Pharmacophore-guided design, synthesis and evaluation of quinazoline-arylpiperazines as new α1-adrenoceptor antagonists

Chinese Chemical Letters

Volumn 18, Issue 1, 2007, Pages 41-44

  Fang, Hao ^a   Li, Min Yong ^b   Xia, Lin ^b  

^a SHANDONG UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

1 Adrenoceptor; Antagonists; Pharmacophore guided design

Indexed keywords

EID: 33847174920     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cclet.2006.11.022     Document Type: Article

References (11)

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9. 2 = -log[B] + log(r - 1), where [B] is concentration of test compound and r is the ratio of concentrations of agonist required to generate 50% maximal response in the presence and absence of test compound.
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11. +). HR-MS: Calcd. 438.237726, Found 438.237923.