Topical capsaicin application and axon reflex vasodilatation of the tongue: Neurogenic involvement in burning mouth syndrome

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 28, Issue 10, 2006, Pages 707-711

  Scardina, Giuseppe Alessandro ^a,b   Carini, F ^a   Valenza, V ^a   Messina, P ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b NONE   (Italy)

Author keywords

Burning mouth syndrome; Neurogenic inflammation; Tongue mucous

Indexed keywords

CAPSAICIN;

ADULT; ARTICLE; BURNING MOUTH SYNDROME; CAPILLAROSCOPY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FEMALE; HUMAN; MALE; NERVE FIBER; NEUROGENIC INFLAMMATION; VASODILATATION;

ADMINISTRATION, TOPICAL; ADULT; AXONS; BURNING MOUTH SYNDROME; CAPILLARIES; CAPSAICIN; FEMALE; HUMANS; MALE; MICROSCOPY, VIDEO; MIDDLE AGED; NEUROGENIC INFLAMMATION; REFLEX; TONGUE; VASODILATION;

EID: 33846880041     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2006.28.10.1037499     Document Type: Article

References (34)

1. Bayliss, W.M. On the origin from the spinal cord of the vasodilator fibres of the hind limb, and on the nature of these fibres. J Physiol 1901, 27: 173-209.
2. Lundy, F.T., Linden, G.J. Neuropeptides and neurogenic mechanism in oral and periodontal inflammation. Crit Rev Oral Biol Med 2004, 15(2): 82-98.
3. Jancsò, N., Jancsò-Gabor, A., Szolcsànyi, J. Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment by capsaicin. Br J Pharmac Chemother 1967, 31: 138-51.
4. Scardina, G.A., Augello, L., Messina, P. The role of neuromodulators (substance P and calcitonin gene-related peptide) in the development of neurogenic inflammation in the oral mucosa. Minerva Stomatol 2004, 53(1): 21-32.
5. Scardina, G.A., Carini, F., Messina, P. Vasodilatation of human gengiva and neurogenic inflammation. Clin Hemorheol Microcirc 2005, 32(4): 279-85.
6. Scardina, G.A., Messina, P. Study of the microcirculation of oral mucosa in healthy subjects. Ital J Anat Embryol 2003, 108: 39-48.
7. Scardina, G. A. The effect of cigar smoking on lingual microcirculation. Odontology 2005, 93: 41-5.
8. Scardina, G.A., Messina, P. Microvascular characteristics of the human filiform papillae: A videocapillaroscopic study. Ann Anat 2006, 188: 183-6.
9. Franco-Cereceda, A., Henke, H., Lundberg, J.M., Petermann, J.B., Hokfelt, T., Fischer, J.A. Calcitonin gene-related peptide (CGRP) in capsaicin sensitive substance P-immunoreactive sensory neurons in animals and man: Distribution and release by capsaicin. Peptides 1987, 8(2): 399-410.
10. Caterina, M.J., Schumacher, M.A., Tominaga, M., Rosen, T.A., Levine, J.D., Julius, D. The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 1997, 389: 816-24.
11. Gunthorpe, M.J., Benham, C.D., Randall, A., Davis, J.B. The diversity in the vanilloid (TRPV) receptor family of ion channels. Trend Pharmacol Sci 2002, 23: 183-91.
12. Yiangou, Y., Facer, P., Dyer, N.H.C., Chan, C.L.H., Knowles, C., Williams, N.S. Vanilloid receptor 1 immunoreactivity in inflamed human bowel. Lancet 2001, 357: 1338-9.
13. Fazekas, A., Vindisch, K., Posch, E., Gyorfi, A. Experimentally- induced neurogenic in the rat oral mucosa. J Periodontal Res 1990, 25(5): 276-82.
14. Gyorfi, A., Fazekas, A., Rosivall, L. Neurogenic inflammation and oral mucosa. J Clin Periodontol 1992, 19(10): 731-6.
15. Flores, C.M., Leong, A.S., Dussor, G.O., Hardine, R.C., Hargreaves, K.M., Kilo, S. Capsaicin-evoked CGRP release from rat buccal mucosa: Development of a model system for studying trigeminal mechanisms of neurogenic inflammation. Eur J Neurosci 2001, 14(7): 1113-20.
16. Bongenhielm, U., Boissonade, F.M., Westermark, A., Robinson, P.P., Fried, K. Sympathetic nerve sprouting fails to occur in the trigeminal ganglion after peripheral nerve injury in the rat. Pain 1999, 82: 283-8.
17. Brain, S.D., Williams, TJ. Substance P regulates the vasodilatator activity of calcitonin gene-related peptide. Nature 1988; 335(6185): 73-5.
18. Brain, S.J., Morris, H., MacIntyre, I. Calcitonin gene-related peptide is a potent vasodilatator. Nature 1985, 313: 54-6.
19. Chahal, L.A. Antidromic vasodilatation and neurogenic inflammation. Pharmacol Ther 1988, 37: 275-300.
20. Couture, R., Cuello, A.C., Henry, J.L. Trigeminal antidromic vasodilatation and plasma extravation in the rat: Effects of sensory, autonomic and motor denervation. Brain Res 1985, 346: 108-14.
21. Dray, A. Inflammatory mediators of pain. Br J Anaesth 1995, 75(2): 125-31.
22. Epstain, J.B., Marcoe, J.H. Topical application of capsaicin for treatment of oral neuropatic pain and trigeminal neuralgia. Oral Surg Oral Med Oral Pathol 1994, 77: 135-40.
23. Gamse, R., Posch, M., Saria, A., Jancsò, G. Several mediators appear to interact in neurogenic inflammation. Acta Physiol Hung 1987, 69(3-4): 343-54.
24. Herbert, M.K., Holzer, P. Neuorogenic inflammation. Anasthesiol Intensivmed Notfallmed Schmerzther 2002, 37(6): 314-25.
25. Hou, M., Uddman, R., Tajti, J., Kanje, M., Edvinsson, L. Capsaicin receptor immunoreactivity in the human trigeminal ganglion. Nuerosci Lett 2002, 330(3): 223-7.
26. Kemppainen, P., Avellan, H., Handwerker, H.O., Forster, C. Difference between tooth stimulation and capsaicin-induced neurogenic vasodilatation in human ginigiva. J Dent Res 2003, 82(4): 303-7.
27. Kenins, P., Hurley, J.V., Bell, C. The role of substance P in the axon reflex in the rat. Br J Dermatol 1984, 111: 551-9.
28. Lee, T., Kawai, Y., Shiosaka, S. Coexistence of calcitonin gene related peptide and subtance P-like peptide in single cells of the trigeminal ganglion of the rat: Immunohistochemical analysis. Brain Res 1985, 330: 194-6.
29. Lin, Q., Zou, X., Fang, L., Willis, W.D. Sympathetic modulation of acute flare induced by intradermal injection of capsaicin in anesthetized rats. J Neurophysiol 2003, 89(2): 853-61.
30. Liu, M., Peril, C., Markowitz, K., Dorscher, K.J., Kim, S. The effects of capsaicin on pulpar blood flow. Proc Finn Dent Soc 1992, 88(Suppl 1): 463-7.
31. Rosell, S., Olgart, L., Gazelius, B., Panopoulos, P., Folkers, K., Horig, J. Inibition of antidromic and substance P-induced vasodilation by a substance P antagonist. Acta Physiol Scand 1981, 111: 381-2.
32. Sawynok, J. Topical and peripherally acting analgesic. Pharmacol Rev 2003, 55(1): 1-20.
33. Ulrich-Lai, Y.M., Flores, C.M., Harding-Rose, C.A., Goodis, H.E., Hargreaves, K.M. Capsaicin-evoked release of immunoreactive calcitonin gene-related peptide from rat trigeminal ganglion: Evidence for intraganglionic neurotransmission. Pain 2001, 91(3): 219-26.
34. Verdickt, G.M., Abbot, P.V. Blood flow changes in human dental pulps when capsaicin is applied to the adjacent ginigival mucosa. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001, 92: 561-5.