A general and convenient synthesis of N-aryl piperazines

Tetrahedron Letters

Volumn 46, Issue 46, 2005, Pages 7921-7922

  Liu, Kevin G ^a   Robichaud, Albert J ^a  

^a PFIZER INC   (United States)

Author keywords

N Aryl piperazines

Indexed keywords

ANILINE DERIVATIVE; DICHLORODIETHYLAMINE; ETHER DERIVATIVE; MONOMETHYL ETHER; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; COLUMN CHROMATOGRAPHY; DRUG SYNTHESIS; ELECTRON; PRECIPITATION; ROOM TEMPERATURE;

EID: 26844562501     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.09.092     Document Type: Article

References (18)

1. K.P. Bogeso, and B. Bang-Andersen Textbook of Drug Design and Discovery 3rd ed. 2002 Taylor & Francis Ltd. London, UK p 299
2. S.J. Oh, H.-J. Ha, D.Y. Chi, and H.K. Lee Curr. Med. Chem. 8 2001 999
3. V. Prelog, and G.J. Driza Collect. Czech. Chem. Commun. 5 1933 497
4. V. Prelog, and Z. Blazek Collect. Czech. Chem. Commun. 6 1934 211
5. S.-H. Zhao, A.K. Miller, J. Berger, and L.A. Flippin Tetrahedron Lett. 37 1996 4463
6. M. Hepperle, J. Eckert, D. Gala, L. Shen, C. Anderson Evans, and A. Goodman Tetrahedron Lett. 43 2002 3359
7. J.P. Wolfe, and S.L. Buchwald J. Org. Chem. 65 2000 1144
8. J.F. Hartwig Angew. Chem., Int. Ed. 37 1998 2047
9. G.S. Poindexter, M.A. Bruce, K.L. LeBoulluec, and I. Monkovic Tetrahedron Lett. 35 1994 7331
10. K. Brewster, D.B. Coult, and R.M. Pinder Chim. Ther. 7 1972 87
11. J.-L. Peglion, H. Canton, K. Bervoets, V. Audinot, M. Brocco, A. Gobert, S. Le Marouille-Girardon, and M.J. Millan J. Med. Chem. 38 1995 4044
12. R.A. Glennon, N.A. Naiman, M.E. Pierson, J.D. Smith, A.M. Ismaiel, M. Titeler, and R.A. Lyon J. Med. Chem. 32 1989 1921
13. R.A. Glennon, R.M. Slusher, R.A. Lyon, M. Titeler, and J.D. McKenney J. Med. Chem. 29 1986 2375
14. I. Van Wijngaarden, C.G. Kruse, J.A.M. Van der Heyden, and M.T.M. Tulp J. Med. Chem. 31 1988 1934
15. C.B. Pollard, and L.G. MacDowell J. Am. Chem. Soc. 56 1934 2199
16. H.G. Jaisinghani, and B.M. Khadilkar Tetrahedron Lett. 38 1997 6875
17. H.G. Jaisinghani, B.R. Chowdhury, and B.M. Khadilkar Synth. Commun. 28 1998 1175
18. The reaction time can be significantly shortened under microwave conditions. For example, in the case of aniline (Table 1, entry 1) the reaction was complete within 10 min under microwave irradiation at 180°C (unoptimized).