Synthesis and structure-antibacterial activity relationship investigation of isomeric 2,3,5-substituted perhydropyrrolo[3,4-d]isoxazole-4,6-diones

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 6, 2007, Pages 2322-2333

  Agirbas, Hikmet ^a   Guner, Selahaddin ^a   Budak, Fatma ^a   Keceli, Sema ^a   Kandemirli, Fatma ^a   Shvets, Nathaly ^b   Kovalishyn, Vasyl ^c   Dimoglo, Anatholy ^b,d  

^a KOCAELI UNIVERSITY   (Turkey)

^b GEBZE TECHNICAL UNIVERSITY   (Turkey)

^c INSTITUTE OF BIOORGANIC CHEMISTRY AND PETROCHEMISTRY   (Ukraine)

^d INSTITUTE OF APPLIED PHYSICS   (Moldova)

Author keywords

Electronic topological method (ETM); ETM ANN application; Isoxazole; Structure antibacterial activity relationship

Indexed keywords

2 METHYL 3 (4 METHYLPHENYL) 5 PHENYLPERHYDROPYRROLO[3,4 D]ISOXAZOLE 4,6 DIONE; 2 METHYL 3,5 DIPHENYLPERHYDROPYRROLO[3,4 D]ISOXAZOLE 4,6 DIONE; 2,5 DIMETHYL 3 (4 METHYLPHENYL)PERHYDROPYRROLO[3,4 D]ISOXAZOLE 4,6 DIONE; 2,5 DIMETHYL 3 PHENYLPERHYDROPYRROLO[3,4 D]ISOXAZOLE 4,6 DIONE; 3 (3 BROMOPHENYL) 2 METHYL 5 PHENYLPERHYDROPYRROLO[3,4 D]ISOXAZOLE 4,6 DIONE; 3 (3 BROMOPHENYL) 2,5 DIMETHYLPERHYDROPYRROLO[3,4 D]ISOXAZOLE 4,6 DIONE; 3 (3 CHLOROPHENYL) 2,5 DIMETHYLPERHYDROPYRROLO[3,4 D]ISOXAZOLE 4,6 DIONE; 3 (4 BENZYLOXY 3 METHOXYPHENYL) 2,5 DIMETHYLPERHYDROPYRROLO[3,4 D]ISOXAZOLE 4,6 DIONE; 3 (4 BROMOPHENYL) 2 METHYL 5 PHENYLPERHYDROPYRROLO[3,4 D]ISOXAZOLE 4,6 DIONE; 3 (4 BROMOPHENYL) 2,5 DIMETHYLPERHYDROPYRROLO[3,4 D]ISOXAZOLE 4,6 DIONE; 3 (4 DIETHYLAMINOPHENYL) 2 METHYL 5 PHENYLPERHYDROPYRROLO[3,4 D]ISOXAZOLE 4,6 DIONE; 3 (4 DIETHYLAMINOPHENYL) 2,5 DIMETHYLPERHYDROPYRROLO[3,4 D]ISOXAZOLE 4,6 DIONE; 3 (4 DIMETHYLAMINOPHENYL) 5 METHYL 2 PHENYLPERHYDROPYRROLO[3,4 D]ISOXAZOLE 4,6 DIONE; 3 (4 METHOXYPHENYL) 2 METHYL 5 PHENYLPERHYDROPYRROLO[3,4 D]ISOXAZOLE 4,6 DIONE; 3 (4 METHOXYPHENYL) 2,5 DIMETHYLPERHYDROPYRROLO[3,4 D]ISOXAZOLE 4,6 DIONE; AMPICILLIN; ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; ARTIFICIAL NEURAL NETWORK; CIS ISOMER; CIS TRANS ISOMERISM; CONTROLLED STUDY; CYCLOADDITION; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; MINIMUM INHIBITORY CONCENTRATION; MODEL; NONHUMAN; PHARMACOPHORE; PREDICTION; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TRANS ISOMER;

ANTI-BACTERIAL AGENTS; ENTEROCOCCUS FAECALIS; ISOXAZOLES; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

ENTEROCOCCUS FAECALIS; STAPHYLOCOCCUS AUREUS;

EID: 33846948977     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.01.029     Document Type: Article

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