Blood flow changes in human dental pulps when capsaicin is applied to the adjacent gingival mucosa

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics

Volumn 92, Issue 5, 2001, Pages 561-565

  Verdickt, Gary Martin ^a   Abbott, Paul Vincent ^b,c  

^a Royal Australian Air Force   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c NONE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS ACTING ON THE PERIPHERAL NERVOUS AND NEUROMUSCULAR SYSTEMS; CAPSAICIN; LIDOCAINE; LOCAL ANESTHETIC AGENT; PRILOCAINE;

ADULT; ARTICLE; BLOOD FLOW; CANINE TOOTH; DRUG EFFECT; FEMALE; GINGIVA; HUMAN; INNERVATION; LASER DOPPLER FLOWMETRY; MALE; MANDIBULAR NERVE; MOUTH MUCOSA; NERVE BLOCK; NERVE FIBER; SENSORY NERVE CELL; TOOTH PULP; VASCULARIZATION; VASODILATATION;

ADULT; ANESTHETICS, LOCAL; AXONS; CAPSAICIN; CUSPID; DENTAL PULP; FEMALE; GINGIVA; HUMANS; LASER-DOPPLER FLOWMETRY; LIDOCAINE; MALE; MANDIBULAR NERVE; MOUTH MUCOSA; NERVE BLOCK; NEURONS, AFFERENT; PRILOCAINE; REGIONAL BLOOD FLOW; SENSORY SYSTEM AGENTS; VASODILATION;

EID: 0035516212     PISSN: 10792104     EISSN: None     Source Type: Journal    
DOI: 10.1067/moe.2001.117806     Document Type: Article

References (38)

1. Atkinson ME, Kenyon C. Collateral branching innervation of rat molar teeth from trigeminal ganglion cells shown by double labelling with fluorescent retrograde tracers. Brain Res 1990; 508:289-92.
2. Lisney SJ, Matthews B. Branched afferent nerves supplying tooth-pulp in the cat. J Physiol 1978;279:509-17.
3. Foster E, Robinson PP. The incidence and distribution of branched pulpal axons in the adult ferret. Arch Oral Biol 1993; 38:965-70.
4. Foster E, Robinson PP. A study of branched pulpal axons in ferrets with supplemental teeth. Arch Oral Biol 1994;39:1003-5.
5. Sasano T, Kuriwada S, Shoji N, Sanjo D, Izumi H, Karita K. Axon reflex vasodilatation in cat dental pulp elicited by noxious stimulation of the gingiva. J Dent Res 1994;73:1797-802.
6. Mengel MK, Jyvasjarvi E, Kniffki KD. Evidence for slowly conducting afferent fibres innervating both tooth pulp and periodontal ligament in the cat. Pain 1996;65:181-8.
7. Capra NF, Anderson KV, Pride JB, Jones TE. Simultaneous demonstration of neuronal somata that innervate the tooth pulp and adjacent periodontal tissues, using two retrogradely transported anatomic markers. Exp Neurol 1984;86:165-70.
8. Brenan A. Innervation of the dental pulp during tooth succession in the cat. Brain Res 1986;382:250-6.
9. Kemppainen P, Leppanen H, Jyvasjarvi E, Pertovaara A. Blood flow increase in the orofacial area of humans induced by painful stimulation. Brain Res Bull 1994;33:655-62.
10. Kenins P. Responses of single nerve fibres to capsaicin applied to the skin. Neurosci Lett 1982;29:83-8.
11. Celander O, Folkow B. The nature and distribution of afferent fibres provided with the axon reflex arrangement. Acta Physiol Scand 1953;29:359-70.
12. Jancso N, Jancso-Gabor A, Szolcsanyi J. Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin. Br J Pharmacol 1967;31:138-51.
13. Carpenter SE, Lynn B. Vascular and sensory responses of human skin to mild injury after topical treatment with capsaicin. Br J Pharmacol 1981;73:755-8.
14. Lembeck F, Holzer P. Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation. Naunyn Schmiedebergs Arch Pharmacol 1979;310:175-83.
15. White DM, Helme RD. Release of substance P from peripheral nerve terminals following electrical stimulation of the sciatic nerve. Brain Res 1985;336:27-31.
16. 133Xenon washout methods. Arch Oral Biol 1990;35:411-3.
17. 125I clearance. Acta Physiol Scand 1987;131:81-91.
18. Vongsavan N, Matthews B. Experiments on extracted teeth into the validity of using laser Doppler techniques for recording pulpal blood flow. Arch Oral Biol 1993;38:431-9.
19. Vongsavan N, Matthews B. Experiments in pigs on the sources of laser Doppler blood-flow signals recorded from teeth. Arch Oral Biol 1996;41:97-103.
20. Odor TM, Watson TF, Pitt Ford TR, McDonald F. Pattern of transmission of laser light in teeth. Int Endod J 1996;29:228-34.
21. Ramsay DS, Artun J, Martinen SS. Reliability of pulpal blood-flow measurements utilizing laser Doppler flowmetry. J Dent Res 1991;70:1427-30.
22. Ingolfsson AE, Tronstad L, Riva CE. Reliability of laser Doppler flowmetry in testing vitality of human teeth. Endod Dent Traumatol 1994;10:185-7.
23. Blumberg H, Wallin BG. Direct evidence of neurally mediated vasodilatation in hairy skin of the human foot. J Physiol (Lond) 1987;382:105-21.
24. Uddman R, Björlin G, Möller B, Sundler F. Occurrence of VIP nerves in mammalian dental pulps. Acta Odontol Scand 1980;38:325-8.
25. Sasano T, Shoji N, Kuriwada S, Sanjo D, Izumi H, Karita K. Direct evidence of parasympathetic vasodilatation in cat periodontal ligament. J Periodontal Res 1996;31:556-62.
26. Aars H, Gazelius B, Edwall L, Olgart L. Effects of autonomic reflexes on tooth pulp blood flow in man. Acta Physiol Scand 1992;146:423-9.
27. Izumi H, Karita K. Reflex vasodilatation in the cat lip elicited by stimulation of nasal mucosa by chemical irritants. Am J Physiol 1993;265:733-8.
28. Izumi H, Karita K. Somatosensory stimulation causes autonomic vasodilatation in cat lip. J Physiol (Lond) 1992;450:191-202.
29. Shoji N. Bilateral reflex vasodilation in the palatal mucosa evoked by unilateral tooth-pulp stimulation in the cat. J Dent Res 1996;75:1637-43.
30. Tonder KH, Naess G. Nervous control of blood flow in the dental pulp in dogs. Acta Physiol Scand 1978;104:13-23.
31. Sasano T, Shoji N, Kuriwada S, Sanjo D, Izumi H, Karita K. Absence of parasympathetic vasodilatation in cat dental pulp. J Dent Res 1995;74:1665-70.
32. Matthews B, Robinson PP. The course of post-ganglionic sympathetic fibres distributed with the trigeminal nerve in the cat. J Physiol (Lond) 1980;303:391-401.
33. Tonder KJH. Effect of vasodilating drugs on external carotid and pulpal blood flow in dogs: "stealing" of dental perfusion pressure. Acta Physiol Scand 1976;97:75-87.
34. Liu M, Kim S, Park DS, Markowitz K, Bilotto G, Dorscher-Kim J. Comparison of the effects of intra-arterial and locally applied vasoactive agents on pulpal blood flow in dog canine teeth determined by laser Doppler velocimetry. Arch Oral Biol 1990;35: 405-10.
35. Izumi H, Karita K. Axon reflex vasodilatation in human skin measured by a laser Doppler technique. Jpn J Physiol 1991;41: 693-702.
36. Buck SH, Miller MS, Burks TF. Depletion of primary afferent substance P by capsaicin and dihydrocapsaicin without altered thermal sensitivity in rats. Brain Res 1982;233:216-20.
37. Bernstein JE, Swift RM, Soltani K, Lorincz AL. Inhibition of axon reflex vasodilatation by topically applied capsaicin. J Invest Dermatol 1981;76:394-5.
38. Gyorfi A, Fazekas A, Suba Z, Ender F, Rosivall L. Neurogenic component in ligature-induced periodontitis in the rat. J Clin Periodontol 1994;21:601-5.