The Aging of the Heart and Blood Vessels: A Consideration of Anatomy and Physiology in the Era of Computed Tomography, Magnetic Resonance Imaging, and Positron Emission Tomographic Imaging Methods With Special Consideration of Atherogenesis

Seminars in Nuclear Medicine

Volumn 37, Issue 2, 2007, Pages 120-143

  Botvinick, Eli H ^a   Perini, Rodolfo ^a   Bural, Gonca ^a   Chen, Wengen ^a   Chryssikos, Timothy ^a   Houseni, Mohamed ^a   Hernandez Pampaloni, Miguel ^a   Torigian, Drew A ^a   Alavi, Abass ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(3 IODOBENZYL)GUANIDINE I 123; ACETIC ACID C 11; APOLIPOPROTEIN E; CARBON 11; CGS 27023A; FLUORINE 18; FLUORODEOXYGLUCOSE; GLUCOSE; GLUCOSE C 11; IODINE 123; IODINE 124; LIPOCORTIN 5; LOW DENSITY LIPOPROTEIN; PALMITIC ACID C 11; TECHNETIUM 99M; TRACER; TRITIUM; UNCLASSIFIED DRUG; WATER O 15;

AGE; AGED; AGING; ANATOMY; APPARATUS; ATHEROGENESIS; ATHEROSCLEROSIS; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; ELECTRON BEAM TOMOGRAPHY; GENETIC ENGINEERING; HEART INNERVATION; HEART MUSCLE METABOLISM; HEART PERFUSION; HEMODYNAMICS; HUMAN; IMAGE ANALYSIS; IMAGING SYSTEM; INTRAVASCULAR ULTRASOUND; LIFE EXPECTANCY; LONGEVITY; MOLECULAR BIOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTICAL COHERENCE TOMOGRAPHY; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; QUANTITATIVE ANALYSIS; REVIEW; SIGNAL NOISE RATIO;

AGING; ATHEROSCLEROSIS; CARDIOVASCULAR SYSTEM; DIAGNOSTIC IMAGING; HUMANS; MAGNETIC RESONANCE IMAGING; POSITRON-EMISSION TOMOGRAPHY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 33846685807     PISSN: 00012998     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.semnuclmed.2006.10.005     Document Type: Review

References (115)

1. Tolson G.C., Barnes J.M., Gay G.A., et al. The 1989 revision of the U.S. Standard Certificates and Reports. Vital Health Stat 4 (1991) 1-34
2. In: Kannel W., Wolf P., and Garrison R. (Eds). The Framingham Study: An Epidemiological Investigation of Cardiovascular Disease (1988), NHLBI, NIH, Bethesda, MD
3. Fleg J.L., Gerstenblith G., Zonderman A.B., et al. Prevalence and prognostic significance of exercise-induced silent myocardial ischemia detected by thallium scintigraphy and electrocardiography in asymptomatic volunteers. Circulation 81 (1990) 428-436
4. Ferrari A.U., Radaelli A., and Centola M. Invited review: aging and the cardiovascular system. J Appl Physiol 95 (2003) 2591-2597
5. U.S. Census Bureau DaIDB. World Health Organization Report (2004), WHO, Geneva
6. Best B. Mechanism of aging. Volume 2006. Available at: http://www.benbest.com/lifeext/aging.html. Accessed November 14, 2006.
7. Rohde D. Afghanistan, symbol for change becomes symbol for failure. New York Times 2006 9/05/2006
8. Gerstenblith G., Frederiksen J., Yin F.C., et al. Echocardiographic assessment of a normal adult aging population. Circulation 56 (1977) 273-278
9. Goor D., Lillehei C.W., and Edwards J.E. The "sigmoid septum." Variation in the contour of the left ventricular outlet. Am J Roentgenol Radium Ther Nucl Med 107 (1969) 366-376
10. Miller T.R., Grossman S.J., Schectman K.B., et al. Left ventricular diastolic filling and its association with age. Am J Cardiol 58 (1986) 531-535
11. Lakatta E.G., Gerstenblith G., Angell C.S., et al. Prolonged contraction duration in aged myocardium. J Clin Invest 55 (1975) 61-68
12. Kitzman D.W., Gardin J.M., Gottdiener J.S., et al., CHS Research Group. Importance of heart failure with preserved systolic function in patients > or = 65 years of age. Cardiovascular Health Study Am J Cardiol 87 (2001) 413-419
13. Levy D., Garrison R.J., Savage D.D., et al. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 322 (1990) 1561-1566
14. Sigwart U.G.M., Payot M., et al. Ischemic events during coronary artery balloon obstruction. In: Rutishauser W., and Roskamm H. (Eds). Silent Myocardial Ischemia (1984), Springer-Verlag, Berlin 29-36
15. Wolf P.A., Abbott R.D., and Kannel W.B. Atrial fibrillation as an independent risk factor for stroke: The Framingham Study. Stroke 22 (1991) 983-988
16. Brand F.N., Abbott R.D., Kannel W.B., et al. Characteristics and prognosis of lone atrial fibrillation. 30-year follow-up in the Framingham Study. JAMA 254 (1985) 3449-3453
17. Lakatta E.G. Cardiovascular regulatory mechanisms in advanced age. Physiol Rev 73 (1993) 413-467
18. Virmani R., Avolio A.P., Mergner W.J., et al. Effect of aging on aortic morphology in populations with high and low prevalence of hypertension and atherosclerosis. Comparison between occidental and Chinese communities. Am J Pathol 139 (1991) 1119-1129
19. O'Leary D.H., Polak J.F., Kronmal R.A., et al., Cardiovascular Health Study Collaborative Research Group. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. N Engl J Med 340 (1999) 14-22
20. Challah M., Nadaud S., Philippe M., et al. Circulating and cellular markers of endothelial dysfunction with aging in rats. Am J Physiol 273 (1997) H1941-H1948
21. Li Z., Froehlich J., Galis Z.S., and Lakatta E.G. Increased expression of matrix metalloproteinase-2 in the thickened intima of aged rats. Hypertension 33 (1999) 116-123
22. Vaitkevicius P.V., Lane M., Spurgeon H., et al. A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys. Proc Natl Acad Sci USA 98 (2001) 1171-1175
23. Lakatta E.G., and Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: A "set up" for vascular disease. Circulation 107 (2003) 139-146
24. Roach M.R., and Burton A.C. The effect of age on the elasticity of human iliac arteries. Can J Biochem Physiol 37 (1959) 557-570
25. Taddei S., Virdis A., Mattei P., et al. Aging and endothelial function in normotensive subjects and patients with essential hypertension. Circulation 91 (1995) 1981-1987
26. Elliott H.L., Sumner D.J., McLean K., et al. Effect of age on the responsiveness of vascular alpha-adrenoceptors in man. J Cardiovasc Pharmacol 4 (1982) 388-392
27. Gimbrone Jr. M.A. Vascular endothelium, hemodynamic forces, and atherogenesis. Am J Pathol 155 (1999) 1-5
28. Fleg J.L., O'Connor F., Gerstenblith G., et al. Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women. J Appl Physiol 78 (1995) 890-900
29. Julius S., Amery A., Whitlock L.S., et al. Influence of age on the hemodynamic response to exercise. Circulation 36 (1967) 222-230
30. Gribbin B., Pickering T.G., Sleight P., et al. Effect of age and high blood pressure on baroreflex sensitivity in man. Circ Res 29 (1971) 424-431
31. Ferrari A.U., Daffonchio A., Albergati F., et al. Differential effects of aging on the heart rate and blood pressure influences of arterial baroreceptors in awake rats. J Hypertens 9 (1991) 615-621
32. Dae M.W., O'Connell J.W., Botvinick E.H., et al. Scintigraphic assessment of regional cardiac adrenergic innervation. Circulation 79 (1989) 634-644
33. Dae M.W., and Botvinick E.H. Imaging of the heart using metaiodobenzylguanidine. J Thorac Imaging 5 (1990) 31-36
34. Dae M.W., Chin M.C., Botvinick E.H., et al. Scintigraphic assessment of postnatal maturation of myocardial sympathetic nerves. Circulation 76 (1988) 455
35. Dae M.W., De Marco T., Botvinick E.H., et al. Scintigraphic assessment of MIBG uptake in globally denervated human and canine hearts-implications for clinical studies. J Nucl Med 33 (1992) 1444-1450
36. Hunt B.E., Farquhar W.B., and Taylor J.A. Does reduced vascular stiffening fully explain preserved cardiovagal baroreflex function in older, physically active men?. Circulation 103 (2001) 2424-2427
37. Tanabe S., and Bunag R.D. Aging escalates baroreceptor reflex suppression by the posterior hypothalamus in rats. Hypertension 17 (1991) 80-90
38. Chapleau M.W., Cunningham J.T., Sullivan M.J., et al. Structural versus functional modulation of the arterial baroreflex. Hypertension 26 (1995) 341-347
39. Ziegler M.G., Lake C.R., and Kopin I.J. Plasma noradrenaline increases with age. Nature 261 (1976) 333-335
40. Mangoni A.A., Mircoli L., Giannattasio C., et al. Effect of sympathectomy on mechanical properties of common carotid and femoral arteries. Hypertension 30 (1997) 1085-1088
41. McLean M.R., Goldberg P.B., and Roberts J. An ultrastructural study of the effects of age on sympathetic innervation and atrial tissue in the rat. J Mol Cell Cardiol 15 (1983) 75-92
42. Rodeheffer R.J., Gerstenblith G., Becker L.C., et al. Exercise cardiac output is maintained with advancing age in healthy human subjects: cardiac dilatation and increased stroke volume compensate for a diminished heart rate. Circulation 69 (1984) 203-213
43. Rywik T.M., Blackman M.R., Yataco A.R., et al. Enhanced endothelial vasoreactivity in endurance-trained older men. J Appl Physiol 87 (1999) 2136-2142
44. Cleroux J., Giannattasio C., Bolla G., et al. Decreased cardiopulmonary reflexes with aging in normotensive humans. Am J Physiol 257 (1989) H961-H968
45. Davy K.P., Seals D.R., and Tanaka H. Augmented cardiopulmonary and integrative sympathetic baroreflexes but attenuated peripheral vasoconstriction with age. Hypertension 32 (1998) 298-304
46. Levy B.I., Michel J.B., Salzmann J.L., et al. Remodeling of heart and arteries by chronic converting enzyme inhibition in spontaneously hypertensive rats. Am J Hypertens 4 (1991) 240S-245S
47. Haberl R., Becker A., Leber A., et al. Correlation of coronary calcification and angiographically documented stenoses in patients with suspected coronary artery disease: Results of 1,764 patients. J Am Coll Cardiol 37 (2001) 451-457
48. Fuster V., Corti R., Fayad Z.A., Schwitter J., and Badimon J.J. Integration of vascular biology and magnetic resonance imaging in the understanding of atherothrombosis and acute coronary syndromes. J Thromb Haemost 1 (2003) 1410-1421
49. Toussaint J.F., Southern J.F., Fuster V., et al. T2-weighted contrast for NMR characterization of human atherosclerosis. Arterioscler Thromb Vasc Biol 15 (1995) 1533-1542
50. Yuan C., Mitsumori L.M., Beach K.W., et al. Carotid atherosclerotic plaque: noninvasive MR characterization and identification of vulnerable lesions. Radiology 221 (2001) 285-299
51. Wilensky R.L., Song H.K., and Ferrari V.A. Role of magnetic resonance and intravascular magnetic resonance in the detection of vulnerable plaques. J Am Coll Cardiol 47 suppl 8 (2006) C48-C56
52. Martin A.J., Gotlieb A.I., and Henkelman R.M. High-resolution MR imaging of human arteries. J Magn Reson Imaging 5 (1995) 93-100
53. Corti R., Fuster V., Fayad Z.A., et al. Lipid lowering by simvastatin induces regression of human atherosclerotic lesions: Two years' follow-up by high-resolution noninvasive magnetic resonance imaging. Circulation 106 (2002) 2884-2887
54. Lima J.A., Desai M.Y., Steen H., et al. Statin-induced cholesterol lowering and plaque regression after 6 months of magnetic resonance imaging-monitored therapy. Circulation 110 (2004) 2336-2341
55. Yuan C., Kerwin W.S., Ferguson M.S., et al. Contrast-enhanced high resolution MRI for atherosclerotic carotid artery tissue characterization. J Magn Reson Imaging 15 (2002) 62-67
56. Li H., Gray B.D., Corbin I., et al. MR and fluorescent imaging of low-density lipoprotein receptors. Acad Radiol 11 (2004) 1251-1259
57. Frias J.C., Williams K.J., Fisher E.A., et al. Recombinant HDL-like nanoparticles: a specific contrast agent for MRI of atherosclerotic plaques. J Am Chem Soc 126 (2004) 16316-16317
58. Kooi M.E., Cappendijk V.C., Cleutjens K.B., et al. Accumulation of ultrasmall superparamagnetic particles of iron oxide in human atherosclerotic plaques can be detected by in vivo magnetic resonance imaging. Circulation 107 (2003) 2453-2458
59. Natori S., Lai S., Finn J.P., et al. Cardiovascular function in multi-ethnic study of atherosclerosis: normal values by age, sex, and ethnicity. AJR Am J Roentgenol 186 suppl 2 (2006) S357-S365
60. Rudd J.H., Warburton E.A., Fryer T.D., et al. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography. Circulation 105 (2002) 2708-2711
61. Ogawa M., Ishino S., Mukai T., et al. (18)F-FDG accumulation in atherosclerotic plaques: Immunohistochemical and PET imaging study. J Nucl Med 45 (2004) 1245-1250
62. Bural G.G., Torigian D.A., Chamroonrat W., et al. Quantitative assessment of atherosclerotic burden of the aorta by combined FDG-PET and CT image analysis: A new concept. Nucl Med Biol 33 (2006) 1037-1043
63. Little W.C., Constantinescu M., Applegate R.J., et al. Can coronary angiography predict the site of a subsequent myocardial infarction in patients with mild-to-moderate coronary artery disease?. Circulation 78 (1988) 1157-1166
64. Ambrose J.A., and Fuster V. Can we predict future acute coronary events in patients with stable coronary artery disease?. JAMA 277 (1997) 343-344
65. Naghavi M., Falk E., Hecht H.S., et al. From vulnerable plaque to vulnerable patient-Part III: Executive summary of the Screening for Heart Attack Prevention and Education (SHAPE) Task Force report. Am J Cardiol 98 (2006) 2H-15H
66. Alderman E.L., Corley S.D., Fisher L.D., et al., CASS Participating Investigators and Staff. Five-year angiographic follow-up of factors associated with progression of coronary artery disease in the Coronary Artery Surgery Study (CASS). J Am Coll Cardiol 22 (1993) 1141-1154
67. Naghavi M., Libby P., Falk E., et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation 108 (2003) 1664-1672
68. Davies M.J., Woolf N., Rowles P., et al. Lipid and cellular constituents of unstable human aortic plaques. Basic Res Cardiol 89 suppl 1 (1994) 33-39
69. Davies J.R., Rudd J.H., and Weissberg P.L. Molecular and metabolic imaging of atherosclerosis. J Nucl Med 45 (2004) 1898-1907
70. O'Malley P.G., Taylor A.J., Jackson J.L., et al. Prognostic value of coronary electron-beam computed tomography for coronary heart disease events in asymptomatic populations. Am J Cardiol 85 (2000) 945-948
71. Poredos P. Endothelial dysfunction and cardiovascular disease. Pathophysiol Haemost Thromb 32 (2002) 274-277
72. Osterud B., and Bjorklid E. Role of monocytes in atherogenesis. Physiol Rev 83 (2003) 1069-1112
73. Galis Z.S., and Khatri J.J. Matrix metalloproteinases in vascular remodeling and atherogenesis: The good, the bad, and the ugly. Circ Res 90 (2002) 251-262
74. Davies M.J. Stability and instability: Two faces of coronary atherosclerosis. The Paul Dudley White Lecture 1995. Circulation 94 (1996) 2013-2020
75. Davies J.R., Rudd J.F., Fryer T.D., et al. Targeting the vulnerable plaque: The evolving role of nuclear imaging. J Nucl Cardiol 12 (2005) 234-246
76. Davies J.R., Rudd J.H., Weissberg P.L., et al. Radionuclide imaging for the detection of inflammation in vulnerable plaques. J Am Coll Cardiol 47 suppl 8 (2006) C57-C68
77. Casscells W., Hathorn B., David M., et al. Thermal detection of cellular infiltrates in living atherosclerotic plaques: possible implications for plaque rupture and thrombosis. Lancet 347 (1996) 1447-1451
78. Verheye S., De Meyer G.R., Van Langenhove G., et al. In vivo temperature heterogeneity of atherosclerotic plaques is determined by plaque composition. Circulation 105 (2002) 1596-1601
79. Nissen S.E., Nicholls S.J., Sipahi I., et al. Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA 295 (2006) 1556-1565
80. Corot C., Petry K.G., Trivedi R., et al. Macrophage imaging in central nervous system and in carotid atherosclerotic plaque using ultrasmall superparamagnetic iron oxide in magnetic resonance imaging. Invest Radiol 39 (2004) 619-625
81. Steffens S., and Mach F. Inflammation and atherosclerosis. Herz 29 (2004) 741-748
82. Falk E. Pathogenesis of atherosclerosis. J Am Coll Cardiol 47 suppl 8 (2006) C7-C12
83. Naghavi M., Libby P., Falk E., et al. From vulnerable plaque to vulnerable patient: A call for new definitions and risk assessment strategies: Part II. Circulation 108 (2003) 1772-1778
84. Virgolini I., Rauscha F., Lupattelli G., et al. Autologous low-density lipoprotein labeling allows characterization of human atherosclerotic lesions in vivo as to presence of foam cells and endothelial coverage. Eur J Nucl Med 18 (1991) 948-951
85. Lees A.M., Lees R.S., Schoen F.J., et al. Imaging human atherosclerosis with 99mTc-labeled low density lipoproteins. Arteriosclerosis 8 (1988) 461-470
86. Virgolini I., Muller C., Fitscha P., et al. Radio labeling autologous monocytes with 111-indium-oxine for reinjection in patients with atherosclerosis. Prog Clin Biol Res 355 (1990) 271-280
87. Rosenfeld M.E. Leukocyte recruitment into developing atherosclerotic lesions: The complex interaction between multiple molecules keeps getting more complex. Arterioscler Thromb Vasc Biol 22 (2002) 361-363
88. Kopka K., Breyholz H.J., Wagner S., et al. Synthesis and preliminary biological evaluation of new radioiodinated MMP inhibitors for imaging MMP activity in vivo. Nucl Med Biol 31 (2004) 257-267
89. Kietselaer B.L., Reutelingsperger C.P., Heidendal G.A., et al. Noninvasive detection of plaque instability with use of radiolabeled annexin A5 in patients with carotid-artery atherosclerosis. N Engl J Med 350 (2004) 1472-1473
90. Kolodgie F.D., Petrov A., Virmani R., et al. Targeting of apoptotic macrophages and experimental atheroma with radiolabeled annexin V: A technique with potential for noninvasive imaging of vulnerable plaque. Circulation 108 (2003) 3134-3139
91. Johnstrom P., Rudd J.H., Richards H.K., et al. Imaging endothelin ET(B) receptors using [18F]-BQ3020: In vitro characterization and positron emission tomography (microPET). Exp Biol Med (Maywood) 231 (2006) 736-740
92. Zhang Z., Machac J., Helft G., et al. Non-invasive imaging of atherosclerotic plaque macrophage in a rabbit model with F-18 FDG PET: A histopathological correlation. BMC Nucl Med 6 (2006) 3
93. Tatsumi M., Cohade C., Nakamoto Y., et al. Fluorodeoxyglucose uptake in the aortic wall at PET/CT: Possible finding for active atherosclerosis. Radiology 229 (2003) 831-837
94. Yun M., Jang S., Cucchiara A., et al. 18F FDG uptake in the large arteries: Acorrelation study with the atherogenic risk factors. Semin Nucl Med 32 (2002) 70-76
95. Dunphy M.P., Freiman A., Larson S.M., et al. Association of vascular 18F-FDG uptake with vascular calcification. J Nucl Med 46 (2005) 1278-1284
96. Rothwell P.M., Eliasziw M., Gutnikov S.A., et al. Analysis of pooled data from the randomized controlled trials of endarterectomy for symptomatic carotid stenosis. Lancet 361 (2003) 107-116
97. Jander S., Sitzer M., Schumann R., et al. Inflammation in high-grade carotid stenosis: A possible role for macrophages and T cells in plaque destabilization. Stroke 29 (1998) 1625-1630
98. Galis Z.S., Sukhova G.K., Lark M.W., et al. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 94 (1994) 2493-2503
99. Boyle J.J., Bowyer D.E., Weissberg P.L., et al. Human blood-derived macrophages induce apoptosis in human plaque-derived vascular smooth muscle cells by Fas-ligand/Fas interactions. Arterioscler Thromb Vasc Biol 21 (2001) 1402-1407
100. Falk E. Why do plaques rupture?. Circulation 86 suppl 6 (1992) III30-III42
101. Libby P., Geng Y.J., Sukhova G.K., et al. Molecular determinants of atherosclerotic plaque vulnerability. Ann N Y Acad Sci 811 (1997) 134-142 discussion 142-135
102. Davies J.R., Rudd J.H., Fryer T.D., et al. Identification of culprit lesions after transient ischemic attack by combined 18F fluorodeoxyglucose positron-emission tomography and high-resolution magnetic resonance imaging. Stroke 36 (2005) 2642-2647
103. Matsunari I., Sauraki M., Chen W., et al. Relationship between serum markers of atherosclerosis and vascular FDG uptake in asymptomatic subjects. J Nucl Med 47 (2006) 127
104. Bural G., Alkhawaldeh K., Houseni M., et al. Differences in FDG uptake in the large arteries of diabetic and age matched normal subject may indicate early atherosclerosis. J Nucl Med 47 (2006) 126
105. Chamroonrat W., Houseni M., Bural G., et al. Correlation of hyperlipidemia with high degree of FDG uptake in human aorta. J Nucl Med 47 (2006) 127
106. Chamroonrat W., Bural G., Houseni M., et al. Obesity correlated with high degree of FDG uptake in the aorta in populations with normal lipid profile of same age group. J Nucl Med 47 (2006) 262
107. Bural G., Chamroonrat M., Houseni M., et al. Degree of FDG uptake and MDP uptake in femoral arteries: changes with age. J Nucl Med 47 (2006) 128
108. Lee S., Lee K., Lee E., et al. Evaluation of arterial FDG uptake and calcification in healthy subjects with serial FDG PET/CT. J Nucl Med 47 (2006) 127
109. McMillin J.B., Taffet G.E., Taegtmeyer H., et al. Mitochondrial metabolism and substrate competition in the aging Fischer rat heart. Cardiovasc Res 27 (1993) 2222-2228
110. Abu-Erreish G.M., Neely J.R., Whitmer J.T., et al. Fatty acid oxidation by isolated perfused working hearts of aged rats. Am J Physiol 232 (1977) E258-E262
111. Kates A.M., Herrero P., Dence C., et al. Impact of aging on substrate metabolism by the human heart. J Am Coll Cardiol 41 (2003) 293-299
112. Acikgoz G., Bural G., Houseni M., et al. Does intense myocardial uptake of fasting FDG-PET scan indicate cardiac disease?. J Nucl Med 47 (2006) 274
113. Kaneta T., Hakamatsuka T., Takanami K., et al. Evaluation of the relationship between physiological FDG uptake in the heart and age, blood glucose level, fasting period, and hospitalization. Ann Nucl Med 20 (2006) 203-208
114. de Groot M., Meeuwis A.P., Kok P.J., et al. Influence of blood glucose level, age and fasting period on non-pathological FDG uptake in heart and gut. Eur J Nucl Med Mol Imaging 32 (2005) 98-101
115. Patlak C.S., and Blasberg R.G. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations. J Cereb Blood Flow Metab 5 (1985) 584-590