The synthesis and structure-activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: Polar region modifications

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 6, 2007, Pages 1803-1807

  Xu, Xiangdong ^a   Weitzberg, Moshe ^a   Keyes, Robert F ^a   Li, Qun ^a   Wang, Rongqi ^a   Wang, Xiaojun ^a   Zhang, Xiaolin ^a   Frevert, Ernst U ^a   Camp, Heidi S ^a   Beutel, Bruce A ^a   Sham, Hing L ^a   Gu, Yu Gui ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

ACC2 inhibitor; Polar region

Indexed keywords

4 (THIAZOL 5 YL) BUT 3 YN 2 AMINO DERIVATIVE; A 80040; ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE INHIBITOR; ENZYME INHIBITOR; HYDROXYUREA; ISOXAZOLE DERIVATIVE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ACETYL-COA CARBOXYLASE; ALKYNES; CHEMISTRY, PHYSICAL; ENZYME INHIBITORS; HUMANS; HYDROXYUREA; ISOXAZOLES; MOLECULAR CONFORMATION; PHYSICOCHEMICAL PHENOMENA; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 33847070311     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.12.047     Document Type: Article

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