메뉴 건너뛰기




Volumn 42, Issue 12, 2006, Pages 791-801

Interleukin-2 for the treatment of human immunodeficiency virus infection

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; DIDANOSINE; INDINAVIR; INTERLEUKIN 2; INTERLEUKIN 2 DERIVATIVE; LAMIVUDINE; NELFINAVIR; PEGYLATED INTERLEUKIN 2; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; STAVUDINE; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE;

EID: 33846986439     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2006.42.12.1025703     Document Type: Review
Times cited : (8)

References (70)
  • 1
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
    • Palella, F.J. Jr., Delaney, K.M., Moorman, A.C. et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N Engl J Med 1998, 338: 853-60.
    • (1998) N Engl J Med , vol.338 , pp. 853-860
    • Palella Jr., F.J.1    Delaney, K.M.2    Moorman, A.C.3
  • 2
    • 0030923798 scopus 로고    scopus 로고
    • Impact of combination therapy for HIV infection on inpatient census
    • Torres, R.A., Barr, M. Impact of combination therapy for HIV infection on inpatient census. N Engl J Med 1997, 336: 1531-2.
    • (1997) N Engl J Med , vol.336 , pp. 1531-1532
    • Torres, R.A.1    Barr, M.2
  • 3
    • 0035423963 scopus 로고    scopus 로고
    • Reconstitution of CD4p T lymphocytes in HIV-infected individuals following antiretroviral therapy
    • Carcelain, G., Debre, P., Autran, B. Reconstitution of CD4p T lymphocytes in HIV-infected individuals following antiretroviral therapy. Curr Opin Immunol 2001, 13: 483-8.
    • (2001) Curr Opin Immunol , vol.13 , pp. 483-488
    • Carcelain, G.1    Debre, P.2    Autran, B.3
  • 4
    • 0037045011 scopus 로고    scopus 로고
    • Rapid reconstitution of humoral immunity against cytomegalovirus but not HIV following highly active antiretroviral therapy
    • Deayton, J.R., Sabin, C.A., Britt, W.B. et al. Rapid reconstitution of humoral immunity against cytomegalovirus but not HIV following highly active antiretroviral therapy. AIDS 2002, 16: 2129-35.
    • (2002) AIDS , vol.16 , pp. 2129-2135
    • Deayton, J.R.1    Sabin, C.A.2    Britt, W.B.3
  • 5
    • 0033010070 scopus 로고    scopus 로고
    • Immunopathology as a result of highly active antiretroviral therapy in HIV-1-infected patients
    • Foudraine, N.A., Hovenkamp, E., Notermans, D.W. et al. Immunopathology as a result of highly active antiretroviral therapy in HIV-1-infected patients. AIDS 1999, 13: 177-84.
    • (1999) AIDS , vol.13 , pp. 177-184
    • Foudraine, N.A.1    Hovenkamp, E.2    Notermans, D.W.3
  • 6
    • 0037045011 scopus 로고    scopus 로고
    • Rapid reconstitution of humoral immunity against cytomegalovirus but not HIV following highly active antiretroviral therapy
    • Deayton, J.R., Sabin, C.A., Britt, W.B. et al. Rapid reconstitution of humoral immunity against cytomegalovirus but not HIV following highly active antiretroviral therapy. AIDS 2002, 16: 2129-35.
    • (2002) AIDS , vol.16 , pp. 2129-2135
    • Deayton, J.R.1    Sabin, C.A.2    Britt, W.B.3
  • 7
    • 0032941595 scopus 로고    scopus 로고
    • HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression
    • Pitcher, C.J., Quittner, C., Peterson, D.M. et al. HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression. Nat Med 1999, 5: 518-25.
    • (1999) Nat Med , vol.5 , pp. 518-525
    • Pitcher, C.J.1    Quittner, C.2    Peterson, D.M.3
  • 8
    • 7144229335 scopus 로고    scopus 로고
    • Discrepant responses to triple combination antiretroviral therapy in advanced HIV disease
    • Piketty, C., Castiel, P., Belec, L. et al. Discrepant responses to triple combination antiretroviral therapy in advanced HIV disease. AIDS 1998, 12: 745-50.
    • (1998) AIDS , vol.12 , pp. 745-750
    • Piketty, C.1    Castiel, P.2    Belec, L.3
  • 9
    • 0033984368 scopus 로고    scopus 로고
    • Immune reconstitution in the first year of potent antiretroviral therapy and its relationship to virologic response
    • Connick, E., Lederman, M., Kotzin, B. et al. Immune reconstitution in the first year of potent antiretroviral therapy and its relationship to virologic response. J Infect Dis 2000, 181: 358-63.
    • (2000) J Infect Dis , vol.181 , pp. 358-363
    • Connick, E.1    Lederman, M.2    Kotzin, B.3
  • 10
    • 0034641205 scopus 로고    scopus 로고
    • Immune restoration with antiretroviral therapies: Implications for clinical management
    • Lederman, M.M., Valdez, H. Immune restoration with antiretroviral therapies: Implications for clinical management. JAMA 2000, 284: 223-8.
    • (2000) JAMA , vol.284 , pp. 223-228
    • Lederman, M.M.1    Valdez, H.2
  • 11
    • 0020565302 scopus 로고
    • Molecular characterization of interleukin 2
    • Watson, J.D., Gillis, D.Y., Mochizuki, S. Molecular characterization of interleukin 2. Fed Proc 1983, 42: 2747-52.
    • (1983) Fed Proc , vol.42 , pp. 2747-2752
    • Watson, J.D.1    Gillis, D.Y.2    Mochizuki, S.3
  • 12
    • 0023907493 scopus 로고
    • Interleukin-2: Inception, impact, and implications
    • Smith, K.A. Interleukin-2: Inception, impact, and implications. Science 1988, 240: 1169-76.
    • (1988) Science , vol.240 , pp. 1169-1176
    • Smith, K.A.1
  • 13
    • 0020580976 scopus 로고
    • Interleukin 2-mediated immune interferon (IFN-gamma) production by human T cells and T cell subsets
    • Kasahara, T., Hooks, J.J., Dougherty, S.F., Oppenheim, J.J. Interleukin 2-mediated immune interferon (IFN-gamma) production by human T cells and T cell subsets. J Immunol 1983, 130: 1784-9.
    • (1983) J Immunol , vol.130 , pp. 1784-1789
    • Kasahara, T.1    Hooks, J.J.2    Dougherty, S.F.3    Oppenheim, J.J.4
  • 14
    • 0020578618 scopus 로고
    • Inter-leukin-2 enhances the depressed natural killer and cytomegalovirus-specific cytotoxic activities of lymphocytes from patients with the acquired immune deficiency syndrome
    • Rook, A.H., Masur, H., Lane, H.C. et al. Inter-leukin-2 enhances the depressed natural killer and cytomegalovirus-specific cytotoxic activities of lymphocytes from patients with the acquired immune deficiency syndrome. J Clin Invest 1983, 72: 398-403.
    • (1983) J Clin Invest , vol.72 , pp. 398-403
    • Rook, A.H.1    Masur, H.2    Lane, H.C.3
  • 15
    • 0021925085 scopus 로고
    • Interleukin 2 enhances the natural killer cell activity of acquired immunodeficiency syndrome patients through a gamma-interferon-independent mechanism
    • Rook, A.H., Masur, H., Lane, H.C. et al. Interleukin 2 enhances the natural killer cell activity of acquired immunodeficiency syndrome patients through a gamma-interferon-independent mechanism. J Immunol 1985, 134: 1503-7.
    • (1985) J Immunol , vol.134 , pp. 1503-1507
    • Rook, A.H.1    Masur, H.2    Lane, H.C.3
  • 16
    • 0036677041 scopus 로고    scopus 로고
    • Molecular virology and immunology of HIV infection
    • Chinen, J., Shearer, W.T. Molecular virology and immunology of HIV infection. J Allergy Clin Immunol 2002, 110: 189-98.
    • (2002) J Allergy Clin Immunol , vol.110 , pp. 189-198
    • Chinen, J.1    Shearer, W.T.2
  • 17
    • 0022314094 scopus 로고
    • Immunologic abnormalities in the acquired immunodeficiency syndrome
    • Lane, H.C., Fauci, A.S. Immunologic abnormalities in the acquired immunodeficiency syndrome. Annu Rev Immunol 1985, 3: 477-500.
    • (1985) Annu Rev Immunol , vol.3 , pp. 477-500
    • Lane, H.C.1    Fauci, A.S.2
  • 18
    • 33846975570 scopus 로고    scopus 로고
    • Immunopathogenesis of the acquired immunodeficiency restored by antiviral or immune-based therapies
    • Bowen, D.L., Lane, H.C., Fauci, A.S. Immunopathogenesis of the acquired immunodeficiency restored by antiviral or immune-based therapies. Nat Med 1997, 3: 533-40.
    • (1997) Nat Med , vol.3 , pp. 533-540
    • Bowen, D.L.1    Lane, H.C.2    Fauci, A.S.3
  • 19
    • 16944367032 scopus 로고    scopus 로고
    • HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies
    • Connors, M., Kovacs, J.A., Krevat, S. et al. HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies. Nat Med 1997, 3: 533-40.
    • (1997) Nat Med , vol.3 , pp. 533-540
    • Connors, M.1    Kovacs, J.A.2    Krevat, S.3
  • 20
    • 0022355372 scopus 로고
    • Production of and in vitro response to interleukin 2 in the acquired immunodeficiency syndrome
    • Murray, H.W., Weite, K., Jacobs, J.L., Rubin, B.Y., Mertelsmann, R., Roberts, R.B. Production of and in vitro response to interleukin 2 in the acquired immunodeficiency syndrome. J Clin Invest 1985, 76: 1959-64.
    • (1985) J Clin Invest , vol.76 , pp. 1959-1964
    • Murray, H.W.1    Weite, K.2    Jacobs, J.L.3    Rubin, B.Y.4    Mertelsmann, R.5    Roberts, R.B.6
  • 21
    • 0026675818 scopus 로고
    • Heterogeneous effects of exogenous IL-2 on HIV-specific cell-mediated immunity (CMI)
    • Bell, S.J., Cooper, D.A., Kemp, B.E., Doherty, R.R., Penny, R. Heterogeneous effects of exogenous IL-2 on HIV-specific cell-mediated immunity (CMI). Clin Exp Immunol 1992, 90: 6-12.
    • (1992) Clin Exp Immunol , vol.90 , pp. 6-12
    • Bell, S.J.1    Cooper, D.A.2    Kemp, B.E.3    Doherty, R.R.4    Penny, R.5
  • 22
    • 23644439060 scopus 로고    scopus 로고
    • Induction of prolonged survival of CD4+ T lymphocytes by intermittent IL-2 therapy in HIV-infected patients
    • Kovacs, J.A., Lempicki, R.A., Sidorov, I.A. et al. Induction of prolonged survival of CD4+ T lymphocytes by intermittent IL-2 therapy in HIV-infected patients. J Clin Invest 2005, 115: 2139-48.
    • (2005) J Clin Invest , vol.115 , pp. 2139-2148
    • Kovacs, J.A.1    Lempicki, R.A.2    Sidorov, I.A.3
  • 23
    • 0029923736 scopus 로고    scopus 로고
    • Interleukin-2 and human immunodeficiency virus infection: Pathogenic mechanisms and potential for immunologic enhancement
    • Kinter, A., Fauci, A.S. Interleukin-2 and human immunodeficiency virus infection: Pathogenic mechanisms and potential for immunologic enhancement. Immunol Res 1996, 15: 1-15.
    • (1996) Immunol Res , vol.15 , pp. 1-15
    • Kinter, A.1    Fauci, A.S.2
  • 24
    • 0028875759 scopus 로고
    • Interleukin 2 induces CD8+ T cell-mediated suppression of human immunodeficiency virus replication in CD4+ T cells and this effect overrides its ability to stimulate virus expression
    • Kinter, A.L., Bende, S.M., Hardy, E.C., Jackson, R., Fauci, A.S. Interleukin 2 induces CD8+ T cell-mediated suppression of human immunodeficiency virus replication in CD4+ T cells and this effect overrides its ability to stimulate virus expression. Proc Natl Acad Sci USA 1995, 92: 10985-9.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10985-10989
    • Kinter, A.L.1    Bende, S.M.2    Hardy, E.C.3    Jackson, R.4    Fauci, A.S.5
  • 25
    • 0023933696 scopus 로고
    • Effects of interleukin 2 and large envelope glycoprotein (gp 120) of human immunodeficiency virus (HIV) on lymphocyte proliferative responses to cytomegalovirus
    • Krowka, J., Stites, D., Mills, J. et al. Effects of interleukin 2 and large envelope glycoprotein (gp 120) of human immunodeficiency virus (HIV) on lymphocyte proliferative responses to cytomegalovirus. Clin Exp Immunol 1988, 72: 179-85.
    • (1988) Clin Exp Immunol , vol.72 , pp. 179-185
    • Krowka, J.1    Stites, D.2    Mills, J.3
  • 26
    • 0030293533 scopus 로고    scopus 로고
    • IL-2 rescues in vitro lymphocyte apoptosis in patients with HIV infection. Correlation with its ability to block culture-induced down-modulation of Bcl-2
    • Adachi, Y., Oyaizu, N., Than, S., McCloskey, T.W., Pahwa, S. IL-2 rescues in vitro lymphocyte apoptosis in patients with HIV infection. Correlation with its ability to block culture-induced down-modulation of Bcl-2. J Immunol 1996, 157: 4184-93.
    • (1996) J Immunol , vol.157 , pp. 4184-4193
    • Adachi, Y.1    Oyaizu, N.2    Than, S.3    McCloskey, T.W.4    Pahwa, S.5
  • 27
    • 22144470799 scopus 로고    scopus 로고
    • In vivo expansion of CD4+CD45RO-CD25+T cells expressing foxP3 in IL-2-treated HIV-infected patients
    • Sereti, I., Imamichi, H., Natarajan, V. et al. In vivo expansion of CD4+CD45RO-CD25+T cells expressing foxP3 in IL-2-treated HIV-infected patients. J Clin Invest 2005, 115: 1839-47.
    • (2005) J Clin Invest , vol.115 , pp. 1839-1847
    • Sereti, I.1    Imamichi, H.2    Natarajan, V.3
  • 28
    • 3242773778 scopus 로고    scopus 로고
    • IL-2-induced CD4+T-cell expansion in HIV-infected patients is associated with long-term decreases in T-cell proliferation
    • Sereti, I., Anthony, K.B., Martinez-Wilson, H. et al. IL-2-induced CD4+T-cell expansion in HIV-infected patients is associated with long-term decreases in T-cell proliferation. Blood 2004, 104: 775-80.
    • (2004) Blood , vol.104 , pp. 775-780
    • Sereti, I.1    Anthony, K.B.2    Martinez-Wilson, H.3
  • 29
    • 0021999943 scopus 로고
    • Preliminary clinical observations with recombinant interleukin-2 in patients with AIDS or LAS
    • Kern, P., Toy, J., Dietrich, M. Preliminary clinical observations with recombinant interleukin-2 in patients with AIDS or LAS. Blut 1985, 50: 1-6.
    • (1985) Blut , vol.50 , pp. 1-6
    • Kern, P.1    Toy, J.2    Dietrich, M.3
  • 30
    • 0022922250 scopus 로고
    • Effects of systemic in vivo interleukin-2 (IL-2) reconstitution in patients with acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC) on phenotypes and functions of peripheral blood mononuclear cells (PBMC)
    • Ernst, M., Kern, P., Flad, H.D., Ulmer, A.J. Effects of systemic in vivo interleukin-2 (IL-2) reconstitution in patients with acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC) on phenotypes and functions of peripheral blood mononuclear cells (PBMC). J Clin Immunol 1986; 6: 170-81.
    • (1986) J Clin Immunol , vol.6 , pp. 170-181
    • Ernst, M.1    Kern, P.2    Flad, H.D.3    Ulmer, A.J.4
  • 32
    • 0026097439 scopus 로고
    • Safety and effects of interleukin 2 plus zidovudine in asymptomatic individuals infected with human immunodeficiency virus
    • Schwartz, D.H., Skowron, G., Merigan, T.C. Safety and effects of interleukin 2 plus zidovudine in asymptomatic individuals infected with human immunodeficiency virus. J Acquir Immune Defic Syndr 1991, 4: 11-23.
    • (1991) J Acquir Immune Defic Syndr , vol.4 , pp. 11-23
    • Schwartz, D.H.1    Skowron, G.2    Merigan, T.C.3
  • 33
    • 0031741466 scopus 로고    scopus 로고
    • Pharmacokinetic modeling of recombinant interleukin-2 in patients with human immunodeficiency virus infection
    • Piscitelli, S.C., Forrest, A., Vogel, S. et al. Pharmacokinetic modeling of recombinant interleukin-2 in patients with human immunodeficiency virus infection. Clin Pharmacol Ther 1998, 64: 492-8.
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 492-498
    • Piscitelli, S.C.1    Forrest, A.2    Vogel, S.3
  • 34
    • 0345700836 scopus 로고    scopus 로고
    • A randomized controlled trial evaluating the efficacy and safety of intermittent 3-, 4-, and 5-day cycles of intravenous recombinant human interleukin-2 combined with antiretroviral therapy (ART) versus ART alone in HIV-seropositive patients with 100-300 CD4+ T cells
    • de Boer, A.W., Markowitz, N., Lane, H.C. et al. A randomized controlled trial evaluating the efficacy and safety of intermittent 3-, 4-, and 5-day cycles of intravenous recombinant human interleukin-2 combined with antiretroviral therapy (ART) versus ART alone in HIV-seropositive patients with 100-300 CD4+ T cells. Clin Immunol 2003, 106: 188-96.
    • (2003) Clin Immunol , vol.106 , pp. 188-196
    • de Boer, A.W.1    Markowitz, N.2    Lane, H.C.3
  • 35
    • 0028912032 scopus 로고
    • Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection. A preliminary study
    • Kovacs, J.A., Baseler, M., Dewar, R.J. et al. Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection. A preliminary study. N Eng J Med 1995, 332: 567-75.
    • (1995) N Eng J Med , vol.332 , pp. 567-575
    • Kovacs, J.A.1    Baseler, M.2    Dewar, R.J.3
  • 36
    • 0013610170 scopus 로고    scopus 로고
    • Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus
    • Kovacs, U.A., Vogel, S., Albert, J.M. et al. Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus. N Eng J Med 1996, 335: 1350-6.
    • (1996) N Eng J Med , vol.335 , pp. 1350-1356
    • Kovacs, U.A.1    Vogel, S.2    Albert, J.M.3
  • 37
    • 0031680651 scopus 로고    scopus 로고
    • Outpatient continuous intravenous interleukin-2 or subcutaneous, polyethylene glycol-modified interleukin-2 in human immunodeficiency virus-infected patients: A randomized, controlled, multicenter study
    • for the Australian IL-2 Study Group
    • Carr, A., Emery, S., Lloyd, A. et al.; for the Australian IL-2 Study Group. Outpatient continuous intravenous interleukin-2 or subcutaneous, polyethylene glycol-modified interleukin-2 in human immunodeficiency virus-infected patients: A randomized, controlled, multicenter study. J Infect Dis 1998, 178: 992-9.
    • (1998) J Infect Dis , vol.178 , pp. 992-999
    • Carr, A.1    Emery, S.2    Lloyd, A.3
  • 38
    • 0033526641 scopus 로고    scopus 로고
    • Comparison of subcutaneous and intravenous interleukin-2 in asymptomatic HIV-1 infection: A randomized controlled trial. ANRS 048 study group
    • Levy, Y., Capitant, C., Houhou, S. et al. Comparison of subcutaneous and intravenous interleukin-2 in asymptomatic HIV-1 infection: A randomized controlled trial. ANRS 048 study group. Lancet 1999, 353: 1923-9.
    • (1999) Lancet , vol.353 , pp. 1923-1929
    • Levy, Y.1    Capitant, C.2    Houhou, S.3
  • 39
    • 0033836422 scopus 로고    scopus 로고
    • Pooled analysis of 3 randomized, controlled trials of interleukin-2 therapy in adult human immunodeficiency virus type 1 disease
    • Emery, S., Capra, W.B., Cooper, D.A. et al. Pooled analysis of 3 randomized, controlled trials of interleukin-2 therapy in adult human immunodeficiency virus type 1 disease. J Infect Dis 2000, 182: 428-34.
    • (2000) J Infect Dis , vol.182 , pp. 428-434
    • Emery, S.1    Capra, W.B.2    Cooper, D.A.3
  • 41
    • 16944364282 scopus 로고    scopus 로고
    • Subcutaneous administration of interleukin-2 in human immunodeficiency virus type 1-infected persons
    • Davey, R.T. Jr., Chaitt, D.G., Piscitelli, S.C. et al. Subcutaneous administration of interleukin-2 in human immunodeficiency virus type 1-infected persons. J Infect Dis 1997, 175: 781-9.
    • (1997) J Infect Dis , vol.175 , pp. 781-789
    • Davey Jr., R.T.1    Chaitt, D.G.2    Piscitelli, S.C.3
  • 42
    • 0001027244 scopus 로고    scopus 로고
    • A randomized trial of high versus low-dose subcutaneous interleukin-2 outpatient therapy for early human immunodeficiency virus type 1 infection
    • Davey, R.T. Jr., Chaitt, D.G., Albert, J.M. et al. A randomized trial of high versus low-dose subcutaneous interleukin-2 outpatient therapy for early human immunodeficiency virus type 1 infection. J Infect Dis 1999, 179: 849-58.
    • (1999) J Infect Dis , vol.179 , pp. 849-858
    • Davey Jr., R.T.1    Chaitt, D.G.2    Albert, J.M.3
  • 44
    • 0033738864 scopus 로고    scopus 로고
    • A randomized, controlled 24-week study of intermittent subcutaneous interleukin-2 in HIV-1 infected patients in Thailand
    • Ruxrungtham, K., Suwanagool, S. Tavel, J.A. et al. A randomized, controlled 24-week study of intermittent subcutaneous interleukin-2 in HIV-1 infected patients in Thailand. AIDS 2000, 14: 2509-13.
    • (2000) AIDS , vol.14 , pp. 2509-2513
    • Ruxrungtham, K.1    Suwanagool, S.2    Tavel, J.A.3
  • 45
    • 0004781509 scopus 로고    scopus 로고
    • Immunologic and virologic effects of subcutaneous interleukin 2 in combination with antiretroviral therapy: A randomized controlled trial
    • Davey, R.T. Jr., Murphy, R.L., Graziano, P.M. et al. Immunologic and virologic effects of subcutaneous interleukin 2 in combination with antiretroviral therapy: A randomized controlled trial. JAMA 2000, 284: 183-9.
    • (2000) JAMA , vol.284 , pp. 183-189
    • Davey Jr., R.T.1    Murphy, R.L.2    Graziano, P.M.3
  • 46
    • 0023038312 scopus 로고
    • A phase I/II trial of recombinant interleukin-2 in AIDS/ARC: Alterations of phenotypes of peripheral blood mononuclear cells
    • Flad, H.D., Ernst, M., Kern, P. A phase I/II trial of recombinant interleukin-2 in AIDS/ARC: Alterations of phenotypes of peripheral blood mononuclear cells. Lymphokine Res 1986, 5 (Suppl. 1): S171-6.
    • (1986) Lymphokine Res , vol.5 , Issue.SUPPL. 1
    • Flad, H.D.1    Ernst, M.2    Kern, P.3
  • 47
    • 0021999943 scopus 로고
    • Preliminary clinical observations with recombinant interleukin-2 in patients with AIDS or LAS
    • Kern, P., Toy, J., Dietrich, M. Preliminary clinical observations with recombinant interleukin-2 in patients with AIDS or LAS. Blut 1985, 50: 1-6.
    • (1985) Blut , vol.50 , pp. 1-6
    • Kern, P.1    Toy, J.2    Dietrich, M.3
  • 49
    • 13144252233 scopus 로고    scopus 로고
    • Regulatory dysfunction of the interleukin-2 receptor during HIV infection and the impact of triple combination therapy
    • David, D., Bani, L., Moreau, J.L. et al. Regulatory dysfunction of the interleukin-2 receptor during HIV infection and the impact of triple combination therapy. Proc Nat Acad Sci USA 1998, 95: 11348-53.
    • (1998) Proc Nat Acad Sci USA , vol.95 , pp. 11348-11353
    • David, D.1    Bani, L.2    Moreau, J.L.3
  • 50
    • 7844229880 scopus 로고    scopus 로고
    • Randomized, controlled phase II trial of subcutaneous interleukin-2 in combination with highly active antiretroviral therapy (HAART) in HIV patients
    • Hengge, U.R., Goos, M., Esser, S. et al. Randomized, controlled phase II trial of subcutaneous interleukin-2 in combination with highly active antiretroviral therapy (HAART) in HIV patients. AIDS 1998, 12: F225-34.
    • (1998) AIDS , vol.12
    • Hengge, U.R.1    Goos, M.2    Esser, S.3
  • 51
    • 0035873085 scopus 로고    scopus 로고
    • Efficacy of low-dose intermittent subcutaneous interleukin (IL)-2 in antiviral drug-experienced human immunodeficiency virus-infected persons with detectable virus load: A controlled study of 3 IL-2 regimens with antiviral drug therapy
    • Tambussi, G., Ghezzi, S., Nozza, S. et al. Efficacy of low-dose intermittent subcutaneous interleukin (IL)-2 in antiviral drug-experienced human immunodeficiency virus-infected persons with detectable virus load: A controlled study of 3 IL-2 regimens with antiviral drug therapy. J Infect Dis 2001, 183: 1476-84.
    • (2001) J Infect Dis , vol.183 , pp. 1476-1484
    • Tambussi, G.1    Ghezzi, S.2    Nozza, S.3
  • 52
    • 0037178320 scopus 로고    scopus 로고
    • Effects of interleukin-2 plus highly active antiretroviral therapy on HIV-1 replication and proviral DNA (COSMIC trial)
    • Stellbrink, H.J., van Lunzen, J., Westby, M. et al. Effects of interleukin-2 plus highly active antiretroviral therapy on HIV-1 replication and proviral DNA (COSMIC trial). AIDS 2002, 16: 1479-87.
    • (2002) AIDS , vol.16 , pp. 1479-1487
    • Stellbrink, H.J.1    van Lunzen, J.2    Westby, M.3
  • 54
    • 0037436193 scopus 로고    scopus 로고
    • ANRS 079 Study Group. Effects of interleukin-2 therapy combined with highly active antiretroviral therapy on immune restoration in HIV-1 infection: A randomized controlled trial
    • Levy, Y., Durier, C., Krzysiek, R. et al. ANRS 079 Study Group. Effects of interleukin-2 therapy combined with highly active antiretroviral therapy on immune restoration in HIV-1 infection: A randomized controlled trial. AIDS 2003, 17: 343-51.
    • (2003) AIDS , vol.17 , pp. 343-351
    • Levy, Y.1    Durier, C.2    Krzysiek, R.3
  • 55
    • 0642347180 scopus 로고    scopus 로고
    • Terry Beirn Community Program for Clinical Research on AIDS. Nadir CD4+ T cell count predicts response to subcutaneous recombinant interleukin-2
    • Markowitz, N., Bebchuk, J.D., Abrams, D.I.; Terry Beirn Community Program for Clinical Research on AIDS. Nadir CD4+ T cell count predicts response to subcutaneous recombinant interleukin-2. Clin Infect Dis 2003, 37: e115-20.
    • (2003) Clin Infect Dis , vol.37
    • Markowitz, N.1    Bebchuk, J.D.2    Abrams, D.I.3
  • 56
    • 0035282639 scopus 로고    scopus 로고
    • Rapid effect of interleukin-2 therapy in human immunodeficiency virus-infected patients whose CD4 cell counts increase only slightly in response to combined antiretroviral treatment
    • David, D., Nait-Ighil, L., Dupont, B., Mara, J., Gachot, B., Theze, J. Rapid effect of interleukin-2 therapy in human immunodeficiency virus-infected patients whose CD4 cell counts increase only slightly in response to combined antiretroviral treatment. J Infect Dis 2001, 183: 730-5.
    • (2001) J Infect Dis , vol.183 , pp. 730-735
    • David, D.1    Nait-Ighil, L.2    Dupont, B.3    Mara, J.4    Gachot, B.5    Theze, J.6
  • 57
    • 0033017140 scopus 로고    scopus 로고
    • Efficacy of low-dose subcutaneous interleukin-2 to treat advanced human immunodeficiency virus type 1 in persons
    • Arno, A., Ruiz, L., Juan, M. et al. Efficacy of low-dose subcutaneous interleukin-2 to treat advanced human immunodeficiency virus type 1 in persons. J Infect Dis 1999, 180: 56-60.
    • (1999) J Infect Dis , vol.180 , pp. 56-60
    • Arno, A.1    Ruiz, L.2    Juan, M.3
  • 58
    • 0034331263 scopus 로고    scopus 로고
    • Low-dose daily subcutaneous interleukin-2 in combination with highly active antiretroviral therapy in HIV+ patients: A randomized controlled trial
    • Lalezari, J.P., Beal, J.A., Ruane, P.J. et al. Low-dose daily subcutaneous interleukin-2 in combination with highly active antiretroviral therapy in HIV+ patients: A randomized controlled trial. HIV Clin Trials 2000, 1: 1-15.
    • (2000) HIV Clin Trials , vol.1 , pp. 1-15
    • Lalezari, J.P.1    Beal, J.A.2    Ruane, P.J.3
  • 59
    • 84878721588 scopus 로고    scopus 로고
    • 3: ACTG 328 - Final results at 84 weeks. 8th Conf Retrovir Oppor Infect, Chicago 2001, Abst. 17.
    • 3: ACTG 328 - Final results at 84 weeks. 8th Conf Retrovir Oppor Infect, Chicago 2001, Abst. 17.
  • 60
    • 0037131199 scopus 로고    scopus 로고
    • Interleukin-2 accelerates CD4 cell reconstitution in HIV-infected patients with severe immunosuppression despite highly active antiretroviral therapy: The ILSTIM study - ANRS 082
    • Katlama, C., Carcelain, G., Duvivier, C. et al. Interleukin-2 accelerates CD4 cell reconstitution in HIV-infected patients with severe immunosuppression despite highly active antiretroviral therapy: The ILSTIM study - ANRS 082. AIDS 2002, 16: 2027-34.
    • (2002) AIDS , vol.16 , pp. 2027-2034
    • Katlama, C.1    Carcelain, G.2    Duvivier, C.3
  • 61
    • 0036720644 scopus 로고    scopus 로고
    • Low-dose prolonged intermittent interleukin-2 adjuvant therapy: Results of a randomized trial among human immunodeficiency virus-positive patients with advanced immune impairment
    • Marchetti, G., Meroni, L., Varchetta, S. et al. Low-dose prolonged intermittent interleukin-2 adjuvant therapy: Results of a randomized trial among human immunodeficiency virus-positive patients with advanced immune impairment. J Infect Dis 2002, 186: 606-16.
    • (2002) J Infect Dis , vol.186 , pp. 606-616
    • Marchetti, G.1    Meroni, L.2    Varchetta, S.3
  • 62
    • 84878731048 scopus 로고    scopus 로고
    • Routy, J.P.; for the International SILCAAT Team. Demographics and visit compliance in SILCAAT, a large international phase III clinical endpoint trial with IL-2 as an immune-based therapy adjunctive to ART. XIV Int Conf AIDS, Barcelona 2002, Abst. WePeB5982.
    • Routy, J.P.; for the International SILCAAT Team. Demographics and visit compliance in SILCAAT, a large international phase III clinical endpoint trial with IL-2 as an immune-based therapy adjunctive to ART. XIV Int Conf AIDS, Barcelona 2002, Abst. WePeB5982.
  • 63
    • 0036209488 scopus 로고    scopus 로고
    • The evaluation of subcutaneous proleukin (interleukin-2) in a randomized international trial: Rationale, design, and methods of ESPRIT
    • Emery, S., Abrams, D.I., Cooper, D.A. et al. The evaluation of subcutaneous proleukin (interleukin-2) in a randomized international trial: Rationale, design, and methods of ESPRIT. Control Clin Trials 2002, 23: 198-220.
    • (2002) Control Clin Trials , vol.23 , pp. 198-220
    • Emery, S.1    Abrams, D.I.2    Cooper, D.A.3
  • 64
    • 33846944430 scopus 로고    scopus 로고
    • A randomized trial of subcutaneous intermittent interleukin-2 without antiretroviral therapy in HIV-Infected patients: The UK-Vanguard Study
    • DOI: 10.1371
    • Youle, M., Emery, S., Fisher, M. et al. A randomized trial of subcutaneous intermittent interleukin-2 without antiretroviral therapy in HIV-Infected patients: The UK-Vanguard Study. PLoS Clin Trials 2006, 1: e3 DOI: 10.1371.
    • (2006) PLoS Clin Trials , vol.1
    • Youle, M.1    Emery, S.2    Fisher, M.3
  • 65
    • 0026515571 scopus 로고
    • Interleukin-2 by inhalation: Local therapy for metastatic renal cell carcinoma
    • Huland, E., Huland, H., Heinzer, H. Interleukin-2 by inhalation: Local therapy for metastatic renal cell carcinoma. J Urol 1992, 147: 344-8.
    • (1992) J Urol , vol.147 , pp. 344-348
    • Huland, E.1    Huland, H.2    Heinzer, H.3
  • 66
    • 0031415256 scopus 로고    scopus 로고
    • Inhaled interleukin-2 therapy in pulmonary metastatic renal cell carcinoma: Six years of experience
    • Huland, E., Heinzer, H., Mir, T.S., Huland, H. Inhaled interleukin-2 therapy in pulmonary metastatic renal cell carcinoma: Six years of experience. Cancer J Sci Am 1997, 3 (Suppl. 1): S98-105.
    • (1997) Cancer J Sci Am , vol.3 , Issue.SUPPL. 1
    • Huland, E.1    Heinzer, H.2    Mir, T.S.3    Huland, H.4
  • 67
    • 0034355109 scopus 로고    scopus 로고
    • A comparison of systemic versus inhaled recombinant IL-2 administration for the treatment of metastatic renal cell carcinoma
    • Huland, E., Heinzer, H., Huland, H. A comparison of systemic versus inhaled recombinant IL-2 administration for the treatment of metastatic renal cell carcinoma. Folia Biol (Krakow) 2000, 46: 241-50.
    • (2000) Folia Biol (Krakow) , vol.46 , pp. 241-250
    • Huland, E.1    Heinzer, H.2    Huland, H.3
  • 68
    • 10744222612 scopus 로고    scopus 로고
    • Efficacy and safety of inhaled recombinant interleukin-2 in high-risk renal cell cancer patients compared with systemic interleukin-2: An outcome study
    • Huland, E., Burger, A., Fleischer, J. et al. Efficacy and safety of inhaled recombinant interleukin-2 in high-risk renal cell cancer patients compared with systemic interleukin-2: An outcome study. Folia Biol 2003, 49: 183-95.
    • (2003) Folia Biol , vol.49 , pp. 183-195
    • Huland, E.1    Burger, A.2    Fleischer, J.3
  • 69
    • 0033840128 scopus 로고    scopus 로고
    • Overview of interleukin-2 inhalation therapy
    • Huland, E., Heinzer, H., Huland, H., Yung, R. Overview of interleukin-2 inhalation therapy. Cancer J Sci Am 2000, 6 (Suppl. 1): S104-12.
    • (2000) Cancer J Sci Am , vol.6 , Issue.SUPPL. 1
    • Huland, E.1    Heinzer, H.2    Huland, H.3    Yung, R.4
  • 70
    • 0033795671 scopus 로고    scopus 로고
    • Inhalational interleukin-2 liposomes for pulmonary metastases: A phase I clinical trial
    • Skubitz, K.M., Anderson, P.M. Inhalational interleukin-2 liposomes for pulmonary metastases: A phase I clinical trial. Anticancer Drugs 2000, 11: 555-63.
    • (2000) Anticancer Drugs , vol.11 , pp. 555-563
    • Skubitz, K.M.1    Anderson, P.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.