Clinical cure and survival in Gram-positive ventilator-associated pneumonia: Retrospective analysis of two double-blind studies comparing linezolid with vancomycin

Intensive Care Medicine

Volumn 30, Issue 3, 2004, Pages 388-394

  Kollef, Marin H ^a   Rello, Jordi ^b   Cammarata, Sue K ^c   Croos Dabrera, Rodney V ^c   Wunderink, Richard G ^d  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

^c PFIZER INC   (United States)

^d Methodist Healthcare   (United States)

Author keywords

Gram positive pneumonia; Linezolid; Mechanical ventilation; Methicillin resistant Staphylococcus aureus; Regression analysis; Vancomycin

Indexed keywords

AZTREONAM; LINEZOLID; METICILLIN; VANCOMYCIN;

ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; GRAM POSITIVE BACTERIUM; GRAM STAINING; HUMAN; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PNEUMONIA; RANDOMIZED CONTROLLED TRIAL; SPUTUM CULTURE; SURVIVAL; THORAX RADIOGRAPHY; VENTILATOR;

ACETAMIDES; ADULT; AGED; ANTI-INFECTIVE AGENTS; CROSS INFECTION; FEMALE; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; OXAZOLIDINONES; PNEUMONIA, BACTERIAL; RESPIRATION, ARTIFICIAL; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; SURVIVAL RATE; VANCOMYCIN;

EID: 1642350291     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-003-2088-1     Document Type: Article

References (15)

1. Kollef MH, Sherman G, Ward S, Fraser VJ (1999) Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest 115:462-474
2. Dupont H, Mentec H, Sollet JP, Bleichner G (2001) Impact of appropriateness of initial antibiotic therapy on the outcome of ventilator-associated pneumonia. Intensive Care Med 27:355-362
3. Rubinstein E, Cammarata S, Oliphant T, Wunderink R (2001) Linezolid (PNU-100766) versus vancomycin in the treatment of hospitalized patients with nosocomial pneumonia: a randomized, double-blind, multicenter study. Clin Infect Dis 32:402-412
4. Wunderink RG, Cammarata SK, Oliphant TH, Kollef MH (2003) Linezolid versus vancomycin in the treatment of patients with nosocomial pneumonia: continuation of a randomized, double-blind, multicenter study. Clin Ther 25:980-992
5. Wunderink RG, Rello J, Cammarata SK, Croos-Dabrera RV, Kollef M (2003) Linezolid versus vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphyloccus aureus nosocomial pneumonia. Chest 2003 (in press)
6. Fagon JY, Chastre J, Hance AJ, Montravers P, Novara A, Gibert C (1993) Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay. Am J Med 94:281-288
7. Fagon J, Patrick H, Haas DW, Torres A, Gibert C, Cheadle WG, Falcone RE, Anholm JD, Paganin F, Fabian TC, Lilienthal F (2000) Treatment of gram-positive nosocomial pneumonia. Prospective randomized comparison of quinupristin/ dalfopristin versus vancomycin. Nosocomial Pneumonia Group. Am J Respir Crit Care Med 161:753-762
8. Cruciani M, Gatti G, Lazzarini L, Furlan G, Broccali G, Malena M, Franchini C, Concia E (1996) Penetration of vancomycin into human lung tissue. J Antimicrob Chemother 38:865-869
9. Georges H, Leroy O, Alfandari S, Guery B, Roussel-Delvallez M, Dhennain C, Beaucaire G (1997) Pulmonary deposition of vancomycin in critically ill patients. Eur J Clin Microbial Infect Dis 16:385-388
10. Lamer C, de Beco V, Soler P, Calvat S, Fagon JY, Dombret MC, Farinotti R, Chastre J, Gibert C (1993) Analysis of vancomycin entry into pulmonary lining fluid by bronchoalveolar lavage in critically ill patients. Antimicrob Agents Chemother 37:281-286
11. Conte JE Jr, Golden JA, Kipps J, Zurlinden E (2002) Intrapulmonary pharmacokinetics of linezolid. Antimicrob Agents Chemother 46:1475-1480
12. Honeybourne D, Tobin C, Jevons G, Andrews A, Wise R (2002) Intrapulmonary penetration of linezolid. Chest 122 (4 Suppl):159S. Abstract
13. Cantu TG, Yamanaka-Yuen NA, Lietman PS (1994) Serum vancomycin concentrations: reappraisal of their clinical value. Clin Infect Dis 18:533-543
14. Moise PA, Forrest A, Bhavnani SM, Birmingham MC, Schentag JJ (2000) Area under the inhibitory curve and a pneumonia scoring system for predicting outcomes of vancomycin therapy for respiratory infections by Staphylococcus aureus. Am J Health Syst Pharm 57 [Suppl 2]:S4-S9
15. Wysocki M, Delatour F, Faurisson F, Rauss A, Pean Y, Misset B, Thomas F, Timsit JF, Similowski T, Mentec H, Mier L, Dreyfuss D (2001) Continuous versus intermittent infusion of vancomycin in severe Staphylococcal infections: prospective multicenter randomized study. Antimicrob Agents Chemother 45:2460-2467