Antecedent hindbrain glucoprivation does not impair the counterregulatory response to hypoglycemia

Diabetes

Volumn 56, Issue 1, 2007, Pages 217-223

  Sanders, Nicole M ^a,b   Taborsky Jr , Gerald J ^a,c   Wilkinson, Charles W ^a,b   Daumen, Wendi ^d   Figlewicz, Dianne P ^a,b  

^a VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d Seattle Institute for Biomedical and Clinical Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLUCOSE; THIOGLUCOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN THIRD VENTRICLE; CONTROLLED STUDY; EXPERIMENTAL RAT; GLUCAGON RELEASE; GLUCOSE METABOLISM; HORMONAL REGULATION; HORMONE RESPONSE; HYPOGLYCEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECURRENT DISEASE; REGULATORY MECHANISM; RHOMBENCEPHALON; SYMPATHETIC FUNCTION;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; BLOOD GLUCOSE; CEREBRAL VENTRICLES; CORTICOSTERONE; EPINEPHRINE; GLUCAGON; GLUCOSE; HOMEOSTASIS; HYPOGLYCEMIA; MALE; NOREPINEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; RECURRENCE; RHOMBENCEPHALON;

EID: 33847054005     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db06-1025     Document Type: Article

References (42)

1. Leese GP, Wang J, Broomhall J, Kelly P, Marsden A, Morrison W, Frier BM, Morris AD: Frequency of severe hypoglycemia requiring emergency treatment in type 1 and type 2 diabetes. Diabetes Care 26:1176-1180, 2003
2. The Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications of insulin-dependent diabetes mellitus. N Engl J Med 329:977-986, 1993
3. The Diabetes Control and Complications Trial Research Group: Hypoglycemia in the diabetes control and complications trial. Diabetes 46:271-286, 1997
4. Dagogo-Jack SE, Craft S, Cryer PE: Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus: recent antecedent hypoglycemia reduces autonomic responses to symptoms of, and defense against subsequent hypoglycemia. J Clin Invest 91:819-828, 1993
5. Segel SA, Paramore DS, Cryer PE: Hypoglycemia-associated autonomic failure in advanced type 2 diabetes. Diabetes 51:724-733, 2002
6. Oomura Y, Ono T, Ooyama H, Wayner MJ: Glucose and osmosensitive neurons of the rat hypothalamus. Nature 222:282-284, 1969
7. Borg WP, During MJ, Sherwin RS, Borg MA, Brines ML, Shulman GI: Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia. J Clin Invest 93:1677-1682, 1994
8. Borg WP, Sherwin RS, During MJ, Borg MA, Shulman GI: Local ventromedial hypothalamic glucopenia triggers counterregulatory hormone release. Diabetes 44:180-184, 1995
9. Borg MA, Sherwin RS, Borg WP, Tamborlane WV, Shulman GI: Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. J Clin Invest 99:361-365, 1997
10. Borg WP, Tamborlane WV, Brines ML, Shulman GI, Sherwin RS: Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxy-glucose perfusion of the ventromedial hypothalamus in rats. Diabetes 48:584-587, 1999
11. de Vries MG, Lawson MA, Beverly JL: Hypoglycemia-induced noradrenergic activation in the VMH is a result of decreased ambient glucose. Am J Physiol 289:977-981, 2005
12. Evans SB, Wilkinson CW, Gronbeck P, Bennett JL, Zavosh A, Taborsky GJ Jr, Figlewicz Lattemann DP: Inactivation of the dorsomedial nucleus of the hypothalamus selectively inhibits the ACTH and corticosterone response to hypoglycemia. Am J Physiol Regul Integr Comp Physiol 286:R123-R128, 2004
13. Evans S, Wilkinson C, Gronbeck P, Bennett J, Taborsky GJ Jr, Figlewicz D: Inactivation of the PVN during hypoglycemia partially simulates hypoglycemia-associated autonomic failure. Am J Physiol Regul Integr Comp Physiol 284:R57-R65, 2003
14. Song Z, Levin BE, McArdle JJ, Bakhos N, Routh VH: Convergence of preand postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus (VMN). Diabetes 50:2673-2681, 2001
15. Ritter RC, Slusser PG, Stone S: Glucoreceptors controlling feeding and blood glucose: location in the hindbrain. Science 213:451-452, 1981
16. DiRocco RJ, Grill HJ: The forebrain is not essential for sympathoadrenal hyperglycemic response to glucoprivation. Science 204:1112-1114, 1979
17. Ritter S, Dinh TT, Zhang Y: Localization of hindbrain glucoreceptive sites controlling food intake and blood glucose. Brain Res 856:37-47, 2000
18. Ritter S, Bugarith K, Dinh TT: Immunotoxic destruction of distinct catecholamine subgroups produces selective impairment of glucoregulatory responses and neuronal activation. J Comp Neurol 432:197-216, 2001
19. Sanders NM, Dunn-Meynell AA, Levin BE: Third ventricular alloxan reversibly impairs glucose counterregulatory responses. Diabetes 53:1230-1236, 2004
20. + channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrent hypoglycemic rats. Diabetes 54:3169-3174, 2005
21. McCrimmon RJ, Song Z, Cheng H, McNay EC, Weikart-Yeckel C, Fan X, Routh VH, Sherwin RS: Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulation. J Clin Invest 116:1723-1730, 2006
22. Evans S, Wilkinson CW, Bentson K, Gronbeck P, Zavosh A, Figlewicz D: PVN activation is suppressed by repeated hypoglycemia but not antecedent corticosterone in the rat. Am J Physiol Regul Integr Comp Physiol 281:R1426-R1436, 2001
23. Paxinos G, Watson C: The Rat Brain in Stereotaxic Coordinates. New York, Academic Press, 1986
24. Tordoff MG, Flynn FW, Grill HJ, Friedman MI: Contribution of fat metabolism to 'glucoprivic' feeding produced by fourth ventricular 5-thio-D-glucose. Brain Res 445:216-222, 1988
25. Slusser PG, Ritter RC: Increased feeding and hyperglycemia elicited by intracerebroventricular 5-thioglucose. Brain Res 202:474-478, 1980
26. Evans MI, Halter JB, Porte D: Comparison of double- and single-isotope enzymatic derivative methods for measuring catecholamines in human plasma. Clin Chem 24:567-570, 1978
27. Van Dijk G, Donahey JC, Thiele TE, Scheurink AJ, Steffens A, Wilkinson CW, Tenenbaum R, Campfield LA, Burn P, Seeley RJ, Woods SC: Central leptin stimulates corticosterone secretion at the onset of the dark phase. Diabetes 46:1911-1914, 1997
28. Marin-Spiotta A, Levin BE, Tkacs NC: A single episode of central glucoprivation reduces the adrenomedullary response to subsequent hypoglycemia in rats. Neurosci Lett 360:81-84, 2004
29. Ritter RC, Slusser PG: 5-thio-D-glucose causes increased feeding and hyperglycemia in the rat. Am J Physiol 238:E141-E144, 1980
30. King AS: Physiological and Clinical Anatomy of the Domestic Mammals. New York, Oxford Univ. Press, 1987, p. 13-23
31. Wang R, Cruciani-Guglielmacci C, Migrenne S, Magnan C, Cotero VE, Routh VH: Effects of oleic acid on distinct populations of neurons in the hypothalamic arcuate nucleus are dependent on extracellular glucose levels. J Neurophysiol 95:1491-1498, 2006
32. Levin BE, Routh VH, Kang L, Sanders NM, Dunn-Meynell A: Neuronal glucosensing: what do we know after 50 years? Diabetes 53:2521-2528, 2004
33. Song Z, Routh VH: Recurrent hypoglycemia reduces the glucose sensitivity of glucose inhibited neurons in the ventromedial hypothalamus nucleus (VMN). Am J Physiol Regul Integr Comp Physiol 291:R1283-R1287, 2006
34. Sanders NM, Ritter S: Repeated 2-deoxy-D-glucose-induced glucoprivation attenuates Fos expression and glucoregulatory responses during subsequent glucoprivation. Diabetes 49:1865-1874, 2000
35. Sandoval DA, Ping L, Neill RA, Gong B, Walsh K, Davis SN: Brain region-dependent effects of dexamethasone on counterregulatory responses to hypoglycemia in conscious rats. Am J Physiol Regul Integr Comp Physiol 288:R413-R419, 2005
36. Shum K, Inouye K, Chan O, Mathoo J, Bilinski D, Matthews SG, Vranic M: Effects of antecedent hypoglycemia, hyperinsulinemia, and excess corticosterone on hypoglycemic counterregulation. Am J Physiol Endocrinol Metab 281:E455-E465, 2001
37. Chen M, Whistler RL: Action of 5-thio-D-glucose and its 1-phosphate with hexokinase and phosphoglucomutase. Arch Biochem Biophys 169:392-396, 1975
38. Song CW, Clement JJ, Levitt SH: Preferential cytotoxicity of 5-thio-D-glucose against hypoxic tumor cells. J Natl Cancer Inst 57:603-605, 1976
39. Davis SN, Shavers C, Davis B, Costa F: Prevention of an increase in plasma cortisol during hypoglycemia preserves subsequent counterregulatory responses. J Clin Invest 100:429-438, 1997
40. Tkacs NC, Dunn-Meynell AA, Levin BE: Presumed apoptosis and reduced arcuate nucleus neuropeptide Y and pro-opiomelanocortin mRNA in non-coma hypoglycemia. Diabetes 49:820-826, 2000
41. De Vries MG, Arseneau LM, Lawson ME, Beverly JL: Extracellular glucose in rat ventromedial hypothalamus during acute and recurrent hypoglycemia. Diabetes 52:2767-2773, 2003
42. Flanagan DE, Keshavarz T, Evans ML, Flanagan S, Fan X, Jacob RJ, Sherwin RS: Role of corticotrophin-releasing hormone in the impairment of counterregulatory responses to hypoglycemia. Diabetes 52:605-613, 2003