Targeting of Apoptotic Macrophages and Experimental Atheroma with Radiolabeled Annexin V: A Technique with Potential for Noninvasive Imaging of Vulnerable Plaque

Circulation

Volumn 108, Issue 25, 2003, Pages 3134-3139

  Kolodgie, Frank D ^a   Petrov, Artiom ^b   Virmani, Renu ^a   Narula, Navneet ^c   Verjans, Johan W ^b   Weber, Deena K ^a   Hartung, Dagmar ^b   Steinmetz, Neil ^d   Vanderheyden, Jean Luc ^d   Vannan, Mani A ^b   Gold, Herman K ^e   Reutelingsperger, Chris P M ^f   Hofstra, Leo ^f   Narula, Jagat ^b,g  

^a ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^d Theseus Imaging Corporation   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f MAASTRICHT UNIVERSITY   (Netherlands)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Atherosclerosis; Imaging; Nuclear medicine

Indexed keywords

LIPOCORTIN 5; PHOSPHATIDYLSERINE; TECHNETIUM 99M;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERY ENDOTHELIUM; ARTICLE; ATHEROMA; ATHEROSCLEROTIC PLAQUE; AUTORADIOGRAPHY; BINDING AFFINITY; CHOLESTEROL DIET; CONTROLLED STUDY; DISEASE SEVERITY; DNA STRAND BREAKAGE; DRUG CLEARANCE; DRUG HALF LIFE; DRUG UPTAKE; EXPLANT; HISTOLOGY; IMAGING; ISOTOPE LABELING; MACROPHAGE; MALE; NONHUMAN; NUCLEAR MEDICINE; PRIORITY JOURNAL; RABBIT;

ANIMALS; ANNEXIN A5; APOPTOSIS; ARTERIOSCLEROSIS; BIOLOGICAL TRANSPORT; DNA FRAGMENTATION; MACROPHAGES; MALE; RABBITS; TECHNETIUM;

EID: 9144246344     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000105761.00573.50     Document Type: Article

References (21)

1. Virmani R, Kolodgie FD, Burke AP, et al. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20:1262-1275.
2. Bjorkerud S, Bjorkerud B. Apoptosis is abundant in human atherosclerotic lesions, especially in inflammatory cells (macrophages and T cells), and may contribute to the accumulation of gruel and plaque instability. Am J Pathol. 1996;149:367-380.
3. Geng YJ, Henderson LE, Levesque EB, et al. Fas is expressed in human atherosclerotic intima and promotes apoptosis of cytokine-primed human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 1997;17:2200-2208.
4. Kolodgie FD, Narula J, Burke AP, et al. Localization of apoptotic macrophages at the site of plaque rupture in sudden coronary death. Am J Pathol. 2000;157:1259-1268.
5. Fadok VA, Voelker DR, Campbell PA, et al. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol. 1992;148:2207-2216.
6. Dachary-Prigent J, Freyssinet JM, Pasquet JM, et al. Annexin V as a probe of aminophospholipid exposure and platelet membrane vesiculation: a flow cytometry study showing a role for free sulfhydryl groups. Blood. 1993;81:2554-2565.
7. Narula J, Hofstra L. Imaging myocardial necrosis and apoptosis. In: Dilsizian V, Narula J, eds. Atlas of Nuclear Cardiology. Philadelphia: Current Medicine; 2003:197-216.
8. Kockx MM, De Meyer GR, Buyssens N, et al. Cell composition, replication, and apoptosis in atherosclerotic plaques after 6 months of cholesterol withdrawal. Circ Res. 1998;83:378-387.
9. Baumgartener H. Eine neue Methode zur Erxeugung von Thromben durch geziette Uberdehnung der Gefasswand. Z Gesamte Exp Med. 1963;137:227-249.
10. Blankenberg FG, Katsikis PD, Tait JF, et al. In vivo detection and imaging of phosphatidylserine expression during programmed cell death. Proc Natl Acad Sci U S A. 1998;95:6349-6354.
11. Stary HC, Chandler AB, Glasgov S, et al. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis: a report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb. 1994;14:840-856.
12. Geng YJ, Wu Q, Muszynski M, et al. Apoptosis of vascular smooth muscle cells induced by in vitro stimulation with interferon-gamma, tumor necrosis factor-alpha, and interleukin-1 beta. Arterioscler Thromb Vasc Biol. 1996;16:19-27.
13. Bennett MR, Evan GI, Schwartz SM, et al. Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques. J Clin Invest. 1995;95:2266-2274.
14. Schaub FJ, Han DK, Liles WC, et al. Fas/FADD-mediated activation of a specific program of inflammatory gene expression in vascular smooth muscle cells. Nat Med. 2000;6:790-796.
15. Mallat Z, Benamer H, Hugel B, et al. Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation. 2000;101:841-843.
16. Fadok VA, de Cathelineau A, Daleke DL, et al. Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts. J Biol Chem. 2001;276:1071-1077.
17. Bratton DL, Fadok VA, Richter DA, et al. Appearance of phosphatidylserine on apoptotic cells requires calcium-mediated nonspecific flip-flop and is enhanced by loss of the aminophospholipid translocase. J Biol Chem. 1997;272:26159-26165.
18. Frasch SC, Henson PM, Kailey JM, et al. Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta. J Biol Chem. 2000;275:23065-23073.
19. Trotter PJ, Orchard MA, Walker JH. Ca2+ concentration during binding determines the manner in which annexin V binds to membranes. Biochem J. 1995;308:591-598.
20. Lupu F, Moldovan N, Ryan J, et al. Intrinsic procoagulant surface induced by hypercholesterolaemia on rabbit aortic endothelium. Blood Coagul Fibrinol. 1993;4:743-752.
21. Moldovan NI, Moldovan L, Simionescu N. Binding of vascular anticoagulant alpha (annexin V) to the aortic intima of the hypercholesterolemic rabbit: an autoradiographic study. Blood Coagul Fibrinolysis. 1994;5:921-928.