The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive effects via distinct descending monoaminergic systems

British Journal of Pharmacology

Volumn 150, Issue 4, 2007, Pages 403-414

  Tanabe, M ^a   Tokuda, Y ^a   Takasu, K ^a   Ono, K ^a   Honda, M ^a   Ono, H ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

2 adrenergic receptors; 5 HT receptors; Descending noradrergic system; Descending serotonergic system; Taltirelin; Thyrotropin releasing hormone

Indexed keywords

FENCLONINE; KETANSERIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; NALOXONE; NORADRENALIN; OXIDOPAMINE; SEROTONIN; TALTIRELIN; YOHIMBINE;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG INHIBITION; DRUG MECHANISM; MALE; MECHANICAL STIMULATION; MONOAMINERGIC SYSTEM; MOUSE; NONHUMAN; PRIORITY JOURNAL; TAIL FLICK TEST; THERMAL STIMULATION;

ADRENERGIC ALPHA-ANTAGONISTS; ANALGESICS; ANIMALS; BIOGENIC MONOAMINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FENCLONINE; HEAT; INJECTIONS, INTRAVENTRICULAR; INJECTIONS, SPINAL; INJECTIONS, SUBCUTANEOUS; KETANSERIN; MALE; MICE; MICE, INBRED ICR; NALOXONE; NARCOTIC ANTAGONISTS; NEURAL PATHWAYS; NOREPINEPHRINE; OXIDOPAMINE; PAIN MEASUREMENT; PHYSICAL STIMULATION; REACTION TIME; SEROTONIN; SEROTONIN AGENTS; SYMPATHOLYTICS; THYROTROPIN; THYROTROPIN-RELEASING HORMONE; YOHIMBINE;

EID: 33847171480     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707125     Document Type: Article

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