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1
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15544362925
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The gut and energy balance: Visceral allies in the obesity wars
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Badman MK, Flier JS. The gut and energy balance: visceral allies in the obesity wars. Science 2005; 307:1909-1914.
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(2005)
Science
, vol.307
, pp. 1909-1914
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Badman, M.K.1
Flier, J.S.2
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2
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0034713266
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Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
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Borovikova LV, Ivanova S, Zhang M, et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000; 405:458-462.
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(2000)
Nature
, vol.405
, pp. 458-462
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Borovikova, L.V.1
Ivanova, S.2
Zhang, M.3
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3
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12344278981
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Sedan O, Sprecher E, Yarnitsky D. Vagal stomach afferents inhibit somatic pain perception. Pain 2005; 113:354-359. This study used gastric distension (rapid drinking) in healthy volunteers to assess the role of gastric vagal afferent activation in heat and mechanical evoked pain perception in human volunteers. They conclude that vagal stomach afferents exert an inhibitory effect on somatic pain perception in humans.
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Sedan O, Sprecher E, Yarnitsky D. Vagal stomach afferents inhibit somatic pain perception. Pain 2005; 113:354-359. This study used gastric distension (rapid drinking) in healthy volunteers to assess the role of gastric vagal afferent activation in heat and mechanical evoked pain perception in human volunteers. They conclude that vagal stomach afferents exert an inhibitory effect on somatic pain perception in humans.
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4
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0041377009
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Interoception: The sense of the physiological condition of the body
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Craig AD. Interoception: the sense of the physiological condition of the body. Curr Opin Neurobiol 2003; 13:500-505.
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(2003)
Curr Opin Neurobiol
, vol.13
, pp. 500-505
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Craig, A.D.1
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5
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29244471304
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Apolipoprotein A-IV is involved in detection of lipid in the rat intestine
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Investigates the role of chylomicron formation in nutrient signalling from the small intestine using apolipoprotein A-IV knockout mice
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Whited KL, Lu D, Tso P, et al. Apolipoprotein A-IV is involved in detection of lipid in the rat intestine. J Physiol 2005; 569:949-958. Investigates the role of chylomicron formation in nutrient signalling from the small intestine using apolipoprotein A-IV knockout mice.
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(2005)
J Physiol
, vol.569
, pp. 949-958
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Whited, K.L.1
Lu, D.2
Tso, P.3
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6
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33745764827
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Whited KL, Thao D, Lloyd KC, et al. Targeted disruption of the murine CCK1 receptor gene reduces intestinal lipid-induced feedback inhibition of gastric function. Am J Physiol Gastrointest Liver Physiol 2006; 291:G156-G162. Despite a relatively normal phenotype the CCK-1R knockout mouse has impaired intestinal feedback in response to lipid and attenuated vagal input to the CNS.
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Whited KL, Thao D, Lloyd KC, et al. Targeted disruption of the murine CCK1 receptor gene reduces intestinal lipid-induced feedback inhibition of gastric function. Am J Physiol Gastrointest Liver Physiol 2006; 291:G156-G162. Despite a relatively normal phenotype the CCK-1R knockout mouse has impaired intestinal feedback in response to lipid and attenuated vagal input to the CNS.
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7
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33845336134
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Integrative capacity of the caudal brainstem in the control of food intake
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Schwartz GJ. Integrative capacity of the caudal brainstem in the control of food intake. Phil Trans R Soc Lond B 2006; 361:1275-1280.
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(2006)
Phil Trans R Soc Lond B
, vol.361
, pp. 1275-1280
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Schwartz, G.J.1
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8
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17044427583
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Proopiomelanocortin neurons in nucleus tractus solitarius are activated by visceral afferents: Regulation by cholecystokinin and opioids
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Paper demonstrating that proopiomelanocortin neurons in the nucleus tractus solitarius integrate information from the gastrointestinal tract with central pathways involved in energy homeostasis
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Appleyard SM, Bailey TW, Doyle MW, et al. Proopiomelanocortin neurons in nucleus tractus solitarius are activated by visceral afferents: regulation by cholecystokinin and opioids. J Neurosci 2005; 25:3578-3585. Paper demonstrating that proopiomelanocortin neurons in the nucleus tractus solitarius integrate information from the gastrointestinal tract with central pathways involved in energy homeostasis.
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(2005)
J Neurosci
, vol.25
, pp. 3578-3585
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Appleyard, S.M.1
Bailey, T.W.2
Doyle, M.W.3
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9
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31144437269
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Feeding-dependent depression of melanin-concentrating hormone and melanin-concentrating hormone receptor-1 expression in vagal afferent neurones
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Receptor expression on vagal sensory neurones is regulated by nutrient availability and serves to integrate orexogenic and anorectic signals that potentially contribute to the adaptive response to food deprivation
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Burdyga G, Varro A, Dimaline R, et al. Feeding-dependent depression of melanin-concentrating hormone and melanin-concentrating hormone receptor-1 expression in vagal afferent neurones. Neuroscience 2006; 137:1405-1415. Receptor expression on vagal sensory neurones is regulated by nutrient availability and serves to integrate orexogenic and anorectic signals that potentially contribute to the adaptive response to food deprivation.
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(2006)
Neuroscience
, vol.137
, pp. 1405-1415
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Burdyga, G.1
Varro, A.2
Dimaline, R.3
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10
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27744600963
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Zhang JV, Ren Avsian-Kretchmer O, et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 2005; 310:996-999. Two peptide hormones with opposing action in weight regulation (ghrelin and obestatin) are derived from the same proghrelin gene.
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Zhang JV, Ren PG, Avsian-Kretchmer O, et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 2005; 310:996-999. Two peptide hormones with opposing action in weight regulation (ghrelin and obestatin) are derived from the same proghrelin gene.
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11
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33751019166
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Lack of interaction between peripheral injection of CCK and obestatin in the regulation of gastric satiety signalling in rodents
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In this study obestatin was not found to influence cumulative food intake, gastric motility or vagal afferent activity and had no effect on cholecystokinin-induced satiety signalling
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Gourcerol G, Million M, Adelson DW, et al. Lack of interaction between peripheral injection of CCK and obestatin in the regulation of gastric satiety signalling in rodents. Peptides 2006; 27:2811-2819. In this study obestatin was not found to influence cumulative food intake, gastric motility or vagal afferent activity and had no effect on cholecystokinin-induced satiety signalling.
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(2006)
Peptides
, vol.27
, pp. 2811-2819
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Gourcerol, G.1
Million, M.2
Adelson, D.W.3
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12
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26844436564
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Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve
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The role for cholecystokinin in food intake regulation is well described. This study links nutritional control with neuroimmunologic pathways that contribute to protective mechanisms against dietary antigen and commensal bacteria
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Luyer MD, Greve JW, Hadfoune M, et al. Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve. J Exp Med 2005; 202:1023-1029. The role for cholecystokinin in food intake regulation is well described. This study links nutritional control with neuroimmunologic pathways that contribute to protective mechanisms against dietary antigen and commensal bacteria.
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(2005)
J Exp Med
, vol.202
, pp. 1023-1029
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Luyer, M.D.1
Greve, J.W.2
Hadfoune, M.3
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13
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33645765281
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Molecular profiling of murine sensory neurons in the nodose and dorsal root ganglia labeled from the peritoneal cavity
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Genome-wide expression profile of sensory neurones supplying the gastrointestinal tract. Describes molecular signatures that underlie functional similarities and differences between nodose and dorsal root ganglia
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Peeters PJ, Aerssens J, de Hoogt R, et al. Molecular profiling of murine sensory neurons in the nodose and dorsal root ganglia labeled from the peritoneal cavity. Physiol Genomics 2006; 24:252-263. Genome-wide expression profile of sensory neurones supplying the gastrointestinal tract. Describes molecular signatures that underlie functional similarities and differences between nodose and dorsal root ganglia.
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(2006)
Physiol Genomics
, vol.24
, pp. 252-263
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Peeters, P.J.1
Aerssens, J.2
de Hoogt, R.3
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14
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29744470942
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Inhibition of mechanosensitivity in visceral primary afferents by GABAB receptors involves calcium and potassium channels
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Demonstrates the differential role of N-type calcium channels and G-protein coupled inward rectifier potassium channels in inhibition of vagal mucosal and muscle mechanosensitivity by GABA-B receptor activation with baclofen
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Page AJ, O'Donnell TA, Blackshaw LA. Inhibition of mechanosensitivity in visceral primary afferents by GABAB receptors involves calcium and potassium channels. Neuroscience 2006; 137:627-636. Demonstrates the differential role of N-type calcium channels and G-protein coupled inward rectifier potassium channels in inhibition of vagal mucosal and muscle mechanosensitivity by GABA-B receptor activation with baclofen.
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(2006)
Neuroscience
, vol.137
, pp. 627-636
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Page, A.J.1
O'Donnell, T.A.2
Blackshaw, L.A.3
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15
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33744952921
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Wedel T, Van Eys GJ, Waltregny D, et al. Novel smooth muscle markers reveal abnormalities of the intestinal musculature in severe colorectal motility disorders. Neurogastroenterol Motil 2006; 18:526-538. This study has two important conclusions: first, altered expression of smooth muscle markers reveal novel pathologies of myogenic gut disorders and, second, identification of such alterations required histopathology in full thickness biopsies.
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Wedel T, Van Eys GJ, Waltregny D, et al. Novel smooth muscle markers reveal abnormalities of the intestinal musculature in severe colorectal motility disorders. Neurogastroenterol Motil 2006; 18:526-538. This study has two important conclusions: first, altered expression of smooth muscle markers reveal novel pathologies of myogenic gut disorders and, second, identification of such alterations required histopathology in full thickness biopsies.
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27744543634
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Niessen P, Rensen S, van Deursen J, et al. Smoothelin-a is essential for functional intestinal smooth muscle contractility in mice. Gastroenterology 2005; 129:1592-1601. Impaired intestinal transit in smoothelin-A/B knockout mice caused obstruction, starvation, and, ultimately, premature death. The pathology of mice lacking smoothelin-A is reminiscent of that seen in patients with chronic intestinal pseudo-obstruction.
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Niessen P, Rensen S, van Deursen J, et al. Smoothelin-a is essential for functional intestinal smooth muscle contractility in mice. Gastroenterology 2005; 129:1592-1601. Impaired intestinal transit in smoothelin-A/B knockout mice caused obstruction, starvation, and, ultimately, premature death. The pathology of mice lacking smoothelin-A is reminiscent of that seen in patients with chronic intestinal pseudo-obstruction.
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17
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33646377142
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The value of myenteric plexitis to predict early postoperative Crohn's disease recurrence
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This paper scored presence and degree of myenteric plexitis at the time of surgery to find that the presence of myenteric plexitis in proximal margins of ileocolonic resection specimens is predictive of early endoscopic Crohn's disease recurrence
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Ferrante M, de Hertogh G, Hlavaty T, et al. The value of myenteric plexitis to predict early postoperative Crohn's disease recurrence. Gastroenterology 2006; 130:1595-1606. This paper scored presence and degree of myenteric plexitis at the time of surgery to find that the presence of myenteric plexitis in proximal margins of ileocolonic resection specimens is predictive of early endoscopic Crohn's disease recurrence.
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(2006)
Gastroenterology
, vol.130
, pp. 1595-1606
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Ferrante, M.1
de Hertogh, G.2
Hlavaty, T.3
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18
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33745920516
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The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver
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This review highlights future research topics related to hydrogen sulphide mediated gut functions
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Fiorucci S, Distrutti E, Cirino G, Wallace JL. The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver. Gastroenterology 2006; 131:259-271. This review highlights future research topics related to hydrogen sulphide mediated gut functions.
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(2006)
Gastroenterology
, vol.131
, pp. 259-271
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Fiorucci, S.1
Distrutti, E.2
Cirino, G.3
Wallace, J.L.4
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19
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0036845556
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2S be the third endogenous gaseous transmitter?
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2S be the third endogenous gaseous transmitter? FASEB J 2002; 16:1792-1798.
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(2002)
FASEB J
, vol.16
, pp. 1792-1798
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Wang, R.1
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21
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0029876402
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The possible role of hydrogen sulfide as an endogenous neuromodulator
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Abe K, Kimura H. The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci 1996; 16:1066-1071.
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(1996)
J Neurosci
, vol.16
, pp. 1066-1071
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Abe, K.1
Kimura, H.2
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22
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33750731999
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Hydrogen sulfide is a novel pro-secretory neuromodulator in the guinea-pig and human colon
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This paper reports on the presence of hydrogen sulphide generating enzymes in the human enteric nervous system and describes hydrogen sulphide as a neuromodulator increasing chloride secretion via activation of extrinsic afferents
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Schicho R, Krueger D, Zeller F, et al. Hydrogen sulfide is a novel pro-secretory neuromodulator in the guinea-pig and human colon. Gastroenterology 2006; 131:1542-1552. This paper reports on the presence of hydrogen sulphide generating enzymes in the human enteric nervous system and describes hydrogen sulphide as a neuromodulator increasing chloride secretion via activation of extrinsic afferents.
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(2006)
Gastroenterology
, vol.131
, pp. 1542-1552
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Schicho, R.1
Krueger, D.2
Zeller, F.3
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23
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4644290608
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Diet and relapsing ulcerative colitis: Take off the meat?
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Tilg H, Kaser A. Diet and relapsing ulcerative colitis: take off the meat? Gut 2004; 53:1399-1401.
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(2004)
Gut
, vol.53
, pp. 1399-1401
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Tilg, H.1
Kaser, A.2
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24
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4644295599
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Influence of dietary factors on the clinical course of ulcerative colitis: A prospective cohort study
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Jowett SL, Seal CJ, Pearce MS, et al. Influence of dietary factors on the clinical course of ulcerative colitis: a prospective cohort study. Gut 2004; 53:1479-1484.
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(2004)
Gut
, vol.53
, pp. 1479-1484
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Jowett, S.L.1
Seal, C.J.2
Pearce, M.S.3
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25
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33846666860
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Grider JR, Piland BE. The peristaltic reflex induced by short chain fatty acids is mediated by sequential release of 5-HT and neuronal CGRP but not BDNF. Am J Physiol Gastrointest Liver Physiol 2006; 14 September [Epub ahead of print]. A thorough study on short-chain fatty acids evoked neurally mediated muscle reflexes. The study also showed the involvement of 5-HT4 receptors and the potentiation of mucosally evoked muscle reflexes by short-chain fatty acids.
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Grider JR, Piland BE. The peristaltic reflex induced by short chain fatty acids is mediated by sequential release of 5-HT and neuronal CGRP but not BDNF. Am J Physiol Gastrointest Liver Physiol 2006; 14 September [Epub ahead of print]. A thorough study on short-chain fatty acids evoked neurally mediated muscle reflexes. The study also showed the involvement of 5-HT4 receptors and the potentiation of mucosally evoked muscle reflexes by short-chain fatty acids.
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26
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33646376658
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Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine
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Karaki S, Mitsui R, Hayashi H, et al. Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine. Cell Tissue Res 2006; 324:353-360.
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(2006)
Cell Tissue Res
, vol.324
, pp. 353-360
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Karaki, S.1
Mitsui, R.2
Hayashi, H.3
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33646260927
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Aube AC, Cabarrocas J, Bauer J, et al. Changes in enteric neurone phenotype and intestinal functions in a transgenic mouse model of enteric glia disruption. Gut 2006; 55:630-637. The authors used transgenic mice expressing haemagglutinin in glia. Glia disruption was induced by injection of activated haemagglutinin-specific CD8+ T cells. One of the first studies demonstrating that impairment of glia resulted in alteration of neuronal phenotypes.
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Aube AC, Cabarrocas J, Bauer J, et al. Changes in enteric neurone phenotype and intestinal functions in a transgenic mouse model of enteric glia disruption. Gut 2006; 55:630-637. The authors used transgenic mice expressing haemagglutinin in glia. Glia disruption was induced by injection of activated haemagglutinin-specific CD8+ T cells. One of the first studies demonstrating that impairment of glia resulted in alteration of neuronal phenotypes.
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33749440834
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Enteric glia inhibits intestinal epithelial cell proliferation partly through a TGF-beta1-dependent pathway
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Gastrointest Liver Physiol, 19 January [Epub ahead of print
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Neunlist M, Aubert P, Bonnaud S, et al. Enteric glia inhibits intestinal epithelial cell proliferation partly through a TGF-beta1-dependent pathway. Am J Physiol Gastrointest Liver Physiol 2006; 19 January [Epub ahead of print].
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(2006)
Am J Physiol
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Neunlist, M.1
Aubert, P.2
Bonnaud, S.3
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29
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33751119918
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The role of enteric glia in intestinal physiology: The effects of the gliotoxin fluorocitrate on motor and secretory function
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Nasser Y, Fernandez E, Keenan CM, et al. The role of enteric glia in intestinal physiology: the effects of the gliotoxin fluorocitrate on motor and secretory function. Am J Physiol Gastrointest Liver Physiol 2006; 291:G912-G927.
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(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.291
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Nasser, Y.1
Fernandez, E.2
Keenan, C.M.3
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30
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33646255429
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Localization of aquaporin-1 water channel in glial cells of the human peripheral nervous system
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Gao H, He C, Fang X, et al. Localization of aquaporin-1 water channel in glial cells of the human peripheral nervous system. Glia 2006; 53:783-787.
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(2006)
Glia
, vol.53
, pp. 783-787
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Gao, H.1
He, C.2
Fang, X.3
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31
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23244448397
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Functional expression of the peptide transporter PEPT2 in the mammalian enteric nervous system
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Ruhl A, Hoppe S, Frey I, et al. Functional expression of the peptide transporter PEPT2 in the mammalian enteric nervous system. J Comp Neurol 2005; 490:1-11.
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(2005)
J Comp Neurol
, vol.490
, pp. 1-11
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Ruhl, A.1
Hoppe, S.2
Frey, I.3
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32
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33644935020
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Distribution of adrenergic receptors in the enteric nervous system of the guinea pig, mouse, and rat
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Nasser Y, Ho W, Sharkey KA. Distribution of adrenergic receptors in the enteric nervous system of the guinea pig, mouse, and rat. J Comp Neurol 2006; 495:529-553.
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(2006)
J Comp Neurol
, vol.495
, pp. 529-553
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Nasser, Y.1
Ho, W.2
Sharkey, K.A.3
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Sander LE, Lorentz A, Sellge G, et al. Selective expression of histamine receptors H1R, H2R, and H4R, but not H3R, in the human intestinal tract. Gut 2006; 55:498-504. This is the first comprehensive evaluation of histamine receptor expression in the human gut. The study points to important species-dependent expression and localization of particularly the histamine 3 receptor. It also reports preliminary data showing that the expression profile of histamine receptors is changed in patients with food allergy and irritable bowel syndrome.
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Sander LE, Lorentz A, Sellge G, et al. Selective expression of histamine receptors H1R, H2R, and H4R, but not H3R, in the human intestinal tract. Gut 2006; 55:498-504. This is the first comprehensive evaluation of histamine receptor expression in the human gut. The study points to important species-dependent expression and localization of particularly the histamine 3 receptor. It also reports preliminary data showing that the expression profile of histamine receptors is changed in patients with food allergy and irritable bowel syndrome.
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33746101483
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Constitutive expression of cyclooxygenase-2 in the neuromuscular compartment of normal human colon
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Bernardini N, Colucci R, Mattii L, et al. Constitutive expression of cyclooxygenase-2 in the neuromuscular compartment of normal human colon. Neurogastroenterol Motil 2006; 18:654-662.
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(2006)
Neurogastroenterol Motil
, vol.18
, pp. 654-662
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Bernardini, N.1
Colucci, R.2
Mattii, L.3
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