Intramuscular absorption and biodistribution of dexamethasone from non-aqueous emulsions in the rat

International Journal of Pharmaceutics

Volumn 331, Issue 2, 2007, Pages 204-210

  Suitthimeathegorn, Orawan ^a   Turton, John A ^a   Mizuuchi, Hiroshi ^a   Florence, Alexander T ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Dexamethasone; Distribution; Intramuscular absorption; Lipophilic drug; Non aqueous emulsions

Indexed keywords

CASTOR OIL; DEXAMETHASONE; INTRALIPID;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG FORMULATION; DRUG SYNTHESIS; DRUG UPTAKE; EMULSION; HALF LIFE TIME; IN VIVO STUDY; KIDNEY; LIVER; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PRIORITY JOURNAL; RAT; SUSTAINED DRUG RELEASE;

ABSORPTION; ANIMALS; DEXAMETHASONE; EMULSIONS; INJECTIONS, INTRAMUSCULAR; KIDNEY; LIVER; OILS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 33846809310     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.11.062     Document Type: Article

References (28)

1. Agnew, R., Finch, N., Healy, L., Helyer, N., Martin, M., Stebbings, 2003. Medicines Compendium, Datapharm Communications and Virtual Health Network, Surrey.
2. Bjerregaard S., Soderberg I., Vermehren C., and Frokjaer S. Formulation and evaluation of release and swelling mechanism of a water-in-oil emulsion using factorial design. Int. J. Pharm. 193 (1999) 1-11
3. Bjerregaard S., Pedersen H., Vedstesen H., Vermehren C., Soderberg I., and Frokjaer S. Parenteral water/oil emulsions containing hydrophilic compounds with enhanced in vivo retention: formulation, rheological characterisation and study of in vivo fate using whole body gamma-scintigraphy. Int. J. Pharm. 215 (2001) 13-27
4. Cameron N.R., and Sherrington D.C. Non-aqueous high internal phase emulsions: preparation and stability. J. Chem. Soc., Faraday Trans. 92 (1996) 1543-1547
5. Davis S.S., Illum L., and Walker I.M. The in vivo evaluation of emulsion formulations administered intramuscularly. Int. J. Pharm. 38 (1987) 133-137
6. Dollery C. Therapeutic Drugs. 2nd ed. (1998), Churchill Livingstone, London
7. Dumasia M.C., Houghton E., Moss M.S., Chakraborty J., and Marks V. The biotransformation and urinary excretion of dexamethasone in equine male castrates. J. Steroid Biochem. 25 (1986) 547-553
8. Farshi F.S., Ozer A.Y., Ercan M.T., and Hincal A.A. In-vivo studies in the treatment of oral ulcers with liposomal dexamethasone sodium phosphate. J. Microencapsul. 13 (1996) 537-544
9. Florence A.T., Jenkins A.W., and Loveless A.H. Effect of formulation of intramuscular injections of phenothiazines on duration of activity. J. Pharm. Sci. 65 (1976) 1665-1668
10. Gibaldi M., and Perrier D. Pharmacokinetics (1975), Marcel Dekker, New York
11. Hamill R.D., Olson F.A., and Petersen R.V. Some interfacial properties of a nonaqueous emulsion. J. Pharm. Sci. 54 (1965) 537-540
12. Hamill R.D., and Petersen R.V. Effects of aging and surfactant concentration on the rheology and droplet size distribution of a nonaqueous emulsion. J. Pharm. Sci. 55 (1966) 1268-1274
13. Hamill R.D., and Petersen R.V. Effect of surfactant concentration on the interfacial viscosity of a nonaqueous system. J. Pharm. Sci. 55 (1966) 1274-1277
14. Hansen D.K., LaBorde J.B., Wall K.S., Holson R.R., and Young J.F. Pharmacokinetic considerations of dexamethasone-induced developmental toxicity in rats. Toxicol. Sci. 48 (1999) 230-239
15. Hashida M., Egawa M., Muranishi S., and Sezaki H. Role of intramuscular administration of water-in-oil emulsions as a method for increasing the delivery of anticancer agents to regional lymphatics. J. Pharmacokinet. Biopharm. 5 (1977) 225-239
16. Hirano K., Ichihashi T., and Yamada H. Studies on the absorption of practically water-insoluble drugs following injection. I. Intramuscular absorption from water-immiscible oil solutions in rats. Chem. Pharm. Bull. (Tokyo) 29 (1981) 519-531
17. Imhof A., and Pine D.J. Stability of nonaqueous emulsions. J. Colloid Interf. Sci. 192 (1997) 368-374
18. Jaitely V., Sakthivel T., Magee G., and Florence A.T. Formulation of oil in oil emulsions: potential drug reservoirs for slow release. J. Drug Del. Sci. Tech. 14 (2004) 113-117
19. Mager D.E., Pyszczynski N.A., and Jusko W.J. Integrated QSPR-pharmacodynamic model of genomic effects of several corticosteroids. J. Pharm. Sci. 92 (2003) 881-889
20. Nakamoto Y., Fujiwara M., Noguchi T., Kimura T., Muranishi S., and Sezaki H. Studies on pharmaceutical modification of anticancer agents. I. Enhancement of lymphatic transport of mitomycin C by parenteral emulsions. Chem. Pharm. Bull. (Tokyo) 23 (1975) 2232-2238
21. Omotosho J.A., Whateley T.L., and Florence A.T. Release of 5-fluorouracil from intramuscular w/o/w multiple emulsions. Biopharm. Drug Dispos. 10 (1989) 257-268
22. Sakthivel T., Jaitely V., Patel N.V., and Florence A.T. Non-aqueous emulsions: hydrocarbon-formamide systems. Int. J. Pharm. 214 (2001) 43-48
23. Samtani M.N., and Jusko W.J. Comparison of dexamethasone pharmacokinetics in female rats after intravenous and intramuscular administration. Biopharm. Drug Dispos. 26 (2005) 85-91
24. Suitthimeathegorn O., Jaitely V., and Florence A.T. Novel anhydrous emulsions: formulation as controlled release vehicles. Int. J. Pharm. 298 (2005) 367-371
25. Tanaka T., Kobayashi H., Okumura K., Uranishi S., and Ezaki H. Intramuscular absorption of drugs from oily solutions in the rat. Chem. Pharm. Bull. 22 (1974) 1275-1284
26. Varma D.R., and Mulay S. Anti-inflammatory and ulcerogenic effects and pharmacokinetics of dexamethasone in protein-deficient rats. J. Pharmacol. Exp. Ther. 214 (1980) 197-202
27. Wagner J.G. Pharmacokinetics for the Pharmaceutical Scientist (1993), Technomic Publishing Company, Pennsylvania
28. Yamaoka K., Nakagawa T., and Uno T. Statistical moments in pharmacokinetics. J. Pharmacokinet. Biopharm. 6 (1978) 547-558