A novel MASH1 enhancer with N-myc and CREB-binding sites is active in neuroblastoma

Cancer Gene Therapy

Volumn 14, Issue 3, 2007, Pages 287-296

  Watt, F ^a,b   Watanabe, R ^b   Yang, W ^b   Agren N ^b,c   Arvidsson, Y ^b,d   Funa, K ^b  

^a Children's Cancer Institute Australia for Medical Research   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

CREB; Enhancer; HASH1; MASH1; N myc; Neuroblastoma

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; DNA; HISTONE DEACETYLASE 1; LUCIFERASE; TRANSCRIPTION FACTOR MASH1;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; COSMID VECTOR; DISEASE MARKER; DNA BINDING; E BOX ELEMENT; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; GENE OVEREXPRESSION; GENE TARGETING; GENE VECTOR; GENETIC TRAIT; GLIOMA; HEMANGIOMA; HUMAN; HUMAN CELL; LUNG SMALL CELL CANCER; MOLECULAR CLONING; NEUROBLASTOMA; ONCOGENE C MYB; PRIORITY JOURNAL; PROGNOSIS;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BINDING SITES; CHROMATIN IMMUNOPRECIPITATION; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; NEUROBLASTOMA; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-MYC; REGULATORY SEQUENCES, NUCLEIC ACID; TUMOR CELLS, CULTURED;

EID: 33847033755     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/sj.cgt.7701012     Document Type: Article

References (30)

1. Guillemot F, Joyner AL. Dynamic expression of the murine Achaete-Scute homologue Mash-1 in the developing nervous system. Mech Dev 1993; 42: 171-175.
2. Ma Q, Kintner C, Anderson DJ. Identification of neurogenin, a vertebrate neuronal determination gene. Cell 1996; 87: 43-52.
3. Johnson JE, Birren SJ, Anderson DJ. Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors. Nature 1990; 346: 858-861.
4. Anderson DJ. Stemcells and transcription factors in the development of the mammalian neural crest. FASEB J 1994;8: 707-713.
5. Guillemot F, Lo LC, Johnson JE, Auerbach A, Anderson DJ, Joyner AL. Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell 1993; 75: 463-476.
6. Huber K, Bruhl B, Guillemot F, Olson EN, Ernsberger U, Unsicker K. Development of chromaffin cells depends on MASH1 function. Development 2002; 129: 4729-4738.
7. Verma-Kurvari S, Savage T, Gowan K, Johnson JE. Lineage-specific regulation of the neural differentiation gene MASH1. Dev Biol 1996; 180: 605-617.
8. GestblomC, Grynfeld A, Ora I, Ortoft E, Larsson C, Axelson H et al. The basic helix-loop-helix transcription factor dHAND, a marker gene for the developing human sympathetic nervous system, is expressed in both high- and low-stage neuroblastomas. Lab Invest 1999; 79: 67-79.
9. Arvidsson Y, Sumantran V, Watt F, Uramoto H, Funa K. Neuroblastoma- specific cytotoxicity mediated by the Mash1- promoter and E. coli purine nucleoside phosphorylase. Pediatric Blood Cancer 2005; 44: 77-84.
10. Akyurek LM, Yang ZY, Aoki K, San H, Nabel GJ, Parmacek MS et al. SM22alpha promoter targets gene expression to vascular smooth muscle cells in vitro and in vivo. Mol Med 2000; 6: 983-991.
11. Watt F, Martorana A, Brookes DE, Ho T, Kingsley E, O'Keefe DS et al. A tissue-specific enhancer of the prostatespecific membrane antigen gene, FOLH1. Genomics 2001; 73: 243-254.
12. Johnson JE, Birren SJ, Saito T, Anderson DJ. DNA binding and transcriptional regulatory activity of mammalian achaete-scute homologous (MASH) proteins revealed by interaction with a muscle-specific enhancer. Proc Natl Acad Sci USA 1992; 89: 3596-3600.
13. Izumi H, Molander C, Penn LZ, Ishisaki A, Kohno K, Funa K. Mechanismfor the transcriptional repression by c-Myc on PDGF beta-receptor. J Cell Sci 2001; 114: 1533-1544.
14. Uramoto H, Wetterskog D, Hackzell A, Matsumoto Y, Funa K. p73 competes with co-activators and recruits histone deacetylase to NF-Y in the repression of PDGF beta-receptor. J Cell Sci 2004; 117: 5323-5331.
15. Mahmoudi T, Katsani KR, Verrijzer CP. GAGA can mediate enhancer function in trans by linking two separate DNA molecules. EMBO J 2002; 21: 1775-1781.
16. Kato H, Okamura K, Kurosawa Y, Kishikawa T, Hashimoto K. Characterization of DNA rearrangements of N-myc gene amplification in three neuroblastoma cell lines by pulsed-field gel electrophoresis. FEBS Lett 1989; 250: 529-535.
17. Ichimiya S, Nimura Y, Seki N, Ozaki T, Nagase T, Nakagawara A. Downregulation of hASH1 is associated with the retinoic acid-induced differentiation of human neuroblastoma cell lines. Med Pediatr Oncol 2001; 36: 132-134.
18. SoderholmH, Ortoft E, Johansson I, Ljungberg J, Larsson C, Axelson H et al. Human achaete-scute homologue 1 (HASH-1) is downregulated in differentiating neuroblastoma cells. Biochem Biophys Res Commun 1999; 256: 557-563.
19. Chen H, Biel MA, Borges MW, ThiagalingamA, Nelkin BD, Baylin SB et al. Tissue-specific expression of human achaetescute homologue-1 in neuroendocrine tumors: transcriptional regulation by dual inhibitory regions. Cell Growth Differ 1997; 8: 677.
20. Ball DW, Azzoli CG, Baylin SB, Chi D, Dou S, Donis-Keller H et al. Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors. Proc Natl Acad Sci USA 1993; 90: 5648-5652.
21. Borges M, Linnoila RI, van de Velde HJ, Chen H, Nelkin BD, Mabry M et al. An achaete-scute homologue essential for neuroendocrine differentiation in the lung. Nature 1997; 386: 852-855.
22. Meredith A, Johnson JE. Negative autoregulation of Mash1 expression in CNS development. Dev Biol 2000; 222: 336-346.
23. Sasai Y, Kageyama R, Tagawa Y, Shigemoto R, Nakanishi S. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes Dev 1992; 6: 2620-2634.
24. Ju BG, SolumD, Song EJ, Lee KJ, Rose DW, Glass CK et al. Activating the PARP-1 sensor component of the groucho/TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway. Cell 2004; 119: 815-829.
25. Carlezon Jr WA, Duman RS, Nestler EJ. The many faces of CREB. Trends Neurosci 2005; 28: 436-445.
26. Zaman K, Ryu H, Hall D, O'Donovan K, Lin KI, Miller MP et al. Protection fromoxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin. J Neurosci 1999; 19: 9821-9830.
27. Blackwell TK, Huang J, Ma A, Kretzner L, Alt FW, Eisenman RN et al. Binding of myc proteins to canonical and noncanonical DNA sequences. Mol Cell Biol 1993; 13: 5216-5224.
28. Brenner C, Deplus R, Didelot C, Loriot A, Vire E, De Smet C et al. Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J 2005; 24: 336-346.
29. Brodeur GM. Molecular pathology of human neuroblastomas. Semin Diagn Pathol 1994; 11: 118-125.
30. Yazawa T, Ito T, Kamma H, Suzuki T, Okudela K, Hayashi H et al. Complicated mechanisms of class II transactivator transcription deficiency in small cell lung cancer and neuroblastoma. Am J Pathol 2002; 161: 291-300.