Effects of curcumin on expression of HIF-1α in human hepatocellular carcinoma BEL-7402 cells

Chinese Pharmacological Bulletin

Volumn 22, Issue 11, 2006, Pages 1379-1383

  Sun, Jun ^a   Li, Yan ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Curcumin; Human hepatocellular carcinoma BEL 7402 cell; Hypoxia inducible factors 1

Indexed keywords

CURCUMIN; HYPOXIA INDUCIBLE FACTOR 1; MESSENGER RNA; TRYPAN BLUE;

ARTICLE; CANCER CELL CULTURE; CELL ASSAY; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; HUMAN; HUMAN CELL; HYPOXIA; LIVER CELL CARCINOMA; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 33847020444     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Gassmann M, Chilov D, Wenger R H. Regulation of the hypoxia-inducible factor-1 alpha. ARNT is not necessary for hypoxic induction of HIF-1 alpha in the nucleus[J]. Adv Exp Med Biol,2000, 475:87-99.
2. Brahimiorn H C, Pouyssegur J. When hypoxia signalling meets the ubiquiti-n-proteasomal pathway, new targets for cancer therapy [J]. Crit Rev Oncol Hematol,2005,53(2):115-23.
3. Gururaj A, Belakavadi M, Venkatesh D, et al. Molecular mechanisms of anti-angiogenic effect of curcunmin[J]. Biochem Biophys Res Commun,2002,297(4):934-42.
4. Wu Q, Chen Y, Li X G. Inhibitory efectory of curcum in on transcriptional co-activator P300 expression of B-NHL cell line Raji cell[J]. Chin Pharmacol Bull,2005,21(10):1180-3.
5. Kallio P J, Pongratz I, Gradin K, et al. Activation of hypoxia-inducible factor-1α: posttranscriptional regulation and conformational change by recruitment of the arnt transcription factor [J]. Proc Natl Acad Sci USA,1997,94:5667-72.
6. Wang G L, Semenza G L. Character-aterization of hypoxia-inducible factor-1 and regulation of DNA binding acti-vity by hypoxia [J]. J Biol Chem,1993,268:21513-8.
7. Forsythe J A, Jiang B H, Iyer N V, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1[J]. Mol Cell Biol,1996,16:4604-13.
8. Linke S, Stojkoski C, Kewley R J, et al. Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor[J]. J Biol Chem,2004,279:14391-7.
9. Maxwell P H, Wiesener M S, Chang G W, et al. The tumour suppressor protein VHL targets hypoxia-inducible factor for oxygen-dependent proteolysis[J]. Nature,1999,399(6773):271-5.