Identification of novel peptide safety markers for exocrine pancreatic toxicity induced by cyanohydroxybutene

Toxicological Sciences

Volumn 96, Issue 1, 2007, Pages 174-183

  Walgren, Jennie L ^a   Mitchell, Michael D ^a   Whiteley, Laurence O ^a   Thompson, David C ^a  

^a PFIZER INC   (United States)

Author keywords

CHB; Pancreatitis; Safety biomarkers; SELDI

Indexed keywords

ALBUMIN; CYANOBUTENOL; ENZYME PRECURSOR; GLUCOSINOLATE; PEPTIDE; PROTEINASE; TRYPSIN; UNCLASSIFIED DRUG;

ACINAR CELL; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE MARKER; DISEASE SEVERITY; ENZYME RELEASE; GASTROINTESTINAL TOXICITY; HISTOPATHOLOGY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS INJURY; PANCREAS NECROSIS; PANCREATITIS; PREDICTION; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEOMICS; RAT; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY;

ACUTE DISEASE; ALKENES; ANIMALS; BIOLOGICAL MARKERS; CELLS, CULTURED; CLUSTER ANALYSIS; DISEASE MODELS, ANIMAL; MALE; NITRILES; PANCREAS, EXOCRINE; PANCREATITIS; PEPTIDE FRAGMENTS; PEPTIDE HYDROLASES; PREDICTIVE VALUE OF TESTS; PROTEIN ARRAY ANALYSIS; PROTEOMICS; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; SEQUENCE ANALYSIS, PROTEIN; SERUM ALBUMIN; SEVERITY OF ILLNESS INDEX; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS; TRYPSIN;

BOVINAE; RATTUS;

EID: 33847278485     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl189     Document Type: Article

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