A fermentation system designed to independently evaluate mixing and/or oxygen tension effects in microbial processes: Development, application and performance

Bioprocess and Biosystems Engineering

Volumn 30, Issue 2, 2007, Pages 115-122

  Rocha Valadez, J A ^a   Albiter, V ^a   Caro, M A ^a   Serrano Carreon L ^a   Galindo, E ^a  

^a INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

Author keywords

Dissolved oxygen tension (DOT); Fermentation system; Power drawn; Rheological complex cultures; Trichoderma harzianum; Xanthomonas campestris

Indexed keywords

BIOREACTORS; BLENDING; DATA ACQUISITION; HYDRODYNAMICS; MICROBIOLOGY; MIXING; OXYGEN; PERSONAL COMPUTERS; PHYSIOLOGY;

DISSOLVED OXYGEN TENSION (DOT); FERMENTATION SYSTEM; POWER DRAWN (P/V); RHEOLOGICAL-COMPLEX CULTURES; TRICHODERMA HARZIANUM; XANTHOMONAS CAMPESTRIS;

FERMENTATION;

DISSOLVED OXYGEN; XANTHAN;

AEROBIC FERMENTATION; AEROBIC REACTOR; ARTICLE; BIOREACTOR EQUIPMENT; BLOOD RHEOLOGY; CELL CULTURE MONITORING; ENVIRONMENTAL CHANGE; EVALUATION; GELATINIZATION; HYDRODYNAMICS; INFORMATION PROCESSING; MICROBIAL RESPIRATION; NONHUMAN; OXYGEN CONCENTRATION; OXYGEN TENSION; PRIORITY JOURNAL; SPECIES CULTIVATION; TORQUE; TRICHODERMA HARZIANUM; VISCOSITY; XANTHOMONAS CAMPESTRIS;

BIOREACTORS; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; FLOW INJECTION ANALYSIS; OXYGEN; RHEOLOGY; SIGNAL PROCESSING, COMPUTER-ASSISTED; TRICHODERMA; XANTHOMONAS;

HYPOCREA LIXII; XANTHOMONAS CAMPESTRIS;

EID: 33847118063     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00449-006-0108-6     Document Type: Article

References (35)

1. Ascanio G, Castro B, Galindo E (2004) Measurement of power consumption in stirred vessels-a review. Trans IChemE Part A 82:1282-1290
2. Nienow AW (1990) Agitators for mycelial fermentations. TIBTECH 8:224-233
3. Nienow AW (1994) Gas-liquid mixing studies: a comparison of Rushton turbines with some modern impellers. Trans IChemE Part A 74:417-423
4. Lara AR, Galindo E, Ramírez OT, Palomares LA (2006) Living with heterogeneities in bioreactors, understanding the effects of environmental gradients on cells. Mol Biotechnol 34:365-381
5. Charles M (1985) Fermentation design and scale-up. In: Moo-Young M (ed) Comprehensive biotechnology, vol. 2. Pergamon Press, Oxford
6. Yegneswaran PK, Gray MR, Thompson BG (1991) Effect of the dissolved oxygen control on growth and antibiotic production in Streptomyces clavuligerus fermentations. Biotechnol Prog 7:246-250
7. Sargantanis IG, Karim MN (1996) Effect of oxygen limitation on β-lactamase production. Biotechnol Prog 12:786-792
8. Henriksen CM, Nielsen J, Villadsen J (1997) Influence of the dissolved oxygen concentration on the penicillin biosynthetic pathway in steady-state cultures of Penicillium chrysogenum. Biotechnol Prog 13:776-782
9. Peña C, Trujillo-Roldán MA, Galindo E (2000) Influence of dissolved oxygen tension and agitation speed on alginate production and its molecular weight in cultures of Azotobacter vinelandii. Enzyme Microbial Technol 27:390-398
10. Joshi J, Elias C, Patole M (1996) Role of hydrodynamic shear in the cultivation of animal, plant and microbial cells. Biochem Eng J 62:121-141
11. Thomas CR, Zhang Z (1998) The effect of hydrodynamics on biological materials. In: Galindo E, Ramírez OT (eds) Adv Bioprocess Eng II. Kluwer, Dordrecht, pp 137-170
12. Nienow AW, Elson TP (1988) Aspects of mixing in rheological-complex fluids. Chem Eng Res Des 66:5-15
13. Nienow AW (1990) Gas dispersion performance in fermenter operation. Chem Eng Progress 86: 61-71
14. Torrestiana B, Galindo E, Xueming Z, Nienow AW (1991) In-fermenter power measurement during a xanthan gum fermentation compared with non-fermentative studies. Trans IChemE Part C 69:149-155
15. Galindo E, Nienow AW, Badham RS (1988) Mixing of simulated xanthan gum broths. In: Proceedings of the 2nd International Conference on Bioreactor Fluid Dynamics, R. King (ed), Cambridge, BHRA. The fluid engineering centre-Elsevier, Amsterdam, pp 65-78
16. Li ZJ, Shukla V, Fordyce AP, Pedersen AG, Wenger KS, Marten MR (2000) Fungal morphology and fragmentation behavior in a fed-batch Aspergillus oryzae fermentation at the production scale. Biotechnol Bioeng 70:300-312
17. Buckland BC, Gbewonyo K, DiMasi D, Hunt G, Westerfield G, Nienow AW (1988) Improved performance in viscous mycelial fermentations by agitator retrofitting. Biotechnol Bioeng 31:737-742
18. Amanullah A, Serrano-Carreón L, Castro B, Galindo E, Nienow AW (1998) The influence of impeller type in pilot scale xanthan fermentations. Biotechnol Bioeng 57:95-108
19. Grimm LH, Kelly S, Völkerding II, Krull R, Hempel DC (2005) Influence of mechanical stress and surface interaction on the aggregation of Aspergillus niger conidia. Biotechnol Bioeng 92:879-888
20. Makagiansar HY, Ayazi-Shamlou P, Thomas CR, Lilly MD (1993) The influence of mechanical forces on the morphology and penicillin production of Penicillium chrysogenum. Bioprocess Eng 9:83-90
21. Cui YQ, van der Lans RGJM, Luyben KCAM (1997) Effect of agitation intensities on fungal morphology of submerged fermentation. Biotechnol Bioeng 55:715-726
22. Peña C, Galindo E, Díaz M (2002) Effectiveness factor in biological external convection: study in high viscosity systems. J Biotechnol 95:1-12
23. Jüsten P, Paul GC, Nienow AW, Thomas CR (1998) Dependence of Penicillium chrysogenum growth, morphology, vacuolation, and productivity in fed-batch fermentations on impeller type and agitation intensity. Biotechnol Bioeng 59:762-775
24. Amanullah A, Tuttiett B, Nienow AW (1998) Agitator speed and dissolved oxygen effects in xanthan fermentations. Biotechnol Bioeng 57:198-210
25. Amanullah A, Christensen LH, Hansen K, Nienow AW, Thomas CR (2002) Dependence of morphology on agitation intensity in fed-batch cultures of Aspergillus oryzae and its implications for recombinant protein production. Biotechnol Bioeng 77:815-826
26. Reyes C, Peña C, Galindo E (2003) Reproducing shake flasks performance in stirred fermentors: production of alginates by Azotobacter vinelandii. J Biotechnol 105:189-198
27. Stephanopoulos G (1984) Chemical process control. Prentice Hall, Englewoods Cliffs, pp 344-363
28. Serrano-Carreón L, Corona RM, Sánchez A, Galindo E (1998) Prediction of xanthan fermentation development by a model linking kinetics, power drawn and mixing. Process Biochem 33:133-146
29. Serrano-Carreón L, Flores C, Galindo E (1997) γ-Decalactone production by Trichoderma harzianum in stirred bioreactors. Biotechnol Prog 13:205-208
30. Lucatero S, Larralde-Corona CP, Corkidi G, Galindo E (2003) Oil and air dispersion in a simulated fermentation broth as a function of mycelial morphology. Biotechnol Prog 19:285-292
31. Galindo E (1994) Aspects of the process for xanthan production. Trans IChemE Part C 72:227-237
32. Rocha-Valadez JA, Hassan M, Corkidi G, Flores C, Galindo E, Serrano-Carreón L (2005) 6-Pentyl-α-pyrone production by Trichoderma harzianum: the influence of energy dissipation rate and its implications on fungal physiology. Biotechnol Bioeng 91:54-61
33. Riley GL, Tucker KG, Paul GC, Thomas CR (2000) Effect of biomass concentration and mycelial morphology on fermentation broth rheology. Biotechnol Bioeng 68:160-172
34. Jüsten P, Paul GC, Nienow AW, Thomas CR (1996) Dependence of mycelial morphology on impeller type and agitation intensity. Biotechnol Bioeng 52:672-684
35. Onken U, Liefke E (1989) Effect of total and partial pressure (oxygen and carbon dioxide) on aerobic microbial processes. Adv Biochem Eng Biotechnol 40:137-169