메뉴 건너뛰기




Volumn 68, Issue 6, 2007, Pages 438-445

Infantile spasm-associated microencephaly in tuberous sclerosis complex and cortical dysplasia

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; AUTOPSY; BRAIN SIZE; CELL DENSITY; CELL NUCLEUS; CHILD; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; CORTICAL DYSPLASIA; DISEASE ASSOCIATION; GRAY MATTER; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; INFANTILE SPASM; MICROCEPHALY; MONOZYGOTIC TWINS; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SURGICAL PATIENT; TUBEROUS SCLEROSIS; WHITE MATTER;

EID: 33846798050     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.wnl.0000252952.62543.20     Document Type: Article
Times cited : (25)

References (49)
  • 1
    • 0036210273 scopus 로고    scopus 로고
    • Neurodevelopmental disorders as a cause of seizures: Neuropathologic, genetic, and mechanistic considerations
    • Crino PB, Miyata H, Vinters HV. Neurodevelopmental disorders as a cause of seizures: neuropathologic, genetic, and mechanistic considerations. Brain Pathol 2002;12:212-233.
    • (2002) Brain Pathol , vol.12 , pp. 212-233
    • Crino, P.B.1    Miyata, H.2    Vinters, H.V.3
  • 2
    • 32144433872 scopus 로고    scopus 로고
    • A developmental and genetic classification for malformations of cortical development
    • Barkovich AJ, Kuzniecky RI, Jackson GD, Guerrini R, Dobyns WB. A developmental and genetic classification for malformations of cortical development. Neurology 2005;65:1873-1887.
    • (2005) Neurology , vol.65 , pp. 1873-1887
    • Barkovich, A.J.1    Kuzniecky, R.I.2    Jackson, G.D.3    Guerrini, R.4    Dobyns, W.B.5
  • 3
    • 0028917340 scopus 로고
    • Cerebral cortical dysplasia associated with pediatric epilepsy. Review of neuropathologic features and proposal for a grading system
    • Mischel PS, Nguyen LP, Vinters HV. Cerebral cortical dysplasia associated with pediatric epilepsy. Review of neuropathologic features and proposal for a grading system. J Neuropathol Exp Neurol 1995;54:137-153.
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 137-153
    • Mischel, P.S.1    Nguyen, L.P.2    Vinters, H.V.3
  • 5
    • 0032167535 scopus 로고    scopus 로고
    • Tuberous sclerosis-related gene expression in normal and dysplastic brain
    • Vinters HV, Kerfoot C, Catania M, et al. Tuberous sclerosis-related gene expression in normal and dysplastic brain. Epilepsy Res. 1998;32:12-23.
    • (1998) Epilepsy Res , vol.32 , pp. 12-23
    • Vinters, H.V.1    Kerfoot, C.2    Catania, M.3
  • 6
    • 0036294216 scopus 로고    scopus 로고
    • Focal cortical dysplasia of Taylor's balloon cell type: Mutational analysis of the TSC1 gene indicates a pathogenic relationship to tuberous sclerosis
    • Becker AJ, Urbach H, Scheffler B, et al. Focal cortical dysplasia of Taylor's balloon cell type: mutational analysis of the TSC1 gene indicates a pathogenic relationship to tuberous sclerosis. Ann Neurol 2002;52:29-37.
    • (2002) Ann Neurol , vol.52 , pp. 29-37
    • Becker, A.J.1    Urbach, H.2    Scheffler, B.3
  • 7
    • 22244447062 scopus 로고    scopus 로고
    • Distinct allelic variants of TSC1 and TSC2 in epilepsy-associated cortical malformations without balloon cells
    • Majores M, Blumcke I, Urbach H, et al. Distinct allelic variants of TSC1 and TSC2 in epilepsy-associated cortical malformations without balloon cells. J Neuropathol Exp Neurol 2005;64:629-637.
    • (2005) J Neuropathol Exp Neurol , vol.64 , pp. 629-637
    • Majores, M.1    Blumcke, I.2    Urbach, H.3
  • 8
    • 0030639826 scopus 로고    scopus 로고
    • Tuberous sclerosis-like lesions in epileptogenic human neocortex lack allelic loss at the TSC1 and TSC2 regions
    • Wolf HK, Normann S, Green AJ, et al. Tuberous sclerosis-like lesions in epileptogenic human neocortex lack allelic loss at the TSC1 and TSC2 regions. Acta Neuropathol (Berl) 1997;93:93-96.
    • (1997) Acta Neuropathol (Berl) , vol.93 , pp. 93-96
    • Wolf, H.K.1    Normann, S.2    Green, A.J.3
  • 9
    • 0035115120 scopus 로고    scopus 로고
    • Selective alterations in glutamate and GABA receptor subunit mRNA expression in dysplastic neurons and giant cells of cortical tubers
    • White R, Hua Y, Scheithauer B, et al. Selective alterations in glutamate and GABA receptor subunit mRNA expression in dysplastic neurons and giant cells of cortical tubers. Ann Neurol 2001;49:67-78.
    • (2001) Ann Neurol , vol.49 , pp. 67-78
    • White, R.1    Hua, Y.2    Scheithauer, B.3
  • 10
    • 0036288603 scopus 로고    scopus 로고
    • Bourneville and Taylor: A developing story?
    • Crino PB. Bourneville and Taylor: a developing story? Ann Neurol 2002;52:6-9.
    • (2002) Ann Neurol , vol.52 , pp. 6-9
    • Crino, P.B.1
  • 11
    • 4844231148 scopus 로고    scopus 로고
    • mTOR cascade activation distinguishes tubers from focal cortical dysplasia
    • Baybis M, Yu J, Lee A, et al. mTOR cascade activation distinguishes tubers from focal cortical dysplasia. Ann Neurol 2004;56:478-487.
    • (2004) Ann Neurol , vol.56 , pp. 478-487
    • Baybis, M.1    Yu, J.2    Lee, A.3
  • 12
    • 4844219873 scopus 로고    scopus 로고
    • Insulin signaling pathways in cortical dysplasia and TSC-tubers: Tissue microarray analysis
    • Miyata H, Chiang AC, Vinters HV. Insulin signaling pathways in cortical dysplasia and TSC-tubers: tissue microarray analysis. Ann Neurol 2004;56:510-519.
    • (2004) Ann Neurol , vol.56 , pp. 510-519
    • Miyata, H.1    Chiang, A.C.2    Vinters, H.V.3
  • 13
    • 0032737776 scopus 로고    scopus 로고
    • Cortical dysplasia, genetic abnormalities and neurocutaneous syndromes
    • Vinters HV, Park SH, Johnson MW, et al. Cortical dysplasia, genetic abnormalities and neurocutaneous syndromes. Dev Neurosci. 1999;21:248-259.
    • (1999) Dev Neurosci , vol.21 , pp. 248-259
    • Vinters, H.V.1    Park, S.H.2    Johnson, M.W.3
  • 14
    • 0032957003 scopus 로고    scopus 로고
    • Co-localization of TSC1 and TSC2 gene products in tubers of patients with tuberous sclerosis
    • Johnson MW, Emelin JK, Park SH, Vinters HV. Co-localization of TSC1 and TSC2 gene products in tubers of patients with tuberous sclerosis. Brain Pathol 1999;9:45-54.
    • (1999) Brain Pathol , vol.9 , pp. 45-54
    • Johnson, M.W.1    Emelin, J.K.2    Park, S.H.3    Vinters, H.V.4
  • 15
    • 33644827461 scopus 로고    scopus 로고
    • Rapamycin causes regression of astrocytomas in tuberous sclerosis complex
    • Franz DN, Leonard J, Tudor C, et al. Rapamycin causes regression of astrocytomas in tuberous sclerosis complex. Ann Neurol 2006;59:490-498.
    • (2006) Ann Neurol , vol.59 , pp. 490-498
    • Franz, D.N.1    Leonard, J.2    Tudor, C.3
  • 16
    • 19944426444 scopus 로고    scopus 로고
    • Human cortical dysplasia and epilepsy: An ontogenetic hypothesis based on volumetric MRI and NeuN neuronal density and size measurements
    • Andres M, Andre VM, Nguyen S, et al. Human cortical dysplasia and epilepsy: an ontogenetic hypothesis based on volumetric MRI and NeuN neuronal density and size measurements. Cereb Cortex 2005;15:194-210.
    • (2005) Cereb Cortex , vol.15 , pp. 194-210
    • Andres, M.1    Andre, V.M.2    Nguyen, S.3
  • 17
    • 31544478559 scopus 로고    scopus 로고
    • Contralateral hemimicrencephaly and clinical-pathological correlations in children with hemimegalencephaly
    • Salamon N, Andres M, Chute DJ, et al. Contralateral hemimicrencephaly and clinical-pathological correlations in children with hemimegalencephaly. Brain 2006;129:352-365.
    • (2006) Brain , vol.129 , pp. 352-365
    • Salamon, N.1    Andres, M.2    Chute, D.J.3
  • 18
    • 0037566738 scopus 로고    scopus 로고
    • Cell output, cell cycle duration and neuronal specification: A model of integrated mechanisms of the neocortical proliferative process
    • Caviness VS Jr, Goto T, Tarui T, et al. Cell output, cell cycle duration and neuronal specification: a model of integrated mechanisms of the neocortical proliferative process. Cereb Cortex 2003;13:592-598.
    • (2003) Cereb Cortex , vol.13 , pp. 592-598
    • Caviness Jr, V.S.1    Goto, T.2    Tarui, T.3
  • 19
    • 0029095348 scopus 로고
    • Numbers, time and neocortical neuronogenesis: A general developmental and evolutionary model
    • Caviness VS, Jr, Takahashi T, Nowakowski RS. Numbers, time and neocortical neuronogenesis: a general developmental and evolutionary model. Trends Neurosci 1995;18:379-383.
    • (1995) Trends Neurosci , vol.18 , pp. 379-383
    • Caviness Jr, V.S.1    Takahashi, T.2    Nowakowski, R.S.3
  • 20
    • 0346463333 scopus 로고    scopus 로고
    • Lissencephaly with agenesis of corpus callosum and rudimentary dysplastic cerebellum: A subtype of lissencephaly with cerebellar hypoplasia
    • Miyata H, Chute DJ, Fink J, Villablanca P, Vinters HV. Lissencephaly with agenesis of corpus callosum and rudimentary dysplastic cerebellum: a subtype of lissencephaly with cerebellar hypoplasia. Acta Neuropathol (Berl) 2004;107:69-81.
    • (2004) Acta Neuropathol (Berl) , vol.107 , pp. 69-81
    • Miyata, H.1    Chute, D.J.2    Fink, J.3    Villablanca, P.4    Vinters, H.V.5
  • 21
    • 33748181142 scopus 로고    scopus 로고
    • Epileptogenesis in pediatric cortical dysplasia: The dysmature cerebral developmental hypothesis
    • Cepeda C, Andre VM, Levine MS, et al. Epileptogenesis in pediatric cortical dysplasia: the dysmature cerebral developmental hypothesis. Epilepsy Behav 2006;9:219-235.
    • (2006) Epilepsy Behav , vol.9 , pp. 219-235
    • Cepeda, C.1    Andre, V.M.2    Levine, M.S.3
  • 23
    • 12144288765 scopus 로고    scopus 로고
    • Terminology and classification of the cortical dysplasias
    • Palmini A, Najm I, Avanzini G, et al. Terminology and classification of the cortical dysplasias. Neurology 2004;62(suppl 3):S2-S8.
    • (2004) Neurology , vol.62 , Issue.SUPPL. 3
    • Palmini, A.1    Najm, I.2    Avanzini, G.3
  • 24
    • 0032806452 scopus 로고    scopus 로고
    • Postoperative seizure control and antiepileptic drug use in pediatric epilepsy surgery patients: The UCLA experience, 1986-1997
    • Mathern GW, Giza CC, Yudovin S, et al. Postoperative seizure control and antiepileptic drug use in pediatric epilepsy surgery patients: the UCLA experience, 1986-1997. Epilepsia 1999;40:1740-1749.
    • (1999) Epilepsia , vol.40 , pp. 1740-1749
    • Mathern, G.W.1    Giza, C.C.2    Yudovin, S.3
  • 25
    • 2442702840 scopus 로고    scopus 로고
    • Cerebral hemispherectomy: Hospital course, seizure, developmental, language, and motor outcomes
    • Jonas R, Nguyen S, Hu B, et al. Cerebral hemispherectomy: hospital course, seizure, developmental, language, and motor outcomes. Neurology 2004;62:1712-1721.
    • (2004) Neurology , vol.62 , pp. 1712-1721
    • Jonas, R.1    Nguyen, S.2    Hu, B.3
  • 26
    • 33748696424 scopus 로고    scopus 로고
    • FDG-PET/MRI co-registration and diffusion-tensor imaging distinguish epileptogenic tubers and cortex in patients with tuberous sclerosis complex: A preliminary report
    • Chandra PS, Salamon N, Huang J, et al. FDG-PET/MRI co-registration and diffusion-tensor imaging distinguish epileptogenic tubers and cortex in patients with tuberous sclerosis complex: a preliminary report. Epilepsia 2006;47:1543-1549.
    • (2006) Epilepsia , vol.47 , pp. 1543-1549
    • Chandra, P.S.1    Salamon, N.2    Huang, J.3
  • 27
    • 33646684081 scopus 로고    scopus 로고
    • Magnetic source imaging localizes epileptogenic zone in children with tuberous sclerosis complex
    • Wu JY, Sutherling WW, Koh S, et al. Magnetic source imaging localizes epileptogenic zone in children with tuberous sclerosis complex. Neurology 2006;66:1270-1272.
    • (2006) Neurology , vol.66 , pp. 1270-1272
    • Wu, J.Y.1    Sutherling, W.W.2    Koh, S.3
  • 28
    • 13844307915 scopus 로고    scopus 로고
    • Surgery for symptomatic infant-onset epileptic encephalopathy with and without infantile spasms
    • Jonas R, Asarnow RF, LoPresti C, et al. Surgery for symptomatic infant-onset epileptic encephalopathy with and without infantile spasms. Neurology 2005;64:746-750.
    • (2005) Neurology , vol.64 , pp. 746-750
    • Jonas, R.1    Asarnow, R.F.2    LoPresti, C.3
  • 29
    • 20844434967 scopus 로고    scopus 로고
    • Pediatric cortical dysplasia: Correlations between neuroimaging, electrophysiology and location of cytomegalic neurons and balloon cells, and glutamate/GABA synaptic circuits
    • Cepeda C, Andre VM, Flores-Hernandez J, et al. Pediatric cortical dysplasia: Correlations between neuroimaging, electrophysiology and location of cytomegalic neurons and balloon cells, and glutamate/GABA synaptic circuits. Dev Neurosci 2005;27:59-76.
    • (2005) Dev Neurosci , vol.27 , pp. 59-76
    • Cepeda, C.1    Andre, V.M.2    Flores-Hernandez, J.3
  • 30
    • 0029013993 scopus 로고
    • Reactive synaptogenesis and neuron densities for neuropeptide Y, somatostatin, and glutamate decarboxylase immunoreactivity in the epileptogenic human fascia dentata
    • Mathern GW, Babb TL, Pretorius JK, Leite JP. Reactive synaptogenesis and neuron densities for neuropeptide Y, somatostatin, and glutamate decarboxylase immunoreactivity in the epileptogenic human fascia dentata. J Neurosci 1995;15:3990-4004.
    • (1995) J Neurosci , vol.15 , pp. 3990-4004
    • Mathern, G.W.1    Babb, T.L.2    Pretorius, J.K.3    Leite, J.P.4
  • 31
    • 0030780112 scopus 로고    scopus 로고
    • Human fascia dentata anatomy and hippocampal neuron densities differ depending on the epileptic syndrome and age at first seizure
    • Mathern GW, Kuhlman PA, Mendoza D, Pretorius JK. Human fascia dentata anatomy and hippocampal neuron densities differ depending on the epileptic syndrome and age at first seizure. J Neuropathol Exp Neurol 1997;56:199-212.
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 199-212
    • Mathern, G.W.1    Kuhlman, P.A.2    Mendoza, D.3    Pretorius, J.K.4
  • 32
    • 0942269004 scopus 로고    scopus 로고
    • Cerebral hemispherectomy for pediatric epilepsy patients: A comparison of three techniques by pathologic substrate in 115 patients
    • Cook SW, Nguyen ST, Hu B, et al. Cerebral hemispherectomy for pediatric epilepsy patients: a comparison of three techniques by pathologic substrate in 115 patients. J Neurosurg 2004;100:125-141.
    • (2004) J Neurosurg , vol.100 , pp. 125-141
    • Cook, S.W.1    Nguyen, S.T.2    Hu, B.3
  • 33
    • 8844247121 scopus 로고    scopus 로고
    • Brain abnormalities in tuberous sclerosis complex
    • DiMario FJ Jr.. Brain abnormalities in tuberous sclerosis complex. J Child Neurol 2004;19:650-657.
    • (2004) J Child Neurol , vol.19 , pp. 650-657
    • DiMario Jr., F.J.1
  • 34
    • 0031054894 scopus 로고    scopus 로고
    • Association of tuberous sclerosis of temporal lobes with autism and atypical autism
    • Bolton PF, Griffiths PD. Association of tuberous sclerosis of temporal lobes with autism and atypical autism. Lancet 1997;349:392-395.
    • (1997) Lancet , vol.349 , pp. 392-395
    • Bolton, P.F.1    Griffiths, P.D.2
  • 35
    • 0034756417 scopus 로고    scopus 로고
    • Widespread anatomical abnormalities of grey and white matter structure in tuberous sclerosis
    • Ridler K, Bullmore ET, De Vries PJ, et al. Widespread anatomical abnormalities of grey and white matter structure in tuberous sclerosis. Psychol Med 2001;31:1437-1446.
    • (2001) Psychol Med , vol.31 , pp. 1437-1446
    • Ridler, K.1    Bullmore, E.T.2    De Vries, P.J.3
  • 36
    • 85070034944 scopus 로고    scopus 로고
    • Ridler K, Suckling J, Higgins NJ, et al. Neuroanatomical correlates of memory deficits in tuberous sclerosis complex. Cereb Cortex 2006 (Epub April 7).
    • Ridler K, Suckling J, Higgins NJ, et al. Neuroanatomical correlates of memory deficits in tuberous sclerosis complex. Cereb Cortex 2006 (Epub April 7).
  • 37
    • 2442692952 scopus 로고    scopus 로고
    • NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue
    • Andre VM, Flores-Hernandez J, Cepeda C, et al. NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue. Cereb Cortex 2004;14:634-646.
    • (2004) Cereb Cortex , vol.14 , pp. 634-646
    • Andre, V.M.1    Flores-Hernandez, J.2    Cepeda, C.3
  • 38
    • 0242516022 scopus 로고    scopus 로고
    • Morphological and electrophysiological characterization of abnormal cell types in pediatric cortical dysplasia
    • Cepeda C, Hurst RS, Flores-Hernandez J, et al. Morphological and electrophysiological characterization of abnormal cell types in pediatric cortical dysplasia. J Neurosci Res 2003;72:472-486.
    • (2003) J Neurosci Res , vol.72 , pp. 472-486
    • Cepeda, C.1    Hurst, R.S.2    Flores-Hernandez, J.3
  • 39
    • 21844436244 scopus 로고    scopus 로고
    • Are cytomegalic neurons and balloon cells generators of epileptic activity in pediatric cortical dysplasia?
    • Cepeda C, Andre VM, Vinters HV, Levine MS, Mathern GW. Are cytomegalic neurons and balloon cells generators of epileptic activity in pediatric cortical dysplasia? Epilepsia. 2005;46(suppl 5):82-88.
    • (2005) Epilepsia , vol.46 , Issue.SUPPL. 5 , pp. 82-88
    • Cepeda, C.1    Andre, V.M.2    Vinters, H.V.3    Levine, M.S.4    Mathern, G.W.5
  • 40
    • 85070033302 scopus 로고    scopus 로고
    • Immature neurons and networks may contribute to epileptogenesis in pediatric cortical dysplasia
    • in press
    • Cepeda C, Andre VM, Wu N, et al. Immature neurons and networks may contribute to epileptogenesis in pediatric cortical dysplasia. Epilepsia 2006 (in press).
    • (2006) Epilepsia
    • Cepeda, C.1    Andre, V.M.2    Wu, N.3
  • 41
    • 0029875394 scopus 로고    scopus 로고
    • Risk factors of infantile spasms compared with other seizures in children under 2 years of age
    • Rantala H, Shields WD, Christenson PD, et al. Risk factors of infantile spasms compared with other seizures in children under 2 years of age. Epilepsia 1996;37:362-366.
    • (1996) Epilepsia , vol.37 , pp. 362-366
    • Rantala, H.1    Shields, W.D.2    Christenson, P.D.3
  • 42
    • 0029664564 scopus 로고    scopus 로고
    • Long-term outcome of West syndrome: A study of adults with a history of infantile spasms
    • Riikonen R. Long-term outcome of West syndrome: a study of adults with a history of infantile spasms. Epilepsia 1996;37:367-372.
    • (1996) Epilepsia , vol.37 , pp. 367-372
    • Riikonen, R.1
  • 43
  • 44
    • 0031983270 scopus 로고    scopus 로고
    • A comparison of the neuropathological effects of vigabatrin and carbamazepine in patients with newly diagnosed localization-related epilepsy using MR-based cerebral T2 relaxation time measurements
    • Van Paesschen W, Duncan JS, Connelly A. A comparison of the neuropathological effects of vigabatrin and carbamazepine in patients with newly diagnosed localization-related epilepsy using MR-based cerebral T2 relaxation time measurements. Epilepsy Res 1998;29:155-160.
    • (1998) Epilepsy Res , vol.29 , pp. 155-160
    • Van Paesschen, W.1    Duncan, J.S.2    Connelly, A.3
  • 45
    • 0034130001 scopus 로고    scopus 로고
    • Effect of long-term vigabatrin administration on the immature rat brain
    • Qiao M, Malisza KL, Del Bigio MR, et al. Effect of long-term vigabatrin administration on the immature rat brain. Epilepsia 2000;41:655-665.
    • (2000) Epilepsia , vol.41 , pp. 655-665
    • Qiao, M.1    Malisza, K.L.2    Del Bigio, M.R.3
  • 46
    • 0031128129 scopus 로고    scopus 로고
    • Low-dose vigabatrin (gamma-vinyl GABA)-induced damage in the immature rat brain
    • Sidhu RS, Del Bigio MR, Tuor UI, Seshia SS. Low-dose vigabatrin (gamma-vinyl GABA)-induced damage in the immature rat brain. Exp Neurol 1997;144:400-405.
    • (1997) Exp Neurol , vol.144 , pp. 400-405
    • Sidhu, R.S.1    Del Bigio, M.R.2    Tuor, U.I.3    Seshia, S.S.4
  • 47
    • 22544488406 scopus 로고    scopus 로고
    • Infantile spasms and intellectual outcomes in children with tuberous sclerosis complex
    • Goh S, Kwiatkowski DJ, Dorer DJ, Thiele EA. Infantile spasms and intellectual outcomes in children with tuberous sclerosis complex. Neurology 2005;65:235-238.
    • (2005) Neurology , vol.65 , pp. 235-238
    • Goh, S.1    Kwiatkowski, D.J.2    Dorer, D.J.3    Thiele, E.A.4
  • 48
    • 8444249008 scopus 로고    scopus 로고
    • The United Kingdom Infantile Spasms Study comparing vigabatrin with prednisolone or tetracosactide at 14 days: A multicentre, randomised controlled trial
    • Lux AL, Edwards SW, Hancock E, et al. The United Kingdom Infantile Spasms Study comparing vigabatrin with prednisolone or tetracosactide at 14 days: a multicentre, randomised controlled trial. Lancet 2004;364:1773-1778.
    • (2004) Lancet , vol.364 , pp. 1773-1778
    • Lux, A.L.1    Edwards, S.W.2    Hancock, E.3
  • 49
    • 26844507605 scopus 로고    scopus 로고
    • The United Kingdom Infantile Spasms Study (UKISS) comparing hormone treatment with vigabatrin on developmental and epilepsy outcomes to age 14 months: A multicentre randomised trial
    • Lux AL, Edwards SW, Hancock E, et al. The United Kingdom Infantile Spasms Study (UKISS) comparing hormone treatment with vigabatrin on developmental and epilepsy outcomes to age 14 months: a multicentre randomised trial. Lancet Neurol 2005;4:712-717.
    • (2005) Lancet Neurol , vol.4 , pp. 712-717
    • Lux, A.L.1    Edwards, S.W.2    Hancock, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.