Dopamine D1 receptor coupling to Gs/olf and Gq in rat striatum and cortex: A scintillation proximity assay (SPA)/antibody-capture characterization of benzazepine agonists

Neuropharmacology

Volumn 52, Issue 3, 2007, Pages 1003-1014

  Mannoury la Cour, C ^a   Vidal, S ^a   Pasteau, V ^a   Cussac, D ^a   Millan, M J ^a  

^a INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

Cortex; Dopamine D1 receptors; G protein; Scintillation proximity assay; Striatum

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 3 ALLYL 6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 3 METHYL 1 (3 METHYLPHENYL) 1H 3 BENZAZEPINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; BENZAZEPINE DERIVATIVE; BRAIN PROTEIN; DOPAMINE; DOPAMINE 1 RECEPTOR; GQ PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); LIGAND; OLF PROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; ANTIBODY; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT;

ANALYTIC METHOD; ANTIBODY CAPTURE; ARTICLE; ASSAY; BRAIN CORTEX; BRAIN REGION; BRAIN TISSUE; CONCENTRATION (PARAMETERS); CORPUS STRIATUM; DRUG POTENCY; DRUG RECEPTOR BINDING; IMMUNOBLOTTING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SCINTILLATION; SCINTILLATION PROXIMITY ASSAY; ANIMAL; ANTIBODY COMBINING SITE; ANTIBODY SPECIFICITY; BINDING COMPETITION; DOSE RESPONSE; DRUG EFFECT; DRUG INTERACTION; IMMUNOLOGY; METABOLISM; METHODOLOGY; RADIOASSAY; RAT;

(R)-2,3,4,5-TETRAHYDRO-8-CHLORO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL; ANIMALS; ANTIBODIES; ANTIBODY SPECIFICITY; BINDING SITES, ANTIBODY; BINDING, COMPETITIVE; CEREBRAL CORTEX; CORPUS STRIATUM; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); RADIOLIGAND ASSAY; RATS; RECEPTORS, DOPAMINE D1;

EID: 33846886516     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2006.10.021     Document Type: Article

References (56)

1. 1 receptor antagonist in primate cells and interacts with others receptors. Eur. J. Pharmacol. 364 (1999) 33-41
2. 1B receptor in central nervous system using anti-receptor antisera. Brain Res. 746 (1997) 141-150
3. 1 receptor agonists in mice and rats: relation between behavioural effects and stimulation of adenylate cyclase activity in vitro. Eur. J. Pharmacol. 213 (1992) 259-267
4. Battaglia G., Norman A.B., Hess E.J., and Cresse I. Forskolin potentiates the stimulation of rat striatal adenylate cyclase mediated by D-1 dopamine receptors, guanine nucleotides, and sodium fluoride. J. Neurochem. 46 (1986) 1180-1185
5. 5 dopamine receptors in primate brain. J. Neurosci. 15 (1995) 7821-7836
6. 2+ connection in dopamine signaling. Trends. Pharmacol. Sci. 24 (2003) 486-492
7. 1-like receptors in the prefrontal cortex and in the nucleus accumbens: a key to its antiparkinsonian effect in animals?. Neuropharmacology 42 (2002) 237-245
8. 2A receptors to adenylyl cyclase in the striatum. J. Neurochem. 76 (2001) 1585-1588
9. 2C receptors revealed by an antibody capture assay: influence of receptor reserve and relationship to agonist-directed trafficking. Mol. Pharmacol. 62 (2002) 578-589
10. 1 receptors using an antibody capture assay: antagonist properties of clozapine. Eur. J. Pharmacol. 485 (2004) 111-117
11. Daaka Y., Luttrell L.M., and Lefkowitz R.J. Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature 390 (1997) 88-91
12. 1 receptor. Nature 347 (1990) 72-76
13. 35S]guanosine-5′-O-(3-thio)triphosphate binding mediated by cholinergic muscarinic receptors in membranes from chinese hamster ovary cells and rat striatum using an anti-G protein scintillation proximity assay. J. Pharmacol. Exp. Ther. 289 (1999) 946-955
14. Deveney A.M., and Waddington J.L. Pharmacological characterization of behavioural responses to SK&F 83959 in relation to "D1-like" dopamine receptors not linked to adenylyl cyclase. Br. J. Pharmacol. 116 (1995) 2120-2126
15. 1A dopamine receptors. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 12564-12568
16. 1 and glutamate NMDA receptors: molecular mechanisms and functional implications. Biochem. Soc. Trans. 32 (2004) 1025-1028
17. 1A knockout mice. Mol. Pharmacol. 51 (1997) 6-11
18. 1 receptors form functionally interacting heteromeric complexes. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 8606-8611
19. 1 receptor with adenylyl cyclase. J. Neusci. 13 (1993) 2237-2248
20. 5 dopamine receptors have increased sympathetic tone and are hypertensive. J. Neurosci. 22 (2002) 10801-10810
21. 1 dopamine receptors couple to multiple Gα proteins in different brain regions. J. Neurosci. 78 (2001) 981-990
22. 1 dopamine receptors in rat brain. J. Neurochem. 85 (2003) 378-386
23. 1 dopamine receptors, adenylate cyclase and the electrophysiological responses of rat nucleus accumbens neurons. J. Neural. Transm. 86 (1991) 97-113
24. Kekabian J.W., Beaulieu M., and Itoh Y. Pharmacological and biochemical evidence for the existence of two categories of dopamine receptor. Can. J. Neurol. Sci. 11 (1984) 114-117
25. 1 dopamine receptors to different guanine nucleotide binding proteins. J. Biol. Chem. 270 (1995) 14672-14678
26. 2 receptor co-activation generates a novel phospholipase C-mediated calcium signal. J. Biol. Chem. 279 (2004) 35671-35678
27. 1 receptors are not linked to stimulation of adenylate cyclase. Synapse 50 (2003) 320-333
28. 1A dopamine receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency. J. Pharmacol. Exp. Ther. 286 (1998) 345-353
29. 5 dopamine receptors stimulate intracellular calcium release in primary cultures of neocortical and hippocampal neurons. J. Neurophysiol. 87 (2001) 2167-2175
30. 2+ mobilization in Xenopus oocytes. Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 2196-2200
31. Mannoury la Cour C., Chaput C., Cussac D., and Millan M.J. No evidence for agonist directed-trafficking at CHO-expressed human corticotrophin-releasing factor 1 receptors by use of antibody capture assays. Soc. Neurosci. Abstr. 352 (2004) 13
32. Mannoury la Cour C., El Mestikawy S., Hanoun N., Hamon M., and Lanfumey L. Regional differences in the coupling of 5-hydroxytryptamine-1A receptors to G proteins in the rat brain. Mol. Pharmacol. 70 (2006) 1013-1021
33. B receptor coupling in rat brain: G-protein subtype dependence revealed by immunocapture scintillation proximity assay. Eur. Neuropsychopharmacol. Suppl. 16 (2006) S304-S305
34. Martin N.P., Whalen E.J., Zamah M.A., Pierce K.L., and Lefkowitz R.J. PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching. Cell Signal 16 (2004) 1397-1403
35. 35S]GTPgammaS binding assay. Trends. Pharmacol. Sci. 24 (2003) 87-90
36. 1A receptor-deficient mice. Synapse 39 (2001) 319-322
37. 1 dopamine receptor. Neuropharmacology 28 (1989) 401-405
38. 1 dopamine receptors. J. Neurochem. 69 (1997) 639-644
39. 1-like receptor agonists. Neurochem. Res. 25 (2000) 759-767
40. 35S]GTP gamma S binding and phosphoinositide hydrolysis in rat and monkey brain. Neuropharmacology 40 (2001) 826-837
41. 1 dopamine receptors can interact with both stimulatory and inhibitory guanine nucleotide binding proteins. J. Neurochem. 57 (1991) 1445-1451
42. 5 dopamine receptors to multiple G proteins. Mol. Neurobiol. 16 (1998) 125-134
43. 2 receptors form heterooligomers and co-internalize following selective activation of either receptor. Mol. Pharmacol. 68 (2005) 568-578
44. 1. Nature 350 (1991) 614-619
45. Tanaka J., Nakagawa S., Kushiya E., Yamasaki M., Fukaya M., Iwanaga T., Simon M., Sakimura K., Kano M., and Watanabe M. Gq protein α subunits Gαq and Gα11 are localized at postsynaptic extra-junctional membrane of cerebellar Purkinje cells and hippocampal pyramidal cells. Eur. J. Neurosci. 12 (2000) 781-792
46. 2+ signaling in striatal medium spiny neurons. J. Biol. Chem. 279 (2004) 42082-42094
47. 1B receptor subtype. J. Biol. Chem. 269 (1994) 27925-27931
48. 1 receptor enhances inositol phosphate formation in rat brain. J. Pharmacol. Exp. Ther. 253 (1990) 987-992
49. 1-like dopamine receptor that couples to activation of phosphoinositide metabolism in brain. J. Neurochem. 62 (1994) 2045-2048
50. Undie A.S., Berki A.C., and Beardsley K. Dopaminergic behaviors and signal transduction mediated through adenylate cyclase and phospholipase C pathways. Neuropharmacology 39 (2000) 75-87
51. Waddington J.L., Daly S.A., Downes R.P., Deveney A.M., McCauley P.G., and O'Boyle K.M. Behavioural pharmacology of "D1-like" dopamine receptors: further subtyping, new pharmacological probes and interactions with "D2-like" receptors. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 19 (1995) 811-831
52. Wallace M.A., and Claro E. Transmembrane signaling through phospholipase C in human cortical membranes. Neurochem. Int. 18 (1993) 139-145
53. 1-like dopamine sites in rat striatum: possible role in dopamine-mediated inositol phosphate formation. Mol. Pharmacol. 48 (1995) 988-994
54. Zamah A.M., Delahunty M., Luttrell L.M., and Lefkowitz R.J. Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system. J. Biol. Chem. 277 (2002) 31249-31256
55. 1 dopamine receptors. Nature 347 (1990) 76-80
56. 1 receptor signalling. J. Neurosci. 20 RC91 (2000) 1-5