Functional profile of activated dendritic cells in unstable atherosclerotic plaque

Basic Research in Cardiology

Volumn 102, Issue 2, 2007, Pages 123-132

  Erbel, Christian ^a   Sato, Kayoko ^b   Meyer, Frederic B ^c   Kopecky, Stephen L ^c   Frye, Robert L ^c   Goronzy, Jörg J ^b   Weyand, Cornelia M ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MAYO CLINIC   (United States)

Author keywords

Atherosclerosis; Dendritic cell; Inflammation; T cell

Indexed keywords

CD40 LIGAND; CD83 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; SECONDARY LYMPHOID TISSUE CHEMOKINE; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN PRESENTING CELL; ARTICLE; ATHEROSCLEROTIC PLAQUE; CAROTID ARTERY; CELL FUNCTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORONARY ARTERY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DENDRITIC CELL; ENDARTERECTOMY; HEART INFARCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS; T LYMPHOCYTE ACTIVATION;

ATHEROSCLEROSIS; CAROTID ARTERIES; CAROTID STENOSIS; CORONARY VESSELS; CYTOKINES; DENDRITIC CELLS; HUMANS; T-LYMPHOCYTES;

EID: 33846677469     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00395-006-0636-x     Document Type: Article

References (42)

1. Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392:245-252
2. Barger AC, Beeuwkes R, Lainey LL, Silverman KJ (1984) Hypothesis: Vasa vasorum and neovascularisation of human coronary arteries: A possible role in the pathophysiology of atherosclerosis. N Engl J Med 310:175-177
3. Binder CJ, Chang MK, Shaw PX, Miller YI, Hartvigsen K, Dewan A et al. (2002) Innate and acquired immunity in atherogenesis. Nat Med 8:1218-1226
4. Bobryshev YV, Lord RS (1998) Mapping of vascular dendritic cells in atherosclerotic arteries suggests their involvement in local immune-inflammatory reactions. Cardiovasc Res 37:799-810
5. Bobryshev YV, Lord RS, Parsson H (1998) Immunophenotypic analysis of the aortic aneurysm wall suggests that vascular dendritic cells are involved in immune responses. Cardiovasc Surg 6:240-249
6. Bobryshev YV, Lord RS, Rainer S, Jamal OS, Munro VF (1996) Vascular dendritic cells and atherosclerosis. Pathol Res Pract 192:462-467
7. Bobryshev YV, Lord RS (2002) Expression of heat shock protein-70 by dendritic cells in the arterial intima and its potential significance in atherogenesis. J Vasc Surg 35:368-375
8. Buono C, Lichtman AH (2004) Co-stimulation and plaque antigen-specific T cell responses in atherosclerosis. Trends Cardiovasc Med 14:166-172
9. Buono C, Pang H, Uchida Y, Libby P, Sharpe AH, Lichtman AH (2004) B7-1/ B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low-density lipoprotein receptor-deficient mice. Circulation 109:2009-2015
10. Cheng GC, Loree HM, Kamm RD, Fishbein MC, Lee RT (1993) Distribution of circumferential stress in ruptured and stable atherosclerotic lesions. Circulation 87:1179-1187
11. Davies MJ, Thomas AC (1985) Plaque fissuring: The cause of acute myocardial infarction, sudden ischemic death, and crescendo angina. Br Heart J 53:363-373
12. Davies MJ (1990) A macro and microview of coronary vascular insult in ischemic heart disease. Circulation 82:38-46
13. Davies MJ, Richardson PD, Woolf N, Katz DR, Mann J (1993) Risk of thrombosis in human atherosclerotic plaques: Role of extracellular lipid, macrophage, and smooth muscle cell content. Br Heart J 69:377-381
14. Edfeldt K, Swedenborg J, Hansson GK, Yan ZQ (2002) Expression of Toll-like receptors in human atherosclerotic lesions: A possible pathway for plaque activation. Circulation 105:1158-1161
15. Falk E (1985) Unstable angina with fatal outcome: Dynamic coronary thrombosis leading to infarction and/or sudden death: Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion. Circulation 71:699-708
16. Forster R, Schubel A, Breitfeld D, Kremmer E, Renner-Muller I, Wolf E et al. (1999) CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99:23-33
17. Frostegård J, Ulfgren AK, Nyberg P,Hedin U, Swedenborg J, Andersson U et al. (1999) Cytokine expression in advanced human atherosclerotic plaques: Dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines. Atherosclerosis 145:33-43
18. Fujii S, Liu K, Smith C, Bonito AJ, SteinmanRM (2004) The Linkage of Innate to Adaptive Immunity via Maturing Dendritic Cells in Vivo - Requires CD40 Ligation in Addition to Antigen Presentation and CD80/86 Costimulation. J Exp Med 199:1607-1618
19. Fuster V, Badimon I, Badimon JJ, Chesebro JH (1992) The pathogenesis of coronary artery disease and the acute coronary syndromes. N Engl J Med 326:242-250
20. Hansson GK, Libby P (1996) The role of the lymphocyte. In: Fuster V, Ross R, Topol EJ (eds) Atherosclerosis and coronary artery disease. Vol. 1. Philadelphia:LIppincott-Raven, pp 557-568
21. Jonasson L, Holm J, Skalli O, Gabbiani G, Hansson GK (1985) Expression of class II transplantation antigen on vascular smooth muscle cells in human atherosclerosis. J Clin Invest 76:125-131
22. Kang YM, Zhang X, Wagner UG, Yang H, Beckenbaugh RD, Kurtin PJ et al. (2002) CD8 T cells are required for the formation of ectopic germinal centers in rheumatoid synovitis. J Exp Med 195:1325-1336
23. Krupa WM, Jeon MS, Spoerl S, Tedder TF, Goronzy JJ, Weyand CM (2004) Activation of Arterial Wall Dendritic Cells and Breakdown of Self-tolerance in Giant Cell Arteritis. J Exp Med 199:173-183
24. Lanzavecchia A (1996) Mechanisms of antigen uptake for presentation. Curr Opin Immunol 8:348-354
25. Libby P, Lee RTL (1995) Role of activated macrophages and T lymphocytes in rupture of coronary plaques. In: Braunwald E (ed) Heart Disease: A Textbook of Cardiovascular Medicine Philadelphia, Pa: Saunders WB, pp 191-195
26. Libby P, Hansson GK, Pober JS (1999) Atherogenesis and inflammation. In: Chien KR (ed) Molecular Basis of Cardiovascular Disease. Philadelphia: Saunders WB, pp 349-366
27. Liuzzo G, Kopecky SL, Frye RL, O'Fallon WM, Goronzy JJ, Weyand CM et al. (1999) Perturbation of the T-cell repertoire in patients with unstable angina. Circulation Nov 23; 100:2135-2139
28. Lutgens E, Gorelik L, Daemen MJAP, deMuinck ED, Grewal IS, Kotelianski VE et al. (1999) Requirement for CD154 in the progression of atherosclerosis. Nat Med 5:1313-1316
29. Lutgens E, Cleutjens KBJM, Heeneman S, Koteliansky VE, Burkly LC, Daemen MJAP (2000) Both early and delayed anti-CD40L antibody treatment induces a stable plaque phenotype. Proc Natl Acad Sci USA 97:7464-7469
30. Ma-Krupa W, Jeon MS, Spoerl S, Tedder TF, Goronzy JJ, Weyand CM (2004) Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis. J Exp Med 199:173-183
31. Ma-Krupa W, Dewan M, Jeon MS, Kurtin PJ, Younge BR, Goronzy JJ et al. (2002) Trapping of Misdirected Dendritic Cells in the Granulomatous Lesions of Giant Cell Arteritis. Am J Pathol 161:1815-1823
32. Nakajima T, Goek O, Zhang X, Kopecky SL, Frye RL, Goronzy JJ et al. (2003) Denovo expression of killer immunoglobulin-like receptors and signaling proteins regulates the cytotoxic function of CD4 T cells in acute coronary syndromes. Circ Res 25; 93:106-113
33. Perrin-Cocon L, Coutant F, Agaugueŕ S, Deforges S, André P, Lotteau V (2001) Oxidized Low-Density Lipoprotein Promotes Mature Dendritic Cell Transition from Differentiating Monocyte. J Immunol 167:3785-3791
34. Raines EW, Rosenfeld ME, Ross R(1996) The role of macrophages. In: Fuster V, Ross R, Topol EJ (eds) Atherosclerosis and coronary artery disease. Vol 1. Philadelphia: Lippincott-Raven, pp 539-555
35. Randolph DA, Huang G, Carruthers C, Bromley LE, Chaplin DA (1999) The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo. Science 286:2159-2162
36. Ross R (1999) Atherosclerosis - an inflammatory disease. N Engl J Med Jan 14, 340:115-126
37. Rossi D, Zlotnik A (2000) The biology of chemokines and their receptors Annu Rev Immunol 18:217-242
38. Summers KL, Hock BD, McKenzie JL, Hart DNJ (2001) Phenotypic Characterization of Five Dendritic Cell Subsets in Human Tonsils. Am J Pathol 159:285-295
39. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM (2000) Lessons from sudden coronary death: A comprehensive morphological classification scheme for atherosclerotic lesions. Arteroscler Thromb Vasc Biol 20:1262-1275
40. Weyand, CM, Kurtin PJ, Goronzy JJ(2001) Ectopic lymphoid organogenesis: A fast track for autoimmunity. Am J Pathol 159:787-793
41. Yilmaz A, Lochno M, Traeg F, Cicha I, Reiss C, Stumpf C et al. (2004) Emergence of dendritic cells in rupture proneregions of vulnerable carotid plaques. Atherosclerosis Sep 176:101-110
42. Zernecke A, Weber C (2005) Inflammatory mediators in atherosclerotic vascular disease. Basic Res Cardiol 100:93-101