메뉴 건너뛰기




Volumn 6, Issue 1, 2007, Pages 227-235

Adenovirus type 5 E1A gene therapy for ovarian clear cell carcinoma: A potential treatment strategy

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CASPASE 9; E1A PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PROTEIN BAX; PROTEIN P53; PROTEIN P73; TRASTUZUMAB;

EID: 33846811285     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-05-0499     Document Type: Article
Times cited : (23)

References (56)
  • 1
    • 0016586886 scopus 로고
    • World Health Organization classification and nomenclature of ovarian cancer
    • Scully RE. World Health Organization classification and nomenclature of ovarian cancer. J Natl Cancer Inst Monogr 1975;42:5-7.
    • (1975) J Natl Cancer Inst Monogr , vol.42 , pp. 5-7
    • Scully, R.E.1
  • 2
    • 7844222815 scopus 로고
    • Mesonephroid tumors of the ovary. Clinical and histopathologic studies
    • Aure JC, Hoeg K, Kolstad P. Mesonephroid tumors of the ovary. Clinical and histopathologic studies. Obstet Gynecol 1971;37:860-7.
    • (1971) Obstet Gynecol , vol.37 , pp. 860-867
    • Aure, J.C.1    Hoeg, K.2    Kolstad, P.3
  • 4
    • 0034213974 scopus 로고    scopus 로고
    • Clinical characteristics of clear cell carcinoma of the ovary: A distinct histologic type with poor prognosis and resistance to platinum-based chemotherapy
    • Sugiyama T, Kamura T, Kigawa J, et al. Clinical characteristics of clear cell carcinoma of the ovary: a distinct histologic type with poor prognosis and resistance to platinum-based chemotherapy. Cancer 2000;88:2584-9.
    • (2000) Cancer , vol.88 , pp. 2584-2589
    • Sugiyama, T.1    Kamura, T.2    Kigawa, J.3
  • 5
    • 0036338490 scopus 로고    scopus 로고
    • Low proliferation activity may be associated with chemoresistance in clear cell carcinoma of the ovary
    • Itamochi H, Kigawa J, Sugiyama T, Kikuchi Y, Suzuki M, Terakawa N. Low proliferation activity may be associated with chemoresistance in clear cell carcinoma of the ovary. Obstet Gynecol 2002;100:281-7.
    • (2002) Obstet Gynecol , vol.100 , pp. 281-287
    • Itamochi, H.1    Kigawa, J.2    Sugiyama, T.3    Kikuchi, Y.4    Suzuki, M.5    Terakawa, N.6
  • 6
    • 0034145440 scopus 로고    scopus 로고
    • Exploratory study of effective chemotherapy to clear cell carcinoma of the ovary
    • Kita T, Kikuchi Y, Kudoh K, et al. Exploratory study of effective chemotherapy to clear cell carcinoma of the ovary. Oncol Rep 2000;7:327-31.
    • (2000) Oncol Rep , vol.7 , pp. 327-331
    • Kita, T.1    Kikuchi, Y.2    Kudoh, K.3
  • 7
    • 0037102445 scopus 로고    scopus 로고
    • Gene expression in ovarian cancer reflects both morphology and biological behavior, distinguishing clear cell from other poor-prognosis ovarian carcinomas
    • Schwartz DR, Kardia SL, Shedden KA, et al. Gene expression in ovarian cancer reflects both morphology and biological behavior, distinguishing clear cell from other poor-prognosis ovarian carcinomas. Cancer Res 2002;62:4722-9.
    • (2002) Cancer Res , vol.62 , pp. 4722-4729
    • Schwartz, D.R.1    Kardia, S.L.2    Shedden, K.A.3
  • 8
    • 0022485548 scopus 로고
    • Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185
    • Bargmann CI, Hung MC, Weinberg RA. Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. Cell 1986;45:649-57.
    • (1986) Cell , vol.45 , pp. 649-657
    • Bargmann, C.I.1    Hung, M.C.2    Weinberg, R.A.3
  • 10
    • 0032430664 scopus 로고    scopus 로고
    • The interactive effect of Ras, HER2, P53 and Bcl-2 expression in predicting the survival of non-small cell lung cancer patients
    • Kim YC, Park KO, Kern JA, et al. The interactive effect of Ras, HER2, P53 and Bcl-2 expression in predicting the survival of non-small cell lung cancer patients. Lung Cancer 1998;22:181-90.
    • (1998) Lung Cancer , vol.22 , pp. 181-190
    • Kim, Y.C.1    Park, K.O.2    Kern, J.A.3
  • 11
    • 0024337144 scopus 로고
    • Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
    • Slamon DJ, Godolphin W, Jones LA, et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989;244:707-12.
    • (1989) Science , vol.244 , pp. 707-712
    • Slamon, D.J.1    Godolphin, W.2    Jones, L.A.3
  • 12
    • 0032793672 scopus 로고    scopus 로고
    • c-myc and chromosome 8 centromere studies of ovarian cancer by interphase FISH
    • Wang ZR, Liu W, Smith ST, Parrish RS, Young SR. c-myc and chromosome 8 centromere studies of ovarian cancer by interphase FISH. Exp Mol Pathol 1999;66:140-8.
    • (1999) Exp Mol Pathol , vol.66 , pp. 140-148
    • Wang, Z.R.1    Liu, W.2    Smith, S.T.3    Parrish, R.S.4    Young, S.R.5
  • 13
    • 0026739541 scopus 로고
    • Transformation mediated by the human HER-2 gene independent of the epidermal growth factor receptor
    • Chazin VR, Kaleko M, Miller AD, Slamon DJ. Transformation mediated by the human HER-2 gene independent of the epidermal growth factor receptor. Oncogene 1992;7:1859-66.
    • (1992) Oncogene , vol.7 , pp. 1859-1866
    • Chazin, V.R.1    Kaleko, M.2    Miller, A.D.3    Slamon, D.J.4
  • 14
    • 0242694519 scopus 로고    scopus 로고
    • HER-2-targeted therapy: Lessons learned and future directions
    • Nahta R, Esteva FJ. HER-2-targeted therapy: lessons learned and future directions. Clin Cancer Res 2003;9:5078-84.
    • (2003) Clin Cancer Res , vol.9 , pp. 5078-5084
    • Nahta, R.1    Esteva, F.J.2
  • 15
    • 0023667757 scopus 로고
    • Multiple functional domains in the adenovirus E1A gene
    • Moran E, Mathews MB. Multiple functional domains in the adenovirus E1A gene. Cell 1987;48:177-8.
    • (1987) Cell , vol.48 , pp. 177-178
    • Moran, E.1    Mathews, M.B.2
  • 16
    • 0025301503 scopus 로고
    • Transcriptional repression of the neu proto-oncogene by the adenovirus 5 E1A gene products
    • Yu D, Suen TC, Yan DH, Chang LS, Hung MC. Transcriptional repression of the neu proto-oncogene by the adenovirus 5 E1A gene products. Proc Natl Acad Sci U S A 1990;87:4499-503.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 4499-4503
    • Yu, D.1    Suen, T.C.2    Yan, D.H.3    Chang, L.S.4    Hung, M.C.5
  • 17
    • 0032578861 scopus 로고    scopus 로고
    • Adenovirus 5 E1A-mediated tumor suppression associated with E1A-mediated apoptosis in vivo
    • Deng J, Xia W, Hung MC. Adenovirus 5 E1A-mediated tumor suppression associated with E1A-mediated apoptosis in vivo. Oncogene 1998; 17:2167-75.
    • (1998) Oncogene , vol.17 , pp. 2167-2175
    • Deng, J.1    Xia, W.2    Hung, M.C.3
  • 18
    • 0025944105 scopus 로고
    • Antioncogenic effect of adenovirus E1A in human tumor cells
    • Frisch SM. Antioncogenic effect of adenovirus E1A in human tumor cells. Proc Natl Acad Sci U S A 1991;88:9077-81.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 9077-9081
    • Frisch, S.M.1
  • 19
    • 0028865226 scopus 로고
    • Adenovirus E1a-mediated tumor suppression by a c-erbB-2/neu-independent mechanism
    • Frisch SM, Dolter KE. Adenovirus E1a-mediated tumor suppression by a c-erbB-2/neu-independent mechanism. Cancer Res 1995;55:5551-5.
    • (1995) Cancer Res , vol.55 , pp. 5551-5555
    • Frisch, S.M.1    Dolter, K.E.2
  • 20
    • 0035879090 scopus 로고    scopus 로고
    • Cationic liposome-mediated E1A gene transfer to human breast and ovarian cancer cells and its biologic effects: A phase I clinical trial
    • Hortobagyi GN, Ueno NT, Xia W, et al. Cationic liposome-mediated E1A gene transfer to human breast and ovarian cancer cells and its biologic effects: a phase I clinical trial. J Clin Oncol 2001; 19:3422-33.
    • (2001) J Clin Oncol , vol.19 , pp. 3422-3433
    • Hortobagyi, G.N.1    Ueno, N.T.2    Xia, W.3
  • 21
    • 0034907553 scopus 로고    scopus 로고
    • Phase I trial of intratumoral liposome E1A gene therapy in patients with recurrent breast and head and neck cancer
    • Yoo GH, Hung MC, Lopez-Berestein G, et al. Phase I trial of intratumoral liposome E1A gene therapy in patients with recurrent breast and head and neck cancer. Clin Cancer Res 2001;7:1237-45.
    • (2001) Clin Cancer Res , vol.7 , pp. 1237-1245
    • Yoo, G.H.1    Hung, M.C.2    Lopez-Berestein, G.3
  • 22
    • 0026034539 scopus 로고
    • Repressed expression of the HER-2/c-erbB-2 proto-oncogene by the adenovirus E1a gene products
    • Yan DH, Chang LS, Hung MC. Repressed expression of the HER-2/c-erbB-2 proto-oncogene by the adenovirus E1a gene products. Oncogene 1991;6:343-5.
    • (1991) Oncogene , vol.6 , pp. 343-345
    • Yan, D.H.1    Chang, L.S.2    Hung, M.C.3
  • 24
    • 0036534121 scopus 로고    scopus 로고
    • Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer
    • Esteva FJ, Valero V, Booser D, et al. Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer. J Clin Oncol 2002;20:1800-8.
    • (2002) J Clin Oncol , vol.20 , pp. 1800-1808
    • Esteva, F.J.1    Valero, V.2    Booser, D.3
  • 25
    • 0034677776 scopus 로고    scopus 로고
    • HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt /NF-κB pathway
    • Zhou BP, Hu MC, Miller SA, et al. HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-κB pathway. J Biol Chem 2000;275:8027-31.
    • (2000) J Biol Chem , vol.275 , pp. 8027-8031
    • Zhou, B.P.1    Hu, M.C.2    Miller, S.A.3
  • 26
    • 0036045373 scopus 로고    scopus 로고
    • Allelotype analysis of common epithelial ovarian cancers with special reference to comparison between clear cell adenocarcinoma with other histological types
    • Okada S, Tsuda H, Takarabe T, Yoshikawa H, Taketani Y, Hirohashi S. Allelotype analysis of common epithelial ovarian cancers with special reference to comparison between clear cell adenocarcinoma with other histological types. Jpn J Cancer Res 2002;93:798-806.
    • (2002) Jpn J Cancer Res , vol.93 , pp. 798-806
    • Okada, S.1    Tsuda, H.2    Takarabe, T.3    Yoshikawa, H.4    Taketani, Y.5    Hirohashi, S.6
  • 27
    • 0035133750 scopus 로고    scopus 로고
    • p53 mutation is infrequent in clear cell carcinoma of the ovary
    • Ho ES, Lai CR, Hsieh YT, et al. p53 mutation is infrequent in clear cell carcinoma of the ovary. Gynecol Oncol 2001;80:189-93.
    • (2001) Gynecol Oncol , vol.80 , pp. 189-193
    • Ho, E.S.1    Lai, C.R.2    Hsieh, Y.T.3
  • 28
    • 0032146795 scopus 로고    scopus 로고
    • E1A signaling to p53 involves the p19(ARF) tumor suppressor
    • de Stanchina E, McCurrach ME, Zindy F, et al. E1A signaling to p53 involves the p19(ARF) tumor suppressor. Genes Dev 1998;12:2434-42.
    • (1998) Genes Dev , vol.12 , pp. 2434-2442
    • de Stanchina, E.1    McCurrach, M.E.2    Zindy, F.3
  • 29
    • 14044251637 scopus 로고    scopus 로고
    • E1A activates transcription of p73 and Noxa to induce apoptosis
    • Flinterman M, Guelen L, Ezzati-Nik S, et al. E1A activates transcription of p73 and Noxa to induce apoptosis. J Biol Chem 2005;280:5945-59.
    • (2005) J Biol Chem , vol.280 , pp. 5945-5959
    • Flinterman, M.1    Guelen, L.2    Ezzati-Nik, S.3
  • 30
    • 24944448983 scopus 로고    scopus 로고
    • Bcl-2 antisense oligonucleotide overcomes resistance to E1A gene therapy in a low HER2-expressing ovarian cancer xenograft model
    • Bartholomeusz C, Itamochi H, Yuan LX, et al. Bcl-2 antisense oligonucleotide overcomes resistance to E1A gene therapy in a low HER2-expressing ovarian cancer xenograft model. Cancer Res 2005;65:8406-13.
    • (2005) Cancer Res , vol.65 , pp. 8406-8413
    • Bartholomeusz, C.1    Itamochi, H.2    Yuan, L.X.3
  • 31
    • 0036869728 scopus 로고    scopus 로고
    • HER2 is frequently overexpressed in ovarian clear cell adenocarcinoma: Possible novel treatment modality using recombinant monoclonal antibody against HER2, trastuzumab
    • Fujimura M, Katsumata N, Tsuda H, et al. HER2 is frequently overexpressed in ovarian clear cell adenocarcinoma: possible novel treatment modality using recombinant monoclonal antibody against HER2, trastuzumab. Jpn J Cancer Res 2002; 93:1250-7.
    • (2002) Jpn J Cancer Res , vol.93 , pp. 1250-1257
    • Fujimura, M.1    Katsumata, N.2    Tsuda, H.3
  • 32
    • 0035874898 scopus 로고    scopus 로고
    • Down-regulation of the erbB-2 receptor by trastuzumab (Herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2
    • Cuello M, Ettenberg SA, Clark AS, et al. Down-regulation of the erbB-2 receptor by trastuzumab (Herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2. Cancer Res 2001;61:4892-900.
    • (2001) Cancer Res , vol.61 , pp. 4892-4900
    • Cuello, M.1    Ettenberg, S.A.2    Clark, A.S.3
  • 33
    • 0037081082 scopus 로고    scopus 로고
    • The NH(2)-terminal and conserved region 2 domains of adenovirus E1A mediate two distinct mechanisms of tumor suppression
    • Deng J, Kloosterbooer F, Xia W, Hung MC. The NH(2)-terminal and conserved region 2 domains of adenovirus E1A mediate two distinct mechanisms of tumor suppression. Cancer Res 2002;62:346-50.
    • (2002) Cancer Res , vol.62 , pp. 346-350
    • Deng, J.1    Kloosterbooer, F.2    Xia, W.3    Hung, M.C.4
  • 34
    • 0029661437 scopus 로고    scopus 로고
    • Degradation of topoisomerase Ilα during adenovirus E1A-induced apoptosis is mediated by the activation of the ubiquitin proteolysis system
    • Nakajima T, Morita K, Ohi N, et al. Degradation of topoisomerase Ilα during adenovirus E1A-induced apoptosis is mediated by the activation of the ubiquitin proteolysis system. J Biol Chem 1996; 271:24842-9.
    • (1996) J Biol Chem , vol.271 , pp. 24842-24849
    • Nakajima, T.1    Morita, K.2    Ohi, N.3
  • 35
    • 0031590459 scopus 로고    scopus 로고
    • Induction of ubiquitin conjugating enzyme activity for degradation of topoisomerase Ilα during adenovirus E1A-induced apoptosis
    • Nakajima T, Kimura M, Kuroda K, et al. Induction of ubiquitin conjugating enzyme activity for degradation of topoisomerase Ilα during adenovirus E1A-induced apoptosis. Biochem Biophys Res Commun 1997;239:823-9.
    • (1997) Biochem Biophys Res Commun , vol.239 , pp. 823-829
    • Nakajima, T.1    Kimura, M.2    Kuroda, K.3
  • 36
  • 37
    • 0031466397 scopus 로고    scopus 로고
    • Inhibition of nuclear factor-κB activity is involved in E1A-mediated sensitization of radiation-induced apoptosis
    • Shao R, Karunagaran D, Zhou BP, et al. Inhibition of nuclear factor-κB activity is involved in E1A-mediated sensitization of radiation-induced apoptosis. J Biol Chem 1997;272:32739-42.
    • (1997) J Biol Chem , vol.272 , pp. 32739-32742
    • Shao, R.1    Karunagaran, D.2    Zhou, B.P.3
  • 38
    • 0029766528 scopus 로고    scopus 로고
    • Carcinoma cell lines become sensitive to DNA-damaging agents by the expression of the adenovirus E1A gene
    • Sanchez-Prieto R, Quintanilla M, Cano A, et al. Carcinoma cell lines become sensitive to DNA-damaging agents by the expression of the adenovirus E1A gene. Oncogene 1996;13:1083-92.
    • (1996) Oncogene , vol.13 , pp. 1083-1092
    • Sanchez-Prieto, R.1    Quintanilla, M.2    Cano, A.3
  • 39
    • 0033618395 scopus 로고    scopus 로고
    • E1A sensitizes cells to tumor necrosis factor-induced apoptosis through inhibition Of IκB kinases and nuclear factor κB activities
    • Shao R, Hu MC, Zhou BP, et al. E1A sensitizes cells to tumor necrosis factor-induced apoptosis through inhibition Of IκB kinases and nuclear factor κB activities. J Biol Chem 1999;274:21495-8.
    • (1999) J Biol Chem , vol.274 , pp. 21495-21498
    • Shao, R.1    Hu, M.C.2    Zhou, B.P.3
  • 40
    • 0034667997 scopus 로고    scopus 로고
    • Adenovirus E1A oncogene expression in tumor cells enhances killing by TNF-related apoptosis-inducing ligand (TRAIL)
    • Routes JM, Ryan S, Clase A, et al. Adenovirus E1A oncogene expression in tumor cells enhances killing by TNF-related apoptosis-inducing ligand (TRAIL). J Immunol 2000;165:4522-7.
    • (2000) J Immunol , vol.165 , pp. 4522-4527
    • Routes, J.M.1    Ryan, S.2    Clase, A.3
  • 42
    • 0034801802 scopus 로고    scopus 로고
    • Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells
    • Chattopadhyay D, Ghosh MK, Mal A, Harter ML. Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells. J Virol 2001;75:9844-56.
    • (2001) J Virol , vol.75 , pp. 9844-9856
    • Chattopadhyay, D.1    Ghosh, M.K.2    Mal, A.3    Harter, M.L.4
  • 43
    • 0037417353 scopus 로고    scopus 로고
    • E1A-mediated suppression of EGFR expression and induction of apoptosis in head and neck squamous carcinoma cell lines
    • Flinterman M, Gaken J, Farzaneh F, Tavassoli M. E1A-mediated suppression of EGFR expression and induction of apoptosis in head and neck squamous carcinoma cell lines. Oncogene 2003;22:1965-77.
    • (2003) Oncogene , vol.22 , pp. 1965-1977
    • Flinterman, M.1    Gaken, J.2    Farzaneh, F.3    Tavassoli, M.4
  • 44
    • 1942469352 scopus 로고    scopus 로고
    • Ovarian tumorigenesis: A proposed model based on morphological and molecular genetic analysis
    • Shihle M, Kurman RJ. Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. Am J Pathol 2004;164:1511-8.
    • (2004) Am J Pathol , vol.164 , pp. 1511-1518
    • Shihle, M.1    Kurman, R.J.2
  • 45
    • 0025743791 scopus 로고
    • Overexpression and mutation of p53 in epithelial ovarian cancer
    • Marks JR, Davidoff AM, Kerns BJ, et al. Overexpression and mutation of p53 in epithelial ovarian cancer. Cancer Res 1991;51:2979-84.
    • (1991) Cancer Res , vol.51 , pp. 2979-2984
    • Marks, J.R.1    Davidoff, A.M.2    Kerns, B.J.3
  • 46
    • 13344249778 scopus 로고    scopus 로고
    • A comparative study of p53 gene mutations, protein accumulation, and response to cisplatin-based chemotherapy in advanced ovarian carcinoma
    • Righetti SC, Delia Torre G, Pilotti S, et al. A comparative study of p53 gene mutations, protein accumulation, and response to cisplatin-based chemotherapy in advanced ovarian carcinoma. Cancer Res 1996;56:689-93.
    • (1996) Cancer Res , vol.56 , pp. 689-693
    • Righetti, S.C.1    Delia Torre, G.2    Pilotti, S.3
  • 47
    • 0026084956 scopus 로고
    • Correlation of metabolic stability and altered quaternary structure of oncoprotein p53 with cell transformation
    • Kraiss S, Spiess S, Reihsaus E, Montenarh M. Correlation of metabolic stability and altered quaternary structure of oncoprotein p53 with cell transformation. Exp Cell Res 1991;192:157-64.
    • (1991) Exp Cell Res , vol.192 , pp. 157-164
    • Kraiss, S.1    Spiess, S.2    Reihsaus, E.3    Montenarh, M.4
  • 48
    • 0028335717 scopus 로고
    • Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
    • Miyashita T, Krajewski S, Krajewska M, et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 1994;9:1799-805.
    • (1994) Oncogene , vol.9 , pp. 1799-1805
    • Miyashita, T.1    Krajewski, S.2    Krajewska, M.3
  • 49
    • 0142117313 scopus 로고    scopus 로고
    • The Bcl-2 family: Roles in cell survival and oncogenesis
    • Cory S, Huang DC, Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003;22:8590-607.
    • (2003) Oncogene , vol.22 , pp. 8590-8607
    • Cory, S.1    Huang, D.C.2    Adams, J.M.3
  • 50
    • 85006277004 scopus 로고    scopus 로고
    • Direct coupling of the cell cycle and cell death machinery by E2F
    • Nahle Z, Polakoff J, Davuluri RV, et al. Direct coupling of the cell cycle and cell death machinery by E2F. Nat Cell Biol 2002;4:859-64.
    • (2002) Nat Cell Biol , vol.4 , pp. 859-864
    • Nahle, Z.1    Polakoff, J.2    Davuluri, R.V.3
  • 51
    • 0030812331 scopus 로고    scopus 로고
    • Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
    • Kaghad M, Bonnet H, Yang A, et al. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 1997;90:809-19.
    • (1997) Cell , vol.90 , pp. 809-819
    • Kaghad, M.1    Bonnet, H.2    Yang, A.3
  • 52
    • 0037041392 scopus 로고    scopus 로고
    • p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
    • Flores ER, Tsai KY, Crowley D, et al. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature 2002;416:560-4.
    • (2002) Nature , vol.416 , pp. 560-564
    • Flores, E.R.1    Tsai, K.Y.2    Crowley, D.3
  • 53
    • 0001388461 scopus 로고    scopus 로고
    • Adenoviral gene therapy for cancer: From vectors to targeted and replication competent agents
    • [review]
    • Bauerschmitz GJ, Barker SD, Hemminki A. Adenoviral gene therapy for cancer: from vectors to targeted and replication competent agents [review]. Int J Oncol 2002;21:1161-74.
    • (2002) Int J Oncol , vol.21 , pp. 1161-1174
    • Bauerschmitz, G.J.1    Barker, S.D.2    Hemminki, A.3
  • 54
    • 0036726589 scopus 로고    scopus 로고
    • Gene therapy for ovarian cancer
    • [review]
    • Wolf JK, Jenkins AD. Gene therapy for ovarian cancer [review]. Int J Oncol 2002;21:461-8.
    • (2002) Int J Oncol , vol.21 , pp. 461-468
    • Wolf, J.K.1    Jenkins, A.D.2
  • 55
    • 0036054333 scopus 로고    scopus 로고
    • Determination of molecules regulating gene delivery using adenoviral vectors in ovarian carcinomas
    • Zeimet AG, Muller-Holzner E, Schuler A, et al. Determination of molecules regulating gene delivery using adenoviral vectors in ovarian carcinomas. Gene Ther 2002;9:1093-100.
    • (2002) Gene Ther , vol.9 , pp. 1093-1100
    • Zeimet, A.G.1    Muller-Holzner, E.2    Schuler, A.3
  • 56
    • 0035077806 scopus 로고    scopus 로고
    • Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies
    • Fisher KD, Stallwood Y, Green NK, Ulbrich K, Mautner V, Seymour LW. Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies. Gene Ther 2001;8:341-8.
    • (2001) Gene Ther , vol.8 , pp. 341-348
    • Fisher, K.D.1    Stallwood, Y.2    Green, N.K.3    Ulbrich, K.4    Mautner, V.5    Seymour, L.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.