New perspectives in ocular pharmacology: Nucleotides as therapeutic agents

Anales de la Real Academia Nacional de Farmacia

Volumn 72, Issue 3, 2006, Pages 519-538

  Pintor, Jesús ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Corneal wound healing; Diadenosine polyphosphates; Dry eye; Glaucoma; Intraocular pressure; Nucleotide receptors

Indexed keywords

DIADENOSINE PENTAPHOSPHATE; DIADENOSINE POLYPHOSPHATE; DIADENOSINE TETRAPHOSPHATE; DIADENOSINE TRIPHOSPHATE; DINUCLEOTIDE; DIQUAFOSOL; LATANOPROST; NUCLEOTIDE; PURINE P2X RECEPTOR; PURINE P2Y RECEPTOR;

ARTICLE; CLINICAL TRIAL; CORNEA EPITHELIUM; CORNEA INJURY; DRUG MECHANISM; DRY EYE; GLAUCOMA; HUMAN; INTRAOCULAR PRESSURE; LACRIMATION; NONHUMAN; WOUND HEALING;

EID: 33846829992     PISSN: None     EISSN: 1697428X     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. RALEVIC, V. and BURNSTOCK, G. (1998): Receptors for purines and pyrimidines. Pharmacol. Rev. 50: 413-492.
2. BURNSTOCK, G. (2005): Purinergic signalling: therapeutic potencial. Anal. Real Acad. Nac. Farm. 71: 283-319.
3. HOLLOPETER, G.; JANTZEN, H. M.; VINCENT, D.; LI, G.; ENGLAND, L.; RAMAKRISHNAN, V.; YANG, R. B.; NURDEN, P.; JULIUS, D. and CONLEY, P. B. (2001): Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 409: 202-207.
4. MARÍN-GARCÍA, P.; GÓMEZ- VILLAFUERTES, R. and GUALIX, J. (2005): Los receptores de nucleótidos P2Y reducen la entrada de calcio inducida por despolarización en terminales sinápticos de cerebro medio de rata. Anal. Real Acad. Nac. Farm. 71: 659-672.
5. HERVÁS, C.; LEÓN, D.; SEN, R. P. and MIRAS-PORTUGAL, M. T. (2005): Activación de la calcio calmodulina quinasa II, CaMKII, por el uridin nucleósido difosfato, UDP, en neuronas granulares de cerebelo. Anal. Real Acad. Nac. Farm. 71: 439-449.
6. WEISMAN, G. A.; GONZÁLEZ, F. A.; ERB, L.; GARRAD, R. C. and TURNER, J. T. (1998): The cloning and expression of G-coupled P2Y nucleotide receptors. In: Turner JT, Weisman GA, Fedan JS, editors. The P2 nucleotide receptors. Totowa, NJ: Humana Press. p. 63-79.
7. COMMUNI, D.; GONZÁLEZ, N. S.; DETHREUX, M.; BREZILLION, S.; LANNOY, V.; PARMENTIER, M. and BOEYNAEMS, J. M. (2001): Identification of a novel human ADP receptor coupled to Gi. J. Biol. Chem. 276: 41479-41485.
8. ZHANG, F. L.; LUO, L.; GUSTAFSON, E.; PALMER, K.; QIAO, X.; FAN, X.; YANG, S.; LAZ, T. M.; BAYNE, M. and MONSMA, F. (2002): P2Y13: identification and characterisation of a novel Gai-coupled ADP receptor from human and mouse. J. Pharmacol. Exp. Ther. 301: 705-713.
9. CHAMBERS, J. K.; MACDONALD, L. E., SARAU, H. M., AMES, R. S.; FREEMAN, K.; FOLEY, J. J., ZHU, Y.; MCLAUGHILIN, M. M.; MURDOCK-MCMILLAN, L.; TRILL, J.; SWIFT, A.; AIYAR, N.; TAYLOR, P.; VAWTER, L.; NAHEED, S.; SZEKERES, P.; HERVIEU, G.; SCOTT, C.; WATSON, J. M.; MURPHY, A. J.; DUZIC, E.; KLEIN, C.; BERGSMA-WILSON, S. and LIVI, G. P. (2000): A G protein-coupled receptor for UDP-glucose. J. Biol. Chem. 275: 10767-10771.
10. NORTH, R. A. and SURPRENANT, A. (2000): Pharmacology of cloned P2X receptors. Annu. Rev. Pharmacol. Toxicol. 40: 563-580.
11. PINTOR, J.; PERAL, A.; INFANTES, J. J. and HERNÁNDEZ, F. (1999): ATP and adenosine: the forgotten transmitters in the eye. Recent. Res Dev. Neurochem. 2: 157-169.
12. PINTOR, J. (2000): Purinergic signalling in the eye. In: Burnstock, G., Sillito, A., editors. Nervous control of the eye. London: Harwood Academic Publishers. p. 171-210.
13. MIRAS-PORTUGAL, M. T.; GUALIX, J.; MATEO, J.; DÍAZ-HERNÁNDEZ, M.; GÓMEZ-VILLAFUERTES, R.; CASTRO, E. and PINTOR, J. (1999): Diadenosine polyphosphates, extracelullar function and catabolism. Progr. Brain. Res. 120: 397-409.
14. PINTOR, J.; PERAL, A.; HOYLE, C. H. V.; REDICK, C., DOUGLASS, J.; SIMS, I. and YERXA, B. R. (2002a): Effects of diadenosine polyphosphates on tear secretion in New Zealand white rabbits. J. Pharmacol. Exp. Ther. 300: 291-297.
15. PINTOR, J.; CARRACEDO, G.; ALONSO, M. C.; BAUTISTA, A. and PERAL, A. (2002b): Presence of diadenosine polyphosphates in human tears. Pflugers. Arch. Eur. J. Physiol. 443: 432-436.
16. PERAL, A.; CARACEDO, G.; ACOSTA, M. C.; GALLAR, J. and PINTOR, J. (2006): Increased levels of diadenosine polyphosphates in dry eye. Invest. Ophthalmol. Vis Sci. 47: 4053-4058.
17. WILSON, P. D.; HOVATER, J. S.; CASEY, C. C.; FORTENBERRY, J. A. and SCHWIEBERT, E. M. (1999): ATP release mechanisms in primary cultures of epithelia derived from the cysts of polycystic kidneys. J. Am. Soc. Nephrol. 10: 218-229.
18. MITCHELL, C. H.; CARRE, D. A.; MCG LINN, A. M.; STONE, R. and CIVAN, M. M. (1998): A release mechanism for stored ATP in ocular ciliary epithelial cells. Proc Natl Acad Sci USA 95: 7174-7178.
19. LAZAROWSKI, E. R.; BOUCHER, R. C. and HARDEN, T. K. (2003): Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules. Mol. Pharmacol. 64: 785-795.
20. ABRAHAM, E. H.; PRAT, A. G., GERWECK, L.; SENEVERATNE, T.; ARCECI, R. J.; KRAMER, R.; GUIDOTTI, C. and CANTIELLO, H. F. (1993): The multidrug resistance (mdrl) gene product functions as an ATP channel. Proc. Natl. Acad. Sci. USA. 90: 312-316.
21. GOMES, P.; SRINIVAS, S. P.; DRIESSCHE, W. V.; VEREECKE, J. and HIMPENS, B. (2005): ATP release through connexin hemichannels in corneal endotelial cells. Invest. Ophthalmol. Vis. Sci. 46: 1208-1218.
22. YERXA, B. R.; ELENA, P. P.; CAILLAUD, T.; AMAR, T. and EVANS, R. (1999): INS365, a P2Y2 receptor agonist increases Schirmer scores in albino rabbits. Invest. Ophthalmol. Vis. Sci. 401: B723.
23. YERXA, B. R. (2001): Therapeutic use of nucleotides in respiratory and ophthalmic diseases. Drug Dev. Res. 52: 196-201.
24. FUJIHARA, T.; MURAKAMI, T.; FUJITA, H.; NAKAMURA, M. and NAKATA, K. (2001): Improvement of corneal barrier function by the P2Y(2) agonist INS365 in a rat dry eye model. Invest. Ophthalmol. Vis. Sci. 42: 96-100.
25. PINTOR, J.; BAUTISTA, A.; CARRACEDO, G. and PERAL, A. (2004a): UTP and diadenosine tetraphosphate accelerate wound healing in the rabbit cornea. Ophthalmic Physiol. Opt. 24: 186-93.
26. MEDIERO, A.; PERAL, A. and PINTOR, J. (2006): Dual roles of diadenosine polyphoshates in corneal epithelial cell migration. Invest. Ophthalmol. Vis. Sci. 47: 4500-4506.
27. LAZAROWSKI, E. R.; WATT, W. C.; STUTTS, M. J.; BOUCHER, R. C. and HARDEN, T. K. (1995): Pharmacological selectivity of the cloned human P2Upurinoceptor: potent activation by diadenosine tetraphosphate. Br. J. Pharmacol. 116: 1619-1627.
28. PATEL, K.; BARNES, A., CAMACHO, J.; PATERSON, C.; BOUGHTFLOWER, R.; COUSENS, D. and MARSHALL, F. (2001): Activity of diadenosine polyphosphates at P2Y receptors stably expressed in 1321N1 cells. Eur. J. Pharmacol. 430: 203-210.
29. PENDERGAST, W.; YERXA, B. R.; DOUGLASS, J. G. 3RD; SHAVER S. R.; DOUGHERTY, R. W.; REDICK, C. C.; SIMS, I. F. and RIDEOUT, J. L. (2001): Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5 -polyphosphates. Bioorg. Med. Chem. Lett. 11: 157-160.
30. YANG, L.; CRASON, D. and TRINKAUS- RANDALL, V. (2004): Cellular injury induces activation of MAPK via P2Y receptors. J. Cell. Biochem. 91: 938-950.
31. KLEPEIS, V. E.; WEINGER, I.; KACZMAREK, E. and TRINKAUS-RANDALL, V. (2004): P2Y receptors play a critical role in epithelial cell communication and migration. J. Cell. Biochem. 93: 1115-1133.
32. WEINGER, I.; KLEPEIS, V. E. and TRINKAUS- RANDALL, V. (2005): Tri-nucleotide receptors play a critical role in epithelial cell wound repair. Purinergic Signalling 1: 281-292.
33. STEELE, C. (2000): Corneal wound healing: a review. Optometry Today. 24: 28-32.
34. PINTOR, J.; PERAL, A.; NAVAS, B.; PELÁEZ, T.; MARTIN, S. and HOYLE, C. H. V. (2003): Presence of Diadenosine Polyphosphates in the Aqueous Humor: Their Effect on Intraocular Pressure. J. Phramacol. Exp. Ther. 304: 342-348.
35. FARAHBAKHSH, N. A. and CILLUFFO, M. (2002): P2 purinergic receptor-coupled signaling in the rabbit ciliary body epithelium. Invest. Ophthalmol. Vis. Sci. 43: 2317-2325.
36. DAVSON, H. (1993): The aqueous humour and the intraocular pressure. In: Physiology of the eye, 5th edition. New York: Pergamon Press. p. 34-95.
37. ROHEN, J. (1964): Das Auge uns seine Hilforgane. In: Haut, Sinnersorgane, Mollendorff Bargmann, editors. Handbuch der Mikroskopischen Anatomie des Menshen, Bd III/2. Berlin: Springer Verlag. p. 189-328.
38. KAUFMAN, P. L.; WIEDMAN, T. and ROBINSON, J. R. (1984): Cholinergics. In: Sears, M. L., editor. Handbook of experimental pharmacology. Berlin: Springer Verlag. p. 149-191.
39. LUTJEN-DRECOLL, J. and ROHEN, E. (1989): Morphology of the aqueous outflow pathways in normal and glaucomatous eyes. In: Klein, E. A., editor. The glaucoma. St. Louis: CV Mosby. p. 89-123.
40. CROSSON, C. E. and GRAY, T. (1994): Modulation of intraocular pressure by adenosine agonists. J. Ocul. Pharmacol. 10: 379-389.