Efficacy on menopausal neurovegetative symptoms and some plasma lipids blood levels of an herbal product containing isoflavones and other plant extracts

Maturitas

Volumn 56, Issue 3, 2007, Pages 249-256

  Cancellieri, F ^a   De Leo, V ^b   Genazzani, A D ^c   Nappi, C ^d   Parenti, G L ^e   Polatti, F ^f   Ragni, N ^g   Savoca, S ^h   Teglio, L ⁱ   Finelli, F ^j   Nichelatti, M ^k  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e S ANNA HOSPITAL   (Italy)

^f PV   (Italy)

^g UNIVERSITY OF GENOA   (Italy)

^h UNIVERSITY OF CATANIA   (Italy)

ⁱ Main Hosp   (Italy)

^j Viatris Inc   (Italy)

^k OSPEDALE NIGUARDA CA GRANDA   (Italy)

more..

Author keywords

Isoflavones; Kupperman Menopause Index; Lipid profile; Menopause

Indexed keywords

HERBACEOUS AGENT; ISOFLAVONE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; PLANT EXTRACT; TRIACYLGLYCEROL;

ADULT; ARTICLE; AUTONOMIC NEUROPATHY; CIMICIFUGA RACEMOSA; CLINICAL GLOBAL IMPRESSION SCALE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG ACTIVITY; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; FLATULENCE; HUMAN; LIPID BLOOD LEVEL; MENOPAUSAL SYNDROME; NAUSEA; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; RANK SUM TEST; RED CLOVER; SOYBEAN; STUDENT T TEST;

AGED; CHOLESTEROL, LDL; COMPLEMENTARY THERAPIES; DOUBLE-BLIND METHOD; ESTROGEN REPLACEMENT THERAPY; FEMALE; HUMANS; ISOFLAVONES; LIPIDS; MENOPAUSE; MIDDLE AGED; PHYTOTHERAPY; PLANT EXTRACTS; PLANT PREPARATIONS; TRIGLYCERIDES;

EID: 33846914606     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.maturitas.2006.07.001     Document Type: Article

References (36)

1. Helkind-Hirsch K. Effect of dietary phytoestrogens on hot flushes: can soy-based proteins substitute for traditional estrogens replacement therapy?. Menopause 8 (2001) 154-156
2. Hully S., Grady D., Bush T., et al. Randomized trial of estrogens plus progestin for secondary prevention of coronary hearth disease in postmenopausal women. [Hearth and Estrogen/progestin Replacement Study (HERS) Research Group]. JAMA 280 (1988) 605-613
3. Writing Group for the Women's Health Initiative Investigators: Risk and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from Women's Healthy Initiative randomized controlled trial. JAMA 2002;288:321-37.
4. Million Women Study Collaborators: Breast Cancer and Hormone Replacement Therapy in the Million Women Study. Lancet 2003;362:419-27.
5. Blumel J.E., Castelo-Branco C., Chedraui P.A., et al. Patients and clinicians attitudes after Women's Health Initiative Study. Menopause 11 (2004) 57-61
6. Hersh A.L., Stefanik M.L., and Stafford R.S. National use of postmenopausal hormone therapy. Annual trends and response to recent evidence. JAMA 291 (2004) 47-53
7. Albertazzi P., Pansini F., Bonaccorsi G., et al. The effects of dietary soy supplementation on hot flushes. Obstet Gynecol 91 (1988) 6-11
8. Kass-Annese B. Alternative therapies for menopause. Clin Obstet Gynecol 43 (2000) 162-183
9. Glazier M., Gina M.B., and Bowman M.A. A review of the evidence for the use of phytoestrogens as a replacement for the traditional estrogen replacement therapy. Arch Int Med 161 (2001) 1161-1172
10. Van Patten C.L., Olivotto I.A., Chambers G.K., et al. Effect of soy phytoestrogens on hot flushes in post-menopausal women with breast cancer: a randomized, controlled, clinical trial. J Clin Oncol 20 (2002) 1449-1455
11. Mackay R., and Eden J. Phytoestrogens and the menopause. Climacteric 1 (1999) 302-308
12. Murkies A.L., Wilcox G., and Davis S.R. Phytoestrogens. J Clin Endocrinol Metab 83 (1998) 297-303
13. Kuiper G.J.M., Lemmen J.G., Carlsson B., et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 139 (1998) 4252-4426
14. Scambia G., Mango D., Signorelli P.G., et al. Clinical effects of standardized soy extract in postmenopausal women: a pilot study. Menopause 7 (2002) 105-111
15. Faure E.D., Chantre P., and Mares P. Effects of standardized soy extract on hot flushes: a multicenter, double blind, randomized, placebo-controlled study. Menopause 9 (2002) 329-342
16. Burke G., Legault C., Antony M., et al. Soy protein and isoflavones effects on vasomotor symptoms in peri- and postmenopausal women: the soy estrogen alternative study. Menopause 10 (2003) 147-153
17. De Aloysio D, Mauloni M, personal communication.
18. Potter S.M., Baum J.A., Teng H., et al. Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am J Nutr 68 (1998) 1375S-1379S
19. Wangen K.E., Duncan A.M., Xu X., et al. Soy isoflavones improves plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women. Am J Clin Nutr 73 (2001) 225-231
20. Kleijn M.J., Van Der Schouw Y.T., Wilson P.V., et al. Dietary intake of phytoestrogens is associated with a favourable metabolic cardiovascular risk profile in postmenopausal US women: the Framingham study. J Nutr 132 (2002) 276-282
21. Petri Nahas E., Nahas Neto J., De Luca L., et al. Benefits of soy germ isoflavones in postmenopausal women with contraindications for conventional hormone replacement therapy. Maturitas 48 (2004) 372-380
22. Anderson J.W., and Johnstone B. Meta-analysis of effects of soy protein intake on serum lipids. N Engl J Med 333 (1995) 276-282
23. Dewell A., Hollenbeck C.B., and Bruce R. The effects of soy-derived phytoestrogens on serum lipids and lipoproteins in moderately hypercholesterolemic postmenopausal women. Metabolism 87 (2000) 118-121
24. Kreijkamp-Kaspers S., Kok L., Grobbee D., et al. Effect of soy protein containing isoflavones on cognitive function, bone mineral density and plasma lipids in postmenopausal women. A randomized trial. JAMA 292 (2004) 65-74
25. Albertazzi P., and Purdie D. The nature and utility of the phytoestrogens: a review of the evidence. Maturitas 42 (2002) 173-185
26. Kupperman H.S., Wetchler B.B., and Blatt M.H.G. Contemporary therapy of the menopausal syndrome. JAMA 171 (1959) 1627-1637
27. Brouns F. Soy isoflavones; a new and promising ingredient for the health food sector. Food Res Int 35 (2002) 187-193
28. Barnes S. Phytoestrogens and osteoporosis: what is a safe dose?. Br J Nutr 89 Suppl. 1 (2003) 898-906
29. Daiber W. Menopause symptoms: success without hormones. Arztl Praxis 35 (1983) 1946-1951
30. Stoll W. Phytotherapy influences atrophic vaginal epithelium: double-blind study of cimicifuga vs. Estrogenic substances. Therapeutikon 1 (1987) 23-31
31. Am. Coll. Obstet. Gynecol. Clinical Management Guidelines for Obstetricians-Gynecologists. Use of botanicals for management of menopausal symptoms. ACOG Practice Bulletin, No. 28, 2001, p. 1-14.
32. Wamecke G. Influence of a phytopharmaceutical on climacteric complaints. Med Welt 36 (1985) 871-874 good
33. Crisafulli A., Marini H., Bitto A., et al. Effects of genistein on hot flushes in early postmenopausal women: a randomized, double-blind, EPT- and placebo-controlled study. Menopause 11 (2004) 400-404
34. Davies S.R. Phytoestrogen therapy for menopausal symptoms: there's no good evidence that it's any better than placebo. Br Med J 323 (2001) 354-355
35. Wuttke W., Seidlowa-Wuttke D., and Gorkow C. The Cimicifuge proparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas 44 Suppl. 1 (2003) S67-S77
36. Osmers R., Friede M., Liske E., et al. Efficacy and safety of isopropanolic black cohosh extract for climacteric complaints. Obstet Gynecol 105 (2005) 1074-1083