. Kaplan H. 1983. The evaluation of sexual disorders: The urologic evaluation of ejaculatory disorders. New York: Brunner/Mazel.
22. Kaplan HS. 1989. PE: How to overcome premature ejaculation. New York: Brunner/Mazel.
23. Kaplan HS, Kohl RN, Pomeroy WB, et al. 1974. Group treatment of premature ejaculation. Arch Sex Behav, 3:443-52.
24. Kim SW, Paick JS. 1999. Short-term analysis of the effects of as needed use of sertraline at 5 PM for the treatment of premature ejaculation. Urology, 54:544-7.
25. Kockott G, Feil W, Revenstorf D, et al. 1980. Symptomatology and psychological aspects of male sexual inadequacy: results of an experimental study. Arch Sex Behav, 9:457-75.
26. Kotin J, Wilbert DE, Verburg D, et al. 1976. Thioridazine and sexual dysfunction. Am J Psychiatry, 133:82-5.
27. Larsson K, Ahlenius S. 1999. Brain and sexual behavior. Ann N Y Acad Sci, 877:292-308.
28. Laumann EO, Nicolosi A, Glasser DB, et al. 2005. Sexual problems among women and men aged 40-80 y: prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors. Int J Impot Res, 17:39-57.
29. Laumann EO, Paik A, Rosen RC. 1999. Sexual dysfunction in the United States: prevalence and predictors. JAMA, 281:537-44.
30. Lipshultz LI, McConnell J, Benson GS. 1981. Current concepts of the mechanisms of ejaculation. Normal and abnormal states. J Reprod Med, 26:499-507.
31. Livni E, Satterlee W, Robey RL, et al. 1994. Synthesis of [11C] dapoxetine.HCl, a serotonin re-uptake inhibitor: biodistribution in rat and preliminary PET imaging in the monkey. Nucl Med Biol, 21:669-75.
32. Lue TF, Basson R, Rosen RC, et al. 2004. Sexual medicine-sexual dysfunctions in men and women. Paris, France: Health Publications.
33. Masters WH, Johnson VE. 1966. Human sexual response. Boston: Little Brown.
34. McCarthy B. 1988. Cognitive-behavioral strategies and techniques in the treatment of early ejaculation. In Principles and practices of sex therapy: update for the 1990's. Leiblum SR, Rosen R. eds. New York: Guilford Press. p 141-67.
35. McMahon CG. 1998. Treatment of premature ejaculation with sertraline hydrochloride: a single-blind placebo controlled crossover study. J Urol, 159:1935-8.
36. McMahon CG. 2002. Long term results of treatment of premature ejaculation with selective serotonin re-uptake inhibitors. Int J Impot Res, 14(Suppl 3):S19.
37. McMahon CG, Touma K. 1999. Treatment of premature ejaculation with paroxetine hydrochloride as needed: 2 single-blind placebo controlled crossover studies. J Urol, 161:1826-30.
38. Modi NB, Dresser M, Desai D. 2005a. Dapoxetine, a new on-demand treatment for premature ejaculation exhibits rapid single and multiple-dose pharmacokinetics. Book of Abstracts - 8th Congress of the European Society for Sexual Medicine. J Sex Med. p. 56: abstract P-02-162.
39. Modi NB, Dresser MJ, Desai et al. 2005b. Dapoxetine for the treatment of premature ejaculation: lack of interaction with ethanol. J Urol, 173:239-Abstract 879.
40. Montague DK, Jarow J, Broderick GA, et al. 2004. AUA guideline on the pharmacologic management of premature ejaculation. J Urol, 172:290-4.
41. Monteiro WO, Noshirvani HF, Marks IM, et al. 1987. Anorgasmia from clomipramine in obsessive-compulsive disorder: A controlled trial. Br J Psychiatry, 151:107-12.
42. Nathan SG. 1986. The epidemiology of the DSM-III psychosexual dysfunctions. J Sex Marital Ther, 12:267-81.
43. Olivier B, van Oorschot R, Waldinger MD. 1998. Serotonin, serotonergic receptors, selective serotonin reuptake inhibitors and sexual behaviour. Int Clin Psychopharmacol, 13(Suppl 6):S9-14.
44. Patrick DL, Althof SE, Pryor JL, et al. 2005. Premature ejaculation: an observational study of men and their partners. J Sex Med, 2:58-67.
45. Perelman MA, McCulloch AR, Bull S. 2004. The impact of self-reported premature ejaculation n other aspects of sexual function. J Sex Med, 1(Suppl 1):59, O98.
46. Pfaus JG. 1999. Neurobiology of sexual behavior. Curr Opin Neurobiol, 9:751-8.
47. Pfaus JG, Heeb MM. 1997. Implications of immediate-early gene induction in the brain following sexual stimulation of female and male rodents. Brain Res Bull, 44:397.
48. Pryor JL, Althof SE, Steidle C, et al. 2005. Efficacy and tolerability of dapoxetine in the treatment of premature ejaculation. J Urol, 173:201, 740.
49. Reading A, Wiest W. 1984. An analysis of self-reported sexual behavior in a sample of normal males. Arch Sex Behav, 13:69.
50. Richardson D, Goldmeier D. 2005. Premature ejaculation-does country of origin tell us anything about etiology? J Sex Med, 2:508-12.
51. Robinson BW, Mishkin M. 1966. Ejaculation evoked by stimulation of the preoptic area in monkeys. Physiol Behav, 1:269-72.
52. Rosen RC, Porst H, Montorsi F. 2004. The premature ejaculation, prevalence and attitudes (PEPA) survey-A multinational survey. J Sex Med, 1(Suppl1):O92.
53. Rowland DL, Cooper SE, Schneider M. 2001. Defining premature ejaculation for experimental and clinical investigations. Arch Sex Behav, 30:235-53.
54. Rust J, Golombok S. 1986. The GRISS: a psychometric instrument for the assessment of sexual dysfunction. Arch Sex Behav, 15:157-65.
55. Schapiro B. 1943. Premature ejaculation, a review of 1130 cases. J Urol, 50:374-9.
56. Sorbera LA, Castaner J, Castanet RM. 2004. Dapoxetine hydrochloride. Drugs Future, 29:1201-5.
57. Spector IP, Carey M. 1990. Incidence and prevalence of the sexual dysfunctions: a critical review of the empirical literature. Arch Sex Behav, 19:389.
58. Spector KR, Boyle M. 1986. The prevalence and perceived actiology of male sexual problems in a non-clinical sample. Br J Med Psychol, 59:351-8.
59. Strassberg DS, de Gouveia Brazao CA, Rowland DL, et al. 1999. Clomipramine in the treatment of rapid (premature) ejaculation. J Sex Marital Ther, 25:89-101.
60. Strassberg DS, Mahoney JM, Schaugaard M, et al. 1990. The role of anxiety in premature ejaculation: a psychophysiological model. Arch Sex Behav, 19:251-7.
61. Symonds T, Althof SE, Rosen R C, et al. 2002. Questionnaire assessment of ejaculatory control: development and validation of a new instrument. Presented at the Fifth Congress of the European Society for Sexual and Impotence Research, Hamburg, Germany.
62. Truitt WA, Coolen LM. 2002. Identification of a potential ejaculation generator in the spinal cord. Science, 297:1566-9.
63. Truitt WA, Shipley MT, Veening JG, et al. 2003. Activation of a subset of lumbar spinothalamic neurons after copulatory behavior in male but not female rats. J Neurosci, 23:325-31.
64. Vandereycken W. 1986. Towards a better delineation of ejaculatory disorders. Acta Psychiatr Belg, 86:57-63.
65. Veening JG, Coolen LM. 1998. Neural activation following sexual behavior in the male and female rat brain. Behav Brain Res, 92:181-93.
66. Verma KK, Khaitan BK, Singh OP. 1998. The frequency of sexual dysfunctions in patients attending a sex therapy clinic in north India. Arch Sex Behav, 27:309-14.
67. Waldinger M. 2003. Towards evidenced based drug treatment research on premature ejaculation: a critical evaluation of methodology. J Impot Res, 15:309-13.
68. Waldinger M, Hengeveld M, Zwinderman A, et al. 1998a. An empirical operationalization of DSM-IV diagnostic criteria for premature ejaculation. Int J Psychiatry Clin Pract, 2:287-93.
69. Waldinger MD, Hengeveld MW, Zwinderman AH, et al. 1998b. Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline. J Clin Psychopharmacol, 18:274-81.
70. Waldinger M, Olivier B. 2001. Hersenonderzoek en farmacologie: serotonine, seks en agressie. In Het Brein Belicht: Opstellen over Niet-Aangeboren Hersenletsel. Wolters-Schweitzer HJ, Beuger CL. eds. Utrecht: Uitgeverij Lemma. p 55-63.
71. Waldinger MD. 2002. The neurobiological approach to premature ejaculation. J Urol, 168:2359-67.
72. Walinger MD, Berendsen HH, Blok BF, et al. 1998. Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system. Behav Brain Res, 92:111-18.
73. Waldinger MD, Hengeveld M. 2000. Neuroseksuologie en seksuele psychofarmacologie. Tijdschr Psychiatr, 8:585.
74. Waldinger MD, Quinn P, Dilleen M, et al. 2005. A multinational population survey of intravaginal ejeculation latency time. J Sex Med, 2:492-7.
75. Waldinger MD, Rietschel M, Nothen MM, et al. 1998. Familial occurrence of primary premature ejaculation. Psychiatr Genet, 8:37-40.
76. Waldinger MD, Zwinderman AH, Olivier B, et al. 2005. Proposal for a definition of lifelong premature ejaculation based on epidemiological stopwatch data. J Sex Med, 2:498-507.
77. Waldinger MD, Zwinderman AH, Schweitzer DH, et al. 2004. Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis. Int J Impot Res, 16:369-81.
78. Williams W. 1984. Secondary premature ejaculation. Aust N Z J Psychiatry, 18:333-40.
79. Williamson IJ, Turner L, Woods K, et al. 2003. The 5-HT1A receptor antagonist robalzotan enhances SSRI-induced ejaculation delay in the rat. Brit J Pharmacol Biochem; Behav, 138(Suppl 1):PO32.
80. Yeates WK. 1987. Andrology. London: Butterworth
81. Yells DP, Hendricks SE, Prendergast MA. 1992. Lesions of the nucleus paragigantocellularis: effects on mating behavior in male rats. Brain Res, 596:73-9.
82. Yuan YM, Xin ZC, Jiang H, et al. 2004. Sexual function of premature ejaculation patients assayed with Chinese Index of Premature Ejaculation. Asian J Androl, 6:121-6.
83. Zilbergeld B. 1978. Male sexuality. Toronto: Bantam.
84. Zilbergeld B. 1992. The new male sexuality. New York: Bantam.