Oleandrin produces changes in intracellular calcium levels in isolated cardiomyocytes: A real-time fluorescence imaging study comparing adult to neonatal cardiomyocytes

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 70, Issue 6, 2007, Pages 568-574

  Poindexter, Brian J ^a   Feng, Wei ^a   Dasgupta, Amitava ^a   Bick, Roger J ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CALCIUM; CALCIUM CHANNEL; OLEANDER EXTRACT; OUABAIN; PLANT EXTRACT; RYANODINE RECEPTOR; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL CULTURE; CELL ISOLATION; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; FLUORESCENCE ANALYSIS; HEART MUSCLE CELL; IMAGING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SARCOLEMMA; SPECTROPHOTOMETRY;

AGING; ANIMALS; ANIMALS, NEWBORN; CALCIUM; CALCIUM CHANNEL BLOCKERS; CARDENOLIDES; CELLS, CULTURED; MALE; MYOCYTES, CARDIAC; NERIUM; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; VERAPAMIL;

ANIMALIA; NERIUM; RATTUS; STROPHANTHUS GRATUS;

EID: 33847078006     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390600882408     Document Type: Article

References (33)

1. Aslani, M. R., Movassaghi, A. R., Mohri, M., Abbasian, A., and Zarehpour, M. 2004. Clinical and pathological aspects of experimental oleander (Nerium oleander) toxicosis in sheep. Vet. Res. Commun. 28:609-616.
2. Bick, R. J., Bagwell, S. H., Jones, C. E., Poindexter, B. J., Buja, L. M., Youker, K., Grigore, A., Clubb, F., Radovancevic, B., and Frazier, O. H. 2005. Fluorescence imaging microscopy of cellular markers in ischemic versus nonischemic cardiomyopathy following left ventricular unloading. J. Heart Lung Transplant. 24:454-461.
3. Bick, R. J., Poindexter, B. J., and Schiess, M. C. 2004. Localization of calcitonin gene-related peptide in cardiomyocytes: comparison of neonatal, adult and dedifferentiating cells. Peptides. 26:331-336.
4. Bick, R. J., Poindexter, B. J., Sweney, R. R., and Dasgupta, A. 2002. Effects of Chan Su, a traditional Chinese medicine, on the calcium transients of isolated cardiomyocytes: Cardiotoxicity due to more than Na, K-ATPase blocking. Life Sci. 72:699-709.
5. Complementary and Alternative Medicine. 2005. Harvard Medical School Consumer Health Information, Natural Standard (http://www. intelihealth .com).
6. Eddleston, M., Ariaratnam, C. A., Sjostrom, L., Jayalath, S., Rajakanthan, K., Rajapakse, S., Colbert, D., Meyer, W. P., Perera, G., Attapattu, S., Kularatne, S., Sheriff, M. R., and Warrell, D. A. 2000a. Acute yellow oleander (Thevetia peruviana) poisoning: Cardiac arrhythmias, electrolyte disturbances and serum cardiac glycoside concentrations on presentation to hospital. Heart 83:301-306.
7. Eddleston, M., Rajapakse, S., Rajakanthan, K., Jayalath, S., Sjostrom, L., Santharaj, W., Thenabadu, P. N., Sheriff, M. H., and Warrell, D. A. 2000b. Anti-digoxin Fab fragments in cardiotoxicity induced by ingestion of yellow oleander: A randomised controlled trial. Lancet 355:967-972.
8. Eddleston, M. Senarathna, L., Mohamed, F., Buckley, N., Juszczak, E., Sheriff, M. H., Ariaratnam, A., Rajapakse, S., Warrell, D., and Rajaakanthan, K. 2003. Deaths due to absence of an affordable antitoxin for plant poisoning. Lancet 362:1041-1044.
9. Eddleston, M., and Warrell, D. A. 1999. Management of acute yellow oleander poisoning. Queensland J. Med. 92:483-485.
10. Galey, F. D., Holstege, D. M., Plumlee, K. H., Tor, E, Johnson, B., Anderson, M. L., Blanchard, P. C., and Brown, F. 1996. Diagnosis of oleander poisoning in livestock. J. Vet. Diag. Invest. 8:358-364.
11. Haeba, M. H., Mohamed, A. I., Mehdi, A. W., and Nair, G. A. 2002. Toxicity of Nerium oleander leaf extract in mice. J. Environ. Biol. 23:231-237.
12. Hulme, C., and Long, A. F. 2005. Square pegs and round holes? A review of economic evaluation in complementary and alternative medicine. J. Alter. Comp. Med. 11:179-188.
13. Imperial College London, Faculty of Physical Sciences, Department of Chemistry. 2005. http://www.ch.ic.ac.uk/vchemlib/mim/bristol/digitalis/ digitalis_text.htm
14. Jortani, S. A., Helm, R. A., and Valdes, R., Jr. 1996. Inhibition of Na,K-ATPase by oleandrin and oleandrigenin and their detection by digoxin immunoassays. Clin. Chem. 42:1654-1658.
15. 2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells. Cancer Res. 60:3807-3812.
16. Meyer, H. P., van der Linden, W. J., and van der Linde-Sipman, J. S. 1993. A case of oleander poisoning in a cat. Tijdschr. Diergeneeskd. 118:436-438.
17. Morishita, S., Shoji, M., Oguni, Y., Ito, C., Higuchi, M., and Sakanashi, M. 1992. Pharmacological actions of "Kyushin," a drug containing toad venom: Cardiotonic and arrhythmogenic effects and excitatory effect on respiration. Am. J. Chin. Med. 20:245-246.
18. Nasu, S., Milas, L., Kawabe, S., Raju, U., and Newman, R. 2002. Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process. Cancer Lett. 185:145-151.
19. Ni, D., Madden, T. L., Johansen, M., Felix, E., Ho, D. H., and Newman, R. A. 2002. Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander. J. Exp. Ther. Oncol. 2:278-285.
20. Osterloh, J. 1988. Cross-reactivity of oleander glycosides. J. Anal. Toxicol. (Lett.) 12:53.
21. Pagan, J. A., and Pauly, M. V. 2005. Access to conventional medical care and the use of complementary and alternative medicine. Health Affairs 24:255-262.
22. Pak, E., Esrason, K. T., and Wu, V. H. 2004. Hepatoxicity of herbal remedies: An emerging dilemma. Prog. Transp. 14:91-96.
23. Pathak, S., Multani, A. S., Narayan, S., Kumar, V. and Newman, R. A. 2000. Anvirzel, and extract of Nerium oleander, induces cell death in human but not murine cancer cells. Anticancer Drugs. 12:635-638.
24. Pietsch, J., Oertel, R., Trautmann, S., Schulz, K., Kopp, B., and Dressler, J. 2005. A non-fatal oleander poisoning. Int. J. Legal. Med. 119:236-240.
25. Poindexter, B. J., Smith, J. R., Buja, L. M., and Bick, R. J. 2001. Calcium signaling mechanisms in dedifferentiated cardiac myocytes: Comparison with neonatal and adult cardiomyocytes. Cell Calcium 30:373-382.
26. Rousseaux, C. G., and Schachter, H. 2003. Regulatory issues concerning the safety, efficacy and quality of herbal remedies. Birth Defects Res. B Dev. Reprod. Toxicol. 68:505-510.
27. Sheikh-Hamad, D., Bick, R., Gang, Y.-W., Christensen, B. M., Razeghi, P., Poindexter, B., Taegtmeyer, H., Padda, R., Entman, M., Neilsen, S., and Youker, K. 2003. Stanniocalcin-1is a naturally occurring L-channel inhibitor in cardiomyocytes: relevance to human heart failure. Am. J. Physiol. (Heart Circ.), 285:H442-H448.
28. Smith, C., Martin, K., Hotham, E., Semples, S., Bloustein, G., and Rao, D. 2005. Naturopaths practice behaviour: Provision and access to information on complementary and alternative medicines. BMC Complement. Altern. Med. 5:15.
29. Sreenivasan, Y., Sarkar, A., and Manna, S. K. 2003. Oleandrin suppresses activation of nuclear transcription factor-kappa B and activator protein-1 and potentiates apoptosis induced by ceramide. Biochem. Pharmacol. 66:2223-2239.
30. Stevinson, C., and Ernst, E. 2004. Can St. John's Wort trigger psychoses? Int. J. Clin. Pharmacol. Ther. 42:473-480.
31. Westphal, L. M., Polan, M. L., Trant, A. S., and Mooney, S. B. 2004. A nutritional supplement for improving fertility in women: A pilot study. J. Reprod. Med. 49:289-294.
32. Woods, L. W., Filigenzi, M. S., Booth, M. C., Rodger, L. D., Arnold, J. S., and Puschner, B. 2004. Summer pheasant's eye (Adonis aestivalis) poisoning in three horses. Vet. Pathol. 41:215-220.
33. Wojtyna, W., and Enseleit, F. 2004. A rare cause of complete heart block after transdermal botanical treatment for psoriasis. Pacing Clin. Electrophysiol. 27:1681-1688.