Proteomics and Metabolomics Combined in Cardiovascular Research

Trends in Cardiovascular Medicine

Volumn 17, Issue 2, 2007, Pages 43-48

  Mayr, Manuel ^a,b   Madhu, Basetti ^a,b   Xu, Qingbo ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b CANCER RESEARCH UK CAMBRIDGE RESEARCH INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; PROTEIN KINASE C DELTA; PYRUVATE DEHYDROGENASE;

ATHEROSCLEROSIS; BIOENERGY; CARDIOVASCULAR FUNCTION; CELL CULTURE; CELL DIFFERENTIATION; GENETIC MANIPULATION; GENOMICS; HEART PROTECTION; HUMAN; IONIZATION; ISCHEMIC PRECONDITIONING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETER; METABOLOMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEOMICS; PROTON NUCLEAR MAGNETIC RESONANCE; REVIEW; SMOOTH MUSCLE FIBER; STEM CELL; TANDEM MASS SPECTROMETRY; TWO DIMENSIONAL GEL ELECTROPHORESIS;

BIOMEDICAL RESEARCH; CARDIOVASCULAR DISEASES; HUMANS; ISCHEMIC PRECONDITIONING; METABOLIC NETWORKS AND PATHWAYS; PHENOTYPE; PROTEOMICS; SIGNAL TRANSDUCTION; STEM CELL TRANSPLANTATION;

EID: 33846849099     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcm.2006.11.004     Document Type: Review

References (40)

1. Anderson N.L., and Anderson N.G. The human plasma proteome: History, character, and diagnostic prospects. Mol Cell Proteomics 1 (2002) 845-867
2. Arrell D.K., Neverova I., and Van Eyk J.E. Cardiovascular proteomics: Evolution and potential. Circ Res 88 (2001) 763-773
3. Asahara T., Murohara T., Sullivan A., et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 275 (1997) 964-967
4. Bernal-Mizrachi C., Gates A.C., Weng S., et al. Vascular respiratory uncoupling increases blood pressure and atherosclerosis. Nature 435 (2005) 502-506
5. Blagoev B., Kratchmarova I., Ong S.E., et al. A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling. Nat Biotechnol 21 (2003) 315-318
6. Caruso M., Maitan M.A., Bifulco G., et al. Activation and mitochondrial translocation of protein kinase C delta are necessary for insulin stimulation of pyruvate dehydrogenase complex activity in muscle and liver cells. J Biol Chem 276 (2001) 45088-45097
7. Churchill E.N., Murriel C.L., Chen C.H., et al. Reperfusion-induced translocation of deltaPKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation. Circ Res 97 (2005) 78-85
8. Edmondson R.D., Vondriska T.M., Biederman K.J., et al. Protein kinase C epsilon signaling complexes include metabolism- and transcription/translation-related proteins: Complimentary separation techniques with LC/MS/MS. Mol Cell Proteomics 1 (2002) 421-433
9. Gorg A., Weiss W., and Dunn M.J. Current two-dimensional electrophoresis technology for proteomics. Proteomics 4 (2004) 3665-3685
10. Gray M.O., Zhou H.Z., Schafhalter-Zoppoth I., et al. Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon. J Biol Chem 279 (2004) 3596-3604
11. Gygi S.P., Rochon Y., Franza B.R., and Aebersold R. Correlation between protein and mRNA abundance in yeast. Mol Cell Biol 19 (1999) 1720-1730
12. Hansson G.K., Libby P., Schonbeck U., and Yan Z.Q. Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ Res 91 (2002) 281-291
13. Hillebrands J.L., Klatter F.A., Van Den Hurk B.M., et al. Origin of neointimal endothelium and alpha-actin-positive smooth muscle cells in transplant arteriosclerosis. J Clin Invest 107 (2001) 1411-1422
14. Horn M. Cardiac magnetic resonance spectroscopy: A window for studying physiology. Methods Mol Med 124 (2006) 225-248
15. Hristov M., and Weber C. Endothelial progenitor cells: Characterization, pathophysiology, and possible clinical relevance. J Cell Mol Med 8 (2004) 498-508
16. Hu Y., Mayr M., Metzler B., et al. Both donor and recipient origins of smooth muscle cells in vein graft atherosclerotic lesions. Circ Res 91 (2002) e13-e20
17. Huber L.A., Pfaller K., and Vietor I. Organelle proteomics: Implications for subcellular fractionation in proteomics. Circ Res 92 (2003) 962-968
18. Inagaki K., Hahn H.S., Dorn II G.W., and Mochly-Rosen D. Additive protection of the ischemic heart ex vivo by combined treatment with delta-protein kinase C inhibitor and epsilon-protein kinase C activator. Circulation 108 (2003) 869-875
19. Kirschenlohr H.L., Griffin J.L., Clarke S.C., et al. Proton NMR analysis of plasma is a weak predictor of coronary artery disease. Nat Med 12 (2006) 705-710
20. Leitges M., Mayr M., Braun U., et al. Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null mice. J Clin Invest 108 (2001) 1505-1512
21. Loscalzo J. Proteomics in cardiovascular biology and medicine. Circulation 108 (2003) 380-383
22. Macri J., and Rapundalo S.T. Application of proteomics to the study of cardiovascular biology. Trends Cardiovasc Med 11 (2001) 66-75
23. Mayr M., Siow R., Chung Y.L., et al. Proteomic and metabolomic analysis of vascular smooth muscle cells: Role of PKCdelta. Circ Res 94 (2004) e87-e96
24. Mayr M., Chung Y.L., Mayr U., et al. Loss of PKC-delta alters cardiac metabolism. Am J Physiol Heart Circ Physiol 287 (2004) H937-H945
25. Mayr M., Metzler B., Chung Y.L., et al. Ischemic preconditioning exaggerates cardiac damage in PKC-delta null mice. Am J Physiol Heart Circ Physiol 287 (2004) H946-H956
26. Mayr M., Chung Y.L., Mayr U., et al. Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism. Arterioscler Thromb Vasc Biol 25 (2005) 2135-2142
27. McGregor E., and Dunn M.J. Proteomics of heart disease. Hum Mol Genet 12 Spec No 2 (2003) R135-R144
28. Pandey A., and Mann M. Proteomics to study genes and genomes. Nature 405 (2000) 837-846
29. Ping P., Song C., Zhang J., et al. Formation of protein kinase C epsilon-Lck signaling modules confers cardioprotection. J Clin Invest 109 (2002) 499-507
30. 1H-MRS in the mouse. Magn Reson Med 52 (2004) 1029-1035
31. Shamir R., Shehadeh N., Rosenblat M., et al. Oral insulin supplementation attenuates atherosclerosis progression in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 23 (2003) 104-110
32. Simper D., Stalboerger P.G., Panetta C.J., et al. Smooth muscle progenitor cells in human blood. Circulation 106 (2002) 1199-1204
33. Tanaka K., Sata M., Hirata Y., and Nagai R. Diverse contribution of bone marrow cells to neointimal hyperplasia after mechanical vascular injuries. Circ Res 93 (2003) 783-790
34. Unlu M., Morgan M.E., and Minden J.S. Difference gel electrophoresis: A single gel method for detecting changes in protein extracts. Electrophoresis 18 (1997) 2071-2077
35. Vanden Hoek T.L., Becker L.B., Shao Z., et al. Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes. J Biol Chem 273 (1998) 18092-18098
36. Wang Y., Takashi E., Xu M., et al. Downregulation of protein kinase C inhibits activation of mitochondrial K(ATP) channels by diazoxide. Circulation 104 (2001) 85-90
37. Washburn M.P., Wolters D., and Yates III J.R. Large-scale analysis of the yeast proteome by multidimensional protein identification technology. Nat Biotechnol 19 (2001) 242-247
38. Xu Q. The impact of progenitor cells in atherosclerosis. Nat Clin Pract Cardiovasc Med 3 (2006) 94-101
39. Yin X., Mayr M., Xiao Q., et al. Proteomic analysis reveals higher demand for antioxidant protection in embyronic stem cell-derived smooth muscle cells. Proteomics 6 (2006) 6437-6446
40. Zampetaki A., Zhang Z., Hu Y., and Xu Q. Biomechanical stress induces IL-6 expression in smooth muscle cells via ras/rac1-p38 MAPK-NFkB signaling pathways. Am J Physiol Heart Circ Physiol 288 (2005) H2946-H2954