Design and characterization of a platelet-targeted plasminogen activator with enhanced thrombolytic and antithrombotic potency

Biotechnology and Applied Biochemistry

Volumn 46, Issue 2, 2007, Pages 115-125

  Yan, Hong Li ^a   Sun, Shu Han ^a   Wang, Wei Ting ^b   Ding, Fei Xiang ^a   Mei, Qian ^a   Xue, Geng ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Annexin B1; Arg Gly Asp (RGD) motif; Plasminogen activator; Single chain urokinase; Thrombolysis; Thrombosis

Indexed keywords

AMINO ACIDS; BLOOD; CELL MEMBRANES; CHROMATOGRAPHIC ANALYSIS; ESCHERICHIA COLI; ION EXCHANGE; MUTAGENESIS;

GEL FILTRATION CHROMATOGRAPHIES; PLASMINOGEN ACTIVATOR; PLATELETS; THROMBOSIS;

PROTEINS;

ARGINYLGLYCYLASPARTYLSERINE; PLASMINOGEN ACTIVATOR;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; BLOOD CLOT LYSIS; CELL INCLUSION; CHIMERA; CONTROLLED STUDY; DOG; DRUG ACTIVITY; DRUG BINDING; DRUG POTENCY; DRUG PURITY; DRUG STRUCTURE; ESCHERICHIA COLI; GEL FILTRATION CHROMATOGRAPHY; GENE DELETION; GENE FUSION; GENE MUTATION; GENE SEQUENCE; HEART INFARCTION; IN VITRO STUDY; IN VIVO STUDY; ION EXCHANGE CHROMATOGRAPHY; MEMBRANE BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMA CLEARANCE; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; RAT; REPERFUSION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE MEMBRANE;

ANIMALS; BLOOD PLATELETS; CELLS, CULTURED; DOGS; DRUG DELIVERY SYSTEMS; DRUG DESIGN; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; MALE; PLASMINOGEN ACTIVATORS; PLATELET ACTIVATION; PROTEIN ENGINEERING; THROMBOLYTIC THERAPY;

ANIMALIA; ESCHERICHIA COLI;

EID: 33847053955     PISSN: 08854513     EISSN: None     Source Type: Journal    
DOI: 10.1042/BA20060061     Document Type: Article

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