Gene transfer of insulin-like growth factor-I providing neuroprotection after spinal cord injury in rats

Journal of Neurosurgery: Spine

Volumn 6, Issue 1, 2007, Pages 35-46

  Hung, Kuo Sheng ^a   Tsai, Shin Han ^a   Lee, Tao Chen ^b   Lin, Jia Wei ^a   Chang, Cheng Kuei ^c   Chiu, Wen Ta ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Gene transfer; Insulin like growth factor I; Spinal cord injury

Indexed keywords

BETA GALACTOSIDASE; CASPASE 9; GLYCOGEN SYNTHASE KINASE 3BETA; PLASMID VECTOR; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P35; SOMATOMEDIN C; VIRUS VECTOR; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; NEUROPROTECTIVE AGENT; TAU PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; CELL COUNT; CONTROLLED STUDY; CONVALESCENCE; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE TRANSFER; HYDRODYNAMICS BASED TRANSFECTION; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; NEUROPROTECTION; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; SPINAL CORD HEMISECTION; SPINAL CORD INJURY; SPRAGUE DAWLEY RAT; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; WESTERN BLOTTING; ANIMAL; DENDRITE; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; EVALUATION; GENETICS; INSTRUMENTATION; LACTOSE OPERON; NERVE CELL; PATHOLOGY; PHOSPHORYLATION; PLASMID; PROTO ONCOGENE; RANDOMIZATION; SYNAPSE; TUMOR SUPPRESSOR GENE;

ANIMALS; ASTROCYTES; BLOTTING, WESTERN; CASPASE 9; DENDRITES; DISEASE MODELS, ANIMAL; GENE TRANSFER TECHNIQUES; GENES, BCL-2; GENES, P53; GLYCOGEN SYNTHASE KINASE 3; INSULIN-LIKE GROWTH FACTOR I; LAC OPERON; MALE; MICROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; PLASMIDS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES; SYNAPSES; TAU PROTEINS;

EID: 33847043605     PISSN: 15475654     EISSN: None     Source Type: Journal    
DOI: 10.3171/spi.2007.6.1.35     Document Type: Article

References (23)

1. Anderson DK, Beattie M, Blesch A, Bresnahan J, Bunge M, Dietrich D, et al: Recommended guidelines for studies of human subjects with spinal cord injury. Spinal Cord 43:453-458, 2005
2. Basso DM, Beattie MS, Bresnahan JC: A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12:1-21, 1995
3. Bracken MB: Methylprednisolone and acute spinal cord injury: an update of the randomized evidence. Spine 26 (24 Suppl):S47-S54, 2001
4. Cheng CM, Mervis RF, Niu SL, Salem N Jr, Witters LA, Tseng V, et al: Insulin-like growth factor-I is essential for normal dendritic growth. J Neurosci Res 73:1-9, 2003
5. Cheng CM, Reinhardt RR, Lee WH, Joncas G, Patel SC, Bondy CA: Insulin-like growth factor-I regulates developing brain glucose metabolism. Proc Natl Acad Sci U S A 97:10236-10241, 2000
6. Davies SJ, Field PM, Raisman G: Regeneration of cut adult axons fails even in the presence of continuous aligned glial pathways. Exp Neurol 142:203-216, 1996
7. Fujiki M, Kobayashi H, Inoue R, Ishii K: Immediate plasticity in the motor pathways after spinal cord hemisection: implications for transcranial magnetic motor-evoked potentials. Exp Neurol 187:468-477, 2004
8. Hashiguchi M, Saito T, Hisanaga S, Hashiguchi T: Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau. J Biol Chem 277:44525-44530, 2002
9. Hong M, Lee VM: Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons. J Biol Chem 272:19547-19553, 1997
10. Hung KS, Hwang SL, Liang CL, Chen YJ, Lee TH, Liu JK, et al: Calpain inhibitor inhibits p35-p25-cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats. J Neuropathol Exp Neurol 64:15-26, 2005
11. Hurlbert RJ: Strategies of medical intervention in the management of acute spinal cord injury. Spine 31 (11 Suppl):S16-S21, S36, 2006
12. Kaspar BK, Llado J, Sherkat N, Rothstein JD, Gage FH: Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science 301:839-842, 2003
13. Lesort M, Johnson GV: Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons. Neuroscience 99:305-316, 2000
14. Maccioni RB, Otth C, Concha II, Munoz JP: The protein kinase Cdk5. Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology. Eur J Biochem 268:1518-1527, 2001
15. Miao CH, Thompson AR, Loeb K, Ye X: Long-term and therapeutic-level hepatic gene expression of human factor IX after naked plasmid transfer in vivo. Mol Ther 3:947-957, 2001
16. Niblock MM, Brunso-Bechtold JK, Riddle DR: Insulin-like growth factor I stimulates dendritic growth in primary somatosensory cortex. J Neurosci 20:4165-4176, 2000
17. Pan W, Kastin A: Interactions of IGF-1 with the blood-brain barrier in vivo and in situ. Neuroendocrinology 72:171-178, 2000
18. Shansky J, Creswick B, Lee P, Wang X, Vandenburgh H: Paracrine release of insulin-like growth factor-I from a bioengineered tissue stimulates skeletal muscle growth in vitro. Tissue Eng 12:1833-1841, 2006
19. Summers SA, Kao AW, Kohn AD, Backus GS, Roth RA, Pessin JE, et al: The role of glycogen synthase kinase 3β in insulin-stimulated glucose metabolism. J Biol Chem 274:17934-17940, 1999
20. Vincent AM, Feldman EL: Control of cell survival by IGF signaling pathways. Growth Horm IGF Res 12:193-197, 2002
21. Wang CH, Jawan B, Lee TH, Hung KS, Chou WY, Lu CN, et al: Single injection of naked plasmid encoding β-melanocyte-stimulating hormone protects against thioacetamide-induced acute liver failure in mice. Biochem Biophys Res Commun 322:153-161, 2004
22. Wang CH, Liang CL, Huang LT, Liu JK, Hung PH, Sun A, et al: Single intravenous injection of naked plasmid DNA encoding erythropoietin provides neuroprotection in hypoxia-ischemia rats. Biochem Biophys Res Commun 314:1064-1071, 2004
23. Whetstone WD, Hsu JY, Eisenberg M, Werb Z, Noble-Haeusslein LJ: Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing. J Neurosci Res 74:227-239, 2003