Use of a fluorescent substrate for the selective quantification of rat CYP3A in the liver and the intestine

Journal of Pharmacological and Toxicological Methods

Volumn 55, Issue 2, 2007, Pages 209-213

  Michaud, Josée ^a   Leblond, Francois A ^a   Naud, Judith ^a   Boisvert, Caroline ^a   Desbiens, Karine ^a   Nicoll Griffith, Deborah A ^b   Pichette, Vincent ^a  

^a MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

^b MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

Cytochrome P450; Drug; Intestine; Liver; Metabolism; Methods; Microsomes; Rat; Specificity

Indexed keywords

3 [(3,4 DIFLUOROBENZYL)OXY] 5,5 DIMETHYL 4 [4 (METHYLSULFONYL)PHENYL]FURAN 2(5H) ONE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; CYTOCHROME P450 3A; FLUORESCENT DYE; MESYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; FLUORESCENCE; INSECT CELL; INTESTINE; LIVER; LIVER MICROSOME; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; RAT;

ANIMALS; ANTIBODIES, BLOCKING; ARYL HYDROCARBON HYDROXYLASES; FLUORESCENCE; FLUORESCENT DYES; FLUOROBENZENES; FURANS; INTESTINES; LIVER; MALE; MEMBRANE PROTEINS; MICROSOMES; RATS; RATS, SPRAGUE-DAWLEY; SUBSTRATE SPECIFICITY;

RATTUS;

EID: 33846909231     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2006.07.002     Document Type: Article

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