The role of prefrontal systems in sexual behavior

International Journal of Neuroscience

Volumn 117, Issue 3, 2007, Pages 369-385

  Spinella, Marcello ^a  

^a RICHARD STOCKTON COLLEGE OF NEW JERSEY   (United States)

Author keywords

Arousal; Dorsolateral prefrontal; Medial prefrontal; Orbitofrontal; Sexual

Indexed keywords

BASAL GANGLION; BRAIN CORTEX; BRAIN FUNCTION; CLINICAL STUDY; COGNITION; CORPUS STRIATUM; EMOTION; FUNCTIONAL ASSESSMENT; HEMISPHERIC DOMINANCE; HUMAN; NEUROIMAGING; NONHUMAN; ORBITAL CORTEX; PREFRONTAL CORTEX; REVIEW; SEXUAL ADDICTION; SEXUAL AROUSAL DISORDER; SEXUAL BEHAVIOR; SEXUAL CRIME; SEXUAL DYSFUNCTION; THALAMUS;

ANIMALS; HUMANS; NEURAL PATHWAYS; PREFRONTAL CORTEX; SEXUAL BEHAVIOR; SEXUAL DYSFUNCTION, PHYSIOLOGICAL;

EID: 33847003053     PISSN: 00207454     EISSN: 15635279     Source Type: Journal    
DOI: 10.1080/00207450600588980     Document Type: Review

References (101)

1. Absher, J. R., Vogt, B. A., Clark, D. G., Flowers, D. L., Gorman, D. G., Keyes, J.W., & Wood, F. B. (2000). Hypersexuality and hemiballism due to subthalamic infarction. Neuropsychiatry, Neuropsychology, & Behavioral Neurology, 13(3), 220-229.
2. Agmo, A., & Villalpando, A. (1995). Central nervous stimulants facilitate sexual behavior in male rats with medial prefrontal cortex lesions. Brain Research, 696(1-2), 187-193.
3. Aloni, R., & Katz, S. (1999). A review of the effect of traumatic brain injury on the human sexual response. Brain Injury, 13(4), 269-280.
4. Arnow, B. A., Desmond, J. E., Banner, L. L., Glover, G. H., Solomon, A., Polan, M. L., Lue, T. F., & Atlas, S. W. (2002). Brain activation and sexual arousal in healthy, heterosexual males. Brain, 125(5), 1014-1023.
5. Bazanis, E., Rogers, R. D., Dowson, J. H., Taylor, P., Meux, C., Staley, C., Nevinson-Andrews, D., Taylor, C., Robbins, T.W., & Sahakian, B. J. (2002). Neurocognitive deficits in decision-making and planning of patients with DSM-III-R borderline personality disorder. Psychological Medicine, 32(8), 1395-1405.
6. Bechara, A. (2003). Risky business: Emotion, decision-making, and addiction. Journal of Gambling Studies, 19(1), 23-51.
7. Bechara, A., Damasio, A. R., Damasio, H., & Anderson, S. W. (1994). Insensitivity to future consequences following damage to human prefrontal cortex. Cognition, 50(1-3), 7-15.
8. Bechara, A., Damasio, H., Damasio, A. R., & Lee, G. P. (1999). Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making. Journal of Neuroscience, 19(13), 5473-5481.
9. Blood, A. J., & Zatorre, R. J. (2001). Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion. Proceedings of the National Academy of Science USA, 98(20), 11818-11823.
10. Breiter, H. C., & Rosen, B. R. (1999). Functional magnetic resonance imaging of brain reward circuitry in the human. Annals of the New York Academy of Science, 877, 523-547.
11. Brody, A. L., Mandelkern, M. A., London, E. D., Childress, A. R., Lee, G. S., Bota, R. G., Ho, M. L., Saxena, S., Baxter, L. R., Jr., Madsen, D., & Jarvik, M. E. (2002). Brain metabolic changes during cigarette craving. Archives of General Psychiatry, 59(12), 1162-1172.
12. Cavedini, P., Riboldi, G., Keller, R., D'Annucci, A., & Bellodii, L. (2002). Frontal lobe dysfunction in pathological gambling patients. Biological Psychiatry, 51(4), 334-341.
13. Chudasama, Y., Bussey, T. J., & Muir, J. L. (2001). Effects of selective thalamic and prelimbic cortex lesions on two types of visual discrimination and reversal learning. European Journal of Neuroscience, 14(6), 1009-1020.
14. Crowe, S. F., & Ponsford, J. (1999). The role of imagery in sexual arousal disturbances in the male traumatically brain injured individual. Brain Injury, 13(5), 347-354.
15. de Bruin, J. P., van Oyen, H.G., & Van de Poll, N. (1983). Behavioural changes following lesions of the orbital prefrontal cortex in male rats. Behavioral Brain Research, 10(2-3), 209-232.
16. Deiber, M. P., Honda, M., Ibanez, V., Sadato, N., & Hallett, M. (1999). Mesial motor areas in self-initiated versus externally triggered movements examined with fMRI: Effect of movement type and rate. Journal of Neurophysiology, 81(6), 3065-3077.
17. Del Parigi, A., Chen, K., Gautier, J. F., Salbe, A.D., Pratley, R. E., Ravussin, E., Reiman, E. M., & Tataranni, P. A. (2002). Sex differences in the human brain's response to hunger and satiation. American Journal of Clinical Nutrition, 75(6), 1017-1022.
18. Dell, D. L., & Halford, J. J. (2002). Dementia presenting as postpartum depression. Obstetrics and Gynecology, 99(5 Pt 2), 925-928.
19. Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995). Contributions of anterior cingulate cortex to behaviour. Brain, 118(Pt 1), 279-306.
20. Dressing, H., Obergriesser, T., Tost, H., Kaumeier, S., Ruf, M., & Braus, D. F. (2001). [Homosexual pedophilia and functional networks - An fMRI case report and literature review]. Fortschritte der Neurologie-Psychiatrie, 69(11), 539-544.
21. Elliott, R., Friston, K. J., & Dolan, R. J. (2000). Dissociable neural responses in human reward systems. Journal of Neuroscience, 20(16), 6159-6165.
22. Elliott, R., Newman, J. L., Longe, O. A., & Deakin, J. F. (2003). Differential response patterns in the striatum and orbitofrontal cortex to financial reward in humans: A parametric functional magnetic resonance imaging study. Journal of Neuroscience, 23(1), 303-307.
23. Eslinger, P. J. (1998). Neurological and neuropsychological bases of empathy. European Neurology, 39(4), 193-199.
24. Everitt, B. J., Cador, M., & Robbins, T. W. (1999). Interactions between the amygdala and ventral striatum in stimulus-reward associations: Studies using a second-order schedule of sexual reinforcement. Neuroscience, 30(1), 63-75.
25. Francis, S., Rolls, E. T., Bowtell, R., McGlone, F., O'Doherty, J., Browning, A., Clare, S., & Smith, E. (1999). The representation of pleasant touch in the brain and its relationship with taste and olfactory areas. Neuroreport, 10(3), 453-459.
26. Frohman, E. M., Frohman, T. C., & Moreault, A. M. (2002). Acquired sexual paraphilia in patients with multiple sclerosis. Archives of Neurology, 59(6), 1006-1010.
27. Gehring, W. J., & Willoughby, A. R. (2002). The medial frontal cortex and the rapid processing of monetary gains and losses. Science, 295(5563), 2279-2282.
28. Ghaem, O., Mellet, E., Crivello, F., Tzourio, N., Mazoyer, B., Berthoz, A., & Denis, M. (1997). Mental navigation along memorized routes activates the hippocampus, precuneus, and insula. Neuroreport, 8(3), 739-744.
29. Giuliano, F., Rampin, O., & Allard, J. (2002). Neurophysiology and pharmacology of female genital sexual response. Journal of Sex & Marital Therapy, 28(Suppl 1), 101-121.
30. Goldenberg, G., Schuri, U., Gromminger, O., & Arnold, U. (1999). Basal forebrain amnesia: Does the nucleus accumbens contribute to human memory? Journal of Neurology, Neurosurgery, & Psychiatry, 67(2), 163-168.
31. Goldstein, R. Z., & Volkow, N. D. (2002). Drug addiction and its underlying neurobiological basis: Neuroimaging evidence for the involvement of the frontal cortex. American Journal of Psychiatry, 159(10), 1642-1652.
32. Gondim Fde, A., & Thomas, F. P. (2001). Episodic hyperlibidinism in multiple sclerosis. Multiple Sclerosis, 7(1), 67-70.
33. Huws, R., Shubsachs, A. P., & Taylor, P. J. (1991). Hypersexuality, fetishism and multiple sclerosis. British Journal of Psychiatry, 158, 280-281.
34. Ikemoto, S., & Panksepp, J. (1999). The role of nucleus accumbens dopamine in motivated behavior: A unifying interpretation with special reference to reward-seeking. Brain Research Brain Research Reviews, 31(1), 6-41.
35. Inzelberg, R., Nisipeanu, P., Joel, D., Sarkantyus, M., & Carasso, R. L. (2001). Acute mania and hemichorea. Clinical Neuropharmacology, 24(5), 300-303.
36. Janszky, J., Szucs, A., Halasz, P., Borbely, C., Hollo, A., Barsii, P., & Mirnics, Z. (2002). Orgasmic aura originates from the right hemisphere. Neurology, 58(2), 302-304.
37. Karama, S., Lecours, A. R., Leroux, J. M., Bourgouin, P., Beaudoin, G., Joubert, S., & Beauregard, M. (2002). Areas of brain activation in males and females during viewing of erotic film excerpts. Human Brain Mapping, 16(1), 1-13.
38. Kawagoe, R., Takikawa, Y., & Hikosaka, O. (1998). Expectation of reward modulates cognitive signals in the basal ganglia. Nature Neuroscience, 1(5), 411-416.
39. Kelley, A. E. (1999). Functional specificity of ventral striatal compartments in appetitive behaviors. Annals of the NY Academy of Science, 877, 71-90.
40. Kilts, C. D., Schweitzer, J. B., Quinn, C. K., Gross, R. E., Faber, T. L., Muhammad, F., Ely, T. D., Hoffman, J. M., & Drexlerm, K. P. (2001). Neural activity related to drug craving in cocaine addiction. Archives of General Psychiatry, 58, 334-341.
41. Knutson, B., Westdorp, A., Kaiser, E., & Hommer, D. (2000). FMRI visualization of brain activity during a monetary incentive delay task. Neuroimage, 12, 20-27.
42. Koob, G. F. (1999). The role of the striatopallidal and extended amygdala systems in drug addiction. Annals of the NY Academy of Science, 877, 445-460.
43. Korpelainen, J. T., Kauhanen, M. L., Kemola, H., Malinen, U., & Myllyla, V. V. (1998). Sexual dysfunction in stroke patients. Acta Neurologica Scandanavica, 98(6), 400-405.
44. Koyama, T., Kato, K., Tanaka, Y. Z., & Mikami, A. (2001). Anterior cingulate activity during pain-avoidance and reward tasks in monkeys. Neuroscience Research, 39(4), 421-430.
45. Kremsdorf, R. B., Holmen, M. L., & Laws, D. R. (1980). Orgasmic reconditioning without deviant imagery: A case report with a pedophile. Behavior Research Therapy, 18(3), 203-207.
46. Levine, S. B., Risen, C. B., & Althof, S. E. (1990). Essay on the diagnosis and nature of paraphilia. Journal of Sex & Marital Therapy, 16(2), 89-102.
47. Liu, Y. C., Sachs, B. D., & Salamone, J. D. (1998). Sexual behavior in male rats after radiofrequency or dopamine-depleting lesions in nucleus accumbens. Pharmacology Biochemistry and Behavior, 60(2), 585-592.
48. Malloy, P., Bihrle, A., & Duffy, J. (1993). The orbitomedial frontal syndrome. Archives of Clinical Neuropsychology, 8(3), 185-201.
49. Marshall, W. L., Hamilton, K., & Fernandez, Y. (2001). Empathy deficits and cognitive distortions in child molesters. Sex Abuse, 13, 123-130.
50. Masterman, D. L., & Cummings, J. L. (1997). Frontal-subcortical circuits: The anatomic basis of executive, social and motivated behaviors. Journal of Psychopharmacology, 11(2), 107-114.
51. McCarthy, G., Puce, A., Constable, R. T., Krystal, J. H., Gore, J. C., & Goldman-Rakic, P. (1996). Activation of human prefrontal cortex during spatial and nonspatial working memory tasks measured by functional MRI. Cerebral Cortex, 6(4), 600-611.
52. McKenna, K. E. (2000). Some proposals regarding the organization of the central nervous system control of penile erection. Neuroscience Biobehavioral Reviews, 24(5), 535-540.
53. McKenna, K. E. (2001). Neural circuitry involved in sexual function. Journal of Spinal Cord Medicine, 24(3), 148-154.
54. McKenna, K. E. (2002). The neurophysiology of female sexual function. World Journal of Urology, 20(2), 93-100.
55. Mega, M. S., & Cohenour, R. C. (1997). Akinetic mutism: Disconnection of frontal-subcortical circuits. Neuropsychiatry Neuropsychology and Behavioral Neurology, 10(4), 254-259.
56. Mendez, M. F., Adams, N. L., & Lewandowski, K. S. (1989). Neurobehavioral changes associated with caudate lesions. Neurology, 39(3), 349-354.
57. Mendez, M. F., Chow, T., Ringman, J., Twitchell, G., & Hinkin, C. H. (2000). Pedophilia and temporal lobe disturbances. Journal of Neuropsychiatry and Clinical Neurosciences, 12(1), 71-76.
58. Meston, C. M., & Frohlich, P. F. (2000). The neurobiology of sexual function. Archives of General Psychiatry, 57(11), 1012-1030.
59. Meunier, M., Bachevalier, J., & Mishkin, M. (1997). Effects of orbital frontal and anterior cingulate lesions on object and spatial memory in rhesus monkeys. Neuropsychologia, 35(7), 999-1015.
60. Miller, B. L., Cummings, J. L., McIntyre, H., Ebers, G., & Grode, M. (1986). Hypersexuality or altered sexual preference following brain injury. Journal of Neurology, Neurosurgery, and Psychiatry, 49(8), 867-873.
61. Montorsi, F., Perani, D., Anchisi, D., Salonia, A., Scifo, P., Rigiroli, P., Deho, F., DeVito, M. L., Heaton, J., Rigatti, P., & Fazio, F. (2003). Brain activation patterns during video sexual stimulation following the administration of apomorphine: Results of a placebo-controlled study. European Urology, 43(4), 405-411.
62. Nims, J. P. (1975). Imagery, shaping, and orgasm. Journal of Sex Marital Therapy, 1(3), 198-203.
63. O'Doherty, J., Kringelbach, M. L., Rolls, E. T., Hornak, J., & Andrews, C. (2000). Medial and lateral orbitofrontal cortex differentially activated by reward and punishment during an emotion-related reversal task. NeuroImage, 11(5), S234.
64. O'Doherty, J., Kringelbach, M. L., Rolls, E. T., Hornak, J., & Andrews, C. (2001). Abstract reward and punishment representations in the human orbitofrontal cortex. Nature Neuroscience, 4(1), 95-102.
65. O'Doherty, J., Winston, J., Critchley, H., Perrett, D., Burt, D. M., & Dolan, R. J. (2003). Beauty in a smile: The role of medial orbitofrontal cortex in facial attractiveness. Neuropsychologia, 41(2), 147-155.
66. Ohkura, S., Fabre-Nys, C., Broad, K. D., & Kendrick, K. M. (1997). Sex hormones enhance the impact of male sensory cues on both primary and association cortical components of visual and olfactory processing pathways as well as in limbic and hypothalamic regions in female sheep. Neuroscience, 80(1), 285-297.
67. Ongur, D., & Price, J. L. (2000). The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans. Cerebral Cortex, 10(3), 206-219.
68. Ortega, N., Miller, N. L., Itabashi, H., & Cummings, J. L. (1993). Altered sexual behavior with multiple sclerosis: A case report. Journal of Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 6, 260-264.
69. Rauch, S. L., Shin, L. M., Dougherty, D. D., Alpert, N. M., Orr, S. P., Lasko, M., Macklin, M. L., Fischman, A. J., & Pitman, R. K. (1999). Neural activation during sexual and competitive arousal in healthy men. Psychiatry Research, 91(1), 1-10.
70. Redoute, J., Stoleru, S., Gregoire, M. C., Costes, N., Cinotti, L., Lavenne, F., Forest, M. G., & Pujol, J. F. (2000). Brain processing of visual sexual stimuli in human males. Human Brain Mapping, 11(3), 162-177.
71. Rivas, F. J., & Mir, D. (1990). Effects of nucleus accumbens lesion on female rat sexual receptivity and proceptivity in a partner preference paradigm. Behavioral Brain Research, 41(3), 239-249.
72. Rivas, F. J., & Mir, D. (1991). Accumbens lesion in female rats increases mount rejection without modifying lordosis. Revista Espanola de Fisiologia, 47(1), 1-6.
73. Robertson, G. S., Pfaus, J. G., Atkinson, L. J., Matsumura, H., Phillips, A. G., & Fibiger, H. C. (1991). Sexual behavior increases c-fos expression in the forebrain of the male rat. Brain Research, 564(2), 352-357.
74. Rolls, E. T. (1996). The orbitofrontal cortex. Philosophical transactions of the Royal Society of London. Series B, Biological Sciences, 351, 1433-1443.
75. Schultz, W., Tremblay, L., & Hollerman, J. R. (1998). Reward prediction in primate basal ganglia and frontal cortex. Neuropharmacology, 37(4-5), 421-429.
76. Sell, L. A., Morris, J. S., Bearn, J., Frackowiak, R. S., Friston, K. J., & Dolan, R. J. (2000). Neural responses associated with cue evoked emotional states and heroin in opiate addicts. Drug & Alcohol Dependence, 60(2), 207-216.
77. Sewards, T. V., & Sewards, M. A. (2003). Representations of motivational drives in mesial cortex, medial thalamus, hypothalamus and midbrain. Brain Research Bulletin, 61(1), 25-49.
78. Simpson, G., Blaszczynski, A., & Hodgkinson, A. (1999). Sex offending as a psychosocial sequela of traumatic brain injury. Journal of Head Trauma Rehabilitation, 14(6), 567-580.
79. Small, D. M., Zatorre, R. J., Dagher, A., Evans, A. C., & Jones-Gotman, M. (2001). Changes in brain activity related to eating chocolate: From pleasure to aversion. Brain, 124(Pt 9), 1720-1733.
80. Spinella, M. (2002). A relationship between smell identification and empathy. International Journal of Neuroscience, 112(6), 605-612.
81. Spinella, M. (2004). Hypersexuality and dysexecutive syndrome after a thalamic infarct. International Journal of Neuroscience, 114(12), 1581-1590.
82. Spinella, M., & White, J. (in review). Prefrontal System Dysfunction and Symptoms of Sexual Addiction.
83. Spinella, M., White, J., Frank, M., & Schiraldi, J. (2007). Evidence of orbitofrontal dysfunction in sex offenders. International Journal of Forensic Psychology, in press
84. Starkstein, S. E., & Robinson, R. G. (1997). Mechanism of disinhibition after brain lesions. Journal of Nervours and Mental Disease, 185(2), 108-114.
85. Starkstein, S. E., Berthier, M. L., & Leiguarda, R. (1989). Psychic akinesia following bilateral pallidal lesions. International Journal of Psychiatry in Medicine, 19(2), 155-164.
86. Stein, E. A., Pankiewicz, J., Harsch, H. H., Cho, J. K., Fuller, S. A., Hoffmann, R. G., Hawkins, M., Rao, S. M., Bandettini, P. A., & Bloom, A. S. (1998). Nicotine-induced limbic cortical activation in the human brain: A functional MRI study. American Journal of Psychiatry, 155(8), 1009-1015.
87. Stoĺeru, S., Gŕegoire,M. C., Ǵerard, D., Decety, J., Lafarge, E., Cinotti, L., Lavenne, F., Le Bars, D., Vernet-Maury, E., Rada, H., Collet, C., Mazoyer, B., Forest, M. G., Magnin, F., Spira, A., & Comar, D. (1999). Neuroanatomical correlates of visually evoked sexual arousal in human males. Archives of Sexual Behavior, 28(1), 1-21.
88. Stuss, D., & Levine, B. (2002). Adult neuropsychology. Lessons from studies of the frontal lobes. Annual Review of Psychology, 53, 401-433.
89. Tataranni, P. A., Gautier, J. F., Chen, K., Uecker, A., Bandy, D., Salbe, A. D., Pratley, R. E., Lawson, M., Reiman, E. M., & Ravussin, E. (1999). Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography. Proceedings of the National Academy of Sciences of the United States of America, 96(8), 4569-4574.
90. Tekin, S., & Cummings, J. L. (2002). Frontal-subcortical neuronal circuits and clinical neuropsychiatry: An update. Journal of Psychosomatic Research, 53(2), 647-654.
91. Thut, G., Schultz, W., Roelcke, U., Nienhusmeier, M., Missimer, J., Maguire, R. P., & Leenders, K. L. (1997). Activation of the human brain by monetary reward. Neuroreport, 8(5), 1225-1228.
92. Tiihonen, J., Kuikka, J., Kupila, J., Partanen, K., Vainio, P., Airaksinen, J., Eronen, M., Hallikainen, T., Paanila, J., Kinnunen, I., & Huttunen, J. (1994). Increase in cerebral blood flow of right prefrontal cortex in man during orgasm. Neuroscience Letters, 170(2), 241-243.
93. Trautner, R. J., Cummings, J. L., Read, S. L., & Benson, D. F. (1988). Idiopathic basal ganglia calcification and organic mood disorder. American Journal of Psychiatry, 145(3), 350-353.
94. Thut, G., Schultz, W., Roelcke, U., Nienhusmeier, M., Missimer, J., Maguire, R. P., & Leenders, K. L. (1997). Activation of the human brain by monetary reward. Neuroreport, 8(5), 1225-1228.
95. Tulving, E., Markowitsch, H. J., Kapur, S., Habib, R., & Houle, S. (1994). Novelty encoding networks in the human brain: Positron emission tomography data. Neuroreport, 5(18), 2525-2528.
96. Tzschentke, T. M. (2000). The medial prefrontal cortex as a part of the brain reward system. Amino Acids, 19(1), 211-219.
97. Whipple, B., Ogden, G., & Komisaruk, B. R. (1992). Physiological correlates of imagery-induced orgasm in women. Archives of Sexual Behavior, 21(2), 121-133.
98. Wright, P., Nobrega, J., & Langevin, R. (1990). Brain density and symmetry in pedophilic and sexually aggressive offenders. Annals of Sex Research, 3(3), 319-328.
99. Yamanouchi, K., & Arai, Y. (1992). Possible role of cingulate cortex in regulating sexual behavior in male rats: Effects of lesions and cuts. Endocrinology Japan, 39(3), 229-234.
100. Yoo, S. S., Freeman,D.K., McCarthy, J. J., 3rd., & Jolesz, F. A. (2003). Neural substrates of tactile imagery: A functional MRI study. Neuroreport, 14(4), 581-585.
101. Zald, D. H., Lee, J. T., Fluegel, K. W., & Pardo, J. V. (1998). Aversive gustatory stimulation activates limbic circuits in humans. Brain, 121(6), 1143-1154.