The influence of drug partition coefficient on follicular penetration: In vitro human skin studies

European Journal of Pharmaceutical Sciences

Volumn 30, Issue 3-4, 2007, Pages 280-287

  Frum, Yakov ^a   Bonner, Michael C ^b   Eccleston, Gillian M ^a   Meidan, Victor M ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

Drug delivery; Hair follicles; Shunts; Skin sandwich; Transdermal; Transfollicular

Indexed keywords

ADENOSINE; ALDOSTERONE; CIMETIDINE; CORTICOSTERONE; DEOXYADENOSINE; ESTRADIOL; HYDROCORTISONE; OCTANOL; WATER;

ARTICLE; DRUG ABSORPTION; DRUG PENETRATION; DRUG SOLUBILITY; DRUG TRANSPORT; HAIR FOLLICLE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; ISOTOPE LABELING; LIPOPHILICITY; MOLECULAR WEIGHT; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SKIN PENETRATION;

AGED; ALGORITHMS; CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; DRUG DELIVERY SYSTEMS; EPIDERMIS; FEMALE; HUMANS; MEMBRANES; MIDDLE AGED; MOLECULAR WEIGHT; OCTANOLS; PHARMACEUTICAL PREPARATIONS; SKIN ABSORPTION; SOLUBILITY; SOLUTIONS; ULTRAVIOLET RAYS; WATER;

EID: 33847112131     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2006.11.014     Document Type: Article

References (28)

1. Alvarez-Roman R., Naik A., Kalia Y.N., Fessi H., and Guy R.H. Visualization of skin penetration using confocal laser scanning microscopy. Eur. J. Pharm. Biopharm. 58 (2004) 301-316
2. Barry B.W. Drug delivery routes in skin: a novel approach. Adv. Drug Deliv. Rev. 54 (2002) S31-S40
3. Buchwald P., and Bodor N. A simple, predictive, structure-based skin permeability model. J. Pharm. Pharmacol. 53 (2001) 1087-1098
4. Dokka S., Cooper S.R., Kelly S., Hardee G.E., and Karras J.G. Dermal delivery of topically applied oligonucleotides via follicular transport in mouse skin. J. Invest. Dermatol. 124 (2005) 971-975
5. El Maghraby G.M.M., Williams A.C., and Barry B.W. Skin hydration and possible shunt route penetration in controlled estradiol delivery from ultradeformable and standard liposomes. J. Pharm. Pharmacol. 53 (2001) 1311-1322
6. El Maghraby G.M.M., Williams A.C., and Barry B.W. Drug Interaction and location in liposomes: correlation with polar surface areas. Int. J. Pharm. 292 (2005) 179-185
7. Essa E.A., Bonner M.C., and Barry B.W. Human skin sandwich for assessing shunt route penetration during passive and iontophoretic drug and liposome delivery. J. Pharm. Pharmacol. 54 (2002) 1481-1490
8. Grams Y.Y., Whitehead L., Cornwell P., and Bouwstra J.A. On-line visualization of dye diffusion in fresh unfixed human skin. Pharm. Res. 21 (2004) 851-859
9. Grams Y.Y., Whitehead L., Cornwell P., and Bouwstra J.A. Time and depth resolved visualization of the diffusion of a lipophilic dye into the hair follicle of fresh unfixed human scalp skin. J. Control. Rel. 98 (2004) 367-378
10. Grams Y.Y., Whitehead L., Lamers G., Sturman N., and Bouwstra J.A. Online diffusion profile of a lipophilic dye in different depths of a hair follicle in human scalp skin. J. Invest. Dermatol. 125 (2005) 775-782
11. Hadgraft J., and Ridout G. Development of model membranes for percutaneous absorption measurements. 1. Isopropyl myristate. Int. J. Pharm. 39 (1987) 149-156
12. Hansch C., Hoekman D., Leo A., Zhang L.T., and Li P. The expanding role of quantitative structure-activity relationships (QSAR) in toxicology. Toxicol. Lett. 79 (1995) 45-53
13. Jacobi U., Toll R., Sterry W., and Lademann J. Do follicles play a role as penetration pathways in in vitro studies on porcine skin? An optical study. Laser Phys. 15 (2005) 1594-1598
14. Johnson M.E., Blankschtein D., and Langer R. Permeation of steroids through human skin. J. Pharm. Sci. 84 (1995) 1144-1146
15. Kligman A.M., and Christophers E. Preparation of isolated sheets of human stratum corneum. Arch. Dermatol. 88 (1963) 70-73
16. Knutson K., Harrison D.J., Pershing L.K., and Goates C.Y. Transdermal absorption of steroids. J. Control. Rel. 24 (1993) 95-108
17. Megrab N.A., Williams A.C., and Barry B.W. Oestradiol permeation through human skin and silastic membrane: effects of propylene glycol and supersaturation. J. Control. Rel. 36 3 (1995) 277-294
18. Meidan V.M., Docker M., Walmsley A.D., and Irwin W.J. Low intensity ultrasound as a probe to elucidate the relative follicular contribution to total transdermal absorption. Pharm. Res. 15 (1998) 85-92
19. Meidan V.M., Bonner M.C., and Michniak B.B. Transfollicular drug delivery-is it a reality?. Int. J. Pharm. 306 (2005) 1-14
20. Mitragotri S. Effect of therapeutic ultrasound on partition and diffusion coefficients in human stratum corneum. J. Control. Rel. 71 (2001) 23-29
21. Ogiso T., Shiraki T., Okajima K., Tanino T., Iwaki M., and Wada T. Transfollicular drug delivery: penetration of drugs through human scalp skin and comparison of penetration between scalp and abdominal skins in vitro. J. Drug Target. 10 (2002) 369-378
22. Scheuplein R.J. Mechanisms of percutaneous absorption. II. Transient diffusion and the relative importance of various routes of skin penetration. J. Invest. Dermatol. 48 (1967) 79-88
23. Scheuplein R.J., Blank I.H., Brauner G.J., and MacFarlane D.J. Percutaneous absorption of steroids. J. Invest. Dermatol. 52 (1969) 63-70
24. Suhonen T.M., Pasonen-Seppanen S., Kirjavainen M., Tammi M., Tammi R., and Urtti A. Epidermal cell culture model derived from rat keratinocytes with permeability characteristics comparable to human cadaver skin. Eur. J. Pharm. Sci. 20 (2003) 107-113
25. Sznitowska M., Janicki S., and Baczek A. Studies on the effect of pH on the lipoidal route of penetration across the stratum corneum. J. Control. Rel. 76 (2001) 327-335
26. Teichmann A., Jacobi U., Ossadnik M., Richter H., Koch S., Sterry W., and Lademann J. Differential stripping: determination of the amount of topically applied substances penetrated into the hair follicles. J. Invest. Dermatol. 125 (2005) 264-269
27. Teichmann A., Ossadnik M., Richter H., Sterry W., and Lademann J. Semiquantitative determination of the penetration of a fluorescent hydrogel formulation into the hair follicle with and without follicular closure by microparticles by means of differential stripping. Skin Pharmacol. Physiol. 19 (2006) 101-105
28. Touitou E., Meidan V.M., and Horwitz E. Methods for quantitative determination of drug localized in the skin. J. Control. Rel. 56 (1998) 7-21