Measurement, Interpretation, and Implications of Proteinuria and Albuminuria

Veterinary Clinics of North America - Small Animal Practice

Volumn 37, Issue 2, 2007, Pages 283-295

  Grauer, Gregory F ^a  

^a KANSAS STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; AMOXICILLIN; BENAZEPRIL; BENCE JONES PROTEIN; CALCIUM CHANNEL BLOCKING AGENT; CARPROFEN; CLAVULANIC ACID; COLLAGEN TYPE 4; CORTICOSTEROID; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; IMMUNOGLOBULIN LIGHT CHAIN; OMEGA 3 FATTY ACID; PLACEBO; PREDNISONE; SULFOSALICYLIC ACID; THROMBOXANE SYNTHASE INHIBITOR;

ALBUMINURIA; CAT DISEASE; CHRONIC KIDNEY DISEASE; CLINICAL TRIAL; COLORIMETRY; DIAGNOSTIC VALUE; DIET SUPPLEMENTATION; DISEASE COURSE; DISEASE MARKER; DISEASE SEVERITY; DOG DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; GLOMERULOPATHY; GLOMERULUS FILTRATION; HEMATURIA; HUMAN; KIDNEY DISEASE; METRITIS; MICROALBUMINURIA; NONHUMAN; PATHOGENESIS; PROSTATITIS; PROTEINURIA; PYURIA; QUANTITATIVE ANALYSIS; RELIABILITY; REVIEW; SCREENING TEST; SENSITIVITY AND SPECIFICITY; TURBIDIMETRY; UREMIA; URINALYSIS; VETERINARY MEDICINE;

ALBUMINURIA; ANIMALS; CAT DISEASES; CATS; DIAGNOSIS, DIFFERENTIAL; DOG DISEASES; DOGS; KIDNEY FAILURE, CHRONIC; PROTEINURIA;

CANIS FAMILIARIS;

EID: 33847263500     PISSN: 01955616     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cvsm.2006.11.003     Document Type: Review

References (40)

1. Grauer G.F., Moore L.E., Smith A.R., et al. Comparison of conventional urine protein test strips and a quantitative ELISA for the detection of canine and feline albuminuria. J Vet Intern Med 18 (2004) 418-419 [abstract]
2. Vaden S.L., Pressler B.M., Lappin M.R., et al. Urinary tract inflammation has a variable effect on urine albumin concentrations. J Vet Intern Med 16 (2002) 378 [abstract]
3. McCaw D.L., Knapp D.W., and Hewett J.E. Effect of collection time and exercise restriction on the prevention of urine protein excretion, using urine protein/creatinine ratio in dogs. Am J Vet Res 46 (1985) 1665-1669
4. Lees G.E., Jensen W.A., Simpson D.F., et al. Persistent albuminuria precedes onset of overt proteinuria in male dogs with X-linked hereditary nephropathy. J Vet Intern Med 16 (2002) 353 [abstract]
5. Lees G.E., Brown S.A., Elliott J., et al. Assessment and management of proteinuria in dogs and cats; 2004 ACVIM Forum Consensus Statement (small animal). J Vet Intern Med 19 (2005) 377-385
6. Kruger M., Gordjani N., and Burghard R. Post exercise albuminuria in children with different duration of type-1 diabetes mellitus. Pediatr Nephrol 10 (1996) 594-597
7. Hebert L.A., Spetie D.N., and Keane W.F. The urgent call of albuminuria/proteinuria: heeding its significance in early detection of kidney disease. Postgrad Med 110 (2001) 79-96
8. Gerstein H.C., Mann J.F., Yi Q., et al. Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. J Am Med Assoc 286 (2001) 421-426
9. Osterby R., Hartmann A., Nyengaard J.R., et al. Development of renal structural lesions in type-1 diabetic patients with microalbuminuria. Observations by light microscopy in 8-year follow-up biopsies. Virchows Arch 440 (2002) 94-101
10. Bakris G.L. Microalbuminuria: what is it? Why is it important? What should be done about it?. J Clin Hypertens 3 (2001) 99-102
11. Pinto-Sietsma S.J., Janssen W.M., Hillege H.L., et al. Urinary albumin excretion is associated with renal functional abnormalities in a nondiabetic population. J Am Soc Nephrol 11 10 (2000) 1882-1888
12. Keane W.F., and Eknoyan G. Proteinuria, albuminuria, risk, assessment, detection, elimination (PARADE): a position paper of the National Kidney Foundation. Am J Kidney Dis 33 (1999) 1004-1010
13. Grauer G.F., Oberhauser E.B., Basaraba R.J., et al. Development of microalbuminuria in dogs with heartworm disease. J Vet Intern Med 16 (2002) 352 [abstract]
14. Vaden S.L., Jensen W.A., Longhofer S.L., et al. Longitudinal study of microalbuminuria in soft-coated wheaten terriers. J Vet Int Med 15 (2001) 300 [abstract]
15. Pressler B.M., Vaden S.L., and Jensen W.A. Prevalence of microalbuminuria in dogs evaluated at a referral veterinary hospital. J Vet Intern Med 15 (2001) 300 [abstract]
16. Whittemore J.C., Jensen W.A., Prause L., et al. Comparison of microalbuminuria, urine protein dipstick, and urine protein creatinine ratio results in clinically ill dogs. J Vet Intern Med 17 (2003) 437 [abstract]
17. Pressler B.M., Proulx D.A., Williams L.E., et al. Urine albumin concentration is increased in dogs with lymphoma or osteosarcoma. J Vet Intern Med 17 (2003) 404 [abstract]
18. Lees G.E., Willard M.D., and Dziezyc J. Glomerular proteinuria is rapidly but reversibly increased by short-term prednisone administration in heterozygous (carrier) female dogs with X-linked hereditary nephropathy. J Vet Intern Med 16 (2002) 352 [abstract]
19. Gary A.T., Cohn L.A., Kerl M.E., et al. The effects of exercise on microalbuminuria in dogs. J Vet Intern Med 17 (2003) 435-436 [abstract]
20. Grauer G.F., Thomas C.B., and Eicker S.W. Estimation of quantitative proteinuria in the dog, using the urine protein-to-creatinine ratio from a random, voided sample. Am J Vet Res 46 (1985) 2116-2119
21. Monroe W.E., Davenport D.J., and Saunders G.K. Twenty-four hour urinary protein loss in healthy cats and the urinary protein to creatinine ratio as an estimate. Am J Vet Res 50 (1989) 1906-1909
22. Adams L.G., Polzin D.J., Osborne C.A., et al. Correlation of urine protein/creatinine ratio and twenty-four urinary protein excretion in normal cats and cats with induced chronic renal failure. J Vet Intern Med 6 (1992) 36-40
23. Jerums G., Panagiotopoulos S., Tsalamandris C., et al. Why is proteinuria such an important risk factor for progression in clinical trials?. Kidney Int 52 (1997) S87-S92
24. Tang S., Sheerin N.S., Zhou W., et al. Apical proteins stimulate complement synthesis by cultured human proximal tubular epithelial cells. J Am Soc Nephrol 10 (1999) 69-76
25. Abrass C.K. Clinical spectrum and complications of the nephrotic syndrome. J Investig Med 45 (1997) 143-153
26. Eddy A. Role of cellular infiltrates in response to proteinuria. Am J Kidney Dis 37 (2001) S25-S29
27. Gansevoort R.T., Navis G.J., Wapstra F.H., et al. Proteinuria and progression or renal disease: therapeutic implications. Curr Opin Nephrol Hypertens 6 (1997) 133-140
28. Maschio G., Alberti D., Janin G., et al. Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. N Engl J Med 334 (1996) 939-945
29. Syme H.M., and Elliott J. Relation of survival time and urinary protein excretion in cats with renal failure and/or hypertension. J Vet Intern Med 17 (2003) 405 [abstract]
30. Brown S.A., and Brown C.A. Single-nephron adaptations to partial renal ablation in cats. Am J Physiol 269 (1995) R1002-R1008
31. Walker D., Syme H.M., Markwell P., et al. Predictors of survival in healthy, non-azotemic cats. J Vet Intern Med 18 (2004) 417 [abstract]
32. Jacob F., Polzin D.J., Osborne C.A., et al. Evaluation of the association between initial proteinuria and morbidity rate or death in dogs with naturally occurring chronic renal failure. J Am Vet Med Assoc 226 (2005) 393-400
33. Brown S.A., Finco D.R., Crowell W.A., et al. Single-nephron adaptation to partial renal ablation in the dog. Am J Physiol 258 (1990) F495-F503
34. Brown S.A., Walton C.L., Crawford P., et al. Long-term effects of antihypertensive regimens on renal hemodynamics and proteinuria. Kidney Int 43 (1993) 1210-1218
35. Brown S.A., Brown C.A., Crowell W.A., et al. Beneficial effects of chronic administration of dietary ω-3 polyunsaturated fatty acids in dogs with renal insufficiency. J Lab Clin Med 131 (1998) 447-455
36. Brown S.A., Finco D.R., Brown C.A., et al. Evaluation of the effects of inhibition of angiotensin converting enzyme with enalapril in dogs with induced chronic renal insufficiency. Am J Vet Res 64 (2003) 321-327
37. Longhofer S.L., Frisbie D.D., Johnson H.C., et al. Effects of thromboxane synthetase inhibition on immune complex glomerulonephritis. Am J Vet Res 52 (1991) 480-487
38. Grauer G.F., Frisbie D.D., Longhofer S.L., et al. Effects of a thromboxane synthetase inhibitor on established immune complex glomerulonephritis in dogs. Am J Vet Res 53 (1992) 808-813
39. Grodecki K.M., Gains M.J., Baumal R., et al. Treatment of X-linked hereditary nephritis in Samoyed dogs with angiotensin converting enzyme (ACE) inhibitor. J Comp Pathol 117 (1997) 209-225
40. Grauer G.F., Greco D.S., Getzy D.M., et al. Effects of enalapril vs placebo as a treatment for canine idiopathic glomerulonephritis. J Vet Intern Med 14 (2000) 526-533