sBAFF mutants induce neutralizing antibodies against BAFF

FEBS Letters

Volumn 581, Issue 4, 2007, Pages 581-586

  Gao, Huiguang ^a,b   Bian, Aina ^a   Zheng, Yingru ^a   Li, Rongfen ^a   Ji, Qing ^a   Huang, Gang ^a   Hu, Daqiang ^a   Zhang, Li ^a   Gong, Wei ^a   Hu, Ying ^a   He, Fengtian ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b PLA   (China)

Author keywords

Autoimmune disorder; B cell activating factor belonging to the TNF family; Immunization

Indexed keywords

B CELL ACTIVATING FACTOR BELONGING TO THE TNF FAMILY PROTEIN; EPITOPE; MEMBRANE PROTEIN; NEUTRALIZING ANTIBODY; NITRILOTRIACETIC ACID; PROTEIN ANTIBODY; RECOMBINANT PROTEIN; SOLUBLE B CELL ACTIVATING FACTOR BELONGING TO THE TNF FAMILY PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE ACTIVATION; CARBOXY TERMINAL SEQUENCE; CHROMATOGRAPHY; CONTROLLED STUDY; CROSS REACTION; ESCHERICHIA COLI; FEMALE; HELPER CELL; IMMUNIZATION; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION;

ANIMALS; ANTIBODIES; B-CELL ACTIVATING FACTOR; CELL PROLIFERATION; FEMALE; HUMANS; IMMUNIZATION; IMMUNOGLOBULIN G; LYMPHOCYTE TRANSFUSION; LYMPHOCYTES; MICE; MICE, INBRED BALB C; MICE, SCID; MUTANT PROTEINS; NEUTRALIZATION TESTS; RECOMBINANT PROTEINS; SOLUBILITY;

ESCHERICHIA COLI; MUS;

EID: 33846781461     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.12.060     Document Type: Article

References (26)

1. Moore P.A., Belvedere O., Orr A., Pieri K., LaFleur D.W., Feng P., Soppet D., Charters M., Gentz R., Parmelee D., Li Y., Galperina O., Giri J., Roschke V., Nardelli B., Carrell J., Sosnovtseva S., Greenfield W., Ruben S.M., Olsen H.S., Fikes J., and Hilbert D.M. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 285 (1999) 260-263
2. Mukhopadhyay A., Ni J., Zhai Y., Yu G.L., and Aggarwal B.B. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase. J. Biol. Chem. 274 (1999) 15978-15981
3. Schneider P., MacKay F., Steiner V., Hofmann K., Bodmer J.L., Holler N., Ambrose C., Lawton P., Bixler S., Acha-Orbea H., Valmori D., Romero P., Werner-Favre C., Zubler R.H., Browning J.L., and Tschopp J. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J. Exp. Med. 189 (1999) 1747-1756
4. Shu H.B., Hu W.H., and Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J. Leukocyte. Biol. 65 (1999) 680-683
5. Tribouley C., Wallroth M., Chan V., Paliard X., Fang E., Lamson G., Pot D., Escobedo J., and Williams L.T. Characterization of a new member of the TNF family expressed on antigen presenting cells. Biol. Chem. 380 (1999) 1443-1447
6. Locksley R.M., Killeen N., and Lenardo M.J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104 (2001) 487-501
7. Hsu B.L., Harless S.M., Lindsley R.C., Hilbert D.M., and Cancro M.P. Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators. J. Immunol. 168 (2002) 5993-5996
8. Cambridge G., Stohl W., Leandro M.J., Migone T.S., Hilbert D.M., and Edwards J.C. Circulating levels of B lymphocyte stimulator in patients with rheumatoid arthritis following rituximab treatment: relationships with B cell depletion, circulating antibodies, and clinical relapse. Arth. Rheum. 54 (2006) 723-732
9. Kalled S.L. The role of BAFF in immune function and implications for autoimmunity. Immunol. Rev. 204 (2005) 43-54
10. Kalled S.L., Ambrose C., and Hsu Y.M. BAFF: B cell survival factor and emerging therapeutic target for autoimmune disorders. Expert. Opin. Ther. Targets 7 (2003) 115-123
11. Pers J.O., Daridon C., Devauchelle V., Jousse S., Saraux A., Jamin C., and Youinou P. BAFF overexpression is associated with autoantibody production in autoimmune diseases. Ann. N. Y. Acad. Sci. 1050 (2005) 34-39
12. Zhang M., Ko K.H., Lam Q.L., Lo C.K., Srivastava G., Zheng B., Lau Y.L., and Lu L. Expression and function of TNF family member B cell-activating factor in the development of autoimmune arthritis. Int. Immunol. 17 (2005) 1081-1092
13. Baker K., Edwards B., Main S., Choi G.H., Wager R.E., Halpern W.G., Lappin P.B., Riccobene T., Abramian D., Sekut L., Sturm B., Poortman C., Minter R.R., Dobson C.L., Williams E., Carmen S., Smith R., Roschke V., Hilbert D.M., Vaughan T.J., and Albert V.R. Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator. Arth. Rheum. 48 (2003) 3253-3265
14. Pelletier M., Thompson J.S., Qian F., Bixler S.A., Gong D., Cachero T., Gilbride K., Day E., Zafari M., Benjamin C., Gorelik L., Whitty A., Kalled S.L., Ambrose C., and Hsu Y.M. Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFF. J. Biol. Chem. 278 (2003) 33127-33133
15. Stohlm W. A therapeutic role for BLyS antagonistsm. Lupus 13 (2004) 317-322
16. Vugmeyster Y., Seshasayee D., Chang W., Storn A., Howell K., Sa S., Nelson T., Martin F., Grewal I., Gilkerson E., Wu B., Thompson J., Ehrenfels B.N., Ren S., Song A., Gelzleichter T.R., and Danilenko D.M. A soluble BAFF antagonist, BR3-Fc, decreases peripheral blood B cells and lymphoid tissue marginal zone and follicular B cells in cynomolgus monkeys. Am. J. Pathol. 168 (2006) 476-489
17. Cheema G.S., Roschke V., Hilbert D.M., and Stohl W. Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases. Arthr. Rheum. 44 (2001) 1313-1319
18. Groom J., Kalled S.L., Cutler A.H., Olson C., Woodcock S.A., Schneider P., Tschopp J., Cachero T.G., Batten M., Wheway J., Mauri D., Cavill D., Gordon T.P., Mackay C.R., and Mackay F. Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome. J. Clin. Invest. 109 (2002) 59-68
19. Jonsson M.V., Szodoray P., Jellestad S., Jonsson R., and Skarstein K. Association between circulating levels of the novel TNF family members APRIL and BAFF and lymphoid organization in primary Sjogren's syndrome. J. Clin. Immunol. 25 (2005) 189-201
20. Marrette X., Roux S., Zhang J., Bengoufa D., Lavie F., Zhou T., and Kimberly R. The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjogren's syndrome. Ann. Rheum. Dis. 62 (2003) 168-171
21. Dalum I., Butler D.M., Jensen M.R., Hindersson P., Steinaa L., Waterston A.M., Grell S.N., Feldmann M., Elsner H.I., and Mouritsen S. Therapeutic antibodies elicited by immunization against TNF-alpha. Nat. Biotechnol. 17 (1999) 666-669
22. Engelhorn M.E., Guevara-Patino J.A., Noffz G., Hooper A.T., Lou O., Gold J.S., Kappel B.J., and Houghton A.N. Autoimmunity and tumor immunity induced by immune responses to mutations in self. Nat. Med. 12 (2006) 198-206
23. Bosma G.C., Caster R.P., and Bosma M.J. A severe combined immunodeficiency mutation in the mouse. Nature 301 (1983) 527-530
24. Bosma M.J., and Carrol A.M. The SCID mouse mutant: definition, characterization and potential uses. Annu. Rev. Immunol. 9 (1991) 323-350
25. Katakura T., Kobayashi M., Herndon D.N., and Suzuki F. Effect of IL-12 and soluble IL-4 receptor on the herpesvirus infection in human SCID chimeras whose Th2 cells predominate. Immunol. Cell. Biol. 82 (2004) 421-426
26. Lazarus A.H., Crow A.R., Semple J.W., Cosgrave D., Kalovsky E.J., Hannach B., Blanchette V., and Freedman J. Induction of a secondary human anti-HLA alloimmune response in severe combined immunodeficient mice engrafted with human lymphocytes. Transfusion 37 (1997) 1192-1199