Methicillin resistant Staphylococcus aureus in the critically ill

British Journal of Anaesthesia

Volumn 92, Issue 1, 2004, Pages 121-130

  Hardy, K J ^a,b   Hawkey, Peter M ^a,b   Gao, F ^a   Oppenheim, B A ^a  

^a BIRMINGHAM HEARTLANDS HOSPITAL   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Complications, infections, methicillin resistant Staphylococcus aureus (MRSA); Epidemiology; Intensive care

Indexed keywords

7BETA [2 (5 AMINO 1,2,4 THIADIAZOL 3 YL) 2 ETHOXYIMINOACETAMIDO] 3 [(1 METHYLAMINOPROPYL 1H IMIDAZO[4,5 B]PYRIDINIUM 4 YL)METHYL] 3 CEPHEM 4 CARBOXYLIC ACID; ANTIBIOTIC AGENT; CARBAPENEM DERIVATIVE; CEFTOBIPROLE; CEPHALOSPORIN DERIVATIVE; CP 5609; CS 023; DALFOPRISTIN PLUS QUINUPRISTIN; LINEZOLID; METICILLIN; PENICILLIN G; TEICOPLANIN; TIGECYCLINE; UNCLASSIFIED DRUG; VANCOMYCIN;

BACTERICIDAL ACTIVITY; BACTERIUM IDENTIFICATION; CLINICAL TRIAL; CRITICAL ILLNESS; DRUG PENETRATION; HOSPITAL INFECTION; HUMAN; INFECTION RISK; INTENSIVE CARE UNIT; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR EVOLUTION; PRIORITY JOURNAL; REVIEW; STAPHYLOCOCCUS INFECTION;

EID: 0348227663     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/aeh008     Document Type: Review

References (95)

1. Abraham EP, Chain E. An enzyme from bacteria able to destroy penicillin. Nature 1940; 146: 837
2. Anon. The first year of the Department of Health's mandatory MRSA bacteraemia surveillance scheme in acute NHS Trusts in England: April 2001-March 2002. CDR Weekly 2002; 12: 6-17
3. Anon. Surgery in General: Changing the way we operate. The 2001 Report of the National Enquiry into Perioperative Deaths. 2001: 84-8
4. Asensio A, Guerrero A, Quereda C, Lizan M, Martinez-Ferrer M. Colonization and Infection with methicillin-resistant Staphylococcus aureus: associated factors and eradication. Infect Control Hosp Epidemiol 1996; 17: 20-8
5. Aucken HM, Ganner M, Murchan S, Cookson B, Johnson AP. A new UK strain of epidemic methicillin-resistant Staphylococcus aureus (EMRSA-17) resistant to multiple antibiotics. J Antimicrob Chemother 2002; 50: 171-5
6. Ayliffe GAJ. The progressive intercontinental spread of methicillin-resistant Staphylococcus aureus. Clin Infect Dis 1997; 24: S74-S9
7. Barakate MS, Yang Y-X, Foo S-H, et al. An epidemiological survey of methicillin-resistant Staphylococcus aureus in a tertiary referral hospital. J Hosp Infect 2000; 44: 19-26
8. Bauer TM, Ofner E, Just HM, Daschner FD. An epidemiological study assessing the relative importance of airborne and direct contact transmission of microorganims in a medical intensive care unit. J Hosp Infect 1990; 15: 301-9
9. Blot SI, Vandewoude KH, Hoste EA, Colardyn FA. Outcome and attributable mortality in critically ill patients with bacteremia involving methicillin-susceptible and methicillin-resistant Staphylococcus aureus. Arch Intern Med 2002; 162: 2229-35
10. Boyce JM, Potter-Boyne G, Chenevert C, King T. Environmental contamination due to methicillin resistant Staphylococcus aureus: possible infection control implications. Infect Control Hosp Epidemiol 1997; 18: 622-7
11. CDC. Public Health Dispatch: vancomycin resistant Staphylococcus aureus - Pennsylvania, 2002. Mor Mortal Wkly Rp 2002; 51: 902-3
12. CDC. Staphylococcus aureus resistant to vancomycin - United States. Mor Mortal Wkly Rp 2002; 51: 565-7
13. Chain E, Florey HW, Gardner AD, et al. Penicillin as a chemotherapeutic agent. Lancet 1940; 2: 226-8
14. Chaix C, Durand-Zaleski I, Alberti C, Brun-Buisson C. Control of endemic methicillin-resistant Staphylococcus aureus. A cost-benefit analysis in an intensive care unit. JAMA 1999; 282: 1745-51
15. Coello R, Glynn JR, Gaspar C, Picazo JJ, Fereres J. Risk factors for developing clinical infection with methicillin resistant Staphylococcus aureus (MRSA) amongst hospital patients initially only colonized with MRSA. J Hosp Infect 1997; 37: 39-46
16. Coello R, Jimenez J, Garcia M, et al. Prospective study of infection, colonisation and carriage of methicillin resistant Staphylococcus aureus in an outbreak affecting 900 patients. Eur J Clin Infect Dis 1994; 13: 74-81
17. Cookson B, Aparicio P, Deplano A, et al. Inter-centre comparison of pulsed-field gel electrophoresis for the typing of methicillin-resistant Staphylococcus aureus. J Med Microbiol 1996; 44: 179-84
18. Cosgrove SE, Sakoulas G, Perencevich EN, et al. Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis. Clin Infect Dis 2003; 36: 53-59
19. Crowcroft NS, Catchpole M. Mortality from methicillin resistant Staphylococcus aureus in England and Wales: analysis of death certificates. BMJ 2002; 325: 1390-1
20. Crowcroft NS, Ronveaux O, Monnet DL, Mertens R. Methicillin-resistant Staphylococcus aureus and antimicrobial use in Belgian hospitals. Infect Control Hosp Epidemiol 1999; 20: 31-6
21. Davies S, Zadik PM. Comparison of methods for the isolation of methicillin-resistant Staphylococcus aureus. J Clin Pathol 1997; 50: 257-8
22. Davies S, Zadik PM, Mason CM, Whittaker SJ. Methicillin-resistant Staphylococcus aureus: evaluation of five selective media. Br J Biomed Sci 2000; 57: 269-72
23. de Irala-Estevez J, Matinez-Concha D, Diaz-Molina C, et al. Comparison of different methological approaches to identify risk factors of nosocomial infection in intensive care units. Intensive Care Med 2001; 27: 1254-62
24. Diekema DJ, Pfaller MA, Schmitz FJ, et al. Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific Region for the SENTRY Antimicrobial Surveillance Program, 1997-1999. Clin Infect Dis 2001; 32: S114-S32
25. Dietze B, Rath A, Wendt C, Martiny H. Survival of MRSA on sterile goods packaging. J Hosp Infect 2001; 49: 255-61
26. Duckworth GJ, Jordens JZ. Adherence and survival properties of an epidemic methicillin resistant strain of Staphylococcus aureus compared with those of methicillin sensitive strains. J Med Microbiol 1990; 32: 195-200
27. Duckworth GJ, Lothian JL, Williams JD. Methicillin-resistant Staphylococcus aureus: report of an outbreak in a London teaching hospital. J Hosp Infect 1988; 11: 1-15
28. Dupeyron C, Campillo B, Bordes M, et al. A clinical trial of mupirocin in the eradication of methicillin-resistant Staphylococcus aureus nasal carriage in a digestive disease unit. J Hosp Infect 2002; 52: 281-7
29. Dziekan G, Hahn A, Thune K, et al. Methicillin-resistant Staphylococcus aureus in a teaching hospital: investigation of nosocomial transmission using a matched case-control study. J Hosp Infect 2000; 46: 263-70
30. Fluit AC, Wielders CLC, Verhoef J, Schmitz FJ. Epidemiology and susceptibility of 3,051 Staphylococcus aureus isolates from 25 university hospitals participating in the European SENTRY study. J Clin Microbiol 2001; 39: 3727-832
31. Francois P, Pittet D, Bento M, et al. Rapid detection of methicillin-resistant Staphylococcus aureus directly from sterile or nonsterile clinical samples by a new molecular assay. J Clin Microbiol 2003; 41: 254-60
32. Fridkin SK, Edwards JR, Pichette SC, et al. Determinants of vancomycin use in adult intensive care units in 41 United States hospitals. Clin Infect Dis 1999; 28: 1119-25
33. Fukuoka T, Puechler K, Rennecke J, Kuwahara S. In vitro activity of CS-023 against European Clinical Relevant Bacterial Isolates. Proceedings of the 42nd ICAAC Conference 2002: F326
34. Girou E, Pujade G, Legrand P, Cizeau F, Brun-Buisson C. Selective screening of carriers for control of methicillin resistant Staphylococcus aureus (MRSA) in high risk hospital areas with a high level of endemic MRSA. Clin Infect Dis 1998; 27: 543-50
35. Gonzalez C, Rubio M, Romero-Vivas J, Gonzalez M, Picazo JJ. Bacteremic pneumonia due to Staphylococcus aureus: a comparison of disease caused by methicillin-resistant and methicillin-susceptible organisms. Clin Infect Dis 1999; 29: 1171-7
36. Graffunder EM, Venezia PA. Risk factors associated with nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection including previous use of antimicrobials. J Antimicrob Chemother 2002; 49: 999-1005
37. Grundmann H, Hori S, Winter B, Tami A, Austin DJ. Risk factors for the transmission of methicillin-resistant Staphylococcus aureus in an Adult Intensive Care Unit: fitting a model to the data. J Infect Dis 2002; 185: 481-8
38. Harbarth S, Albrich W, Goldmann D, Huebner J. Control of multiply resistant cocci: do international comparisons help? Lancet Infect Dis 2001; 1: 251-61
39. Harbarth S, Dharan S, Liassine N, et al. Randomized, placebo-controlled, double-blind trial to evaluate the efficacy of mupirocin for eradicating carriage of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 1999; 43: 1412-6
40. Hawkey PM. Quinolones in sweat and quinolone resistance. Lancet 1997; 349: 148-9
41. Hershow RC, Khayr MD, Smith NL. A comparison of clinical virulence of nosocomially acquired emthicillin-resistant and methicillin-sensitive Staphylococcus aureus infections in a university hospital. Infect Control Hosp Epidemiol 1992; 13: 587-93
42. Hill DA, Herford T, Parratt D. Antibiotic usage and methicillin-resistant Staphylococcus aureus: an analysis. J Antimicrob Chemother 1998; 42: 676-7
43. Hill RA, Duckworth GJ, Casewell M. Elimination of nasal carriage of methicillin-resistant Staphylococcus aureus with mupirocin during a hospital outbreak. J Antimicrob Chemother 1988; 22: 377-84
44. Hiramatsu K. The emergence of Staphylococcus aureus with reduced susceptibility to vancomycin in Japan. Am J Med 1998; 104: 7S-10S
45. Hoefnagels-Schuermans A, Borremans A, Peetermans W, et al. Origin and transmission of methicillin resistant Staphylococcus aureus in an endemic situation: differences between geriatric and intensive care patients. J Hosp Infect 1997; 36: 209-22
46. Hoiby N, Jarlov JO, Kemp M, et al. Excretion of ciprofloxacin in sweat and multiresistant Staphylococcus epidermidis. Lancet 1997; 349: 167-9
47. Hoiby N, Pers C, Johansen HK, Hansen H. Excretion of beta lactam antibiotics in sweat - a neglected mechanism for development of antibiotic resistance? Antimicrob Agents Chemother 2000; 44: 2855-7
48. Ibelings MMS, Bruining HA. Methicillin-resistant Staphylococcus aureus: acquisition and risk of death in patients in the Intensive Care Unit. Eur J Surg 1998; 164: 411-8
49. Jawad A, Heritage J, Snelling AM, Gascoyne-Binzi DM, Hawkey PM. Influence of relative humidity and suspending menstrua on survival of acinetobacter spp. on dry surfaces. J Clin Microbiol 1996; 34: 2881-7
50. Jevons MP. 'Celbenin' - resistant Staphylococci. BMJ 1961; 1: 124-5
51. Johnson AP, Aucken HM, Cavendish S, et al. Dominance of EMRSA-15 and -16 among MRSA causing nosocomial bacteraemia in the UK: analysis of isolates from the European Antimicrobial Resistance Surveillance System (EARSS). J Antimicrob Chemother 2001; 48: 143-4
52. Jonas D, Speck M, Daschner FD, Grundmann H. Rapid PCR-based identification of methicillin-resistant Staphylococcus aureus from screening swabs. J Clin Microbiol 2002; 40: 1821-3
53. Jones RN, Deshpande LM, Mutnick AH, Biedenbach DJ. In vitro evaluation of BAL9141, a novel parenteral cephalosporin active against oxacillin-resistant staphylococci. J Antimicrob Chemother 2002; 50: 915-32
54. Karabey S, Ay P, Derbentli S, Nakipoglu Y, Esen F. Hand washing frequencies in an intensive care unit. J Hosp Infect 2002; 50: 36-41
55. Katayama Y, Ito T, Hiramatsu K. A new class of genetic element, Staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus. Antimicrob Agents Chemother 2000; 44: 1549-55
56. Klutymans JA, Mouton JW, Ijzerman EP, et al. Nasal carriage of Staphylococcus aureus as a major risk factor for wound infections after cardiac surgery. J Infect Dis 1995; 171: 216-9
57. Lacey RW, Barr KW, Barr VE, Inglis TJ. Properties of methicillin-resistant Staphylococcus aureus colonising patients in a burns unit. J Hosp Infect 1986; 7: 137-48
58. Lamb HM, Figgilt DP, Faulds D. Quinopristin/dalfopristin: a review of its use in the management of serious Gram positive infections. Drugs 1999; 58: 1061-97
59. Larson EL, McGinley KJ, Foglia AR, Talbot GH, Leyden JJ. Composition and antimicrobic resistance of skin flora in hospitalized and healthy adults. J Clin Microbiol 1986; 23: 604-8
60. Law MR, Gill ON. Hospital acquired infection with methicillin-resistant and methicillin-sensitive staphylococci. Epidemiol Infect 1988; 101: 623-9
61. Louie L, Goodfellow J, Mathieu P, et al. Rapid detection of methicillin-resistant Staphylococci from blood culture bottles by using a multiplex PCR assay. J Clin Microbiol 2002; 40: 2786-90
62. Manhold C, von Rolbicki U, Brase R, et al. Outbreaks of Staphylococcus aureus infections during treatment of late onset pneumonia with ciprofloxacin in prospective, randomized study. Intensive Care Med 1998; 24: 1327-30
63. Merrer J, Santoli F, Vecchi C, et al. Colonization pressure and risk of acquisition of methicillin resistant Staphylococcus aureus in a medical intensive care unit. Infect Control Hosp Epidemiol 2000; 21: 718-23
64. Miller MA, Dascal A, Portnoy J, Mendelson J. Development of mupirocin resistance among methicillin-resistant Staphylococcus aureus after widespread use of nasal mupirocin ointment. Infect Control Hosp Epidemiol 1996; 17: 811-3
65. Moore PCL, Lindsay JA. Molecular characterisation of the dominant UK methicillin-resistant Staphylococcus aureus strains, EMRSA-15 and EMRSA-16. J Med Microbiol 2002; 51: 516-21
66. Mortimer EA, Wolinsky E, Gonzaga AJ, Rammelkamp CH. Role of airborne transmission in Staphylococcal infections. BMJ 1966; 1: 318-22
67. Nagura J, Sugano T, Yamamoto A, et al. CP5609, a novel parenteral carbapenem: efficacy on experimental endocarditis due to methicillin-resistant Staphylococcus aureus. Proceedings of the 42nd ICAAC Conference 2002: F321
68. Neely AN, Maley MP. Survival of Enterococci and Staphylococci on hospital fabrics and plastics. J Clin Microbiol 2000; 38: 724-6
69. Noble WC, Virani Z, Cree RGA. Co-transfer of vancomycin and other resistance genes from Enterococcus faecalis NCTC 12201 to Staphylococcus aureus. FEMS Microbiol Lett 1992; 93: 195-8
70. Petersen PJ, Bradford PA, Weiss WJ, et al. In vitro and in vivo activities of tigecycline (GAR-936), daptomycin, and comparative antimicrobial agents against glycopeptide-intermediate Staphylococcus aureus and other resistant Gram-positive pathogens. Antimicrob Agents Chemother 2002; 46: 2595-601
71. Pittet D, Hugonnet S, Harbarth S, et al. Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Lancet 2000; 356: 1307-12
72. Pittet D, Mourouga P, Perneger TV. Compliance with handwashing in a teaching hospital. Ann Intern Med 1999; 130: 126-30
73. Pujol M, Pena C, Pallares R, et al. Risk factors for nosocomial bacteraemia due to methicillin-resistant Staphylococcus aureus. Eur J Clin Microbiol Infect Dis 1994; 13: 96-102
74. Rampling A, Wiseman S, Davis L, et al. Evidence that hospital hygiene is important in the control of methicillin-resistant Staphylococcus aureus. J Hosp Infect 2001; 49: 109-16
75. Rello J, Torres A, Ricart M, et al. Ventilator-associated pneumonia by Staphylococcus aureus. Comparison of methicillin-resistant and methicillin-sensitive episodes. Am J Respir Crit Care Med 1994; 150: 1545-9
76. Rolinson GN. Letter. BMJ 1961; 1: 125-6
77. Rubinstein E, Cammarata SE, Oliphant TH, Wunderink RG, Group LNPS. Linezolid (PNU-100766) versus vancomycin in the treatment of hospitalized patients with nosocomial pneumonia: a randomized, double-blind, multicenter study. Clin Infect Dis 2001; 32: 402-12
78. Rutala WA, Blythe Setzer Katz E, Sherertz RJ, Sarubbi FA. Environmental study of a methicillin-resistant Staphylococcus aureus epidemic in a burn unit. J Clin Microbiol 1983; 18: 683-8
79. Scheme NINS. Surveillance of hospital-acquired bacteraemia in English hospitals 1997-2002. In: Report, Public Health Laboratory Service. London, 2002: 8-9
80. Scheme NINS. Surveillance of surgical site infection in English hospitals 1997-2001. In: Report, Public Health Laboratory Service. London, 2002: 8-9
81. Sebille V, Cheveret S, Valleron AJ. Modeling the spread of resistant nosocomial pathogens in an intensive-care unit. Infect Control Hosp Epidemiol 1997; 18: 84-92
82. Shiomori T, Miyamoto H, Makishima K. Significance of airborne transmission of methicillin-resistant Staphylococcus aureus in an otolaryngology head and neck surgery unit. Arch Otolaryngol Head Neck Surg 2001; 127: 644-8
83. Shiomori T, Miyamoto H, Makishima K, et al. Evaluation of bedmaking-related airborne and surface methicillin-resistant Staphylococcus aureus contamination. J Hosp Infect 2002; 50: 30-5
84. Talon D: The role of the hospital environment in the epidemiology of multi-resistant bacteria. J Hosp Infect 1999; 43: 13-7
85. Theaker C, Ormond-Walshe S, Azadian B, Soni N. MRSA in the critically ill. J Hosp Infect 2001; 48: 98-102
86. Thompson BL, Dwyer DM, Ussery XT, et al. Handwashing and glove use in a long term care facility. Infect Control Hosp Epidemiol 1997; 18: 97-103
87. Towner KJ, Talbot DC, Curran R, Webster CA, Humphreys H. Development and evaluation of a PCR-based immunoassay for the rapid detection of methicillin-resistant Staphylococcus aureus. J Med Microbiol 1998; 47: 607-13
88. Tsuji M, Matsuda H, Miwa H, Shimada J, Kuwahara S. S-3578, a new broad spectrum cephalosporin with anti-MRSA activity: II. In vitro activity against experimental animal infection models. Proceedings of the 42nd ICAAC Conference 2002: F339
89. Utsui Y, Yokota T. Role of an altered penicillin-binding protein in methicillin and cephem-resistant Staphylococcus aureus. Antimicrob Agents Chemother 1985; 28: 397-403
90. vanBelkum A, Van Leeuwen WJ, Kaufmann ME, et al. Assessment of resolution and intercenter reproducibility of results of genotyping Staphylococcus aureus by pulsed field gel electrophoresis of Smal macrorestriction fragments: a multicenter study. J Clin Microbiol 1998; 36: 1653-9
91. Vandenbroucke-Grauls CMJE. Methicillin-resistant Staphylococcus aureus control in hospitals: the Dutch experience. Infect Control Hosp Epidemiol 1996; 17: 512-3
92. Vicca AF. Nursing staff workload as a determinant of methicillin-resistant Staphylococcus aureus spread in an adult intensive therapy unit. J Hosp Infect 1999; 43: 109-13
93. Vincent J-L, Bihari DJ, Suter PM, et al. The Prevalence of nosocomial infection in intensive care (EPIC) study. JAMA 1995; 274: 639-44
94. Weller T. Methicillin-resistant Staphylococcus aureus typing methods: which should be the International standard? J Hosp Infect 2000; 46: 160-72
95. Wilson P, Andrews JA, Charlesworth R, et al. Linezolid resistance in clinical isolates of Staphylococcus aureus. J Antimicrob Chemother 2003; 51: 186-8