Cyclic peptide analysis of the biologically active loop region in the laminin α3 chain LG4 module demonstrates the importance of peptide conformation on biological activity

Biochemistry

Volumn 46, Issue 7, 2007, Pages 1952-1960

  Kato Takagaki, Kozue ^a,b   Suzuki, Nobuharu ^b   Yokoyama, Fumiharu ^b   Takaki, Shu ^a   Umezawa, Koji ^a   Higo, Junichi ^a   Mochizuki, Mayumi ^b   Kikkawa, Yamato ^a   Oishi, Shinya ^c   Utani, Atsushi ^c   Nomizu, Motoyoshi ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARIN; LAMININ; NERVE REGENERATION; PEPTIDES;

BIOSYNTHESIS; COMPUTER SIMULATION; CRYSTAL STRUCTURE; GROWTH KINETICS; MOLECULAR DYNAMICS; PROTEINS;

AMINO ACIDS;

ARGININE; CYCLOPEPTIDE; CYSTEINYLLEUCYLTYROSYLLEUCYLSERYLLYSYLGLYCYLARGINYLLEUCYLVALYLPHENYLALANYLALANYLCYSTEINE; HEPARIN; LAMININ; LAMININ ALPHA3; LYSINE; LYSYLASPARAGINYLSERYLPHENYLALANYLMETHIONYLALANYLLEUCYLTYROSYLLEUCYLSERYLLYSYLGLYCYLARGINYLLEUCYLVALYLPHENYLALANYLALANYLLEUCYLGLYCINE; PEPTIDE; SYNDECAN 4; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BETA SHEET; BIOLOGICAL ACTIVITY; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL MIGRATION; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; NERVE FIBER GROWTH; NERVE REGENERATION; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; RAT; SEQUENCE ALIGNMENT; STRUCTURE ANALYSIS; WOUND HEALING;

AMINO ACID SEQUENCE; CELL ADHESION; CELL LINE; HEPARIN; HUMANS; LAMININ; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEURITES; OLIGOPEPTIDES; PEPTIDES, CYCLIC; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SYNDECAN-4;

EID: 33847034142     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi062098l     Document Type: Article

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