Cage-like complexes formed by DOTAP, Quil-A and cholesterol

International Journal of Pharmaceutics

Volumn 332, Issue 1-2, 2007, Pages 192-195

  Lendemans, D G ^a   Egert, A M ^a   Hook, S ^a   Rades, T ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Cationic; Cholesterol; DOTAP; ISCOMs; Quil A; Quillaja saponins; Vaccine delivery

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; CHOLESTEROL; ISCOM; PHOSPHOLIPID; QUIL A;

ARTICLE; CHEMICAL COMPOSITION; DIALYSIS; DRUG FORMULATION; DRUG SYNTHESIS; HYDRATION; LASER DOPPLER FLOWMETRY; MATERIALS TESTING; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY;

ADJUVANTS, IMMUNOLOGIC; CHEMISTRY, PHARMACEUTICAL; CHOLESTEROL; COLLOIDS; DRUG COMPOUNDING; FATTY ACIDS, MONOUNSATURATED; ISCOMS; LASER-DOPPLER FLOWMETRY; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, CHEMICAL; QUATERNARY AMMONIUM COMPOUNDS; SAPONINS; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 33846873441     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.09.029     Document Type: Article

References (11)

1. Bangham A.D., and Horne R.W. Action of saponin on biological cell membranes. Nature 196 (1962) 952-953
2. Copland M.J., Rades T., and Davies N.M. Hydration of lipid films with an aqueous solution of Quil A: a simple method for the preparation of immune-stimulating complexes. Int. J. Pharmaceut. 196 (2000) 135-139
3. Dalsgaard K. Saponin adjuvants. III. Isolation of a substance from Quillaja saponaria Molina with adjuvant activity in foot-and-mouth disease vaccines. Archiv fuer die gesamte Virusforschung 44 (1974) 243-254
4. Demana P., Davies N., Berger B., Vosgerau U., and Rades T. A comparison of pseudo-ternary diagrams of aqueous mixtures of Quil A, cholesterol and phospholipid prepared by lipid-film hydration and dialysis. J. Pharm. Pharmacol. 56 (2004) 573-580
5. Demana P.H., Davies N.M., Vosgerau U., and Rades T. Pseudo-ternary phase diagrams of aqueous mixtures of Quil A, cholesterol and phospholipid prepared by the lipid-film hydration method. Int. J. Pharmaceut. 270 (2004) 229-239
6. Horbaschek K., Hoffmann H., and Hao J. Classic La phases as opposed to vesicle phases in cationic-anionic surfactant mixtures. J. Phys. Chem. B 104 (2000) 2781-2784
7. Horbaschek K., Hoffmann H., and Thunig C. Formation and properties of lamellar phases in systems of cationic surfactants and hydroxy-naphtoate. J. Colloid Interf. Sci. 206 (1998) 439-456
8. Kersten G.F., Spiekstra A., Beuvery E.C., and Crommelin D.J. On the structure of immune-stimulating saponin-lipid complexes (ISCOMs). Biochim. Biophys. Acta 1062 (1991) 165-171
9. Lendemans D.G., Myschik J., Hook S., and Rades T. Cationic cage-like complexes formed by DC-cholesterol, Quil-A and phospholipid. J. Pharmaceut. Sci. 94 (2005) 1794-1807
10. Mitra S., and Dungan S.R. Micellar properties of Quillaja saponin. 1. Effects of temperature, salt, and pH on solution properties. J. Agric. Food Chem. 45 (1997) 1587-1595
11. Sanders T.S., Brown L.E., Deliyannis G., and Pearse M.J. ISCOM-based vaccines: the second decade. Immunol. Cell Biol. 83 (2005) 119-128