Synthesis and anti-HIV activity evaluation of 1-[(alkenyl or alkynyl or alkyloxy)methyl]-5-alkyl-6-(1-naphthoyl)-2,4-pyrimidinediones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

European Journal of Medicinal Chemistry

Volumn 42, Issue 2, 2007, Pages 198-204

  Ji, Lei ^a   Chen, Fen Er ^a   Xie, Bin ^a   De Clercq, Erik ^b   Balzarini, Jan ^b   Pannecouque, Christophe ^b  

^a FUDAN UNIVERSITY   (China)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

2,4 Pyrimidinediones; 6 (1 Naphthoyl); Anti HIV activity; Non nucleoside HIV 1 reverse transcriptase inhibitors; Synthesis

Indexed keywords

1 BENZYLOXYMETHYL 5 ISOPROPYL 6 (1 NAPHTHOYL) 2,4 PYRIMIDINEDIONE; 6 (1 NAPHTHOYL) 2,4 PYRIMIDINEDIONE DERIVATIVE; PYRIMIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS REPLICATION;

ALKENES; ALKYNES; ANTI-HIV AGENTS; CELL LINE, TUMOR; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; NAPHTHALENES; REVERSE TRANSCRIPTASE INHIBITORS; URACIL;

EID: 33847129744     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.09.018     Document Type: Article

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