An altered immunity hypothesis for the development of symptomatic bacterial vaginosis

Clinical Infectious Diseases

Volumn 44, Issue 4, 2007, Pages 554-557

  Witkin, Steven S ^a   Linhares, Iara M ^a,b   Giraldo, Paulo ^c   Ledger, William J ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 70; MANNOSE BINDING LECTIN; TOLL LIKE RECEPTOR;

BACTERIAL GROWTH; FEMALE; HUMAN; HYPOTHESIS; IMMUNE RESPONSE; INNATE IMMUNITY; LACTOBACILLUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN SYNTHESIS; REVIEW; VAGINA FLORA; VAGINITIS;

ADULT; FEMALE; GARDNERELLA VAGINALIS; HUMANS; IMMUNITY, NATURAL; IMMUNOCOMPETENCE; IMMUNOCOMPROMISED HOST; LACTOBACILLUS; MIDDLE AGED; PROGNOSIS; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; TOLL-LIKE RECEPTOR 4; VAGINOSIS, BACTERIAL;

EID: 33846917728     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/511045     Document Type: Review

References (32)

1. Sobel JD. Bacterial vaginosis. Annu Rev Med 2000; 51:349-56.
2. Verstraelen H, Verhelst R, Claeys G, Temmerman M, Vaneechoutte M. Culture-independent analysis of vaginal microflora: the unrecognized association of Atopobium vaginae with bacterial vaginosis. Am J Obstet Gynecol 2004; 191:1130-2.
3. Schwebke JR, Richey CM, Weiss HL. Correlation of behaviors with microbiological changes in vaginal flora. J Infect Dis 1999; 180:1632-6.
4. McGregor JA, French JI. Bacterial vaginosis in pregnancy. Obstet Gynecol Surv 2000; 55:S1-19.
5. Sweet RL. Gynecologic conditions and bacterial vaginosis: implications for the non-pregnant patient. Infect Dis Obstet Gynecol 2000; 8:184-90.
6. Guaschino S, De Santo D, De Seta F. New perspectives in antibiotic prophylaxis for obstetric and gynecologic surgery. J Hosp Infect 2002; 50 (Suppl A):S13-6.
7. Sewankambo N, Gray RH, Wawer MJ, et al. HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis. Lancet 1997; 350:546-50.
8. Cauci S, McGregor J, Thorsen P, Grove J, Guaschino S. Combination of vaginal pH with vaginal sialidase and prolidase activities for prediction of low birth weight and preterm birth. Am J Obstet Gynecol 2005; 192:489-96.
9. Culhane JF, Rauh V, McCollum KF, Elo IT, Hogan V. Exposure to chronic stress and ethnic differences in rates of bacterial vaginosis among pregnant women. Am J Obstet Gynecol 2002; 187:1272-6.
10. Janssens S, Beyaert R. Role or Toll-like receptors in pathogen recognition. Clin Microbiol Rev 2003; 16:637-46.
11. O'Connell RM, Saha SK, Cheng G. Combating bacterial pathogens through host defense gene programs. Current Immnological Rev 2005; 1:43-54.
12. Strober W. Epithelial cells pay a toll for protection. Nature Med 2004; 10:898-900.
13. Fazeli A, Bruce C, Anumba DO. Characterization of toll-like receptors in the female reproductive tract in humans. Hum Reprod 2005; 20:1372-8.
14. Abrahams VM. Toll-like receptors in the cycling female reproductive tract and during pregnancy. Current Women's Health Rev 2005; 1:35-42.
15. Voellmy R. The stress protein response: consequences of stress exposure-cytoprotectionpotential diagnostic and therapeutic applications. Methods 2005; 35:115-6.
16. Campisi J, Leem TH, Fleshner M. Stress-induced extracellular hsp72 is a functionally significant danger signal to the immune system. Cell Stress Chaperones 2003; 8:272-86.
17. Panjwani NN, Popova L, Srivastava PK. Heat shock proteins gp96 and hsp70 activate the release of nitric oxide by APCs. J Immunol 2002; 168:2997-3003.
18. Babovic-Vuksanovic D, Snow K, Ten RM. Mannose-binding lectin (MBL) deficiency: variant alleles in a Midwestern population of the United States. Ann Allergy Asthma Immunol 1999; 82:134-43.
19. Fujita T, Matsushita M, Endo Y. The lectin-complement pathway: its role in innate immunity and evolution. Immunol Rev 2001; 198:185-202.
20. Babula O, Lazdane G, Kroica J, Ledger WJ, Witkin SS. Relation between recurrent vulvovaginal candidiasis, vaginal concentrations of mannose-binding lectin, and a mannosebinding lectin gene polymorphism in Latvian women. Clin Infect Dis 2003; 37:733-7.
21. Donders GG, Vereecken A, Bosmans E, Spitz B. Vaginal cytokines in normal pregnancy. Am J Obstet Gynecol 2003; 189:1433-8.
22. Netea MG, Van der Meer JWM, Kullberg BI. Toll-like receptors as an escape mechanism from the host defense. Trends Microbiol 2004; 12:484-8.
23. Greene CM, McElvaney NG, O'Neill SI, Taggart CC. Secretory leukoprotease inhibitor impairs Toll-like receptor-2. and 4-mediated responses in monocytic cells. Infect Immun 2004; 72:3684-7.
24. Lee JY, Plakidas A, Lee WH, et al. Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. J Lipid Res 2003; 44:479-86.
25. Genc MR, Vardhana S, Delaney ML, Onderdonk A, Tuomala R, Norwitz W, Witkin SS. Relationship between a Toll-like receptor 4 gene polymorphism, bacterial vaginosis-related flora and vaginal cytokine responses in pregnant women. Eur J Obstet Gynecol Reprod Biol 2004; 116:152-6.
26. Giraldo P, Neuer A, Korneeva IL, Ribeiro-Filho A, Simoes JA, Witkin SS. Vaginal heat shock protein expression in symptom-free women with a history of recurrent vulvovaginitis. Am J Obstet Gynecol 1999; 180:524-9.
27. Genc MR, Karasahin E, Onderdonk AB, Bongiovanni AM, Delaney ML, Witkin SS. Association between vaginal 70-kd heat shock protein, interleukin-1 receptor antagonist, and microbial flora in mid trimester pregnant women. Am J Obstet Gynecol 2005; 192:916-21.
28. Genc MR, Delaney ML, Onderdonk AB, Witkin SS. Vaginal nitric oxide in pregnant women with bacterial vaginosis. Am J Reprod Immunol 2006; 56:86-90.
29. Neth O, Jack DL, Johnson M, Klein NJ, Turner MW. Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin-associated serine protease after binding to Staphylococcus aureus. J Immunol 2002; 169:4430-6.
30. Pellis V, De Seta F, Crovella S, et al. Mannose binding lectin and C3 act as recognition molecules for infectious agents in the vagina. Clin Exp Immunol 2005; 139:120-6.
31. Lipscombe RJ, Sumiya M, Summerfield JA, Turner MW. Distinct physiochemical characteristics of human mannose binding protein expressed by individuals of differing genotype. Immunology 1995; 85:660-7.
32. Babula O, Danielsson I, Sjoberg I, Ledger WJ, Witkin SS. Altered distribution of mannose-binding lectin alleles at exon I codon 54 in women with vulvar vestibulitis syndrome. Am J Obstet Gynecol 2004; 191:762-6.